Brief Reports
Copyright ©The Author(s) 2004. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 1, 2004; 10(11): 1672-1674
Published online Jun 1, 2004. doi: 10.3748/wjg.v10.i11.1672
Effects of mu and kappa opioid receptor agonists and antagonists on contraction of isolated colon strips of rats with cathartic colon
Bao-Hua Liu, Ping Mo, Sheng-Ben Zhang
Bao-Hua Liu, Ping Mo, Sheng-Ben Zhang, Department of General Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Bao-Hua Liu, Department of General Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China. lbh57268@163.com
Telephone: +86-23-68757248
Received: July 12, 2003
Revised: August 4, 2003
Accepted: August 18, 2003
Published online: June 1, 2004
Abstract

AIM: To study the effects of mu and kappa opioid receptor agonists and antagonists on the isolated colon strips of rats with cathartic colon.

METHODS: Cathartic colon model was established by feeding rats with contact laxatives, and effects of mu and kappa opioid receptor agonists and antagonists on electricity-stimulated contraction of isolated colon strips of rats with cathartic colon were observed.

RESULTS: Compared with control group, exogenous mu and kappa agonists inhibited significantly electricity-stimulated contraction of strips of cathartic colon (8.50 ± 0.89 mm, 6.24 ± 0.91 mm, 3.35 ± 0.6 mm vs 11.40 ± 0.21 mm P < 0.01; 8.98 ± 0.69 mm, 6.89 ± 0.71 mm, 4.43 ± 0.99 mm vs 11.40 ± 0.21 mm, P < 0.01). In contrast, the exogenous mu antagonist significantly enhanced electricity-stimulated contraction of isolated colon strips (13.18 ± 0.93 mm, 15.87 ± 0.98 mm, 19.46 ± 1.79 mm vs 11.40 ± 0.21 mm, P < 0.01), but kappa antagonist had no effect on the isolated colon strips of rats with cathartic colon.

CONCLUSION: Mu and kappa opioid receptors are involved in the regulation of colon motility of rats with cathartic colon.

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