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Chen Y, Jan J, Yang C, Yen T, Linh TTD, Annavajjula S, Satapathy MK, Tsao S, Hsieh C. Cognitive Sequelae of COVID-19: Mechanistic Insights and Therapeutic Approaches. CNS Neurosci Ther 2025; 31:e70348. [PMID: 40152069 PMCID: PMC11950837 DOI: 10.1111/cns.70348] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/11/2024] [Revised: 03/10/2025] [Accepted: 03/13/2025] [Indexed: 03/29/2025] Open
Abstract
BACKGROUND The COVID-19 pandemic has left an indelible mark on the world, with mounting evidence suggesting that it not only posed acute challenges to global healthcare systems but has also unveiled a complex array of long-term consequences, particularly cognitive impairment (CI). As the persistence of post-COVID-19 neurological syndrome could evolve into the next public health crisis, it is imperative to gain a better understanding of the intricate pathophysiology of CI in COVID-19 patients and viable treatment strategies. METHODS This comprehensive review explores the pathophysiology and management of cognitive impairment across the phases of COVID-19, from acute infection to Long-COVID, by synthesizing findings from clinical, preclinical, and mechanistic studies to identify key contributors to CI, as well as current therapeutic approaches. RESULTS Key mechanisms contributing to CI include persistent neuroinflammation, cerebrovascular complications, direct neuronal injury, activation of the kynurenine pathway, and psychological distress. Both pharmacological interventions, such as anti-inflammatory therapies and agents targeting neuroinflammatory pathways, and non-pharmacological strategies, including cognitive rehabilitation, show promise in addressing these challenges. Although much of the current evidence is derived from preclinical and animal studies, these findings provide foundational insights into potential treatment approaches. CONCLUSION By synthesizing current knowledge, this review highlights the importance of addressing COVID-19-related cognitive impairment and offers actionable insights for mitigation and recovery as the global community continues to grapple with the pandemic's long-term impact.
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Affiliation(s)
- Yu‐Hao Chen
- Section of Neurosurgery, Department of SurgeryDitmanson Medical Foundation, Chia‐Yi Christian HospitalChia‐Yi CityTaiwan
- Chung‐Jen Junior College of Nursing, Health Sciences and ManagementChia‐Yi CountryTaiwan
- Department of PharmacologySchool of Medicine, College of Medicine, Taipei Medical UniversityTaipeiTaiwan
| | - Jing‐Shiun Jan
- Department of PharmacologySchool of Medicine, College of Medicine, Taipei Medical UniversityTaipeiTaiwan
| | - Chih‐Hao Yang
- Department of PharmacologySchool of Medicine, College of Medicine, Taipei Medical UniversityTaipeiTaiwan
| | - Ting‐Lin Yen
- Department of PharmacologySchool of Medicine, College of Medicine, Taipei Medical UniversityTaipeiTaiwan
- Department of Medical ResearchCathay General HospitalTaipeiTaiwan
| | - Tran Thanh Duy Linh
- Department of PharmacologySchool of Medicine, College of Medicine, Taipei Medical UniversityTaipeiTaiwan
- Family Medicine Training Center, University of Medicine and Pharmacy at Ho Chi Minh CityHo Chi Minh CityVietnam
| | - Saileela Annavajjula
- Department of PharmacologySchool of Medicine, College of Medicine, Taipei Medical UniversityTaipeiTaiwan
| | - Mantosh Kumar Satapathy
- Department of PharmacologySchool of Medicine, College of Medicine, Taipei Medical UniversityTaipeiTaiwan
| | - Shin‐Yi Tsao
- Department of PharmacologySchool of Medicine, College of Medicine, Taipei Medical UniversityTaipeiTaiwan
- Division of Endocrinology and Metabolism, Department of Internal MedicineTaipeiTaiwan
| | - Cheng‐Ying Hsieh
- Department of PharmacologySchool of Medicine, College of Medicine, Taipei Medical UniversityTaipeiTaiwan
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Machado L, Prudente R, Franco E, Gatto M, Mota G, Pagan L, Brizola L, dos Santos M, Cunha T, Sabino-Silva R, Goulart L, Martins M, Santos P, Maia L, Albuquerque A, Ferreira E, Baldi B, Okoshi M, Tanni S. Salivary Metabolomics in Patients with Long COVID-19 Infection. Metabolites 2024; 14:598. [PMID: 39590834 PMCID: PMC11596941 DOI: 10.3390/metabo14110598] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/06/2024] [Revised: 08/24/2024] [Accepted: 10/17/2024] [Indexed: 11/28/2024] Open
Abstract
Background: Long COVID-19 has been characterized by the presence of symptoms lasting longer than 4 weeks after the acute infection. The pathophysiology of clinical manifestations still lacks knowledge. Objective: The objective of this paper was to evaluate metabolite abundance in the saliva of long COVID patients 60 days after hospital discharge. Methods: A convenience sample was composed of 30 post-discharge patients with long COVID and seven non-COVID-19 controls. All COVID-19 patients were evaluated by demographic characteristics, spirometry, 6 min walk test (6mWT), Saint George Respiratory Questionnaire (SGRQ), and body composition. Metabolomics was performed on saliva. Results: The long COVID-19 patients were 60.4 ± 14.3 years-old, and 66% male. Their lean body mass was 30.7 ± 7.3 kg and fat mass, 34.4 ± 13.7 kg. Spirometry evaluation showed forced vital capacity (FVC) of 3.84 ± 0.97 L with 96.0 ± 14.0% of the predicted value, and forced expiratory volume in the first second (FEV1) of 3.11 ± 0.83 L with 98.0 ± 16.0 of the predicted value. The long COVID-19 patients had reduced maximal inspiratory (90.1 ± 31.6 cmH2O) and maximal expiratory (97.3 ± 31.0 cmH2O) pressures. SGRQ showed domain symptoms of 32.3 ± 15.2, domain activities of 41.9 ± 25.6, and domain impact 13.7 ± 11.4, with a mean of 24.3 ± 14.9%. Physical capacity measured by distance covered in the 6mWT was 418.2 ± 130 m with a 73.3% (22.3-98.1) predictive value. The control group consisted of 44.1 ± 10.7-year-old men with a body mass index of 26.5 ± 1.66 Kg/m2. Metabolomics revealed 19 differentially expressed metabolites; expression was lower in 16 metabolites, and 2 metabolites were absent in the COVID-19 patients compared to controls. Calenduloside G methyl ester (p = 0.03), Gly Pro Lys (p = 0.0001), and creatine (p = 0.0001) expressions were lower in patients than controls. Conclusions: Long COVID-19 patients present less abundance of calenduloside G methyl ester, Gly Pro Lys, and creatine in saliva than healthy controls. Lower creatine abundance may be related to reduced physical capacity and fatigue.
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Affiliation(s)
- Luiz Machado
- Botucatu Medical School, São Paulo State University, Botucatu 18618-970, Brazil; (R.P.); (E.F.); (M.G.); (G.M.); (L.P.); (L.B.); (M.d.S.); (M.O.); (S.T.)
| | - Robson Prudente
- Botucatu Medical School, São Paulo State University, Botucatu 18618-970, Brazil; (R.P.); (E.F.); (M.G.); (G.M.); (L.P.); (L.B.); (M.d.S.); (M.O.); (S.T.)
| | - Estefânia Franco
- Botucatu Medical School, São Paulo State University, Botucatu 18618-970, Brazil; (R.P.); (E.F.); (M.G.); (G.M.); (L.P.); (L.B.); (M.d.S.); (M.O.); (S.T.)
| | - Mariana Gatto
- Botucatu Medical School, São Paulo State University, Botucatu 18618-970, Brazil; (R.P.); (E.F.); (M.G.); (G.M.); (L.P.); (L.B.); (M.d.S.); (M.O.); (S.T.)
| | - Gustavo Mota
- Botucatu Medical School, São Paulo State University, Botucatu 18618-970, Brazil; (R.P.); (E.F.); (M.G.); (G.M.); (L.P.); (L.B.); (M.d.S.); (M.O.); (S.T.)
| | - Luana Pagan
- Botucatu Medical School, São Paulo State University, Botucatu 18618-970, Brazil; (R.P.); (E.F.); (M.G.); (G.M.); (L.P.); (L.B.); (M.d.S.); (M.O.); (S.T.)
| | - Luís Brizola
- Botucatu Medical School, São Paulo State University, Botucatu 18618-970, Brazil; (R.P.); (E.F.); (M.G.); (G.M.); (L.P.); (L.B.); (M.d.S.); (M.O.); (S.T.)
| | - Maércio dos Santos
- Botucatu Medical School, São Paulo State University, Botucatu 18618-970, Brazil; (R.P.); (E.F.); (M.G.); (G.M.); (L.P.); (L.B.); (M.d.S.); (M.O.); (S.T.)
| | - Thulio Cunha
- Faculty of Medicine of the Federal, University of Uberlandia, Uberlândia 38408-100, Brazil; (T.C.); (R.S.-S.); (M.M.); (P.S.); (L.M.)
| | - Robinson Sabino-Silva
- Faculty of Medicine of the Federal, University of Uberlandia, Uberlândia 38408-100, Brazil; (T.C.); (R.S.-S.); (M.M.); (P.S.); (L.M.)
| | - Luiz Goulart
- Faculty of Medicine of the Federal, University of Uberlandia, Uberlândia 38408-100, Brazil; (T.C.); (R.S.-S.); (M.M.); (P.S.); (L.M.)
| | - Mario Martins
- Faculty of Medicine of the Federal, University of Uberlandia, Uberlândia 38408-100, Brazil; (T.C.); (R.S.-S.); (M.M.); (P.S.); (L.M.)
| | - Paula Santos
- Faculty of Medicine of the Federal, University of Uberlandia, Uberlândia 38408-100, Brazil; (T.C.); (R.S.-S.); (M.M.); (P.S.); (L.M.)
| | - Larissa Maia
- Faculty of Medicine of the Federal, University of Uberlandia, Uberlândia 38408-100, Brazil; (T.C.); (R.S.-S.); (M.M.); (P.S.); (L.M.)
| | - André Albuquerque
- Department of Pneumology, University of São Paulo, São Paulo 05403-000, Brazil; (A.A.); (B.B.)
| | - Eloara Ferreira
- Department of the Federal, University of São Paulo, São Paulo 01246-903, Brazil;
| | - Bruno Baldi
- Department of Pneumology, University of São Paulo, São Paulo 05403-000, Brazil; (A.A.); (B.B.)
| | - Marina Okoshi
- Botucatu Medical School, São Paulo State University, Botucatu 18618-970, Brazil; (R.P.); (E.F.); (M.G.); (G.M.); (L.P.); (L.B.); (M.d.S.); (M.O.); (S.T.)
| | - Suzana Tanni
- Botucatu Medical School, São Paulo State University, Botucatu 18618-970, Brazil; (R.P.); (E.F.); (M.G.); (G.M.); (L.P.); (L.B.); (M.d.S.); (M.O.); (S.T.)
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Askey D, Smith A. Are Pre-Hospitalization ECG Abnormalities Associated With Increased Mortality in COVID-19 Patients? A Quantitative Systematic Literature Review. Ann Noninvasive Electrocardiol 2024; 29:e70016. [PMID: 39394768 PMCID: PMC11470194 DOI: 10.1111/anec.70016] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/13/2023] [Revised: 07/21/2024] [Accepted: 09/09/2024] [Indexed: 10/14/2024] Open
Abstract
BACKGROUND While COVID-19 is predominantly a respiratory disease, cardiovascular complications occur and are associated with worse outcomes. Electrocardiogram (ECG) abnormalities are frequently observed in hospitalized COVID-19 patients, some of which are associated with increased mortality. It is unclear whether ECG abnormalities occurring before hospitalization are associated with increased mortality. This quantitative systematic literature review aims to determine which ECG changes occurring before hospitalization are associated with mortality and discuss whether these findings can aid the assessment of patients and decision-making in the pre-hospital environment. METHODS A systematic search of the following digital databases was conducted: CINAL, PUBMED, MEDLINE, and Coronavirus Research Database. Eight cohort studies (primary papers) including COVID-19 patients with ECGs taken in the Emergency Department before hospitalization were selected for quantitative synthesis and results were obtained for the prevalence of ECG changes among survivors compared with non-survivors. Odds and hazard ratios for ECG abnormalities associated with mortality were also collected and compared. RESULTS Identification of ECG abnormalities on pre-hospitalization ECG is associated with increased mortality in COVID-19 patients. These ECG abnormalities include non-sinus rhythm, QTc prolongation, left bundle branch block, axis deviation, atrial fibrillation, atrial flutter, right ventricular strain patterns, ST segment changes, T wave abnormalities, and evidence of left ventricular hypertrophy. CONCLUSION Electrocardiogram assessment in the pre-hospital environment may be beneficial when assessing COVID-19 patients and could help identify patients at increased risk of mortality.
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Affiliation(s)
- Danielle Askey
- Hazardous Area Response Team Paramedic, South Western Ambulance Service NHS Foundation TrustNorth Bristol Operations CentreBristolUK
| | - Ann Smith
- Senior Lecturer in Health StatisticsUniversity of the West of EnglandBristolUK
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Li P, Liu H, Li F, Sui M, Liu K, Fu H. Genetic effect of thyroid function-related diseases on acute respiratory distress syndrome: a Mendelian randomization study. Aging (Albany NY) 2024; 16:12209-12224. [PMID: 39225634 PMCID: PMC11424573 DOI: 10.18632/aging.205996] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/13/2023] [Accepted: 05/30/2024] [Indexed: 09/04/2024]
Abstract
BACKGROUND Previous studies have shown an association between acute respiratory distress syndrome (ARDS) and thyroid function. However, their causal relationship remains unspecified. Therefore, this study aims to explore the causal relationship between ARDS and thyroid function-related diseases with Mendelian Randomization (MR) analysis. METHODS ARDS dataset finn-b-J10_ARDS, finn-b-E4_THYROID dataset of disorders of the thyroid gland (DTG) and finn-b-E4_HYTHYNAS of hypothyroidism were acquired from public database. In univariate MR (UVMR), causal effects between DTG, hypothyroidism and ARDS were investigated using 5 types of algorithms, and reliability was validated by sensitivity analysis. Moreover, multivariate MR (MVMR), enrichment and interaction network analyses of genes corresponding to SNPs of DTG and hypothyroidism were carried out. Significant level was chosen as p<0.05. RESULTS UVMR identified DTG and hypothyroidism (P < 0.05, OR > 1) as risk factors, and were causally related to ARDS. Reliability of UVMR results was confirmed through sensitivity analysis, and results were stable and reliable. However, DTG and hypothyroidism had no effect on ARDS in MVMR, possibly because these factors had independent effects on ARDS. Ultimately, 96 and 113 genes corresponding to SNPs of DTG and hypothyroidism were found closely related to immune-related pathways. CONCLUSIONS UVMR and MVMR analysis revealed a causal connection between DTG and hypothyroidism as risk factors with ARDS, providing robust evidence for investigation into relationship of hypothyroidism on ARDS and between DTG and ARDS.
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Affiliation(s)
- Peilong Li
- Children’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China
- Department of Pulmonary and Critical Care Medicine, Kunming Children’s Hospital and Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, P.R. China
| | - Haifeng Liu
- Children’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China
- Department of Pulmonary and Critical Care Medicine, Kunming Children’s Hospital and Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, P.R. China
| | - Feng Li
- Children’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China
| | - Mingze Sui
- Children’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China
- Department of Pulmonary and Critical Care Medicine, Kunming Children’s Hospital and Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, P.R. China
| | - Kai Liu
- Children’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China
| | - Hongmin Fu
- Children’s Hospital Affiliated to Kunming Medical University, Kunming Medical University and Kunming Children’s Hospital, Kunming, P.R. China
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Alsaffar SF, Baqer NN. Association between Methylenetetrahydrofolate Reductase ( MTHFR) and 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase ( MTRR) Polymorphisms in Iraqi Patients with COVID-19. IRANIAN JOURNAL OF MEDICAL SCIENCES 2024; 49:430-440. [PMID: 39114635 PMCID: PMC11300940 DOI: 10.30476/ijms.2023.99555.3162] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 07/22/2023] [Revised: 08/20/2023] [Accepted: 09/15/2023] [Indexed: 08/10/2024]
Abstract
Background The methylenetetrahydrofolate reductase (MTHFR) gene is an essential gene in the metabolism of folate-homocysteine. Recently, the level of homocysteine was found to be a significant marker in the follow-up of COVID-19 infection. Thus, this study aimed to detect the effect of genetic polymorphisms for single nucleotide polymorphisms (SNPs) (c.66A>G, c.1298A>C, and c.677CT) on COVID-19 infection. Methods Blood samples were collected from 270 patients with COVID-19 in the medical center of Al-Shifa (Baghdad, Iraq) from November 2020 to March 2021. Tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) technique was used for the detection of genotypes of SNPs. The odds ratio (OR) was used to detect the relationship between SNPs and COVID-19 infections. Haplotype analysis was performed by SHEsis software. Results There was a significant difference between mild/moderate cases and severe/critical cases for ages (35-45), (46-55), and (56-65) years (P<0.0001, P=0.01, and P=0.006, respectively). The results showed significant differences in the T allele for SNP c.677>C (P<0.0001 and OR=4.58). The C allele for SNP c.1298A>C indicated significant differences (P<0.001 and OR=3.15). Besides, the G allele for SNP c.677C>T showed significant differences (P<0.001 and OR=6.64). Consequently, these SNPs showed a predisposition to the development of COVID-19 infection. With regard to the C-A-A, T-A-A and T-C-G haplotypes indicated significant differences between the control and patient groups. The C-A-A was related to a decreased risk and indicated a protective effect against COVID-19 infection development (P<0.0001 and OR=0.218). The increased risk was associated with T-A-A and T-C-G haplotypes and indicated the risk impact on COVID-19 infection development (P<0.0001, P=0.004, and OR=15.5, OR=6.772, respectively). Furthermore, the linkage disequilibrium (LD) for SNPs was studied, and the complete D' value was 99. Conclusion The genetic polymorphisms of SNPs (c.66A>G, c.1298A>C, and c.677C>T) in the Iraqi population were associated with COVID-19 infection.
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Affiliation(s)
- Sura F. Alsaffar
- Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq
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Rafaqat W, Abiad M, Lagazzi E, Argandykov D, Proaño-Zamudio JA, Velmahos GC, Hwabejire JO, Parks JJ, Luckhurst CM, DeWane MP. Analyzing the Impact of Concomitant COVID-19 Infection on Outcomes in Trauma Patients. Am Surg 2024:31348241246176. [PMID: 38613452 DOI: 10.1177/00031348241246176] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/15/2024]
Abstract
BACKGROUND The impact of COVID-19 infection at the time of traumatic injury remains understudied. Previous studies demonstrate that the rate of COVID-19 vaccination among trauma patients remains lower than in the general population. This study aims to understand the impact of concomitant COVID-19 infection on outcomes in trauma patients. METHODS We conducted a retrospective cohort study of patients ≥18 years old admitted to a level I trauma center from March 2020 to December 2022. Patients tested for COVID-19 infection using a rapid antigen/PCR test were included. We matched patients using 2:1 propensity accounting for age, gender, race, comorbidities, vaccination status, injury severity score (ISS), type and mechanism of injury, and GCS at arrival. The primary outcome was inpatient mortality. Secondary outcomes included hospital length of stay (LOS), Intensive Care Unit (ICU) LOS, 30-day readmission, and major complications. RESULTS Of the 4448 patients included, 168 (3.8%) were positive (COV+). Compared with COVID-19-negative (COV-) patients, COV+ patients were similar in age, sex, BMI, ISS, type of injury, and regional AIS. The proportion of White and non-Hispanic patients was higher in COV- patients. Following matching, 154 COV+ and 308 COV- patients were identified. COVID-19-positive patients had a higher rate of mortality (7.8% vs 2.6%; P = .010), major complications (15.6% vs 8.4%; P = .020), and thrombotic complications (3.9% vs .6%; P = .012). Patients also had a longer hospital LOS (median, 9 vs 5 days; P < .001) and ICU LOS (median, 5 vs 3 days; P = .025). CONCLUSIONS Trauma patients with concomitant COVID-19 infection have higher mortality and morbidity in the matched population. Focused interventions aimed at recognizing this high-risk group and preventing COVID-19 infection within it should be undertaken.
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Affiliation(s)
- Wardah Rafaqat
- Division of Trauma, Emergency General Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, MA, USA
| | - May Abiad
- Division of Trauma, Emergency General Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, MA, USA
| | - Emanuele Lagazzi
- Division of Trauma, Emergency General Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, MA, USA
| | - Dias Argandykov
- Division of Trauma, Emergency General Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, MA, USA
| | - Jefferson A Proaño-Zamudio
- Division of Trauma, Emergency General Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, MA, USA
| | - George C Velmahos
- Division of Trauma, Emergency General Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, MA, USA
| | - John O Hwabejire
- Division of Trauma, Emergency General Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, MA, USA
| | - Jonathan J Parks
- Division of Trauma, Emergency General Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, MA, USA
| | - Casey M Luckhurst
- Division of Trauma, Emergency General Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, MA, USA
| | - Michael P DeWane
- Division of Trauma, Emergency General Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, MA, USA
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Elhommosani MR, Sakr MM, Abbas RM, Aboshanab KM. Evaluation of clinically relevant serum proteins as biomarkers for monitoring COVID-19 severity, and end-organ damage among hospitalized unvaccinated patients. BMC Infect Dis 2024; 24:231. [PMID: 38378528 PMCID: PMC10880310 DOI: 10.1186/s12879-024-09113-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/01/2023] [Accepted: 02/08/2024] [Indexed: 02/22/2024] Open
Abstract
BACKGROUND The extensive variability and conflicting information in Coronavirus Disease 2019 (COVID-19) patient data have made it difficult for the medical community to gain a comprehensive understanding and develop clear, reliable guidelines for managing COVID-19 cases. As the world uncovers the diverse side effects of the pandemic, the pursuit of knowledge about COVID-19 has become crucial. The present study aimed to evaluate some clinically relevant serum proteins, providing analysis of the obtained results to employ them in the diagnosis, prognosis, and disease monitoring among COVID-19 patients. METHODS Samples were collected from 262 COVID-19 unvaccinated hospitalized patients. Measurement of certain serum proteins, namely C-reactive protein (CRP), ferritin, D-dimer, procalcitonin, interleukin-6 (IL-6), serum creatinine (SCr), alanine transaminase (ALT), aspartate transaminase (AST) was done using standard methods. Statistical analysis was performed on the obtained data and the results were correlated to the severity and prognosis. RESULTS The calculated Mortality rate was found to be 30% with a higher percentage observed among females. The results showed elevation in serum CRP, ferritin, D-dimer, and procalcitonin in most of the patients, also some patients had elevated SCr, ALT, and AST levels indicating end-organ damage. The statistical analysis displayed a strong correlation between serum levels of CRP and ferritin, between D-dimer and ferritin, and between ferritin and procalcitonin. No significant difference was observed between male and female patients' serum levels of the tested serum proteins. A significant correlation between increased serum procalcitonin and mortality was observed. CONCLUSION The levels of measured serum proteins were impacted by SARS-CoV-2 infection. Serum ferritin, CRP, D-dimer, and procalcitonin are good predicting tools for end-organ damage and acute kidney impairment in COVID-19. Procalcitonin is a strong indicator of severity and mortality in hospitalized COVID-19 patients.
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Affiliation(s)
- Mahetab R Elhommosani
- Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt
| | - Masarra M Sakr
- Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt
| | - Rania M Abbas
- Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, 11566, Cairo, Egypt
| | - Khaled M Aboshanab
- Department of Microbiology and Immunology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.
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Stark J, Kuster SP, Hungerbühler V. Impact of COVID-19 disease on the male factor in reproductive medicine - how-to advise couples undergoing IVF/ICSI. Reprod Fertil Dev 2024; 36:RD23205. [PMID: 38185121 DOI: 10.1071/rd23205] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/25/2023] [Accepted: 12/13/2023] [Indexed: 01/09/2024] Open
Abstract
CONTEXT The COVID-19 pandemic has caused widespread concern about its potential impact on various aspects of human health. AIMS This narrative review aims to summarise the current knowledge about the impact of COVID-19 on sperm quality and its effect on assisted reproductive technology. METHODS In this narrative review, a literature search using the PubMed and MEDLINE databases was conducted to identify relevant original research articles published up to 29 January 2023. RESULTS Thirty original studies were included in our review. There is evidence that SARS-CoV-2 is detectable in seminal fluid during the acute phase of infection and for up to 1month. However, the fact that SARS-CoV-2 is barely detectable in semen makes sexual transmission very unlikely. COVID-19 infection has been associated with the following changes in sperm quality: morphology, altered motility, changed DNA fragmentation-index (DFI), decreased sperm concentration, lower total number of sperm, and a significant increase in leukocytes and cytokines. The effects mostly seem to be reversible and have not been shown to negatively affect the outcome of assisted reproductive technology but should lead to further research concerning the health of the offspring, because a correlation of increased DFI after COVID-19 even 5months after disease could be assumed. CONCLUSIONS The findings of this narrative review suggest that SARS-CoV-2 may harm sperm quality in the acute phase. IMPLICATIONS A recovery time of at least 3months regarding assisted reproductive therapy could be reasonable.
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Affiliation(s)
- Julia Stark
- Kantonsspital St. Gallen, Department of Gynecological Endocrinology and Reproductive Medicine, St. Gallen, Switzerland
| | - Stefan P Kuster
- Kantonsspital St. Gallen, Division of Infectious Diseases and Hospital Epidemiology, Rorschacher Str. 95, 9007 St. Gallen, Switzerland
| | - Vera Hungerbühler
- Kantonsspital St. Gallen, Department of Gynecological Endocrinology and Reproductive Medicine, Fiore Praxis AG, Brauerstrasse 95, 9016 St. Gallen, Switzerland
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Neelima M, Chivukula SK. Assessment of health-related quality of life and its determinants among COVID-19 intensive care unit survivors. J Family Med Prim Care 2023; 12:3319-3325. [PMID: 38361881 PMCID: PMC10866247 DOI: 10.4103/jfmpc.jfmpc_739_23] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/03/2023] [Revised: 07/27/2023] [Accepted: 08/03/2023] [Indexed: 02/17/2024] Open
Abstract
Background Health-related quality of life (HRQoL) is a multidimensional concept encompassing the physical, functional, emotional, and social/family well-being of an individual. Recent reports suggest that Covid-19 may lead to poorer HRQoL of the patients infected both in the short and long term. The present study aimed to assess the health-related quality of life and their determinants among COVID-19 intensive care unit (ICU) survivors. Materials and Methods In the study, 107 COVID-19 (RTPCR positive) patients admitted to the (ICU) of a tertiary care centre from August 2021-January 2022 were taken from the hospital records. Line listing of all the patients was done, and the study population was selected using the lottery method under a simple random sampling method. The study population was contacted by telephone and requested their willingness to participate in the study. EQ-5D-5L was used to assess quality of life, which is a standard instrument to assess HRQoL (developed by the EuroQol group in 2011). The EQ-5D-5L essentially consists of the EQ-5D descriptive system and the EQ visual analogue scale (EQ-VAS). Data entry was done using Microsoft excel 2019 version and data analysis using MedCalc version 20.015. Results The mean EQ-5D-5L utility score was 0.51 ± 0.43. The mean EQ-VAS score was 68.97 ± 22.27. A significant association between co-morbidities and EQ-5D-5L utility score where those with co-morbidities had a lesser EQ-5D-5L score compared to those without co-morbidities. The mean duration of ICU stay in days was 12.29 ± 12.17. A significant negative correlation between the duration of ICU stay and EQ-5D-5L. (r = -0.26, P = 0.0006*). Conclusion COVID-19 patients with comorbidities had a significantly poor quality of life. These findings may help healthcare professionals and decision-makers to better understand the consequences of COVID-19 on the HRQoL.
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Affiliation(s)
- Mariyala Neelima
- Department of Community Medicine, Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research Foundation, Chinnaavutapalli, Gannavaram, Andhra Pradesh, India
| | - Satya K. Chivukula
- Department of Community Medicine, Government Siddhartha Medical College, Vijayawada, Andhra Pradesh, India
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Sanches CA, Silva GA, Librantz AFH, Sampaio LMM, Belan PA. Wearable Devices to Diagnose and Monitor the Progression of COVID-19 Through Heart Rate Variability Measurement: Systematic Review and Meta-Analysis. J Med Internet Res 2023; 25:e47112. [PMID: 37820372 PMCID: PMC10685286 DOI: 10.2196/47112] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/08/2023] [Revised: 06/28/2023] [Accepted: 10/10/2023] [Indexed: 10/13/2023] Open
Abstract
BACKGROUND Recent studies have linked low heart rate variability (HRV) with COVID-19, indicating that this parameter can be a marker of the onset of the disease and its severity and a predictor of mortality in infected people. Given the large number of wearable devices that capture physiological signals of the human body easily and noninvasively, several studies have used this equipment to measure the HRV of individuals and related these measures to COVID-19. OBJECTIVE The objective of this study was to assess the utility of HRV measurements obtained from wearable devices as predictive indicators of COVID-19, as well as the onset and worsening of symptoms in affected individuals. METHODS A systematic review was conducted searching the following databases up to the end of January 2023: Embase, PubMed, Web of Science, Scopus, and IEEE Xplore. Studies had to include (1) measures of HRV in patients with COVID-19 and (2) measurements involving the use of wearable devices. We also conducted a meta-analysis of these measures to reduce possible biases and increase the statistical power of the primary research. RESULTS The main finding was the association between low HRV and the onset and worsening of COVID-19 symptoms. In some cases, it was possible to predict the onset of COVID-19 before a positive clinical test. The meta-analysis of studies reported that a reduction in HRV parameters is associated with COVID-19. Individuals with COVID-19 presented a reduction in the SD of the normal-to-normal interbeat intervals and root mean square of the successive differences compared with healthy individuals. The decrease in the SD of the normal-to-normal interbeat intervals was 3.25 ms (95% CI -5.34 to -1.16 ms), and the decrease in the root mean square of the successive differences was 1.24 ms (95% CI -3.71 to 1.23 ms). CONCLUSIONS Wearable devices that measure changes in HRV, such as smartwatches, rings, and bracelets, provide information that allows for the identification of COVID-19 during the presymptomatic period as well as its worsening through an indirect and noninvasive self-diagnosis.
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Affiliation(s)
- Carlos Alberto Sanches
- Informatics and Knowledge Management Graduate Program, Universidade Nove de Julho, São Paulo, Brazil
| | - Graziella Alves Silva
- Informatics and Knowledge Management Graduate Program, Universidade Nove de Julho, São Paulo, Brazil
| | | | | | - Peterson Adriano Belan
- Informatics and Knowledge Management Graduate Program, Universidade Nove de Julho, São Paulo, Brazil
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Cozzolino A, Hasenmajer V, Newell-Price J, Isidori AM. COVID-19 pandemic and adrenals: deep insights and implications in patients with glucocorticoid disorders. Endocrine 2023; 82:1-14. [PMID: 37338722 PMCID: PMC10462567 DOI: 10.1007/s12020-023-03411-w] [Citation(s) in RCA: 6] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/13/2023] [Accepted: 05/25/2023] [Indexed: 06/21/2023]
Abstract
PURPOSE Coronavirus disease-19 (COVID-19) has spread throughout the world. It was initially defined as a potentially severe syndrome affecting the respiratory tract, but it has since been shown to be a systemic disease with relevant extrapulmonary manifestations that increase mortality. The endocrine system has been found to be vulnerable to COVID-19 infection. The current review aims to evaluate the available data on the impact of COVID-19 infection and treatment, as well as COVID-19 vaccines, on adrenal gland function, particularly in patients with GC disorders. METHODS A thorough search of published peer-reviewed studies in PubMed was performed using proper keywords. RESULTS Adrenal viral tropism and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in the adrenal glands have been demonstrated, and adrenal insufficiency (AI) is a rare, but potentially severe complication in COVID-19 disease, whose recognition can be difficult if only for the empirical treatments administered in the early stages. Glucocorticoid (GC) treatment have had a pivotal role in preventing clinical deterioration in patients with COVID-19, but long-term GC use may increase COVID-19-related mortality and the development of iatrogenic AI. Patients with GC disorders, especially AI and Cushing's syndrome, have been identified as being at high risk of COVID-19 infection and complications. Published evidence suggests that AI patient awareness and proper education may help adjust GC replacement therapy appropriately when necessary, thereby reducing COVID-19 severity. The COVID-19 pandemic has had an impact on AI management, particularly in terms of adherence to patients' care plans and self-perceived challenges. On the other hand, published evidence suggests that the clinical course of COVID-19 may be affected by the severity of hypercortisolism in patients with CS. Therefore, to ameliorate the risk profile in these patients, cortisol levels should be adequately controlled, along with careful monitoring of metabolic and cardiovascular comorbidities. To date, the COVID-19 vaccine remains the only available tool to face SARS-CoV-2, and it should not be treated differently in patients with AI and CS. CONCLUSION SARS-CoV-2 infection has been linked to adrenal damage and AI is a rare complication in COVID-19 disease, requiring prompt recognition. Educational efforts and patient awareness may reduce COVID-19 severity in patients with AI. Control of cortisol levels and monitoring of complications may improve the clinical course of COVID-19 in patients with CS.
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Affiliation(s)
- Alessia Cozzolino
- Department of Experimental Medicine, Sapienza University of Rome, IT, Rome, Italy
| | - Valeria Hasenmajer
- Department of Experimental Medicine, Sapienza University of Rome, IT, Rome, Italy
| | - John Newell-Price
- Department of Oncology and Metabolism, The University of Sheffield, Sheffield, UK
| | - Andrea M Isidori
- Department of Experimental Medicine, Sapienza University of Rome, IT, Rome, Italy.
- Centre for Rare Diseases (ENDO-ERN accredited), Policlinico Umberto I, Rome, Italy.
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Shaked O, Korn L, Shapiro Y, Zwilling M, Zigdon A. Medical and social factors influencing the utilization of healthcare services among older adults in Israel during the COVID-19 lockdown. Front Public Health 2023; 11:1218507. [PMID: 37829095 PMCID: PMC10565215 DOI: 10.3389/fpubh.2023.1218507] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/07/2023] [Accepted: 08/29/2023] [Indexed: 10/14/2023] Open
Abstract
Background The corona virus disease 2019 (COVID-19) pandemic significantly impacted older adults. However, most older communities focused on the medical issues. The aims of this study were to identify the medical and social factors linked with the usage of medical services during the COVID-19 lockdown in Israel. Methods The study was conducted Over two periods of time from February to April in 2019 (P1), before the COVID-19 and from February to April in 2020 (P2), during the first lockdown. The study was conducted on people aged 65 and older in Israel. The variable statistics were analyzed using frequency tabulation, cross-tabulation frequencies, and t-tests. Two hierarchical logistic regressions were conducted over four steps for each period. Results The participants (n = 102,303) comprised 64.5% female (65,946) and 35.5% male (36,357) (mean age 80.5, SD- 7.46). It was found that participants who had not subscribed to the supportive community services were 7.47 times more likely to access medical services in P1 and 12.417 times more likely to access medical services during the lockdown. This variable was also found to be a strong predictor in the final model. The most significant variable for predicting the participants' needs during P2 was their previous needs in P1. Other social variables were living in assisted living home and living in community settlements. The presence of 12 diseases in this study did not predict service demand. Conclusion Community support reduces medical service demands during disasters and provides services for older adults. During pandemics, however, social services need to be expanded and made more easily accessible to older adults.
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Affiliation(s)
- Ohad Shaked
- Department of Health Systems Management, School of Health Sciences, Ariel University, Ariel, Israel
- Natali, Ramat Gan, Israel
| | - Liat Korn
- Department of Health Systems Management, School of Health Sciences, Ariel University, Ariel, Israel
| | - Yair Shapiro
- Department of Health Systems Management, School of Health Sciences, Ariel University, Ariel, Israel
| | - Moti Zwilling
- Department of Economics and Business Administration, Ariel University, Ariel, Israel
| | - Avi Zigdon
- Department of Health Systems Management, School of Health Sciences, Ariel University, Ariel, Israel
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Bin KJ, De Pretto LR, Sanchez FB, De Souza E Castro FPM, Ramos VD, Battistella LR. Digital Platform for Continuous Monitoring of Patients Using a Smartwatch: Longitudinal Prospective Cohort Study. JMIR Form Res 2023; 7:e47388. [PMID: 37698916 PMCID: PMC10523215 DOI: 10.2196/47388] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/17/2023] [Revised: 08/01/2023] [Accepted: 08/02/2023] [Indexed: 09/13/2023] Open
Abstract
BACKGROUND Since the COVID-19 pandemic, there has been a boost in the digital transformation of the human society, where wearable devices such as a smartwatch can already measure vital signs in a continuous and naturalistic way; however, the security and privacy of personal data is a challenge to expanding the use of these data by health professionals in clinical follow-up for decision-making. Similar to the European General Data Protection Regulation, in Brazil, the Lei Geral de Proteção de Dados established rules and guidelines for the processing of personal data, including those used for patient care, such as those captured by smartwatches. Thus, in any telemonitoring scenario, there is a need to comply with rules and regulations, making this issue a challenge to overcome. OBJECTIVE This study aimed to build a digital solution model for capturing data from wearable devices and making them available in a safe and agile manner for clinical and research use, following current laws. METHODS A functional model was built following the Brazilian Lei Geral de Proteção de Dados (2018), where data captured by smartwatches can be transmitted anonymously over the Internet of Things and be identified later within the hospital. A total of 80 volunteers were selected for a 24-week follow-up clinical trial divided into 2 groups, one group with a previous diagnosis of COVID-19 and a control group without a previous diagnosis of COVID-19, to measure the synchronization rate of the platform with the devices and the accuracy and precision of the smartwatch in out-of-hospital conditions to simulate remote monitoring at home. RESULTS In a 35-week clinical trial, >11.2 million records were collected with no system downtime; 66% of continuous beats per minute were synchronized within 24 hours (79% within 2 days and 91% within a week). In the limit of agreement analysis, the mean differences in oxygen saturation, diastolic blood pressure, systolic blood pressure, and heart rate were -1.280% (SD 5.679%), -1.399 (SD 19.112) mm Hg, -1.536 (SD 24.244) mm Hg, and 0.566 (SD 3.114) beats per minute, respectively. Furthermore, there was no difference in the 2 study groups in terms of data analysis (neither using the smartwatch nor the gold-standard devices), but it is worth mentioning that all volunteers in the COVID-19 group were already cured of the infection and were highly functional in their daily work life. CONCLUSIONS On the basis of the results obtained, considering the validation conditions of accuracy and precision and simulating an extrahospital use environment, the functional model built in this study is capable of capturing data from the smartwatch and anonymously providing it to health care services, where they can be treated according to the legislation and be used to support clinical decisions during remote monitoring.
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Affiliation(s)
- Kaio Jia Bin
- Instituto de Medicina Física e Reabilitação, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
| | - Lucas Ramos De Pretto
- Instituto de Medicina Física e Reabilitação, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
| | - Fábio Beltrame Sanchez
- Instituto de Medicina Física e Reabilitação, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
| | | | - Vinicius Delgado Ramos
- Instituto de Medicina Física e Reabilitação, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
| | - Linamara Rizzo Battistella
- Instituto de Medicina Física e Reabilitação, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
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Hadi MU, Qureshi R, Ahmed A, Iftikhar N. A lightweight CORONA-NET for COVID-19 detection in X-ray images. EXPERT SYSTEMS WITH APPLICATIONS 2023; 225:120023. [PMID: 37063778 PMCID: PMC10088342 DOI: 10.1016/j.eswa.2023.120023] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 10/08/2022] [Revised: 03/28/2023] [Accepted: 03/31/2023] [Indexed: 06/19/2023]
Abstract
Since December 2019, COVID-19 has posed the most serious threat to living beings. With the advancement of vaccination programs around the globe, the need to quickly diagnose COVID-19 in general with little logistics is fore important. As a consequence, the fastest diagnostic option to stop COVID-19 from spreading, especially among senior patients, should be the development of an automated detection system. This study aims to provide a lightweight deep learning method that incorporates a convolutional neural network (CNN), discrete wavelet transform (DWT), and a long short-term memory (LSTM), called CORONA-NET for diagnosing COVID-19 from chest X-ray images. In this system, deep feature extraction is performed by CNN, the feature vector is reduced yet strengthened by DWT, and the extracted feature is detected by LSTM for prediction. The dataset included 3000 X-rays, 1000 of which were COVID-19 obtained locally. Within minutes of the test, the proposed test platform's prototype can accurately detect COVID-19 patients. The proposed method achieves state-of-the-art performance in comparison with the existing deep learning methods. We hope that the suggested method will hasten clinical diagnosis and may be used for patients in remote areas where clinical labs are not easily accessible due to a lack of resources, location, or other factors.
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Affiliation(s)
- Muhammad Usman Hadi
- Nanotechnology and Integrated Bio-Engineering Centre (NIBEC), School of Engineering, Ulster University, BT15 1AP Belfast, UK
| | - Rizwan Qureshi
- Department of Imaging Physics, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
| | - Ayesha Ahmed
- Department of Radiology, Aalborg University Hospital, Aalborg 9000, Denmark
| | - Nadeem Iftikhar
- University College of Northern Denmark, Aalborg 9200, Denmark
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15
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Roshani D, Saboni K, Amjadian M. The anxiety associated with COVID-19, general health, spiritual health, and job satisfaction in healthcare providers: a cross-sectional study. BMC Psychol 2023; 11:240. [PMID: 37612747 PMCID: PMC10464281 DOI: 10.1186/s40359-023-01283-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/09/2023] [Accepted: 08/10/2023] [Indexed: 08/25/2023] Open
Abstract
BACKGROUND Previous research has shown the impact of pandemic communicable diseases on the mental health of healthcare providers. This study examined the relationship between general health, spiritual health, anxiety associated with COVID-19, job satisfaction, and the mediating role of sex in healthcare providers in Iran in 2021. METHODS This was a descriptive-analytical and cross-sectional study performed on 163 healthcare providers of which 71.8% were female and 28.2% were male with an age range between 21 and 58 years, an average work experience of 9.5 years, and working as nurses, doctors, laboratory technicians, etc. in some hospitals in Sanandaj. Data were collected using COVID-19 Anxiety, General Health, job satisfaction, and Spiritual Health questionnaires. Then, the data were analyzed using SPSS-22 software, regression test, and path analysis. RESULTS Although women averaged lower levels of general health, job satisfaction, and anxiety associated with COVID-19, and higher scores in spiritual health than men, none of these differences were statistically significant, and sex didn't play a significant role here. Also, general health and spiritual health could significantly predict 17.1% of the variance in job satisfaction in the path analysis. However, sex and Covid-19 anxiety could not significantly predict this variable. CONCLUSION The results showed that there was not a significant difference between the male and female workers' general health when facing such pandemics. However, we may prepare interventions to promote their general and spiritual health and to promote healthcare providers' job satisfaction during such pandemics.
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Affiliation(s)
- Daem Roshani
- Health Metrics and Evaluation Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
| | - Keivan Saboni
- Department of Surgery, School of Medicine, Kurdistan Medical Sciences University, Sanandaj, Iran
| | - Mohiadin Amjadian
- English Language Department, School of Medicine, Kurdistan Medical Sciences University, Sanandaj, Iran.
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Kloping YP, Hidayatullah F, Rahman ZA, Chung E, Hakim L. Male Reproductive Tract Involvement and Sperm Parameters in SARS-CoV-2 Patients: A Systematic Review and Meta-Analysis. World J Mens Health 2023; 41:538-557. [PMID: 36102101 PMCID: PMC10307665 DOI: 10.5534/wjmh.220019] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/05/2022] [Revised: 05/06/2022] [Accepted: 05/15/2022] [Indexed: 11/26/2023] Open
Abstract
PURPOSE There is a growing concern regarding the impact of SARS-CoV-2 infection on the male reproductive tract due to ACE2 receptor expression, however, its impact remains unclear. We performed this review to evaluate whether SARS-CoV-2 infection affects the male reproductive system. MATERIALS AND METHODS We conducted a search in the Embase, Scopus, and MEDLINE databases, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline. Eligible studies comprised articles reporting viral RNA presence in semen, sperm parameters, and orchitis or orchiepididymitis occurrence in SARS-CoV-2 patients. Observational studies' quality was determined using the Newcastle-Ottawa Scale (NOS). Case reports were assessed using the Joanna Briggs Institute (JBI)'s checklist. RESULTS A total of 32 relevant articles were included. Viral RNA was found in 7% of infected patients' semen (95% CI, -0.01 to 0.15) from 3 studies. There were also only 7% of patients with orchitis or orchiepididymitis clinical manifestations (95% CI, 0.05-0.10). The semen volume and concentration were 2.34 mL (95% CI, 1.87-2.81) and 51.73 million/mL (95% CI, 31.60-71.85). The progressive and total motility percentages were 36.11% (95% CI, 28.87-43.35) and 43.07% (95% CI, 28.57-57.57), respectively. The morphology was 6.03% (95% CI, -1.05 to 13.10). There is a difference in semen volume between moderate and severe infections (MD, 0.52; 95% CI, 0.27-0.76; p<0.0001) and concentration between mild and moderate (MD, 18.74; 95% CI, 1.02-36.46; p=0.04), mild and severe (MD, 43.50; 95% CI, 13.86-73.14; p=0.004), as well as moderate and severe (MD, 22.25; 95% CI, 9.33-35.17; p=0.0007). CONCLUSIONS SARS-CoV-2 infection may result in decreased sperm concentration in severe cases and the mechanism relates to potential reproductive tract inflammation. The absence of large viral RNA detection in the semen indicates a systemic effect, although this is largely unproven.
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Affiliation(s)
- Yudhistira Pradnyan Kloping
- Department of Urology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia
- Department of Urology, Dr. Soetomo General-Academic Hospital, Surabaya, East Java, Indonesia
| | - Furqan Hidayatullah
- Department of Urology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia
- Department of Urology, Dr. Soetomo General-Academic Hospital, Surabaya, East Java, Indonesia
| | - Zakaria Aulia Rahman
- Department of Urology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia
- Department of Urology, Dr. Soetomo General-Academic Hospital, Surabaya, East Java, Indonesia
| | - Eric Chung
- Department of Urology, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia
| | - Lukman Hakim
- Department of Urology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia
- Department of Urology, Universitas Airlangga Teaching Hospital, Surabaya, East Java, Indonesia.
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Hernández-Dehesa IA, Alvarez-Castro JA, Aguilar-Hidalgo KM, Santellán-Hernández JO, Castro-Soto F. Acute Necrotizing Encephalopathy Post SARS-CoV-2 Infection in an Adult Patient: Case Report. SN COMPREHENSIVE CLINICAL MEDICINE 2023; 5:149. [PMID: 37275566 PMCID: PMC10227787 DOI: 10.1007/s42399-023-01491-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Accepted: 05/22/2023] [Indexed: 06/07/2023]
Abstract
To show the MRI findings in a rare case of acute necrotizing encephalopathy following SARS-CoV-2 infection in an adult patient. Acute necrotizing encephalopathy is a rare condition characterized by the presence of symmetrical multifocal lesions with predominantly thalamic involvement, as well as the brainstem and cerebellum. We describe the case of a 26-year-old male with a medical history of medulloblastoma that was disease-free after treatment and who tested positive in a PCR for SARS-CoV-2 in cerebrospinal fluid. Upon evaluation at the emergency department one week later, the patient was found to be awake, oriented, and focused and could maintain attention for periods of time. Mixed dysarthria persisted, characterized by being flaccid and hypokinetic. On magnetic resonance imaging, there were multiple hemorrhagic lesions with surrounding edema in the right thalamus with an extension to the posterior arm of the internal capsule, a smaller one in the left thalamus, and another expanded to the ipsilateral peduncle. Acute necrotizing encephalopathy presents a great clinical and diagnostic challenge, close clinical and radiological follow-up is essential, and magnetic susceptibility sequences (T2 or SWI) should be included in the diagnosis protocol.
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Affiliation(s)
| | - José Alfonso Alvarez-Castro
- Department of Oncological Neurosurgery, National Institute of Neurology and Neurosurgery “Manuel Velasco Suarez”, Mexico City, Mexico
| | - Keren Magaly Aguilar-Hidalgo
- Department of Oncological Neurosurgery, National Institute of Neurology and Neurosurgery “Manuel Velasco Suarez”, Mexico City, Mexico
| | - José Omar Santellán-Hernández
- Department of Oncological Neurosurgery, National Institute of Neurology and Neurosurgery “Manuel Velasco Suarez”, Mexico City, Mexico
| | - Fernando Castro-Soto
- Department of Oncological Neurosurgery, National Institute of Neurology and Neurosurgery “Manuel Velasco Suarez”, Mexico City, Mexico
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Rahman T, Chowdhury MEH, Khandakar A, Mahbub ZB, Hossain MSA, Alhatou A, Abdalla E, Muthiyal S, Islam KF, Kashem SBA, Khan MS, Zughaier SM, Hossain M. BIO-CXRNET: a robust multimodal stacking machine learning technique for mortality risk prediction of COVID-19 patients using chest X-ray images and clinical data. Neural Comput Appl 2023; 35:1-23. [PMID: 37362565 PMCID: PMC10157130 DOI: 10.1007/s00521-023-08606-w] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/13/2022] [Accepted: 04/11/2023] [Indexed: 06/28/2023]
Abstract
Nowadays, quick, and accurate diagnosis of COVID-19 is a pressing need. This study presents a multimodal system to meet this need. The presented system employs a machine learning module that learns the required knowledge from the datasets collected from 930 COVID-19 patients hospitalized in Italy during the first wave of COVID-19 (March-June 2020). The dataset consists of twenty-five biomarkers from electronic health record and Chest X-ray (CXR) images. It is found that the system can diagnose low- or high-risk patients with an accuracy, sensitivity, and F1-score of 89.03%, 90.44%, and 89.03%, respectively. The system exhibits 6% higher accuracy than the systems that employ either CXR images or biomarker data. In addition, the system can calculate the mortality risk of high-risk patients using multivariate logistic regression-based nomogram scoring technique. Interested physicians can use the presented system to predict the early mortality risks of COVID-19 patients using the web-link: Covid-severity-grading-AI. In this case, a physician needs to input the following information: CXR image file, Lactate Dehydrogenase (LDH), Oxygen Saturation (O2%), White Blood Cells Count, C-reactive protein, and Age. This way, this study contributes to the management of COVID-19 patients by predicting early mortality risk. Supplementary Information The online version contains supplementary material available at 10.1007/s00521-023-08606-w.
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Affiliation(s)
- Tawsifur Rahman
- Department of Electrical Engineering, Qatar University, P.O. Box 2713, Doha, Qatar
| | | | - Amith Khandakar
- Department of Electrical Engineering, Qatar University, P.O. Box 2713, Doha, Qatar
| | - Zaid Bin Mahbub
- Department of Physics and Mathematics, North South University, Dhaka, 1229 Bangladesh
| | | | - Abraham Alhatou
- Department of Biology, University of South Carolina (USC), Columbia, SC 29208 USA
| | - Eynas Abdalla
- Anesthesia Department, Hamad General Hospital, P.O. Box 3050, Doha, Qatar
| | - Sreekumar Muthiyal
- Department of Radiology, Hamad General Hospital, P.O. Box 3050, Doha, Qatar
| | | | - Saad Bin Abul Kashem
- Department of Computer Science, AFG College with the University of Aberdeen, Doha, Qatar
| | - Muhammad Salman Khan
- Department of Electrical Engineering, Qatar University, P.O. Box 2713, Doha, Qatar
| | - Susu M. Zughaier
- Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar
| | - Maqsud Hossain
- NSU Genome Research Institute (NGRI), North South University, Dhaka, 1229 Bangladesh
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Kakodkar P, Dokouhaki P, Wu F, Shavadia J, Nair R, Webster D, Sawyer T, Huan T, Mostafa A. The role of the HLA allelic repertoire on the clinical severity of COVID-19 in Canadians, living in the Saskatchewan province. Hum Immunol 2023; 84:163-171. [PMID: 36707385 PMCID: PMC9852320 DOI: 10.1016/j.humimm.2023.01.003] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/05/2022] [Revised: 01/11/2023] [Accepted: 01/11/2023] [Indexed: 01/22/2023]
Abstract
AIMS The HLA system has been implicated as an underlying determinant for modulating the immune response to SARS-CoV-2. In this study, we aimed to determine the association of patients' HLA genetic profiles with the disease severity of COVID-19 infection. METHODS Prospective study was conducted on COVID-19 patients (n = 40) admitted to hospitals in Saskatoon, Canada, between March and December 2020. Next-generation sequencing was performed on the patient samples to obtain high-resolution HLA typing profiles. The statistical association between HLA allelic frequency and disease severity was examined. The disease severity was categorized based on the length of hospital stay and intensive care needs or demise during the hospital stay. RESULTS HLA allelic frequencies of the high and low-severity cohorts were normalized against corresponding background allelic frequencies. In the high-severity cohort, A*02:06 (11.8-fold), B*51:01 (2.4-fold), B*15:01(3.1-fold), C*01:02 (3.3-fold), DRB1*08:02 (31.2-fold), DQ*06:09 (11-fold), and DPB1*04:02(4-fold) were significantly overrepresented (p < 0.05) making these deleterious alleles. In the low-severity cohort, A*24:02 (2.8-fold), B*35:01 (2.8-fold), DRB1*04:07 (5.3-fold), and DRB1*08:11 (22-fold) were found to be significantly overrepresented (p < 0.05) making these protective alleles. These above alleles interact with NK cell antiviral activity via the killer immunoglobulin-like receptors (KIR). The high-severity cohort had a higher predilection for HLA alleles associated with KIR subgroups; Bw4-80I (1.1-fold), and C1 (1.6-fold) which promotes NK cell inhibition, while the low-severity cohort had a higher predilection for Bw4-80T (1.6-fold), and C2 (1.6-fold) which promote NK cell activation. CONCLUSION In this study, the HLA allelic repository with the distribution of deleterious and protective alleles was found to correlate with the severity of the clinical course in COVID-19. Moreover, the interaction of specific HLA alleles with the KIR-associated subfamily modulates the NK cell-mediated surveillance of SARS-CoV-2. Both deleterious HLA alleles and inhibitory KIR appear prominently in the severe COVID-19 group focusing on the importance of NK cells in the convalescence of COVID-19.
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Affiliation(s)
- Pramath Kakodkar
- Department of Pathology and Laboratory Medicine, University of Saskatchewan College of Medicine, Canada.
| | - Pouneh Dokouhaki
- Department of Pathology and Laboratory Medicine, University of Saskatchewan College of Medicine, Canada.
| | - Fang Wu
- Department of Pathology and Laboratory Medicine, University of Saskatchewan College of Medicine, Canada.
| | - Jay Shavadia
- Division of Cardiology, Department of Medicine, University of Saskatchewan, Canada.
| | - Revathi Nair
- College of Medicine, University of Saskatchewan, Canada.
| | - Destinie Webster
- Department of Pathology and Laboratory Medicine, University of Saskatchewan College of Medicine, Canada.
| | - Terry Sawyer
- Department of Pathology and Laboratory Medicine, University of Saskatchewan College of Medicine, Canada.
| | - Tao Huan
- Department of Chemistry, University of British Columbia, Canada.
| | - Ahmed Mostafa
- Department of Pathology and Laboratory Medicine, University of Saskatchewan College of Medicine, Canada.
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Yang L, Iwami M, Chen Y, Wu M, van Dam KH. Computational decision-support tools for urban design to improve resilience against COVID-19 and other infectious diseases: A systematic review. PROGRESS IN PLANNING 2023; 168:100657. [PMID: 35280114 PMCID: PMC8904142 DOI: 10.1016/j.progress.2022.100657] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/09/2023]
Abstract
The COVID-19 pandemic highlighted the need for decision-support tools to help cities become more resilient to infectious diseases. Through urban design and planning, non-pharmaceutical interventions can be enabled, impelling behaviour change and facilitating the construction of lower risk buildings and public spaces. Computational tools, including computer simulation, statistical models, and artificial intelligence, have been used to support responses to the current pandemic as well as to the spread of previous infectious diseases. Our multidisciplinary research group systematically reviewed state-of-the-art literature to propose a toolkit that employs computational modelling for various interventions and urban design processes. We selected 109 out of 8,737 studies retrieved from databases and analysed them based on the pathogen type, transmission mode and phase, design intervention and process, as well as modelling methodology (method, goal, motivation, focus, and indication to urban design). We also explored the relationship between infectious disease and urban design, as well as computational modelling support, including specific models and parameters. The proposed toolkit will help designers, planners, and computer modellers to select relevant approaches for evaluating design decisions depending on the target disease, geographic context, design stages, and spatial and temporal scales. The findings herein can be regarded as stand-alone tools, particularly for fighting against COVID-19, or be incorporated into broader frameworks to help cities become more resilient to future disasters.
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Affiliation(s)
- Liu Yang
- School of Architecture, Southeast University, Nanjing, China
- Research Center of Urban Design, Southeast University, Nanjing, China
| | - Michiyo Iwami
- Department of Infectious Disease, Faculty of Medicine, Imperial College London, UK
| | - Yishan Chen
- Architecture and Urban Design Research Center, China IPPR International Engineering CO., LTD, Beijing, China
| | - Mingbo Wu
- State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China
- University of Chinese Academy of Sciences, Beijing, China
| | - Koen H van Dam
- Centre for Process Systems Engineering, Department of Chemical Engineering, Imperial College London, UK
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21
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Muacevic A, Adler JR. The Role of Vitamin C in Human Immunity and Its Treatment Potential Against COVID-19: A Review Article. Cureus 2023; 15:e33740. [PMID: 36793827 PMCID: PMC9925039 DOI: 10.7759/cureus.33740] [Citation(s) in RCA: 9] [Impact Index Per Article: 4.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/01/2022] [Accepted: 01/12/2023] [Indexed: 01/15/2023] Open
Abstract
The outbreak of the COVID-19 pandemic has left clinicians around the world searching for viable prevention and treatment options to use against the virus. The important physiologic properties of vitamin C have been well documented regarding its use by immune cells and its role as an antioxidant. It has previously shown potential as a prophylactic and treatment option for other respiratory viruses, and because of this, there has been intrigue into whether these positive outcomes translate into a cost-effective prevention and treatment option for COVID-19. To this point, there have only been a few clinical trials performed to assess the validity of this notion, with very few showing definitive positive outcomes when vitamin C has been incorporated into prophylactic or treatment protocols to use against coronavirus. When being used to specifically treat the severe complications that arise from COVID-19, vitamin C is a reliable option to treat COVID-19-induced sepsis but not pneumonia or acute respiratory distress syndrome (ARDS). As a treatment option, high-dose therapy has shown flashes of promise in a few studies although investigators in these studies often subject the testing group to multimodal therapies that include vitamin C as opposed to just vitamin C alone. Given the role that vitamin C has shown to uphold regarding the human immune response, it is currently advised for all individuals to maintain a normal physiologic range of plasma vitamin C through diet or supplements for adequate prophylactic protection against the virus. More research with definitive outcomes will be needed before it is recommended to provide high-dose vitamin C therapy to prevent or treat COVID-19.
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Mukherjee S, Kshirsagar M, Becker N, Xu Y, Weeks WB, Patel S, Ferres JL, Jackson ML. Identifying long-term effects of SARS-CoV-2 and their association with social determinants of health in a cohort of over one million COVID-19 survivors. BMC Public Health 2022; 22:2394. [PMID: 36539760 PMCID: PMC9765366 DOI: 10.1186/s12889-022-14806-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/29/2021] [Accepted: 12/05/2022] [Indexed: 12/24/2022] Open
Abstract
BACKGROUND Despite an abundance of information on the risk factors of SARS-CoV-2, there have been few US-wide studies of long-term effects. In this paper we analyzed a large medical claims database of US based individuals to identify common long-term effects as well as their associations with various social and medical risk factors. METHODS The medical claims database was obtained from a prominent US based claims data processing company, namely Change Healthcare. In addition to the claims data, the dataset also consisted of various social determinants of health such as race, income, education level and veteran status of the individuals. A self-controlled cohort design (SCCD) observational study was performed to identify ICD-10 codes whose proportion was significantly increased in the outcome period compared to the control period to identify significant long-term effects. A logistic regression-based association analysis was then performed between identified long-term effects and social determinants of health. RESULTS Among the over 1.37 million COVID patients in our datasets we found 36 out of 1724 3-digit ICD-10 codes to be statistically significantly increased in the post-COVID period (p-value < 0.05). We also found one combination of ICD-10 codes, corresponding to 'other anemias' and 'hypertension', that was statistically significantly increased in the post-COVID period (p-value < 0.05). Our logistic regression-based association analysis with social determinants of health variables, after adjusting for comorbidities and prior conditions, showed that age and gender were significantly associated with the multiple long-term effects. Race was only associated with 'other sepsis', income was only associated with 'Alopecia areata' (autoimmune disease causing hair loss), while education level was only associated with 'Maternal infectious and parasitic diseases' (p-value < 0.05). CONCLUSION We identified several long-term effects of SARS-CoV-2 through a self-controlled study on a cohort of over one million patients. Furthermore, we found that while age and gender are commonly associated with the long-term effects, other social determinants of health such as race, income and education levels have rare or no significant associations.
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Affiliation(s)
- Sumit Mukherjee
- Insitro Labs, work done while at Microsoft, South San Francisco, USA
| | - Meghana Kshirsagar
- grid.419815.00000 0001 2181 3404AI for Good Research Lab, Microsoft Corporation, 1 Microsoft Way, WA 98052 Redmond, USA
| | - Nicholas Becker
- grid.419815.00000 0001 2181 3404AI for Good Research Lab, Microsoft Corporation, 1 Microsoft Way, WA 98052 Redmond, USA ,grid.34477.330000000122986657University of Washington, Seattle, USA
| | - Yixi Xu
- grid.419815.00000 0001 2181 3404AI for Good Research Lab, Microsoft Corporation, 1 Microsoft Way, WA 98052 Redmond, USA
| | - William B. Weeks
- grid.419815.00000 0001 2181 3404AI for Good Research Lab, Microsoft Corporation, 1 Microsoft Way, WA 98052 Redmond, USA
| | - Shwetak Patel
- grid.34477.330000000122986657University of Washington, Seattle, USA
| | - Juan Lavista Ferres
- grid.419815.00000 0001 2181 3404AI for Good Research Lab, Microsoft Corporation, 1 Microsoft Way, WA 98052 Redmond, USA
| | - Michael L. Jackson
- grid.488833.c0000 0004 0615 7519Kaiser Permanente Washington, Seattle, USA
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Reis N, Dias MJC, Sousa L, Agostinho I, Ricco MT, Henriques MA, Baixinho CL. Telerehabilitation in the Transitional Care of Patients with Sequelae Associated with COVID-19: Perception of Portuguese Nurses. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:17096. [PMID: 36554975 PMCID: PMC9779261 DOI: 10.3390/ijerph192417096] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 11/17/2022] [Revised: 12/15/2022] [Accepted: 12/16/2022] [Indexed: 06/17/2023]
Abstract
The COVID-19 pandemic brought many changes and challenges to health professionals, due to a lack of knowledge when dealing with the disease, fear of contagion, and the sequelae that characterize long COVID. To deal with this situation, respiratory rehabilitation programs are recommended in face-to-face and/or telerehabilitation modalities. (1) Background: This study had as its primary aim identifying the aspects/components to be considered in the planning and implementation of telerehabilitation interventions that guarantee transitional care for people with long COVID-19 after hospitalization and as a secondary aim identifying the positive aspects of telerehabilitation. (2) Methods: The method used to answer the research question was a focus group, carried out online with eight nurses specialized in rehabilitation nursing. The answers to the semi-structured interview were subjected to content analysis, and qualitative data analysis software (WebQDA®) was used to organize and analyze the findings. (3) Results: Four categories emerged from the content analysis: coordination between care levels; transitional care telerehabilitation intervention; advantages of telerehabilitation; and opportunities. (4) Conclusions: These findings make an important contribution to the reorganization of transitional care, allowing the identification of central aspects to be considered in the planning and implementation of telerehabilitation programs for people with long COVID.
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Affiliation(s)
- Neuza Reis
- Nursing Research, Innovation and Development Centre of Lisbon (CIDNUR), 1900-160 Lisbon, Portugal
- Centro Hospitalar Universitário de Lisboa Central (CHULC), 1169-050 Lisboa, Portugal
| | - Maria José Costa Dias
- Centro Hospitalar Universitário de Lisboa Central (CHULC), 1169-050 Lisboa, Portugal
| | - Luís Sousa
- Higher School of Atlantic Health, 2730-036 Barcarena, Portugal
- Portugal Comprehensive Health Research Centre (CHRC), 7000-811 Evora, Portugal
| | | | - Miguel Toscano Ricco
- NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), 169-056 Lisboa, Portugal
| | - Maria Adriana Henriques
- Nursing Research, Innovation and Development Centre of Lisbon (CIDNUR), 1900-160 Lisbon, Portugal
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Shaked O, Korn L, Shapiro Y, Koren G, Zigdon A. Socio-demographic characteristics and their relation to medical service consumption among elderly in Israel during the COVID-19 lockdown in 2020 as compared to the corresponding period in 2019. PLoS One 2022; 17:e0278893. [PMID: 36520880 PMCID: PMC9754223 DOI: 10.1371/journal.pone.0278893] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/26/2022] [Accepted: 11/25/2022] [Indexed: 12/23/2022] Open
Abstract
PURPOSE The COVID-19 pandemic has led to the isolation of the population in Israel, including the elderly. The present study aimed to compare the consumption of medical services among adults over the age of 65 in Israel at the time of the first COVID-19 lockdown relative to the corresponding period the year before. METHODS We conducted a retrospective longitudinal observational quantitative research based on the Natali Healthcare Solutions Israel database of subscribers. Company subscribers over the age of 65 (N = 103,955) were included in the sample (64.5% women) in two time periods, before the COVID-19 outbreak-P1, in 2019, and during the first COVID-19 lockdown- P2 in 2020. Logistic regression was applied to examine service consumption for study variables. RESULTS The average number of referrals to services was lower during the COVID-19 lockdown period (M = 0.3658, SD = 0.781) compared to the corresponding period in the previous year (M = 0.5402, SD = 0.935). The average number of ambulance orders, doctor home visits and service refusals were higher when compared to the same period in the previous year. During both time periods, women (P1- M = 0.5631, SD = 0.951; P2- M = 0.3846, SD = 0.800) required significantly more (p < .000) services than men (P1- M = 0.5114, SD = 0.910; P2- M = 0.3417, SD = 0.753). Older, widowed people, living in non-Jewish/mixed localities, or in average or below average socioeconomic status localities required relatively more services to those with opposite socio-demographic traits (p < .000). SUMMARY AND CONCLUSIONS In a large sample of elderly in Israel, findings indicate a decrease in referrals to medical care during the first COVID-19 lockdown period, yet an increase in ambulance orders, doctor visits and service refusals. Socio-demographic characteristics showed a similar effect in both time periods. The period of the first COVID-19 lockdown was characterized by a higher incidence of medical service refusals as compared to the equivalent period in the previous year.
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Affiliation(s)
- Ohad Shaked
- School of Graduate Studies, Ariel University, Ariel, Israel
- Disaster Research Center, IL, Ariel University, Ariel, Israel
- Medical Call Centers, Natali, Ramat Gan, Israel
| | - Liat Korn
- Department of Health Systems Management, School of Health Sciences, Ariel University, Ariel, Israel
- * E-mail:
| | - Yair Shapiro
- Department of Health Systems Management, School of Health Sciences, Ariel University, Ariel, Israel
| | - Gideon Koren
- Adelson Faculty of Medicine, Ariel University, Ariel, Israel
| | - Avi Zigdon
- Disaster Research Center, IL, Ariel University, Ariel, Israel
- Department of Health Systems Management, School of Health Sciences, Ariel University, Ariel, Israel
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Alkhatib B, Al Hourani HM, Al-Shami I. Using inflammatory indices for assessing malnutrition among COVID-19 patients: A single-center retrospective study. J Infect Public Health 2022; 15:1472-1476. [PMID: 36403404 PMCID: PMC9650260 DOI: 10.1016/j.jiph.2022.11.006] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/30/2022] [Revised: 10/14/2022] [Accepted: 11/08/2022] [Indexed: 11/13/2022] Open
Abstract
BACKGROUND Coronavirus disease 2019 (COVID-19) causes malnutrition in infected patients. This study aimed to investigate the use of systemic immune-inflammatory index (SII), platelet-to-lymphocyte ratio (PLR), the Glasgow Prognostic Score (GPS), and neutrophil-to-lymphocyte ratio (NLR) for malnutrition assessment among COVID-19 inpatients. METHODS This is a single-center retrospective study on 108 hospitalized COVID-19 patients; 14 were admitted to the intensive care unit (ICU). Data were collected from patients' profiles while NLR, PLR, GPS, and SII were calculated. Inflammatory indices' predictive power was analyzed using the receiver operating characteristic curve (ROC). A P-value of < 0.05 was considered statistically significant. RESULTS Hospitalization days, neutrophils count, C-reactive protein (CRP), and serum urea levels were significantly higher in ICU patients. None of SII, PLR, and NLR were significantly different between ICU and non-ICU groups. Also, albumin and GPS showed a higher sensitivity level (100.0), followed by PLR and SII (78.57 and 71.34, respectively). Regarding ROC curves, even though NLR, PLR, and SII provided the largest area under the curve (AUC) (0.687, 0.682, 0.645; respectively), they have shown a poor discrimination ability, while GPS and albumin were ineffective in predicting malnutrition in COVID-19 patients. CONCLUSION NLR, SII, and PLR showed poor predicting ability for malnutrition among COVID-19 inpatients. Additional consideration should be taken for using inflammatory parameters (SII, PLR, GPS, and NLR) to predict malnutrition in COVID-19 inpatients.
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Affiliation(s)
- Buthaina Alkhatib
- Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences, The Hashemite University, P.O. Box 330127, Zarqa 13133, Jordan.
| | - Huda M Al Hourani
- Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences, The Hashemite University, P.O. Box 330127, Zarqa 13133, Jordan.
| | - Islam Al-Shami
- Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences, The Hashemite University, P.O. Box 330127, Zarqa 13133, Jordan.
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MANRIKYAN GE, SPIRITO F, MARKARYAN MM, VARDANYAN IF, LO MUZIO L, MANRIKYAN ME. Clinical manifestations of oral mucosa lesions in patients with SARS-CoV-2 infection. GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE 2022. [DOI: 10.23736/s0393-3660.22.04915-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/30/2022]
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Baj-Korpak J, Zaworski K, Szymczuk E, Shpakou A. Physical Activity and Mental Health of Medical Students from Poland and Belarus-Countries with Different Restrictive Approaches during the COVID-19 Pandemic. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:13994. [PMID: 36360873 PMCID: PMC9658944 DOI: 10.3390/ijerph192113994] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/11/2022] [Accepted: 10/25/2022] [Indexed: 06/16/2023]
Abstract
BACKGROUND COVID-19 pandemic has struck all of us suddenly and unexpectedly; it deprived the society of a sense of control over their lives on different levels. In a short period of time, it led to a number of changes in everyday life of people all over the world. In particular, these changes affected medical staff, who, all of a sudden, were burdened with new work-related responsibilities and duties. This situation may have had a detrimental effect on their mental health. Due to the unpredictability of the COVID-19 pandemic, we attempted to assess its consequences in terms of mental health and physical fitness of university students from countries in which different approaches to these issues were adopted. METHODS A total of 779 medical students (374 students from John Paul II University of Applied Sciences (ABNS) in Biala Podlaska, Poland, and 405 students from Yanka Kupala State University of Grodno (YKSUG), Belarus) took part in the survey. Three standardised psychometric tools were used in the study: The Satisfaction With Life Scale (SWLS), The General Health Questionnaire (GHQ-28) and Stress Coping Inventory (Mini-COPE). In addition, the International Physical Activity Questionnaire (IPAQ) was applied. RESULTS The vast majority of students both from Poland and Belarus demonstrated high levels of physical activity. However, students from ABNS manifested significantly higher levels of physical activity compared to their counterparts from YKSUG. Students from Biala Podlaska had greater satisfaction with life during the COVID-19 pandemic, whereas their peers from Grodno exhibited higher levels of mental distress. CONCLUSION The COVID-19 pandemic resulted in a significant exacerbation of mental health issues among medical students. In order to alleviate negative effects of the pandemic, it seems necessary for universities to monitor the physical and mental health state of students and to implement prevention programmes.
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Affiliation(s)
- Joanna Baj-Korpak
- Department of Physiotherapy, Faculty of Health Sciences, John Paul II University of Applied Sciences in Biala Podlaska, 21-500 Biala Podlaska, Poland
| | - Kamil Zaworski
- Department of Physiotherapy, Faculty of Health Sciences, John Paul II University of Applied Sciences in Biala Podlaska, 21-500 Biala Podlaska, Poland
| | - Ewa Szymczuk
- Department of Nursing, Faculty of Health Sciences, John Paul II University of Applied Sciences in Biala Podlaska, 21-500 Biala Podlaska, Poland
| | - Andrei Shpakou
- Department of Theory of Physical Culture and Sports Medicine, Yanka Kupala State University of Grodno, 230023 Grodno, Belarus
- Department of Integrated Medical Care, Faculty of Health Sciences, Medical University of Bialystok, 15-089 Bialystok, Poland
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Wen J, Al Sayah F, Simon R, Lahtinen M, Johnson JA, Ohinmaa A. Self-reported health-related quality of life of the general population in Alberta, Canada during the COVID-19 pandemic. J Patient Rep Outcomes 2022; 6:109. [PMID: 36224297 PMCID: PMC9556143 DOI: 10.1186/s41687-022-00518-y] [Citation(s) in RCA: 6] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/14/2022] [Accepted: 10/02/2022] [Indexed: 11/10/2022] Open
Abstract
BACKGROUND The COVID-19 pandemic has impacted various aspects of people's life and wellbeing around the world. This study aimed to examine the impact of the COVID-19 pandemic on health-related quality of life (HRQL), measured by the EQ-5D-5L, amongst the general population in the province of Alberta, Canada, and explore whether the impact varied across population subgroups based on age, gender, and dwelling. METHODS Data came from two waves of a repeated cross-sectional population-based survey, the COVID-19 Experiences and Impact Survey, administered by the Health Quality Council of Alberta. The first data collection (survey 1: n = 8790) was during May/June 2020 and the second (survey 2: n = 9263) during Oct 2020. We examined the comparability of weighted survey data and their representativeness to Alberta's general population. We then explored between-survey differences in EQ-5D-5L index, EQ-VAS and dimension responses, and differences across subgroups within each survey. We compared HRQL of the pooled sample (survey 1&2) with the Alberta population norms data from the pre-pandemic period. RESULTS Mean EQ-5D-5L index and EQ-VAS scores were 0.81 (0.15) and 72.54 (18.57), and 0.82 (0.14) and 71.98 (18.96) in surveys 1 and 2, respectively. The anxiety/depression dimension had the most reported problems (survey 1: 69.5%, survey 2: 70.2%). Respondents aged 16-24 or 75 and older, who identified themselves as a woman, or residing in urban areas had significantly lower EQ-5D-5L index scores compared to their counterparts in both surveys. Between-survey differences were not substantially different. Comparing the pooled sample with the pre-pandemic Alberta population norms, EQ-5D-5L index scores (0.82 vs. 0.84) and EQ-VAS scores (72.26 vs. 77.40) were significantly lower, and respondents aged 16-44, women, or urban residents were more impacted. More problems were reported in the anxiety/depression (69.9% vs. 37.2%) and usual activities dimensions (40.5% vs. 26.0%) during the pandemic period, especially for respondents aged 16-44, women, and those residing in urban areas. CONCLUSIONS Lower HRQL was reported during the COVID-19 pandemic compared to pre-pandemic HRQL in this population, with anxiety/depression and usual activities affected the most. People who were younger, women, and residing in urban areas were most impacted. The government responses to COVID-19 policies during population outbreaks should consider the needs of Albertans in these particular groups.
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Affiliation(s)
- Jiabi Wen
- School of Public Health, 3-267 Edmonton Clinic Health Academy, University of Alberta, 11405 - 87 Ave NW, Edmonton, AB, T6G 1C9, Canada
| | - Fatima Al Sayah
- School of Public Health, 3-267 Edmonton Clinic Health Academy, University of Alberta, 11405 - 87 Ave NW, Edmonton, AB, T6G 1C9, Canada
| | - Roland Simon
- Health Quality Council of Alberta, Calgary, AB, Canada
| | | | - Jeffrey A Johnson
- School of Public Health, 3-267 Edmonton Clinic Health Academy, University of Alberta, 11405 - 87 Ave NW, Edmonton, AB, T6G 1C9, Canada
| | - Arto Ohinmaa
- School of Public Health, 3-267 Edmonton Clinic Health Academy, University of Alberta, 11405 - 87 Ave NW, Edmonton, AB, T6G 1C9, Canada.
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Shaked O, Korn L, Shapiro Y, Zigdon A. Social Factors Contributing to Healthcare Service Requirements during the First COVID-19 Lockdown among Older Adults. Healthcare (Basel) 2022; 10:1854. [PMID: 36292300 PMCID: PMC9601430 DOI: 10.3390/healthcare10101854] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/15/2022] [Revised: 09/14/2022] [Accepted: 09/19/2022] [Indexed: 12/04/2022] Open
Abstract
This study examined social characteristics and their relations to healthcare service demand among older adults during the first COVID-19 lockdown in 2020. The sample was based on a cohort of 103,955 adults over the age of 65. A general index of needs was composed based on healthcare service use data and was predicted in a multi-nominal logistic regression. The frequency of the total needs significantly (p < 0.000) declined while supportive community services (4.9%, 2.0%), living in a community framework (27.0%, 15.2%), and living in a private residence (29.7%, 20.1%) were significantly associated (p < 0.000) with less frequent needs compared to the complementary groups. Supportive communities turned out to be an extremely important service for older adults. Policy makers should consider expanding supportive community services for older adults, as it was shown to have a positive correlation with lower healthcare service use, which might be an indicator of better overall health.
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Affiliation(s)
- Ohad Shaked
- School of Graduate Studies, Ariel University, Ariel 40700, Israel
- Natali Healthcare Solutions, Ramat Gan 15208, Israel
- Disaster Research Center IL, Ariel University, Ariel 40700, Israel
| | - Liat Korn
- Department of Health Systems Management, School of Health Sciences, Ariel University, Ariel 40700, Israel
| | - Yair Shapiro
- Department of Health Systems Management, School of Health Sciences, Ariel University, Ariel 40700, Israel
| | - Avi Zigdon
- Disaster Research Center IL, Ariel University, Ariel 40700, Israel
- Department of Health Systems Management, School of Health Sciences, Ariel University, Ariel 40700, Israel
- Health Promotion and Well-Being Research Center, Ariel University, Ariel 40700, Israel
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30
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Kushner P, McCarberg BH, Grange L, Kolosov A, Haveric AL, Zucal V, Petruschke R, Bissonnette S. The use of non-steroidal anti-inflammatory drugs (NSAIDs) in COVID-19. NPJ Prim Care Respir Med 2022; 32:35. [PMID: 36127354 PMCID: PMC9489480 DOI: 10.1038/s41533-022-00300-z] [Citation(s) in RCA: 33] [Impact Index Per Article: 11.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/06/2021] [Accepted: 07/26/2022] [Indexed: 11/19/2022] Open
Abstract
Early in the COVID-19 pandemic, anecdotal reports emerged suggesting non-steroidal anti-inflammatory drugs (NSAIDs) may increase susceptibility to infection and adversely impact clinical outcomes. This narrative literature review (March 2020–July 2021) attempted to clarify the relationship between NSAID use and COVID-19 outcomes related to disease susceptibility or severity. Twenty-four relevant publications (covering 25 studies) reporting original research data were identified; all were observational cohort studies, and eight were described as retrospective. Overall, these studies are consistent in showing that NSAIDs neither increase the likelihood of SARS-CoV-2 infection nor worsen outcomes in patients with COVID-19. This is reflected in current recommendations from major public health authorities across the world, which support NSAID use for analgesic or antipyretic treatment during COVID-19. Thus, there is no basis on which to restrict or prohibit use of these drugs by consumers or patients to manage their health conditions and symptoms during the pandemic.
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Affiliation(s)
- Pamela Kushner
- Kushner Wellness Center, Los Angeles, CA, USA. .,Department of Family Medicine, University of California, Irvine, CA, USA.
| | - Bill H McCarberg
- Department of Family Medicine, University of California at San Diego School of Medicine, San Diego, CA, USA
| | - Laurent Grange
- Rheumatology Department, Grenoble-Alpes University Hospital, Echirolles, France.,President of the French League Against Rheumatism (AFLAR), Paris, France
| | - Anton Kolosov
- Medical Affairs, GSK Consumer Healthcare, Rochester Park, Singapore, Singapore
| | | | - Vincent Zucal
- Consumer Safety, GSK Consumer Healthcare, Warren, NJ, USA
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31
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Adedeji AA, Vijayakumar PP. The propensity of fomite spread of SARS-CoV-2 virus through produce supply chain. BULLETIN OF THE NATIONAL RESEARCH CENTRE 2022; 46:245. [PMID: 36156873 PMCID: PMC9483276 DOI: 10.1186/s42269-022-00935-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 06/16/2022] [Accepted: 09/09/2022] [Indexed: 06/16/2023]
Abstract
Background The global community has battled the spread of SAR-CoV-2 for almost 2 years, and the projection is that the virus may be recurrent like the seasonal flu. The SARS-CoV-2 pandemic disrupted activities within the food supply chain that cost billions of dollars globally. This has heightened concerns about fomite spread of the virus through surfaces. There is an urgent need to understand the risk portends by this virus along the produce supply chain with conditions (low temperature and high relative humidity) conducive to extended survival of the virus. Main body Pre-dating SARS-CoV-2 are other types of coronaviruses that had lower infection and mortality rates. There are some similarities between the former and the new coronavirus, especially with regards to transmission modes and their survivability on surfaces. There is evidence of other coronaviruses' survival on surfaces for weeks. Currently, there are limited evidence-based studies to enlighten us on how the virus is transmitted within the produce supply chain. A few studies claim that the virus could spread through the cold supply chains. However, these are not sufficient to make a conclusive inference about the deadly SARS-CoV-2. Conclusions This paper provides a succinct review of the literature on current understanding of the transmission, survivability, and risk SARS-CoV-2 portend to humans within the produce supply chain and calls for more evidence-based research to allay or alert us of the potential risk of fomite transmission of SARS-CoV-2. The paper also highlights examples of conventional and novel non-thermal inactivation and sanitation methods applicable to this type of virus.
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Affiliation(s)
- Akinbode A. Adedeji
- Department of Biosystems and Agricultural Engineering, University of Kentucky, Lexington, KY USA
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32
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Bin KJ, De Pretto LR, Sanchez FB, Battistella LR. Digital Platform to Continuously Monitor Patients Using a Smartwatch: Preliminary Report. JMIR Form Res 2022; 6:e40468. [PMID: 36107471 PMCID: PMC9523529 DOI: 10.2196/40468] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/22/2022] [Revised: 08/01/2022] [Accepted: 08/23/2022] [Indexed: 11/28/2022] Open
Abstract
Background Monitoring vital signs such as oximetry, blood pressure, and heart rate is important to follow the evolution of patients. Smartwatches are a revolution in medicine allowing the collection of such data in a continuous and organic way. However, it is still a challenge to make this information available to health care professionals to make decisions during clinical follow-up. Objective This study aims to build a digital solution that displays vital sign data from smartwatches, collected remotely, continuously, reliably, and from multiple users, with trigger warnings when abnormal results are identified. Methods This is a single-center prospective study following the guidelines “Evaluating digital health products” from the UK Health Security Agency. A digital platform with 3 different applications was created to capture and display data from the mobile phones of volunteers with smartwatches. We selected 80 volunteers who were followed for 24 weeks each, and the synchronization interval between the smartwatch and digital solution was recorded for each vital sign collected. Results In 14 weeks of project progress, we managed to recruit 80 volunteers, with 68 already registered in the digital solution. More than 2.8 million records have already been collected, without system downtime. Less than 5% of continuous heart rate measurements (bpm) were synchronized within 2 hours. However, approximately 70% were synchronized in less than 24 hours, and 90% were synchronized in less than 119 hours. Conclusions The digital solution is working properly in its role of displaying data collected from smartwatches. Vital sign values are being monitored by the research team as part of the monitoring of volunteers. Although the digital solution proved unsuitable for monitoring urgent events, it is more than suitable for use in outpatient clinical use. This digital solution, which is based on cloud technology, can be applied in the future for telemonitoring in regions lacking health care professionals. Accuracy and reliability studies still need to be performed at the end of the 24-week follow-up.
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Affiliation(s)
- Kaio Jia Bin
- Instituto de Medicina Física e Reabilitação do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
| | - Lucas Ramos De Pretto
- Instituto de Medicina Física e Reabilitação do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
| | - Fabio Beltrame Sanchez
- Instituto de Medicina Física e Reabilitação do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
| | - Linamara Rizzo Battistella
- Instituto de Medicina Física e Reabilitação do Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
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33
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Hu S, Chen C, Yang B, Liu Q, Hu H. Experience of rehabilitation management in public hospital after it was identified as designated rehabilitation hospital for COVID-19 patients: A qualitative study. Front Public Health 2022; 10:919730. [PMID: 35958844 PMCID: PMC9362772 DOI: 10.3389/fpubh.2022.919730] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/13/2022] [Accepted: 06/27/2022] [Indexed: 01/08/2023] Open
Abstract
Objective It is essential to focus on the rehabilitation of COVID-19 patients after discharge to prevent their long-term sequelae, but there is less research on healthcare organizations enhancing rehabilitation services for patients discharged from COVID-19. Therefore, this study aimed to describe how a public hospital provides better rehabilitation services for patients after being identified as a designated rehabilitation hospital for patients with COVID-19 and attempted to combine the theory of organizational change to analyze how the hospital finally successfully transformed. Methods A tertiary public hospital located in the center of Xi'an was selected for the study. It was identified as a designated hospital for the rehabilitation of patients discharged from the hospital with COVID-19. Nine hospital leaders and group leaders closely related to the rehabilitation management work were invited to participate in interviews to explore the fact about the hospital's rehabilitation work. The semi-structured interview with the hospital director and the focus group interview with group leaders were used for data collection. Two researchers independently conducted a thematic analysis of these responses. Results One hundred and seventy-eight primary codes, 22 subcategories, six main categories, and one core theme were obtained from data analysis. The main categories include organization and coordination (overall deployment, transfer patient, and external coordination), hospital infection prevention and control (process transformation, ward disinfection, hospital infection training, inspection, and supervision), staff management (staff classification, closed-loop management, and staff health screening), individual services for patients (create an individual scheme, humanistic care, organize special activities, and strengthen communication and guidance), comprehensive supporting (basic medical guarantee, daily necessities guarantee, health and nutrition guarantee, and assistance fund guarantee) and positive transformation (strategic thinking, benchmarking, strengthen cohesion, and expand influence). Conclusion The hospital had to transform its operations in the face of a complex environment during the pandemic. After deciding to transform, the hospital effectively prevented nosocomial infections and provided rehabilitation services to 583 patients through systematic management measures such as organizational coordination, staff classification, and personalized services. In the end, it has been successfully transformed and has grown rapidly. To ensure that it can continue to grow sustainably, the hospital enhanced the new ways that have emerged from this transformation.
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Affiliation(s)
- Shuxiao Hu
- School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, China
| | - Changfu Chen
- School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, China
| | - Biwen Yang
- School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, China
| | - Qing Liu
- School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, China
- First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China
| | - Han Hu
- School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, China
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Буйваленко УВ, Перепелова МА, Золотарева РА, Белая ЖЕ, Мельниченко ГА. [Pituitary and COVID-19: review]. PROBLEMY ENDOKRINOLOGII 2022; 68:14-23. [PMID: 36337014 PMCID: PMC9762450 DOI: 10.14341/probl13108] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 04/19/2022] [Revised: 07/15/2022] [Accepted: 07/20/2022] [Indexed: 06/16/2023]
Abstract
A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread around the world since was first scientifically described in December 2019. At present approximately 400 million people have suffered from the disease, almost 6 million people have died.SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) and the serine protease TMPRSS2 for S protein priming. ACE2 and TMPRSS2 are expressed in several endocrine glands, including the pituitary, pancreas, thyroid, ovaries, and testes. Thus, the endocrine glands may be a direct target for SARS-CoV-2. The main risk factors for severity of the COVID-19 are obesity, arterial hypertension, diabetes mellitus (DM), vertebral fractures, which potentially predisposes patients to a severe course of COVID-19.In this review, we present current data on the course of COVID-19 in patients with hypothalamic-pituitary diseases, and also discuss treatment for endocrinopathies during to COVID-19.
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Affiliation(s)
| | | | | | - Ж. Е. Белая
- Национальный медицинский исследовательский центр эндокринологии
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35
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Pereira FM, Salomão de Araujo A, Catarina Martins Reis A, Santos da Hora A, Pinotti F, Paton RS, Vilas Boas Figueiredo C, Lopes Damasceno C, Carlos dos Santos D, Souza de Santana D, Freitas Sales D, Ariana Andrade Brandão E, da Silva Batista E, Campos de Sousa FS, Santana Menezes G, Silveira dos Santos J, Gomes Lima J, Tadeu Brito J, Dandara dos Santos L, Reboredo L, Santana Santos M, Kelly Astete Gomez M, Freitas da Cruz M, Rosa Ampuero M, Guerra Lemos da Silva M, S. da Paixão Melo M, Ferreira da Silva M, de Jesus Gonçalves dos Santos N, de Souza Pessoa N, Silva de Araujo R, de Macedo Godim T, Fraga de Oliveira Tosta S, Brandão Nardy V, Cristina Faria E, Frederico de Carvalho Dominguez Souza B, Laís Almeida dos Santos J, Wikramaratna P, Giovanetti M, Alcântara LCJ, Lourenço J, Leal e Silva de Mello A. Dynamics and Determinants of SARS-CoV-2 RT-PCR Testing on Symptomatic Individuals Attending Healthcare Centers during 2020 in Bahia, Brazil. Viruses 2022; 14:v14071549. [PMID: 35891528 PMCID: PMC9321627 DOI: 10.3390/v14071549] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/01/2022] [Revised: 07/03/2022] [Accepted: 07/05/2022] [Indexed: 02/05/2023] Open
Abstract
RT-PCR testing data provides opportunities to explore regional and individual determinants of test positivity and surveillance infrastructure. Using Generalized Additive Models, we explored 222,515 tests of a random sample of individuals with COVID-19 compatible symptoms in the Brazilian state of Bahia during 2020. We found that age and male gender were the most significant determinants of test positivity. There was evidence of an unequal impact among socio-demographic strata, with higher positivity among those living in areas with low education levels during the first epidemic wave, followed by those living in areas with higher education levels in the second wave. Our estimated probability of testing positive after symptom onset corroborates previous reports that the probability decreases with time, more than halving by about two weeks and converging to zero by three weeks. Test positivity rates generally followed state-level reported cases, and while a single laboratory performed ~90% of tests covering ~99% of the state's area, test turn-around time generally remained below four days. This testing effort is a testimony to the Bahian surveillance capacity during public health emergencies, as previously witnessed during the recent Zika and Yellow Fever outbreaks.
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Affiliation(s)
- Felicidade Mota Pereira
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Aline Salomão de Araujo
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Ana Catarina Martins Reis
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Anadilton Santos da Hora
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Francesco Pinotti
- Department of Zoology, University of Oxford, Oxford OX1 3SZ, UK; (F.P.); (R.S.P.)
| | - Robert S. Paton
- Department of Zoology, University of Oxford, Oxford OX1 3SZ, UK; (F.P.); (R.S.P.)
| | - Camylla Vilas Boas Figueiredo
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Caroline Lopes Damasceno
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Daiana Carlos dos Santos
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Daniele Souza de Santana
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Danielle Freitas Sales
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Evelyn Ariana Andrade Brandão
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Everton da Silva Batista
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Fulvia Soares Campos de Sousa
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Gabriela Santana Menezes
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Jackeline Silveira dos Santos
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Jaqueline Gomes Lima
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Jean Tadeu Brito
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Lenisa Dandara dos Santos
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Luciana Reboredo
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Maiara Santana Santos
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Marcela Kelly Astete Gomez
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Marcia Freitas da Cruz
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Mariana Rosa Ampuero
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Mariele Guerra Lemos da Silva
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Mariza S. da Paixão Melo
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Marta Ferreira da Silva
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Nadja de Jesus Gonçalves dos Santos
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Núbia de Souza Pessoa
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Ramile Silva de Araujo
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Taiane de Macedo Godim
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | | | - Vanessa Brandão Nardy
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Elaine Cristina Faria
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Breno Frederico de Carvalho Dominguez Souza
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | - Jessica Laís Almeida dos Santos
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
| | | | - Marta Giovanetti
- Laboratório de Flavivírus, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro 21045-900, Brazil;
- Department of Science and Technology for Humans and the Environment, University of Campus Bio-Medico di Roma, 00128 Rome, Italy
| | - Luiz Carlos Junior Alcântara
- Laboratório de Flavivírus, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro 21045-900, Brazil;
- Correspondence: (L.C.J.A.); (J.L.)
| | - José Lourenço
- Biosystems and Integrative Sciences Institute, Faculdade de Ciências, 1749-016 Lisboa, Portugal
- Correspondence: (L.C.J.A.); (J.L.)
| | - Arabela Leal e Silva de Mello
- Laboratório Central de Saúde Pública Professor Gonçalo Muniz, Salvador 40295-010, Brazil; (F.M.P.); (A.S.d.A.); (A.C.M.R.); (A.S.d.H.); (C.V.B.F.); (C.L.D.); (D.C.d.S.); (D.S.d.S.); (D.F.S.); (E.A.A.B.); (E.d.S.B.); (F.S.C.d.S.); (G.S.M.); (J.S.d.S.); (J.G.L.); (J.T.B.); (L.D.d.S.); (L.R.); (M.S.S.); (M.K.A.G.); (M.F.d.C.); (M.R.A.); (M.G.L.d.S.); (M.S.d.P.M.); (M.F.d.S.); (N.d.J.G.d.S.); (N.d.S.P.); (R.S.d.A.); (T.d.M.G.); (V.B.N.); (E.C.F.); (B.F.d.C.D.S.); (J.L.A.d.S.); (A.L.e.S.d.M.)
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A Review on Risk Management of Coronavirus Disease 19 (COVID-19) Infection in Dental Practice: Focus on Prosthodontics and All-Ceramic Materials. PROSTHESIS 2022. [DOI: 10.3390/prosthesis4030028] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/16/2022]
Abstract
Background: A novel β-coronavirus infection (COVID-19) was first detected in Wuhan city, spreading rapidly to other countries and leading to a pandemic. Dental professionals and patients are exposed to a high risk of COVID-19 infection, particularly in the prosthodontic practice, because of the bio-aerosol produced during teeth preparation with dental handpieces and the strict contact with oral fluids during impression making. This paper aimed to provide an overview to limit the risk of transmission of COVID-19 infections during prosthetic procedures in dental offices. Methods: An electronic search was conducted on the electronic databases of PubMed/Medline, Google Scholar, Embase, Scopus, Dynamed, and Open Grey with the following queries: (COVID-19) AND/OR (SARS-CoV-2) AND/OR (Coronavirus) AND/OR (contaminated surface) AND/OR (cross-infection) AND/OR (Prosthodontics) AND/OR (dental ceramic) AND/OR (glass-ceramic). A manual search was performed as well. Results: From the 1023 collected records, 32 papers were included. Conclusions: Dental offices are at high risk of spreading SARS-CoV-2 infection due to the close contact with patients and continuous exposure to saliva during dental procedures. Therefore, pre-check triages via telephone, decontamination, the disinfection of impressions, the sterilization of scanner tips, and the use of specific personal protective equipment, dental high-speed handpieces with dedicated anti-retraction valves, and effective mouthwashes are strongly recommended.
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Meyer CH, Grant A, Sola R, Gills K, Mora AN, Tracy BM, Muralidharan VJ, Koganti D, Todd SR, Butler C, Nguyen J, Hurst S, Udobi K, Sciarretta J, Williams K, Davis M, Dente C, Benjamin E, Ayoung-Chee P, Smith RN. Presentation, clinical course and complications in trauma patients with concomitant COVID-19 infection. Am J Surg 2022; 224:607-611. [PMID: 35534294 PMCID: PMC8978444 DOI: 10.1016/j.amjsurg.2022.03.040] [Citation(s) in RCA: 6] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/06/2022] [Revised: 03/20/2022] [Accepted: 03/23/2022] [Indexed: 12/15/2022]
Abstract
BACKGROUND This study investigated the impact of COVID-19 infection on hospitalized trauma patients. METHODS A retrospective review of hospitalized trauma patients at a level I trauma center was performed from March-December 2020. Data pertaining to patient demographics, presentation and hospital course was compared between COVID positive and negative trauma patients. RESULTS There were 4,912 patients and 179 (3.64%) were COVID-19 positive. Demographics and clinical presentation did not differ significantly between those with and without concomitant COVID-19. However, COVID positive trauma patients had higher rates of acute kidney injury (p = 0.016), sepsis (p = 0.016), unplanned intubation (p = 0.002) and unplanned return to the ICU (p = 0.01). The COVID positive cohort also had longer hospital stays (p < 0.01) with no significant difference in mortality. CONCLUSIONS In the setting of an ongoing pandemic, awareness of the complications COVID positive trauma patients are predisposed to is important for providers.
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Affiliation(s)
- C H Meyer
- Grady Health System, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA; Rollins School of Public Health, Emory University, Atlanta, GA, USA.
| | - A Grant
- Grady Health System, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
| | - Richard Sola
- Grady Health System, Atlanta, GA, USA; Morehouse School of Medicine, Atlanta, GA, USA.
| | - K Gills
- Grady Health System, Atlanta, GA, USA; Morehouse School of Medicine, Atlanta, GA, USA.
| | - Ariana N Mora
- Emory University School of Medicine, Atlanta, GA, USA; Rollins School of Public Health, Emory University, Atlanta, GA, USA.
| | - B M Tracy
- The Ohio State University Wexner Medical Center, Columbus, OH, USA.
| | | | - D Koganti
- Grady Health System, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
| | - S R Todd
- Grady Health System, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
| | - C Butler
- Grady Health System, Atlanta, GA, USA; Morehouse School of Medicine, Atlanta, GA, USA.
| | - J Nguyen
- Grady Health System, Atlanta, GA, USA; Morehouse School of Medicine, Atlanta, GA, USA.
| | - S Hurst
- Grady Health System, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
| | - K Udobi
- Grady Health System, Atlanta, GA, USA; Morehouse School of Medicine, Atlanta, GA, USA.
| | - J Sciarretta
- Grady Health System, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
| | - K Williams
- Grady Health System, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
| | - M Davis
- Grady Health System, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
| | - C Dente
- Grady Health System, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
| | - E Benjamin
- Grady Health System, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
| | - P Ayoung-Chee
- Grady Health System, Atlanta, GA, USA; Morehouse School of Medicine, Atlanta, GA, USA.
| | - R N Smith
- Grady Health System, Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA; Rollins School of Public Health, Emory University, Atlanta, GA, USA.
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Alahmad AM, Kamel SA, Alsulimani ST, Alharbi MS, Alyazidi FR, Allhaybi YA. Types of Variants Among Increased Cases of COVID-19 in the Western Region of Saudi Arabia in June 2021. Cureus 2022; 14:e26016. [PMID: 35859956 PMCID: PMC9288303 DOI: 10.7759/cureus.26016] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 06/16/2022] [Indexed: 11/09/2022] Open
Abstract
Background The western region of Saudi Arabia is the most populous and diverse. This study aimed to identify the types and distribution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants causing cases of coronavirus disease 2019 (COVID-19) in this region in June 2021. Methods We conducted a cross-sectional study. All genetically tested COVID-19 patients were included. We investigated the types, distribution, and magnitude of SARS-CoV-2 variants among cases of COVID-19 in June 2021. We gathered patient demographic data, clinical profiles, and epidemiology data. Results Of 115 COVID-19 confirmed patients (mean age, 40 years), 56.5% were males and 43.5% were females. Of those vaccinated, 47.1% had received a one-dose vaccination; 52.9% had received two-dose vaccinations, and 23.6% were unvaccinated. Of those vaccinated, 72.1% had received the Pfizer BioNTech vaccine, and 16.5% had received the Oxford-AstraZeneca vaccine. The Delta variant of SARS-CoV-2 was prevalent in most (87.8%) patients. Among those infected, 28.8% reported contact with another COVID-19 case, and 19.8% reported a travel history. Most cases (68.6%) were moderate, 99.4% of patients recovered, and one patient died from COVID-19. Conclusion Most of the cases were primary infections, and the Delta variant was predominant and highly transmissible. Most COVID-19 patients were mild to moderately ill. A better understanding of the transmission and diagnosis of these variants will help in early detection and reduction of infection by application of the best preventive measures.
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Shafiee A, Teymouri Athar MM, Kohandel Gargari O, Jafarabady K, Siahvoshi S, Mozhgani SH. Ivermectin under scrutiny: a systematic review and meta-analysis of efficacy and possible sources of controversies in COVID-19 patients. Virol J 2022; 19:102. [PMID: 35698151 PMCID: PMC9191543 DOI: 10.1186/s12985-022-01829-8] [Citation(s) in RCA: 16] [Impact Index Per Article: 5.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/24/2022] [Accepted: 06/02/2022] [Indexed: 12/26/2022] Open
Abstract
BACKGROUND We conducted a systematic review and meta-analysis to evaluate the efficacy of ivermectin for COVID-19 patients based on current peer-reviewed RCTs and to address disputes over the existing evidence. METHODS MEDLINE (Pubmed), Scopus, Web of Science, Cochrane library, Google scholar and Clinicaltrials.gov were searched for RCTs assessing the efficacy of Ivermectin up to 20 February 2022. A systematic review and meta-analysis of studies was performed based on the PRISMA 2020 statement criteria. RESULTS 19 and 17 studies were included in this systematic review and meta-analysis, respectively. There was no significant difference in progression to severe disease (log OR - 0.27 [95% CI - 0.61 to 0.08], I2 = 42.29%), negative RT-PCR (log OR 0.25 [95% CI - 0.18-0.68], I2 = 58.73%), recovery (log OR 0.11 [95% CI - 0.22-0.45], I2 = 13.84%), duration of hospitalization (SMD - 0.40 [95% CI - 0.85-0.06], I2 = 88.90%), time to negative RT-PCR (SMD - 0.36 [95% CI - 0.89-0.17], I2 = 46.2%), and viral load (SMD -0.17 [95% CI -0.45 to 0.12], I^2 = 0%). It is worth noting that, based on low-certainty evidence, ivermectin may possibly reduce mortality (log OR - 0.67 [95% CI - 1.20 to - 0.13], I2 = 28.96%). However, studies with a higher risk of bias were more likely to indicate positive effects on the efficacy of this drug, according to our subgroup analyses based on study quality. CONCLUSION Ivermectin did not have any significant effect on outcomes of COVID-19 patients and as WHO recommends, use of ivermectin should be limited to clinical trials.
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Affiliation(s)
- Arman Shafiee
- Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
- School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
| | | | | | - Kyana Jafarabady
- Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
| | - Sepehr Siahvoshi
- Dental Materials Research Center, Dental School, Islamic Azad University of Medical Sciences, Tehran, Iran
| | - Sayed-Hamidreza Mozhgani
- Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
- Non-Communicable Disease Research Center, Alborz University of Medical Sciences, Karaj, Iran.
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Lung’s Segmentation Using Context-Aware Regressive Conditional GAN. APPLIED SCIENCES-BASEL 2022. [DOI: 10.3390/app12125768] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/16/2022]
Abstract
After declaring COVID-19 pneumonia as a pandemic, researchers promptly advanced to seek solutions for patients fighting this fatal disease. Computed tomography (CT) scans offer valuable insight into how COVID-19 infection affects the lungs. Analysis of CT scans is very significant, especially when physicians are striving for quick solutions. This study successfully segmented lung infection due to COVID-19 and provided a physician with a quantitative analysis of the condition. COVID-19 lesions often occur near and over parenchyma walls, which are denser and exhibit lower contrast than the tissues outside the parenchyma. We applied Adoptive Wallis and Gaussian filter alternatively to regulate the outlining of the lungs and lesions near the parenchyma. We proposed a context-aware conditional generative adversarial network (CGAN) with gradient penalty and spectral normalization for automatic segmentation of lungs and lesion segmentation. The proposed CGAN implements higher-order statistics when compared to traditional deep-learning models. The proposed CGAN produced promising results for lung segmentation. Similarly, CGAN has shown outstanding results for COVID-19 lesions segmentation with an accuracy of 99.91%, DSC of 92.91%, and AJC of 92.91%. Moreover, we achieved an accuracy of 99.87%, DSC of 96.77%, and AJC of 95.59% for lung segmentation. Additionally, the suggested network attained a sensitivity of 100%, 81.02%, 76.45%, and 99.01%, respectively, for critical, severe, moderate, and mild infection severity levels. The proposed model outperformed state-of-the-art techniques for the COVID-19 segmentation and detection cases.
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Breastfeeding, Complementary Feeding, Physical Activity, Screen Use, and Hours of Sleep in Children under 2 Years during Lockdown by the COVID-19 Pandemic in Chile. CHILDREN 2022; 9:children9060819. [PMID: 35740756 PMCID: PMC9221584 DOI: 10.3390/children9060819] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Subscribe] [Scholar Register] [Received: 04/28/2022] [Revised: 05/26/2022] [Accepted: 05/30/2022] [Indexed: 11/16/2022]
Abstract
Infants and children are a risk group in terms of developing healthy habits, an important aspect if we consider that many of them were born during the COVID-19 pandemic. Our objective was to evaluate compliance with lifestyle recommendations proposed at the national and international levels in children aged 0 to 23 months during confinement due to the COVID-19 pandemic in Chile. A cross-sectional study was conducted, and 211 online questionnaires were completed with sociodemographic and lifestyle information of children. Our results show high compliance with the recommendations on breastfeeding intake (78.3% and 69.5% in 0–5-month-old and 6–23-month-old children, respectively); age of starting complementary feeding (87.4%); non-consumption of salt and sugar (80.1%), non-caloric sweeteners (90.7%), and sweet and salty snacks (68.9%); and hours of physical activity (66.8%) and sleep (65.4%). However, we observed low compliance with the recommendations on the age of introduction of dinner (58.0%), eggs (23.0%), legumes (39.2%), and fish (35.1%); low consumption of legumes (43.4%) and fish (20.5%); and low compliance with the recommendations on screen use during meals (59.2%) and daily screen hours (41.2%). In conclusion, feeding behavior, physical activity, use of screens, and hours of sleep in children were altered by confinement during the pandemic, harming the development of healthy lifestyles.
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Al-Mulla NA, Mahfoud ZR. The Impact of the COVID-19 Lockdown “Home Quarantine” on the Physical Activity and Lifestyle of Children in Qatar. Front Public Health 2022; 10:877424. [PMID: 35692309 PMCID: PMC9174584 DOI: 10.3389/fpubh.2022.877424] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/16/2022] [Accepted: 04/19/2022] [Indexed: 12/16/2022] Open
Abstract
Background Several studies have investigated how the coronavirus disease 2019 (COVID-19) pandemic impacted children's lifestyle. To our knowledge, this is the first study that assesses the impact of quarantine on physical activity, screen time, sleep, and diet in children aged 5 to 12 in Qatar. Methods Cross-sectional data from an online survey distributed in Qatar was analyzed. The survey measured the parents' or caregivers' assessment on the change in the child's physical activity, sleep, screen time, and diet between the two periods (before quarantine and during quarantine). The data was analyzed using frequency distributions, paired t-test and McNemar's test. Results Data from 144 respondents were analyzed. Due to the quarantine, the total weekly average hours of physical activity significantly decreased with a greatest reduction for the school and after school durations. Only 4.5% of the children were engaging in at least 60 minutes of physical activity per day (in contrast to 25.6% prior to quarantine). The reported barriers for physical activity were screen time for school (52.8%) and leisure (51.4%). There was a significant increase in the total number of main meals per day, with a higher consumption of unhealthy food. The majority of the children had their bedtime and waketime shifted to later because of the quarantine. The parents' or caregivers' satisfaction with the child's lifestyle during quarantine showed that 49.1% were disappointed or very disappointed. Also, 53.8% described their child's mental health as “better before quarantine.” Conclusions Quarantine had a negative impact on the lifestyle of children in Qatar. When implementing restrictions, authorities should consider some interventions to counterpart such impact.
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Affiliation(s)
- Nada A. Al-Mulla
- Department of Medical Education, Weill Cornell Medicine - Qatar, Doha, Qatar
| | - Ziyad R. Mahfoud
- Department of Medical Education, Weill Cornell Medicine - Qatar, Doha, Qatar
- Division of Epidemiology, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States
- *Correspondence: Ziyad R. Mahfoud
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Dholariya S, Parchwani DN, Singh R, Radadiya M, Katoch CDS. Utility of P-SEP, sTREM-1 and suPAR as Novel Sepsis Biomarkers in SARS-CoV-2 Infection. Indian J Clin Biochem 2022; 37:131-138. [PMID: 34642555 PMCID: PMC8494168 DOI: 10.1007/s12291-021-01008-6] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/15/2021] [Accepted: 09/18/2021] [Indexed: 12/22/2022]
Abstract
The coronavirus disease 2019 is a highly contagious viral infection caused by SARS-CoV-2 virus, member of coronaviridae family. It causes life threatening complications due to complexity and rapid onset course of the disease. Early identification of high-risk patients who require close monitoring and aggressive treatment remains challengeable till date. Novel biomarkers which help to identify high risk patients at the early stage is high priority. Objective of this review to find utility of P-SEP, sTREM-1 and suPAR for diagnosis, risk stratification and prognosis of SARS-CoV-2 infected cases. Soluble receptors like, P-SEP, sTREM-1 and suPAR have been involved in immune regulation in SARS-CoV-2 infection and elevate more in severe cases. A comprehensive research of databases like PubMed, EMBASE, CNKI and Web of Science was performed for relevant studies. A total of nine out of fifteen research literature in initial screening were included for this review. Interestingly all studies have reported high levels of P-SEP, sTREM-1 and suPAR in SARS-CoV-2 infected cases and the biomarkers positively correlated with severity of infection. This implies that P-SEP, sTREM-1 and suPAR can be implemented as surrogate marker in blood profile for early diagnosis, risk stratification and prognosis in SARS-CoV-2 for better management in Indian population at the current situation.
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Affiliation(s)
- Sagar Dholariya
- All India Institute of Medical Sciences, Rajkot, Gujarat India
| | | | - Ragini Singh
- All India Institute of Medical Sciences, Rajkot, Gujarat India
| | | | - C. D. S. Katoch
- All India Institute of Medical Sciences, Rajkot, Gujarat India
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Vogel F, Reincke M. Endocrine risk factors for COVID-19: Endogenous and exogenous glucocorticoid excess. Rev Endocr Metab Disord 2022; 23:233-250. [PMID: 34241765 PMCID: PMC8267234 DOI: 10.1007/s11154-021-09670-0] [Citation(s) in RCA: 9] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 06/21/2021] [Indexed: 01/08/2023]
Abstract
Patients with endogenous or exogenous glucocorticoid (GC) excess exhibit a range of side effects, including an increased risk of infections. Via both mechanism, immune impairments and cardiometabolic concomitant diseases, patients with GC excess could be at increased risk for COVID-19. The impact on incidence and outcome of a SARS-CoV-2 infection in this population are not yet completely clear. This review aims to compile the data available to date and to discuss the existing literature on this topic. Further we highlight potential effects of SARS-CoV-2 on the hypothalamic-pituitary-adrenal axis as well as the influence of endogenous or exogenous GC excess on SARS-CoV-2 mRNA vaccination. There is growing evidence suggesting an increased risk of infection and severe outcome in patients with high-dose GC therapy after contracting SARS-CoV-2. The few data and case reports on patients with endogenous GC excess and SARS-CoV-2 infection point in a similar direction: chronic GC excess seems to be associated with an unfavorable course of COVID-19. Whether this is mainly a primary immune-mediated effect, or also triggered by the many GC-associated comorbidities in this population, is not yet fully understood. Patients with endogenous or exogenous GC excess should be considered as a vulnerable group during the SARS-CoV-2 pandemic. Regardless of the cause, vaccination and consistent surveillance and control of associated comorbidities are recommended.
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Affiliation(s)
- Frederick Vogel
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Munich, Germany
| | - Martin Reincke
- Medizinische Klinik und Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Munich, Germany.
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He S, Gui J, Xiong K, Chen M, Gao H, Fu Y. A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases. J Nanobiotechnology 2022; 20:101. [PMID: 35241085 PMCID: PMC8892824 DOI: 10.1186/s12951-022-01307-x] [Citation(s) in RCA: 73] [Impact Index Per Article: 24.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/02/2021] [Accepted: 01/17/2022] [Indexed: 12/18/2022] Open
Abstract
Pulmonary drug delivery is a highly attractive topic for the treatment of infectious lung diseases. Drug delivery via the pulmonary route offers unique advantages of no first-pass effect and high bioavailability, which provides an important means to deliver therapeutics directly to lung lesions. Starting from the structural characteristics of the lungs and the biological barriers for achieving efficient delivery, we aim to review literatures in the past decade regarding the pulmonary delivery strategies used to treat infectious lung diseases. Hopefully, this review article offers new insights into the future development of therapeutic strategies against pulmonary infectious diseases from a delivery point of view.
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Affiliation(s)
- Siqin He
- Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China
| | - Jiajia Gui
- Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China
| | - Kun Xiong
- Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China
| | - Meiwan Chen
- State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
| | - Huile Gao
- Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
| | - Yao Fu
- Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610041, China.
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Hadi MU, Khurshid M. SARS-CoV-2 Detection Using Optical Fiber Based Sensor Method. SENSORS (BASEL, SWITZERLAND) 2022; 22:751. [PMID: 35161497 PMCID: PMC8839674 DOI: 10.3390/s22030751] [Citation(s) in RCA: 10] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 12/19/2021] [Revised: 01/18/2022] [Accepted: 01/18/2022] [Indexed: 01/27/2023]
Abstract
The SARS-CoV-2 Coronavirus disease, also known as the COVID-19 pandemic, has engendered the biggest challenge to human life for the last two years. With a rapid increase in the spread of the Omicron variant across the world, and to contain the spread of COVID-19 in general, it is crucial to rapidly identify this viral infection with minimal logistics. To achieve this, a novel plastic optical fiber (POF) U-shaped probe sensing method is presented for accurate detection of SARS-CoV-2, commonly known as the COVID-19 virus, which has the capability to detect new variants such as Omicron. The sample under test can be taken from oropharyngeal or nasopharyngeal via specific POF U-shaped probe with one end that is fed with a laser source while the other end is connected to a photodetector to receive the response and postprocess for decision-making. The study includes detection comparison with two types of POF with diameters of 200 and 500 µm. Results show that detection is better when a smaller-diameter POF is used. It is also seen that the proposed test bed and its envisaged prototype can detect the COVID-19 variants within 15 min of the test. The proposed approach will make the clinical diagnosis faster, cheaper and applicable to patients in remote areas where there are no hospitals or clinical laboratories due to poverty, geographic obstacles, or other factors.
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Affiliation(s)
| | - Menal Khurshid
- Akbar Niazi Teaching Hospital (ANTH), Islamabad Medical and Dental College (IMDC), Bharakahu, Islamabad 45400, Pakistan;
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Tahir AM, Qiblawey Y, Khandakar A, Rahman T, Khurshid U, Musharavati F, Islam MT, Kiranyaz S, Al-Maadeed S, Chowdhury MEH. Deep Learning for Reliable Classification of COVID-19, MERS, and SARS from Chest X-ray Images. Cognit Comput 2022; 14:1752-1772. [PMID: 35035591 PMCID: PMC8747861 DOI: 10.1007/s12559-021-09955-1] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/24/2020] [Accepted: 04/09/2021] [Indexed: 12/29/2022]
Abstract
Novel coronavirus disease (COVID-19) is an extremely contagious and quickly spreading coronavirus infestation. Severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), which outbreak in 2002 and 2011, and the current COVID-19 pandemic are all from the same family of coronavirus. This work aims to classify COVID-19, SARS, and MERS chest X-ray (CXR) images using deep convolutional neural networks (CNNs). To the best of our knowledge, this classification scheme has never been investigated in the literature. A unique database was created, so-called QU-COVID-family, consisting of 423 COVID-19, 144 MERS, and 134 SARS CXR images. Besides, a robust COVID-19 recognition system was proposed to identify lung regions using a CNN segmentation model (U-Net), and then classify the segmented lung images as COVID-19, MERS, or SARS using a pre-trained CNN classifier. Furthermore, the Score-CAM visualization method was utilized to visualize classification output and understand the reasoning behind the decision of deep CNNs. Several deep learning classifiers were trained and tested; four outperforming algorithms were reported: SqueezeNet, ResNet18, InceptionV3, and DenseNet201. Original and preprocessed images were used individually and all together as the input(s) to the networks. Two recognition schemes were considered: plain CXR classification and segmented CXR classification. For plain CXRs, it was observed that InceptionV3 outperforms other networks with a 3-channel scheme and achieves sensitivities of 99.5%, 93.1%, and 97% for classifying COVID-19, MERS, and SARS images, respectively. In contrast, for segmented CXRs, InceptionV3 outperformed using the original CXR dataset and achieved sensitivities of 96.94%, 79.68%, and 90.26% for classifying COVID-19, MERS, and SARS images, respectively. The classification performance degrades with segmented CXRs compared to plain CXRs. However, the results are more reliable as the network learns from the main region of interest, avoiding irrelevant non-lung areas (heart, bones, or text), which was confirmed by the Score-CAM visualization. All networks showed high COVID-19 detection sensitivity (> 96%) with the segmented lung images. This indicates the unique radiographic signature of COVID-19 cases in the eyes of AI, which is often a challenging task for medical doctors.
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Affiliation(s)
- Anas M. Tahir
- Department of Electrical Engineering, Qatar University, 2713 Doha, Qatar
| | - Yazan Qiblawey
- Department of Electrical Engineering, Qatar University, 2713 Doha, Qatar
| | - Amith Khandakar
- Department of Electrical Engineering, Qatar University, 2713 Doha, Qatar
| | - Tawsifur Rahman
- Department of Electrical Engineering, Qatar University, 2713 Doha, Qatar
| | - Uzair Khurshid
- Department of Electrical Engineering, Qatar University, 2713 Doha, Qatar
| | - Farayi Musharavati
- Mechanical & Industrial Engineering Department, Qatar University, 2713 Doha, Qatar
| | - M. T. Islam
- Department of Electrical, Electronic & Systems Engineering, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor Malaysia
| | - Serkan Kiranyaz
- Department of Electrical Engineering, Qatar University, 2713 Doha, Qatar
| | - Somaya Al-Maadeed
- Department of Computer Science and Engineering, Qatar University, 2713 Doha, Qatar
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BABAYEVA A, COŞKUN M, YALÇIN MM, ÜNLÜ S, ÖZGER HS, BATMAZ L, EROĞLU ALTINOVA A, AKTURK M, BALOŞ TÖRÜNER F, YETKİN İ. Challenges in the Management of the Patients with COVID-19 Infected Cushing’s Syndrome: Two Cases And Literature Review. TURKISH JOURNAL OF INTERNAL MEDICINE 2022. [DOI: 10.46310/tjim.975133] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/27/2022] Open
Abstract
Coronavirus disease-2019 (COVID-19) has become a serious health problem in Turkey and the world. The diagnosis stage of many chronic diseases, the treatment process and the status of being affected by COVID-19 have become the focus of attention in the medical community during the pandemic, which has been continuing for nine months. We will discuss the course of COVID-19 infection over a 32-year-old and 76-year-old female patient with Cushing syndrome who applied to our clinic as a tertiary referral centre.
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Affiliation(s)
| | - Meriç COŞKUN
- GAZI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES
| | - Mehmet Muhittin YALÇIN
- GAZI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES
| | - Serkan ÜNLÜ
- GAZI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF CARDIOLOGY
| | - Hasan Selçuk ÖZGER
- GAZI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INFECTIOUS DISEASES
| | | | - Alev EROĞLU ALTINOVA
- GAZI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES
| | - Mujde AKTURK
- GAZI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES
| | - Füsun BALOŞ TÖRÜNER
- GAZI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES
| | - İlhan YETKİN
- GAZI UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ENDOCRINOLOGY AND METABOLIC DISEASES
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49
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Arbel Y, Fialkoff C, Kerner A, Kerner M. Can Obesity Prevalence Explain COVID-19 Indicators (Cases, Mortality, and Recovery)? A Comparative Study in OECD Countries. J Obes 2022; 2022:4320120. [PMID: 35747744 PMCID: PMC9211382 DOI: 10.1155/2022/4320120] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/20/2021] [Revised: 04/12/2022] [Accepted: 05/13/2022] [Indexed: 12/26/2022] Open
Abstract
SARS-CoV-2 virus disease (COVID-19) is declared a global pandemic with multiple risk factors. Obesity is considered by several researchers as one of the serious risk factors for SARS-CoV-2 virus complications based on recent empirical studies. Yet, other scholars argue in favor of the existence of an obesity survival paradox and criticize the former group of studies on the grounds that they lack controls for race, socioeconomic status, or quality of care. The objective of the current study is to analyze the potential relationships between different SARS-CoV-2 virus indicators and obesity on a country-wide level based on an OECD report. In an attempt to test the counterintuitive possibility of an obesity survival paradox, the proposed empirical model relaxes the assumption of monotonic change by applying the quadratic design and testing which one of the two competing models (i.e., quadratic or linear) better fits the data. Findings suggest more complex relationships between SARS-CoV-2 virus indices and obesity rates than previously thought. Consequently, ethical guidelines referring to priority in intubation and intensive care treatments-published by the Israeli Ministry of Health in April 2020-should account for these complex relationships between obesity and SARS-CoV-2 virus. Indeed, there is a linear increase in mortality rate from SARS-CoV-2 virus with an elevated prevalence of obesity. Yet, other indicators, such as the number of infected per 10,00,000 persons, rates of severe SARS-CoV-2 virus cases, rates of recovered SARS-CoV-2 virus patients, and SARS-CoV-2 virus, as the cause of death exhibit quadratic, rather than linear, patterns. The reasons for these nonlinear patterns might be explained by several conditions such as increased metabolic reserves, more aggressive treatment, other non-SARS-CoV-2 virus complications for obese persons, and unidentified factors that should be examined in future research.
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Affiliation(s)
- Yuval Arbel
- Sir Harry Solomon School of Economics and Management, Western Galilee College, Acre 2412101, Israel
| | - Chaim Fialkoff
- Institute of Urban and Regional Studies, Hebrew University of Jerusalem, Mt. Scopus, Jerusalem 9190501, Israel
| | - Amichai Kerner
- School of Real Estate, Netanya Academic College, 1 University Street, Netanya 4223587, Israel
| | - Miryam Kerner
- Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
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Abstract
The current coronavirus disease 2019 pandemic has exceeded any epidemiologic prevision, but increasing information suggests some analogies with the major viral outbreaks in the last century, and a general warning has been issued on the possibility that coinfections can make the differential diagnosis and treatment difficult, especially in tropical countries. Some reports have noted that the presence of high dengue antibodies can give a false-negative result when testing for severe acute respiratory syndrome coronavirus 2. Mucocutaneous manifestations are very frequent, with an apparent overlap among different pathogens. However, strong clinicopathologic correlation might provide some clues to address differentials. Waiting for laboratory and instrumental results, the timing and distribution of skin lesions is often pathognomonic. Histopathologic findings characterize certain reaction patterns and provide insights on pathogenetic mechanisms. Unfortunately, skin assessment, especially invasive examinations such as biopsy, takes a back seat in severely ill patients. A literature retrieval was performed to collect information from other epidemics to counteract what has become the most frightening disease of our time.
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Key Words
- (covid-19), coronavirus 2019 disease
- (who), world health organization
- (sars), severe acute respiratory syndrome coronavirus
- (sars-cov-2), novel coronavirus
- (mers), middle east respiratory syndrome
- (r0), basic reproductive number
- (mis), multisystem inflammatory syndrome
- (iga), immunoglobulin a
- (ace-2), angiotensin‐converting enzyme 2
- (dengv), dengue virus
- (ttp), thrombotic thrombocytopenic purpura
- (vwf), von willebrand factor
- (cd1a), cluster of diffentiation 1-a
- (rt-pcr), reverse transcription polymerase chain reaction
- (chikv), chikungunya virus
- (e1, e2), envelope glycoprotein
- (ifn-i), interferon-type-i
- (zikv), zika virus
- (ebov), ebola virus
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