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©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 1, 2004; 10(13): 1857-1861
Published online Jul 1, 2004. doi: 10.3748/wjg.v10.i13.1857
Published online Jul 1, 2004. doi: 10.3748/wjg.v10.i13.1857
Cytomegalovirus and chronic allograft rejection in liver transplantation
Liang-Hui Gao, Shu-Sen Zheng, Department of Hapatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 30170899
Correspondence to: Liang-Hui Gao, PO Box 4193, Hubin Campus, 353 Yan’an Road, Hangzhou 310031, Zhejiang Province, China. gaolh@zju.edu.cn
Telephone: +86-571-87230531 Fax: +86-571-87072577
Received: February 20, 2004
Revised: March 5, 2004
Accepted: March 12, 2004
Published online: July 1, 2004
Revised: March 5, 2004
Accepted: March 12, 2004
Published online: July 1, 2004
Abstract
Cytomegalovirus (CMV) remains one of the most frequent viral infections and the most common cause of death after liver transplantation (LT). Chronic allograft liver rejection remains the major obstacle to long-term allograft survival and CMV infection is one of the suggested risk factors for chronic allograft rejection. The precise relationship between cytomegalovirus and chronic rejection remains uncertain. This review addresses the morbidity of cytomegalovirus infection and the risk factors associated with it, the relationship between cytomegalovirus and chronic allograft liver rejection and the potential mechanisms of it.
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