Accuracy of indocyanine green pulse spectrophotometry clearance test for liver function prediction in transplanted patients

doi:10.3748/wjg.v10.i16.2394

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Aug 15, 2004 (publication date) through Apr 29, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Aug 15, 2004; 10(16): 2394-2396
Published online Aug 15, 2004. doi: 10.3748/wjg.v10.i16.2394

Accuracy of indocyanine green pulse spectrophotometry clearance test for liver function prediction in transplanted patients

Chung-Bao Hsieh, Chung-Jueng Chen, Teng-Wei Chen, Jyh-Cherng Yu, Kuo-Liang Shen, Tzu-Ming Chang, Yao-Chi Liu

Chung-Bao Hsieh, Chung-Jueng Chen, Teng-Wei Chen, Jyh-Cherng Yu, Kuo-Liang Shen, Yao-Chi Liu, Division of General Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, China

Tzu-Ming Chang, Department of Surgery, Tungs’ Taichung Metroharbor Hospital, Taichung, Taiwan, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Chung-Bao Hsieh, 325, sec 2, Cheng-Kung Rd, Taipei, Taiwan, China. albert0920@yahoo.com.tw

Telephone: +886-2-87927191 Fax: +866-2-87927372

Received: November 12, 2003
Revised: November 21, 2003
Accepted: December 16, 2003
Published online: August 15, 2004

Abstract

AIM: To investigate whether the non-invasive real-time Indocynine green (ICG) clearance is a sensitive index of liver viability in patients before, during, and after liver transplantation.

METHODS: Thirteen patients were studied, two before, three during, and eight following liver transplantation, with two patients suffering acute rejection. The conventional invasive ICG clearance test and ICG pulse spectrophotometry non-invasive real-time ICG clearance test were performed simultaneously. Using linear regression analysis we tested the correlation between these two methods. The transplantation condition of these patients and serum total bilirubin (T. Bil), alanine aminotransferase (ALT), and platelet count were also evaluated.

RESULTS: The correlation between these two methods was excellent (r² = 0.977).

CONCLUSION: ICG pulse spectrophotometry clearance is a quick, non-invasive, and reliable liver function test in transplantation patients.

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