Zhang QX, Ding Y, Li Z, Le XP, Zhang W, Sun L, Shi HR. Comparison of nuclear matrix proteins between gastric cancer and normal gastric tissue. World J Gastroenterol 2004; 10(12): 1819-1821 [PMID: 15188514 DOI: 10.3748/wjg.v10.i12.1819]
Corresponding Author of This Article
Professor. Qin-Xian Zhang, Molecular Cell Biology Research Center, Medical College of Zhengzhou University, 40 Daxue Lu, Zhengzhou 450052, Henan Province, China. qxz53@zzu.edu.cn
Article-Type of This Article
Brief Reports
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World J Gastroenterol. Jun 15, 2004; 10(12): 1819-1821 Published online Jun 15, 2004. doi: 10.3748/wjg.v10.i12.1819
Comparison of nuclear matrix proteins between gastric cancer and normal gastric tissue
Qin-Xian Zhang, Yi Ding, Zhuo Li, Xiao-Ping Le, Wei Zhang, Ling Sun, Hui-Rong Shi
Qin-Xian Zhang, Yi Ding, Xiao-Ping Le, Wei Zhang, Molecular Cell Biology Research Center, Medical College of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Zhuo Li, Ling Sun, Hui-Rong Shi, Henan Key Laboratory of Molecular Medicine, Zhengzhou 450052, Henan Province, China
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No. 39170440
Correspondence to: Professor. Qin-Xian Zhang, Molecular Cell Biology Research Center, Medical College of Zhengzhou University, 40 Daxue Lu, Zhengzhou 450052, Henan Province, China. qxz53@zzu.edu.cn
Telephone: +86-371-6977002
Received: August 5, 2003 Revised: October 15, 2003 Accepted: October 22, 2003 Published online: June 15, 2004
Abstract
AIM: To study the alteration of nuclear matrix proteins (NMPs) in gastric cancer.
METHODS: The NMPs extracted from 22 cases of gastric cancer and normal gastric tissues were investigated by SDS-PAGE technique and the data were analyzed using Genetools analysis software.
RESULTS: Compared with normal gastric tissue, the expression of 30 ku and 28 ku NMPs in gastric cancer decreased significantly (P = 0.002, P = 0.001, P < 0.05). No significant difference was found in the expression of the two NMPs between the various differentiated grades (P = 0.947, P = 0.356) and clinical stages of gastric cancer (P = 0.920, P = 0.243, P > 0.05).
CONCLUSION: The results suggested that the alteration of NMPs in gastric cancer occurred at the early stage of gastric cancer development.
