Influence of Helicobacter pylori on the gastric mucosal barrier

doi:10.3748/wjg.v1.i1.41

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Articles

World J Gastroenterol. Oct 1, 1995; 1(1): 41-42
Published online Oct 1, 1995. doi: 10.3748/wjg.v1.i1.41

Influence of Helicobacter pylori on the gastric mucosal barrier

Cai-Pu Xu, Xian-Yong Gui, Wei-Wen Liu, Zhen-Hua Wang, Shao-Wu Pan

Cai-Pu Xu, Department of Gastroenterology, Southwest Hospital, 3^rd Military Medical University, Chongqing 630038, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Cai-Pu Xu, professor, Department of Gastroenterology, Southwest Hospital, 3^rd Military Medical University, Chongqing 630038, China

Telephone: +86-811-5318301-73374

Received: March 31, 1995
Revised: June 14, 1995
Accepted: August 20, 1995
Published online: October 1, 1995

Abstract

AIM: To study the influence of Helicobacter pylori (Hp) on the gastric mucosal barrier (GMB) by the measurement of the potential difference (PD).

METHODS: Fifty seven chronic gastritis cases were diagnosed endoscopically and confirmed by forceps mucosal biopsy. PD was measured by the Takeuchi method, and Hp was detected by both culture (modified Skirrow method) and press printing method with the Giemsa stain. Patients were divided randomly into three groups (De-Nol, WeiTong-Ling, and Placebo) for a course of 6 wk therapy.

RESULTS: PD across the mucosa of antrum was significantly lower in Hp (+) patients than in Hp (-) patients (16.44 ± 2.36 vs 19.58 ± 2.44, P < 0.0001). In Hp (+) patients, PD in the antrum increased markedly (16.88 ± 2.56 vs 20.03 ± 2.21, P < 0.0001) after Hp was cleared up by the De-Nol treatment.

CONCLUSION: Our data strongly indicated that Hp infection might cause a gastric mucosal barrier to be impaired markedly while the clearance of Hp by De-Nol recovered the integrity of the gastric mucosal barrier significantly.

Keywords: Helicobacter pylori; Gastric transmucosal potential difference; Gastric mucosal barrier