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Zhang H, Xu L, Yi X, Zhang X. Modulation mode of amygdala morphology and cognitive function under acute sleep deprivation in healthy male. Sleep Med 2025; 127:55-63. [PMID: 39799823 DOI: 10.1016/j.sleep.2025.01.008] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/23/2024] [Revised: 12/25/2024] [Accepted: 01/07/2025] [Indexed: 01/15/2025]
Abstract
The amygdala plays a crucial role in various behavioral functions and psychiatric conditions, with its morphology showing alterations in sleep disorders. While the impact of chronic sleep disorders on amygdala morphology has been studied, the effects of acute sleep deprivation (ASD) remain largely unexplored. The present study aimed to investigate the modulation between amygdala sub-region volumes and spatial working memory (SWM) performance under ASD conditions. Twenty-eight healthy male participants underwent MRI scanning and performed SWM tasks before and after 24 h of ASD. Amygdala sub-region volumes were segmented into nine sub-regions, and Granger causality analysis was employed to examine the relationship between amygdala morphology and SWM performance. Results revealed significant decreases in SWM accuracy and increases in reaction time following ASD. Localized changes in amygdala sub-regions were observed, with increased left cortico-amygdaloid transition area (CAT) volume and decreased right paralaminar nucleus (PL) volume. Granger causality analysis uncovered a bidirectional modulation between centromedial and cortical-like nuclei, and a progressive involvement of amygdala sub-regions in modulating SWM performance as task difficulty increased. These findings demonstrate a complex interplay between sleep, amygdala morphology, and cognitive function, suggesting that the amygdala plays a crucial role in modulating cognitive performance under ASD conditions. The differential involvement of amygdala sub-regions across varying cognitive loads indicates a flexible and adaptive system attempting to maintain performance in the face of sleep loss.
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Affiliation(s)
- Haoyuan Zhang
- School of Psychology, Northwest Normal University, Lanzhou, Gansu, China
| | - Lili Xu
- Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou, Gansu, China
| | - Xiaohan Yi
- School of Psychology, Northwest Normal University, Lanzhou, Gansu, China
| | - Xiangzi Zhang
- School of Psychology, Northwest Normal University, Lanzhou, Gansu, China.
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Harrington MO, Karapanagiotidis T, Phillips L, Smallwood J, Anderson MC, Cairney SA. Memory control deficits in the sleep-deprived human brain. Proc Natl Acad Sci U S A 2025; 122:e2400743122. [PMID: 39739795 PMCID: PMC11725914 DOI: 10.1073/pnas.2400743122] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/17/2024] [Accepted: 12/02/2024] [Indexed: 01/02/2025] Open
Abstract
Sleep disturbances are associated with intrusive memories, but the neurocognitive mechanisms underpinning this relationship are poorly understood. Here, we show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep. The functional impairments arising from sleep deprivation are linked to a behavioral deficit in the ability to downregulate unwanted memories, and coincide with a deterioration of deliberate patterns of self-generated thought. We conclude that sleep deprivation gives rise to intrusive memories via the disruption of neural circuits governing mnemonic inhibitory control, which may rely on REM sleep.
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Affiliation(s)
- Marcus O. Harrington
- Department of Psychology, University of York, YorkYO10 5DD, United Kingdom
- School of Psychology, University of East Anglia, NorwichNR4 7TJ, United Kingdom
| | | | - Lauryn Phillips
- Department of Psychology, University of York, YorkYO10 5DD, United Kingdom
| | | | - Michael C. Anderson
- Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, CambridgeCB2 7EF, United Kingdom
| | - Scott A. Cairney
- Department of Psychology, University of York, YorkYO10 5DD, United Kingdom
- York Biomedical Research Institute, University of York, YorkYO10 5NG, United Kingdom
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3
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Porcheron A, Latreille J, Sauvet F, Bardel MH. Evaluation of a daily facial massage on perceived sleep quality and well-being: A pilot study. Int J Cosmet Sci 2024; 46:734-745. [PMID: 38561643 DOI: 10.1111/ics.12963] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/11/2023] [Revised: 01/04/2024] [Accepted: 02/26/2024] [Indexed: 04/04/2024]
Abstract
OBJECTIVE Sleep disorders are widespread and constitute a major public health risk. The present study thus aims to investigate the effect of a facial cosmetic self-massage daily routine on women's sleep and well-being. METHODS The present pilot study was conducted on 62 middle-aged women declaring daily tiredness and sleep troubles. We examined the effect of a regular facial cosmetic self-massage routine on sleep patterns, daytime sleepiness, and well-being over the course of 2 months. RESULTS After 1 and 2 months, our results show improved sleep quality (Pittsburgh Sleep Quality Index, PSQI - -20.2% after 2 months), reduced daytime sleepiness (Epworth Sleepiness Scale, ESS, -31.2% after 2 months), and increased well-being measures. The number of participants with abnormal sleep (PSQI >5) decreased over the course of the experiment as well, from 71.9% to 49.2% at the end of the 2 months [odds ratio 95% CI for decrease: 0.38 (0.18-0.81)]. Similarly, the number of participants with excessive daytime sleepiness (>10 on the ESS) decreased over the course of the study from 44.3% to 21% after 1 month [95% CI: 0.33 (0.15-0.73)] and to 16.1% after 2 months [95% CI: 0.24 (0.10-0.56)]. CONCLUSIONS These results suggest that a facial cosmetic self-massage routine may improve sleep patterns and is likely to be a useful addition to a standard sleep hygiene routine.
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Affiliation(s)
| | - Julie Latreille
- Biological and Clinical Department, CHANEL Parfums Beauté, Pantin, France
| | - Fabien Sauvet
- UPR7330 VIFASOM, Hôtel Dieu (APHP), Université de Paris, Paris, France
- Institut de Recherche Biomédicale Des Armées (IRBA), Brétigny sur Orge, France
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Huang MH, Kuan YH, Chan YLE, Mao WC, Su TP. Poor subjective sleep quality and trait impulsivity in patients with bipolar disorder. CNS Spectr 2024; 29:289-295. [PMID: 38708739 DOI: 10.1017/s109285292400021x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 05/07/2024]
Abstract
BACKGROUND Sleep disturbance and impulsivity are key components of mood vulnerability in bipolar disorder (BD), but few studies have assessed the association between these two symptoms among patients with BD. METHODS Forty-seven euthymic patients with bipolar I disorder (BDI) or bipolar II disorder (BDII) and 58 age- and sex-matched healthy controls were enrolled in this cross-sectional study. Trait impulsivity was measured using the Barratt Impulsiveness Scale Version 11 (BIS-11), which yielded 3 second-order factors: attention, motor, and non-planning. Subjective sleep quality was assessed using the self-reported Pittsburgh Sleep Quality Index (PSQI). General linear models (GLMs) were used to assess the associations between subjective poor sleep and trait impulsivity with multiple testing corrections. RESULTS Patients with BD scored higher in BIS-11 and PSQI than healthy controls. PSQI total scores positively correlated with BIS-11 total scores, while sleep disturbance and daytime dysfunction were associated with attentional impulsiveness after controlling for covariates. Participants with higher PSQI total scores (>10) had higher scores in BIS-11 total, attention, and non-planning than those with low PSQI scores (≤5). CONCLUSION These findings support the hypothesis that poor sleep quality might lead to impulsivity and add to the growing evidence that improving sleep quality may be a therapeutic target for patients with BD.
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Affiliation(s)
- Mao-Hsuan Huang
- Department of Psychiatry, YuanShan and Suao Branches of Taipei Veterans General Hospital, Ilan, Taiwan
- Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Institute of Brain Science, National Yang Ming Chao Tung University, Taipei, Taiwan
| | - Yi-Hsuan Kuan
- Institute of Brain Science, National Yang Ming Chao Tung University, Taipei, Taiwan
| | - Yee-Lam E Chan
- Department of Psychiatry, General Cheng Hsin Hospital, Taipei, Taiwan
| | - Wei-Chung Mao
- Department of Psychiatry, General Cheng Hsin Hospital, Taipei, Taiwan
| | - Tung-Ping Su
- Division of Psychiatry, Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan
- Institute of Brain Science, National Yang Ming Chao Tung University, Taipei, Taiwan
- Department of Psychiatry, General Cheng Hsin Hospital, Taipei, Taiwan
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Lee K, Wang Y, Cross NE, Jegou A, Razavipour F, Pomares FB, Perrault AA, Nguyen A, Aydin Ü, Uji M, Abdallah C, Anticevic A, Frauscher B, Benali H, Dang-vu TT, Grova C. NREM sleep brain networks modulate cognitive recovery from sleep deprivation. BIORXIV : THE PREPRINT SERVER FOR BIOLOGY 2024:2024.06.28.601285. [PMID: 39005401 PMCID: PMC11244911 DOI: 10.1101/2024.06.28.601285] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 07/16/2024]
Abstract
Decrease in cognitive performance after sleep deprivation followed by recovery after sleep suggests its key role, and especially non-rapid eye movement (NREM) sleep, in the maintenance of cognition. It remains unknown whether brain network reorganization in NREM sleep stages N2 and N3 can uniquely be mapped onto individual differences in cognitive performance after a recovery nap following sleep deprivation. Using resting state functional magnetic resonance imaging (fMRI), we quantified the integration and segregation of brain networks during NREM sleep stages N2 and N3 while participants took a 1-hour nap following 24-hour sleep deprivation, compared to well-rested wakefulness. Here, we advance a new analytic framework called the hierarchical segregation index (HSI) to quantify network segregation across spatial scales, from whole-brain to the voxel level, by identifying spatio-temporally overlapping large-scale networks and the corresponding voxel-to-region hierarchy. Our results show that network segregation increased in the default mode, dorsal attention and somatomotor networks during NREM sleep compared to wakefulness. Segregation within the visual, limbic, and executive control networks exhibited N2 versus N3 sleep-specific voxel-level patterns. More segregation during N3 was associated with worse recovery of working memory, executive attention, and psychomotor vigilance after the nap. The level of spatial resolution of network segregation varied among brain regions and was associated with the recovery of performance in distinct cognitive tasks. We demonstrated the sensitivity and reliability of voxel-level HSI to provide key insights into within-region variation, suggesting a mechanistic understanding of how NREM sleep replenishes cognition after sleep deprivation.
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Affiliation(s)
- Kangjoo Lee
- Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA, 06510
- Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Montréal, QC, Canada H3A 2B4
| | - Yimeng Wang
- Multimodal Functional Imaging Lab, Department of Physics, Concordia University, Montréal, QC, Canada H4B 2A7
- Concordia School of Health / PERFORM Centre, Concordia University, Montréal, QC, Canada H4B 1R6
- Institute for Medical Imaging Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 200025
- Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 200025
| | - Nathan E. Cross
- Concordia School of Health / PERFORM Centre, Concordia University, Montréal, QC, Canada H4B 1R6
- Sleep, Cognition and Neuroimaging Lab, Department of Health, Kinesiology and Applied Physiology & Center for Studies in Behavioral Neurobiology, Concordia University, Montréal, QC, Canada H4B 1R6
- Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, CIUSSS Centre-Sud-de-l’Ile-de-Montréal, Montréal, QC, Canada H3W 1W5
| | - Aude Jegou
- Multimodal Functional Imaging Lab, Department of Physics, Concordia University, Montréal, QC, Canada H4B 2A7
- Concordia School of Health / PERFORM Centre, Concordia University, Montréal, QC, Canada H4B 1R6
- Sleep, Cognition and Neuroimaging Lab, Department of Health, Kinesiology and Applied Physiology & Center for Studies in Behavioral Neurobiology, Concordia University, Montréal, QC, Canada H4B 1R6
| | - Fatemeh Razavipour
- Multimodal Functional Imaging Lab, Department of Physics, Concordia University, Montréal, QC, Canada H4B 2A7
- Concordia School of Health / PERFORM Centre, Concordia University, Montréal, QC, Canada H4B 1R6
| | - Florence B. Pomares
- Concordia School of Health / PERFORM Centre, Concordia University, Montréal, QC, Canada H4B 1R6
- Sleep, Cognition and Neuroimaging Lab, Department of Health, Kinesiology and Applied Physiology & Center for Studies in Behavioral Neurobiology, Concordia University, Montréal, QC, Canada H4B 1R6
- Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, CIUSSS Centre-Sud-de-l’Ile-de-Montréal, Montréal, QC, Canada H3W 1W5
| | - Aurore A. Perrault
- Concordia School of Health / PERFORM Centre, Concordia University, Montréal, QC, Canada H4B 1R6
- Sleep, Cognition and Neuroimaging Lab, Department of Health, Kinesiology and Applied Physiology & Center for Studies in Behavioral Neurobiology, Concordia University, Montréal, QC, Canada H4B 1R6
- Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, CIUSSS Centre-Sud-de-l’Ile-de-Montréal, Montréal, QC, Canada H3W 1W5
| | - Alex Nguyen
- Concordia School of Health / PERFORM Centre, Concordia University, Montréal, QC, Canada H4B 1R6
- Sleep, Cognition and Neuroimaging Lab, Department of Health, Kinesiology and Applied Physiology & Center for Studies in Behavioral Neurobiology, Concordia University, Montréal, QC, Canada H4B 1R6
- Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, CIUSSS Centre-Sud-de-l’Ile-de-Montréal, Montréal, QC, Canada H3W 1W5
| | - Ümit Aydin
- Multimodal Functional Imaging Lab, Department of Physics, Concordia University, Montréal, QC, Canada H4B 2A7
- Concordia School of Health / PERFORM Centre, Concordia University, Montréal, QC, Canada H4B 1R6
- School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom, RG6 6ET
| | - Makoto Uji
- Concordia School of Health / PERFORM Centre, Concordia University, Montréal, QC, Canada H4B 1R6
- Sleep, Cognition and Neuroimaging Lab, Department of Health, Kinesiology and Applied Physiology & Center for Studies in Behavioral Neurobiology, Concordia University, Montréal, QC, Canada H4B 1R6
| | - Chifaou Abdallah
- Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Montréal, QC, Canada H3A 2B4
- Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montréal, QC, Canada H3A 1A1
- Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada H3A 2B4
| | - Alan Anticevic
- Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA, 06510
- Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut, USA, 06510
- Department of Psychology, Yale University School of Medicine, New Haven, Connecticut, USA, 06510
| | - Birgit Frauscher
- Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montréal, QC, Canada H3A 1A1
- Analytical Neurophysiology Lab, Department of Neurology, Duke University Medical Center, Durham, NC, USA
- Analytical Neurophysiology Lab, Montreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada H3A 2B4
| | - Habib Benali
- Concordia School of Health / PERFORM Centre, Concordia University, Montréal, QC, Canada H4B 1R6
- Biomedical Imaging and Healthy Aging Laboratory, Department of Electrical and Computer Engineering, Concordia University, Montréal, Québec, Canada H3G 1S6
| | - Thien Thanh Dang-vu
- Concordia School of Health / PERFORM Centre, Concordia University, Montréal, QC, Canada H4B 1R6
- Sleep, Cognition and Neuroimaging Lab, Department of Health, Kinesiology and Applied Physiology & Center for Studies in Behavioral Neurobiology, Concordia University, Montréal, QC, Canada H4B 1R6
- Centre de Recherche de l’Institut Universitaire de Gériatrie de Montréal, CIUSSS Centre-Sud-de-l’Ile-de-Montréal, Montréal, QC, Canada H3W 1W5
| | - Christophe Grova
- Multimodal Functional Imaging Lab, Biomedical Engineering Department, McGill University, Montréal, QC, Canada H3A 2B4
- Multimodal Functional Imaging Lab, Department of Physics, Concordia University, Montréal, QC, Canada H4B 2A7
- Concordia School of Health / PERFORM Centre, Concordia University, Montréal, QC, Canada H4B 1R6
- Neurology and Neurosurgery Department, Montreal Neurological Institute, McGill University, Montréal, QC, Canada H3A 1A1
- Centre De Recherches En Mathématiques, Montréal, Québec, Canada H3C 3J7
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Chen S, Song T, Peng Z, Xu L, Lian J, An X, Shao Y. Total Sleep Deprivation Triggers a Compensatory Mechanism During Conflict Monitoring Process: Evidence From Event-Related Potentials. Arch Clin Neuropsychol 2024; 39:367-377. [PMID: 37930794 DOI: 10.1093/arclin/acad083] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 09/22/2023] [Indexed: 11/07/2023] Open
Abstract
Sleep deprivation impairs cognitive function and is accompanied by a simultaneous compensatory effect, one of the brain's capacities to maintain function in emergency situations. However, the time course of the compensatory effect is unclear. In this study, 22 male participants completed a pronunciation working memory task that included congruent and incongruent stimuli trials with EEG recordings before and after total sleep deprivation (TSD). Behavioral performance analysis showed that after TSD, the participants' reaction time (RT) was shortened, but accuracy was reduced significantly. Analysis of event-related potential (ERP) results showed that the amplitude of N2 (an early visual ERP) was larger (i.e., more negative) after TSD than at baseline. A significant interaction between congruency and sleep condition was seen. Compared to that before TSD, the increase in amplitude of P3 (a stimulus-induced positive deflection component) under an incongruent stimulus was larger than that under a congruent stimulus after TSD. Moreover, a significant negative correlation was found between P3 amplitude and RT. Our results suggest that TSD impairs cognitive function. Meanwhile, the brain activates a compensatory mechanism after TSD, which is comprehensive during the conflict-detection and information-updating stages. This study provides a fresh viewpoint for understanding how TSD affects cognitive function.
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Affiliation(s)
- Shufang Chen
- School of Psychology, Beijing Sport University, Beijing, China
| | - Tao Song
- School of Psychology, Beijing Sport University, Beijing, China
| | - Ziyi Peng
- School of Psychology, Beijing Sport University, Beijing, China
| | - Lin Xu
- School of Psychology, Beijing Sport University, Beijing, China
| | - Jie Lian
- School of Psychology, Beijing Sport University, Beijing, China
| | - Xin An
- School of Psychology, Beijing Sport University, Beijing, China
| | - Yongcong Shao
- School of Psychology, Beijing Sport University, Beijing, China
- Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, China
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7
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Campbell E, Figueiro MG. Postoperative cognitive dysfunction: spotlight on light, circadian rhythms, and sleep. Front Neurosci 2024; 18:1390216. [PMID: 38699675 PMCID: PMC11064652 DOI: 10.3389/fnins.2024.1390216] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/22/2024] [Accepted: 04/04/2024] [Indexed: 05/05/2024] Open
Abstract
Postoperative cognitive dysfunction (POCD) is a neurological disorder characterized by the emergence of cognitive impairment after surgery. A growing body of literature suggests that the onset of POCD is closely tied to circadian rhythm disruption (CRD). Circadian rhythms are patterns of behavioral and physiological change that repeat themselves at approximately, but not exactly, every 24 h. They are entrained to the 24 h day by the daily light-dark cycle. Postoperative CRD affects cognitive function likely by disrupting sleep architecture, which in turn provokes a host of pathological processes including neuroinflammation, blood-brain barrier disturbances, and glymphatic pathway dysfunction. Therefore, to address the pathogenesis of POCD it is first necessary to correct the dysregulated circadian rhythms that often occur in surgical patients. This narrative review summarizes the evidence for CRD as a key contributor to POCD and concludes with a brief discussion of how circadian-effective hospital lighting can be employed to re-entrain stable and robust circadian rhythms in surgical patients.
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Affiliation(s)
| | - Mariana G. Figueiro
- Light and Health Research Center, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States
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8
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Peng C, Guo D, Liu L, Xiao D, Nie L, Liang H, Guo D, Yang H. Total sleep deprivation alters spontaneous brain activity in medical staff during routine clinical work: a resting-state functional MR imaging study. Front Neurosci 2024; 18:1377094. [PMID: 38638698 PMCID: PMC11025562 DOI: 10.3389/fnins.2024.1377094] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/26/2024] [Accepted: 03/21/2024] [Indexed: 04/20/2024] Open
Abstract
Objectives To assess the effect of total sleep deprivation (TSD) on spontaneous brain activity in medical staff during routine clinical practice. Methods A total of 36 medical staff members underwent resting-state functional MRI (rs-fMRI) scans and neuropsychological tests twice, corresponding to rested wakefulness (RW) after normal sleep and 24 h of acute TSD. The rs-fMRI features, including the mean fractional amplitude of low-frequency fluctuation (mfALFF), z-score transformed regional homogeneity (zReHo), and functional connectivity (zFC), were compared between RW and TSD. Correlation coefficients between the change in altered rs-fMRI features and the change in altered scores of neuropsychological tests after TSD were calculated. Receiver operating characteristic (ROC) and logistic regression analyses were performed to evaluate the diagnostic efficacy of significantly altered rs-fMRI features in distinguishing between RW and TSD states. Results Brain regions, including right superior temporal gyrus, bilateral postcentral gyrus, left medial superior frontal gyrus, left middle temporal gyrus, right precentral gyrus, and left precuneus, showed significantly enhanced rs-fMRI features (mfALFF, zReHo, zFC) after TSD. Moreover, the changes in altered rs-fMRI features of the right superior temporal gyrus, bilateral postcentral gyrus, left middle temporal gyrus, and left precuneus were significantly correlated with the changes in several altered scores of neuropsychological tests. The combination of mfALFF (bilateral postcentral gyrus) and zFC (left medial superior frontal gyrus and left precuneus) showed the highest area under the curve (0.870) in distinguishing RW from TSD. Conclusion Spontaneous brain activity alterations occurred after TSD in routine clinical practice, which might explain the reduced performances of these participants in neurocognitive tests after TSD. These alterations might be potential imaging biomarkers for assessing the impact of TSD and distinguishing between RW and TSD states.
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Affiliation(s)
- Cong Peng
- The Department of Radiology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China
- Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
- Department of Radiology, Chongqing General Hospital, Chongqing, China
| | - Dingbo Guo
- The Department of Radiology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China
| | - Liuheng Liu
- The Department of Radiology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China
| | - Dongling Xiao
- Department of Anatomy, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Army Medical University (Third Military Medical University), Chongqing, China
| | - Lisha Nie
- GE Healthcare, MR Research, Beijing, China
| | | | - Dajing Guo
- Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
| | - Hua Yang
- The Department of Radiology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China
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9
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Ambrosanio M, Troisi Lopez E, Polverino A, Minino R, Cipriano L, Vettoliere A, Granata C, Mandolesi L, Curcio G, Sorrentino G, Sorrentino P. The Effect of Sleep Deprivation on Brain Fingerprint Stability: A Magnetoencephalography Validation Study. SENSORS (BASEL, SWITZERLAND) 2024; 24:2301. [PMID: 38610512 PMCID: PMC11014248 DOI: 10.3390/s24072301] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/06/2024] [Revised: 03/29/2024] [Accepted: 04/02/2024] [Indexed: 04/14/2024]
Abstract
This study examined the stability of the functional connectome (FC) over time using fingerprint analysis in healthy subjects. Additionally, it investigated how a specific stressor, namely sleep deprivation, affects individuals' differentiation. To this aim, 23 healthy young adults underwent magnetoencephalography (MEG) recording at three equally spaced time points within 24 h: 9 a.m., 9 p.m., and 9 a.m. of the following day after a night of sleep deprivation. The findings indicate that the differentiation was stable from morning to evening in all frequency bands, except in the delta band. However, after a night of sleep deprivation, the stability of the FCs was reduced. Consistent with this observation, the reduced differentiation following sleep deprivation was found to be negatively correlated with the effort perceived by participants in completing the cognitive task during sleep deprivation. This correlation suggests that individuals with less stable connectomes following sleep deprivation experienced greater difficulty in performing cognitive tasks, reflecting increased effort.
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Affiliation(s)
- Michele Ambrosanio
- Department of Economics, Law, Cybersecurity and Sports Sciences (DiSEGIM), University of Naples “Parthenope”, 80035 Nola, Italy
| | - Emahnuel Troisi Lopez
- Institute of Applied Sciences and Intelligent Systems, National Research Council, 80078 Pozzuoli, Italy
| | - Arianna Polverino
- Institute of Diagnosis and Treatment Hermitage Capodimonte, 80145 Naples, Italy
| | - Roberta Minino
- Department of Medical, Movement and Wellness Sciences (DiSMMEB), University of Naples “Parthenope”, 80133 Naples, Italy
| | - Lorenzo Cipriano
- Department of Medical, Movement and Wellness Sciences (DiSMMEB), University of Naples “Parthenope”, 80133 Naples, Italy
| | - Antonio Vettoliere
- Institute of Applied Sciences and Intelligent Systems, National Research Council, 80078 Pozzuoli, Italy
| | - Carmine Granata
- Institute of Applied Sciences and Intelligent Systems, National Research Council, 80078 Pozzuoli, Italy
| | - Laura Mandolesi
- Department of Humanities, University of Naples Federico II, 80133 Naples, Italy
| | - Giuseppe Curcio
- Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
| | - Giuseppe Sorrentino
- Institute of Applied Sciences and Intelligent Systems, National Research Council, 80078 Pozzuoli, Italy
- Institute of Diagnosis and Treatment Hermitage Capodimonte, 80145 Naples, Italy
- Department of Medical, Movement and Wellness Sciences (DiSMMEB), University of Naples “Parthenope”, 80133 Naples, Italy
| | - Pierpaolo Sorrentino
- Institute of Applied Sciences and Intelligent Systems, National Research Council, 80078 Pozzuoli, Italy
- Institut de Neurosciences des Systèmes, Aix-Marseille Université, 13005 Marseille, France
- Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
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Smith M, Murrell JC, Mendl M. Spatial working memory in a disappearing object task is impaired in female but not male dogs with chronic osteoarthritis. Anim Cogn 2024; 27:13. [PMID: 38429533 PMCID: PMC10907419 DOI: 10.1007/s10071-024-01845-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/30/2023] [Revised: 10/31/2023] [Accepted: 11/18/2023] [Indexed: 03/03/2024]
Abstract
Chronic pain in humans is associated with impaired working memory but it is not known whether this is the case in long-lived companion animals, such as dogs, who are especially vulnerable to developing age-related chronic pain conditions. Pain-related impairment of cognitive function could have detrimental effects on an animal's ability to engage with its owners and environment or to respond to training or novel situations, which may in turn affect its quality of life. This study compared the performance of 20 dogs with chronic pain from osteoarthritis and 21 healthy control dogs in a disappearing object task of spatial working memory. Female neutered osteoarthritic dogs, but not male neutered osteoarthritic dogs, were found to have lower predicted probabilities of successfully performing the task compared to control dogs of the same sex. In addition, as memory retention interval in the task increased, osteoarthritic dogs showed a steeper decline in working memory performance than control dogs. This suggests that the effects of osteoarthritis, and potentially other pain-related conditions, on cognitive function are more clearly revealed in tasks that present a greater cognitive load. Our finding that chronic pain from osteoarthritis may be associated with impaired working memory in dogs parallels results from studies of human chronic pain disorders. That female dogs may be particularly prone to these effects warrants further investigation.
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Affiliation(s)
- Melissa Smith
- Bristol Veterinary School, University of Bristol, Langford House, Langford, BS40 5DU, UK
| | - Joanna C Murrell
- Bristol Veterinary School, University of Bristol, Langford House, Langford, BS40 5DU, UK
- Highcroft Veterinary Referrals, 615 Wells Rd, Whitchurch, Bristol, BS14 9BE, UK
| | - Michael Mendl
- Bristol Veterinary School, University of Bristol, Langford House, Langford, BS40 5DU, UK.
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11
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Li J, Cao Y, Ou S, Jiang T, Wang L, Ma N. The effect of total sleep deprivation on working memory: evidence from diffusion model. Sleep 2024; 47:zsae006. [PMID: 38181126 DOI: 10.1093/sleep/zsae006] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/15/2023] [Revised: 11/30/2023] [Indexed: 01/07/2024] Open
Abstract
STUDY OBJECTIVES Working memory is crucial in human daily life and is vulnerable to sleep loss. The current study investigated the impact of sleep deprivation on working memory from the information processing perspective, to explore whether sleep deprivation affects the working memory via impairing information manipulation. METHODS Thirty-seven healthy adults attended two counterbalanced protocols: a normal sleep night and a total sleep deprivation (TSD). The N-back and the psychomotor vigilance task (PVT) assessed working memory and sustained attention. Response time distribution and drift-diffusion model analyses were applied to explore cognitive process alterations. RESULTS TSD increased the loading effect of accuracy, but not the loading effect of response time in the N-back task. TSD reduced the speed of information accumulation, increased the variability of the speed of accumulation, and elevated the decision threshold only in 1-back task. Moreover, the slow responses of PVT and N-back were severely impaired after TSD, mainly due to increased information accumulation variability. CONCLUSIONS The present study provides a new perspective to investigate behavioral performance by using response time distribution and drift-diffusion models, revealing that sleep deprivation affected multicognitive processes underlying working memory, especially information accumulation processes.
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Affiliation(s)
- Jiahui Li
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China
- Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Yixuan Cao
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China
- Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Simei Ou
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China
- Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Tianxiang Jiang
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China
- Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Ling Wang
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China
- Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Ning Ma
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China
- Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health and Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China
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12
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Feng S, Yao H, Zheng S, Feng Z, Liu X, Liu R, Dong L, Cai Y, Jia H, Ning Y. Altered Functional Connectivity in Working Memory Network After Acute Sleep Deprivation. Neuroscience 2023; 535:158-167. [PMID: 37944581 DOI: 10.1016/j.neuroscience.2023.11.003] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/13/2023] [Revised: 10/25/2023] [Accepted: 11/01/2023] [Indexed: 11/12/2023]
Abstract
Acute sleep deprivation (SD) has a detrimental effect on working memory (WM). However, prior functional magnetic resonance imaging (fMRI) studies have failed to reach consistent results on brain functions underlying WM decline after acute SD. Thus, we aimed to identify convergent patterns of abnormal brain functions due to WM decline after acute SD. A coordinate-based activation likelihood estimation (ALE) meta-analysis of task-state fMRI studies testing the effects of acute SD on WM was performed to construct WM network. Then 26 healthy subjects with regular sleep performed the n-back task and underwent resting-state fMRI scanning before and after 24 h of SD. The functional connectivity (FC) among these brain regions and correlations with WM performance were calculated. The ALE results displayed that SD subjects performing WM-related tasks had consistent hypoactivation in the occipital lobe, left middle occipital gyrus, parietal lobe, precuneus, inferior parietal lobule, right sub-gyral, right cuneus, right limbic lobe, and right posterior cingulate. Consistent hyperactivation was showed in the left cerebrum, including the lingual gyrus, posterior lobe, cuneus, temporal lobe, and fusiform gyrus. These identified brain regions as the seeds to construct WM network. The increased FC between the left declive and right sub-gyral, left cuneus and left lingual gyrus, and left cuneus and right post cingulate were found. Furthermore, the impaired WM performance negatively correlated with increased FC. Taken together, our findings highlight that the altered FC in WM network may be the underlying mechanisms of WM decline after acute SD.
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Affiliation(s)
- Sitong Feng
- The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
| | - Hao Yao
- Guang'an Men Hospital, China Academy of Chinese Medical Sciences, Beijing, China
| | - Sisi Zheng
- The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
| | - Zhengtian Feng
- The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
| | - Xinzi Liu
- The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
| | - Rui Liu
- The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
| | - Linrui Dong
- The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
| | - Yongli Cai
- The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
| | - Hongxiao Jia
- The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
| | - Yanzhe Ning
- The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
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13
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Yao L, Wang Y, Gao Y, Gao H, Guo X. The role of the fronto-parietal network in modulating sustained attention under sleep deprivation: an functional magnetic resonance imaging study. Front Psychiatry 2023; 14:1289300. [PMID: 38034912 PMCID: PMC10687171 DOI: 10.3389/fpsyt.2023.1289300] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/05/2023] [Accepted: 10/27/2023] [Indexed: 12/02/2023] Open
Abstract
Objective The intricate relationship between sleep deprivation (SD) and cognitive performance has long been a subject of research. Our study offers a novel angle by closely examining the neurobiological underpinnings of sustained attention deficits through the lens of the fronto-parietal network (FPN). Using state-of-the-art imaging techniques, we delve into the changes in spontaneous brain activity after SD and explore their associations with performance on the psychomotor vigilance task (PVT). Methods We conducted an elaborate investigation involving 64 healthy, right-handed participants who underwent resting-state functional MRI scans before and after experiencing 24 h of sleep deprivation. Employing sophisticated statistical analyses, we scrutinized the changes in fractional amplitude of low-frequency fluctuations (fALFF) through paired t-tests. Pearson correlation analyses were then applied to dissect the associations between these neurobiological shifts and behavioral outcomes in PVT. Results The study yielded remarkable findings, revealing a dramatic decrease in fALFF values within critical areas of the FPN following SD. These alterations predominantly occurred in the frontal and parietal gyri and were inversely correlated with PVT performance metrics. Furthermore, we discovered that baseline fALFF values in the left dorsolateral prefrontal cortex (DLPFC) have the potential to serve as compelling neurobiological markers, with high discriminatory power in identifying individual responses to the adverse effects of SD on cognitive performance. Conclusion Our groundbreaking research underscores the pivotal role that the FPN plays in modulating attention and executive function, especially under the challenging conditions brought about by sleep deprivation. The findings offer critical insights that could shape the way we understand, assess, and potentially mitigate the cognitive impacts of SD, setting the stage for future research in this riveting domain.
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Affiliation(s)
- Linming Yao
- The Tuberculosis Control and Prevention Hospital of Shaanxi Province (The Fifth People’s Hospital of Shaanxi Province), Xi’an, China
| | - Yajing Wang
- Department of Orthopaedics, Xi’an No. 9 Hospital, Xi’an, China
| | - Yanzhong Gao
- Department of Orthopaedics, Xi’an No. 9 Hospital, Xi’an, China
| | - Hongwei Gao
- Department of Orthopaedics, Xi’an No. 9 Hospital, Xi’an, China
| | - Xufeng Guo
- Department of Orthopaedics, Xi’an No. 9 Hospital, Xi’an, China
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14
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Ou S, Cao Y, Xie T, Jiang T, Li J, Luo W, Ma N. Effect of homeostatic pressure and circadian arousal on the storage and executive components of working memory: Evidence from EEG power spectrum. Biol Psychol 2023; 184:108721. [PMID: 37952693 DOI: 10.1016/j.biopsycho.2023.108721] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/22/2023] [Revised: 09/08/2023] [Accepted: 11/08/2023] [Indexed: 11/14/2023]
Abstract
Diurnal fluctuations in working memory (WM) performance, characterized by task-specific peaks and troughs, are likely attributed to the differential regulation of WM subcomponents by interactions between circadian and homeostatic processes. The current study aimed to investigate the independent effects of circadian and homeostatic processes on the storage and executive subcomponents of WM. We assessed the change in frontal-midline theta (FMT) power supporting WM executive component and posterior alpha/beta power supporting WM storage during N-back tasks in the morning, midafternoon with and without a nap from 31 healthy adults. The results suggested that when the accumulated sleep homeostasis was alleviated in the midafternoon by a daytime nap, higher ACC, less number of omissions, and a stronger increase in FMT power from the no nap to nap conditions. Compared to the morning, a stronger decrease in posterior alpha power, and posterior beta power (only in the 3-back task), was observed in the no-nap condition because of circadian arousal regulation. These findings suggest that the circadian process primarily influences the storage aspect of WM supported by posterior alpha and beta activity, while sleep homeostasis has a greater impact on the execution aspect supported by FMT activity.
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Affiliation(s)
- Simei Ou
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China; Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health & Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Yixuan Cao
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China; Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health & Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Tian Xie
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China; Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health & Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Tianxiang Jiang
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China; Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health & Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Jiahui Li
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China; Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health & Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Wei Luo
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China; Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health & Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Ning Ma
- Philosophy and Social Science Laboratory of Reading and Development in Children and Adolescents (South China Normal University), Ministry of Education, Guangzhou 510631, China; Center for Sleep Research, Center for Studies of Psychological Application, Guangdong Key Laboratory of Mental Health & Cognitive Science, School of Psychology, South China Normal University, Guangzhou 510631, China.
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15
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Li S, Ru T, He M, Chen Q, Luo X, Zhou G. Alternated emotional working memory in individuals with subclinical insomnia disorder: An electrophysiological study. Neurobiol Learn Mem 2023; 205:107843. [PMID: 37844757 DOI: 10.1016/j.nlm.2023.107843] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/10/2022] [Revised: 09/22/2023] [Accepted: 10/13/2023] [Indexed: 10/18/2023]
Abstract
The deleterious effects of sleep loss on sleep-dependent memory and emotional function have been documented in the current literature. Yet, the effects of insomnia-induced chronic sleep disturbance on emotional short-term memory have been scarcely investigated. Twenty-one participants with subclinical insomnia disorder (SID) and 20 healthy participants (healthy control, HC) performed a delayed recognition task of emotional faces, and event-related potentials (ERPs) involved in memory encoding, retention, and retrieval of faces across different emotional valences were assessed. Behavioral findings revealed that participants in the SID group had a larger response bias, being more likely to perceive negative faces as "old" faces presented in the retrieval phase than those in the HC group. ERP findings revealed that emotional faces in the SID vs. HC group induced significantly smaller P1 and late P3b and larger N170 amplitudes in the encoding phase and smaller negative slow wave (NSW) in the retention phase. In retrieval phase, the interaction between Sleep group and Valence were revealed for P1 and early P3b amplitudes, but no group differences were found after Bonferroni correction. These findings suggested that insomnia induced chronic sleep disturbance would influence performance on emotional working memory and induced processing phase specific regulation of neurophysiology in emotional working memory regardless of valence.
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Affiliation(s)
- Siyu Li
- School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Taotao Ru
- Lab of Light and Physio-psychological Health, National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China.
| | - Meiheng He
- School of Psychology, South China Normal University, Guangzhou 510631, China
| | - Qingwei Chen
- Lab of Light and Physio-psychological Health, National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China
| | - Xue Luo
- Department of Psychiatry, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China
| | - Guofu Zhou
- Lab of Light and Physio-psychological Health, National Center for International Research on Green Optoelectronics, South China Normal University, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China
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16
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Yang B, Zhang H, Jiang T, Yu S. Natural brain state change with E/I balance shifting toward inhibition is associated with vigilance impairment. iScience 2023; 26:107963. [PMID: 37822500 PMCID: PMC10562778 DOI: 10.1016/j.isci.2023.107963] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/20/2023] [Revised: 07/25/2023] [Accepted: 09/15/2023] [Indexed: 10/13/2023] Open
Abstract
The delicate balance between cortical excitation and inhibition (E/I) plays a pivotal role in brain state changes. While previous studies have associated cortical hyperexcitability with brain state changes induced by sleep deprivation, whether cortical hypoexcitability is also linked to brain state changes and, if so, how it could affect cognitive performance remain unknown. Here, we address these questions by examining the brain state change occurring after meals, i.e., postprandial somnolence, and comparing it with that induced by sleep deprivation. By analyzing features representing network excitability based on electroencephalogram (EEG) signals, we confirmed cortical hyperexcitability under sleep deprivation but revealed hypoexcitability under postprandial somnolence. In addition, we found that both sleep deprivation and postprandial somnolence adversely affected the level of vigilance. These results indicate that cortical E/I balance toward inhibition is associated with brain state changes, and deviation from the balanced state, regardless of its direction, could impair cognitive performance.
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Affiliation(s)
- Binghao Yang
- Brainnetome Center, Laboratory of Brain Atlas and Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
- School of Future Technology, University of Chinese Academy of Sciences, Beijing 101408, China
| | - Haoran Zhang
- Brainnetome Center, Laboratory of Brain Atlas and Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
- School of Future Technology, University of Chinese Academy of Sciences, Beijing 101408, China
| | - Tianzi Jiang
- Brainnetome Center, Laboratory of Brain Atlas and Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
- School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing 101408, China
- Research Center for Augmented Intelligence, Zhejiang Lab, Hangzhou 311121, China
| | - Shan Yu
- Brainnetome Center, Laboratory of Brain Atlas and Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
- School of Future Technology, University of Chinese Academy of Sciences, Beijing 101408, China
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17
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Gonzales JU, Dellinger JR, Clark C. Chronotype predicts working memory-dependent regional cerebral oxygenation under conditions of normal sleep and following a single night of sleep extension. Sci Rep 2023; 13:17897. [PMID: 37857769 PMCID: PMC10587096 DOI: 10.1038/s41598-023-45238-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/31/2023] [Accepted: 10/16/2023] [Indexed: 10/21/2023] Open
Abstract
The aim of this study was to test the hypothesis that the association between sleep duration and brain activation as assessed by regional cerebral oxygenation using near-infrared spectroscopy (NIRS) is dependent on chronotype. Sleep was tracked across two weeks by actigraphy in 22 adults instructed to keep their normal sleep behavior. Chronotype was assessed by the midpoint of sleep on free days corrected for sleep debt on workdays (MSFsc). Prefrontal cerebral oxygenation (ΔHbDiff) during a visuospatial working memory task was measured in the morning after a night of normal sleep and after one night of extended sleep. Sleep extension was included to experimentally test the robustness of the association between sleep duration and ΔHbDiff. Habitual sleep duration (r = 0.43, p = 0.04) and MSFsc (r = - 0.66, p < 0.001) were significantly correlated with ΔHbDiff. After adjusting for MSFsc the relationship between sleep duration and ΔHbDiff was reduced to nonsignificant levels (r = 0.34, p = 0.11), while adjusting for sleep duration did not change the significant relationship between MSFsc and ΔHbDiff (r = - 0.62, p = 0.001). One night of sleep extension increased sleep duration by 140 min, on average, but no change in ΔHbDiff was observed. Dividing participants into earlier and later chronotypes revealed greater ΔHbDiff responses in earlier chronotypes that persisted after the night of sleep extension (mean ΔHbDiff difference = 1.35 μM, t = 2.87, p = 0.006, Hedges' g = 0.89). These results find chronotype to predict regional cerebral oxygenation responses during working memory processing under conditions of normal sleep and following a single night of sleep extension.
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Affiliation(s)
- Joaquin U Gonzales
- Department of Kinesiology and Sport Management, Texas Tech University, Box 43011, Lubbock, TX, 79409-3011, USA.
| | - Jacob R Dellinger
- Department of Kinesiology and Sport Management, Texas Tech University, Box 43011, Lubbock, TX, 79409-3011, USA
| | - Cayla Clark
- Department of Kinesiology and Sport Management, Texas Tech University, Box 43011, Lubbock, TX, 79409-3011, USA
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18
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Shao Y, Peng Z, Xu L, Lian J, An X, Cheng MY. Decrease in the P2 Amplitude of Object Working Memory after 8 h-Recovery Sleep Following 36 h-Total Sleep Deprivation: An ERP Study. Brain Sci 2023; 13:1470. [PMID: 37891837 PMCID: PMC10605542 DOI: 10.3390/brainsci13101470] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/05/2023] [Revised: 10/09/2023] [Accepted: 10/11/2023] [Indexed: 10/29/2023] Open
Abstract
The impact of sleep deprivation on working memory can only be reversed by recovery sleep (RS). However, there are limited electrophysiological studies on the effect of RS on the improvement in working memory after sleep deprivation, and the changes in the early components of event-related potentials (ERPs) before and after RS are still unclear. Therefore, this study aims to explore the effects of RS on the earlier ERP components related to object working memory following 36 h of total sleep deprivation (TSD). Twenty healthy male participants performed an object working memory task after 36 h of TSD and after 8 h of RS. Electroencephalogram data were recorded accordingly while the task was performed. Repeated ANOVA showed that P2 amplitudes related to object working memory decreased significantly after 8 h of RS compared to after a 36 h period of TSD, but there was no significant difference from baseline (BS), which indicates a trend of recovery to the baseline state. An 8 h RS can partially improve impaired object working memory caused by TSD. However, a longer period of RS is needed for the complete recovery of cognitive function after a long period of TSD.
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Affiliation(s)
| | | | | | | | | | - Ming-Yang Cheng
- School of Psychology, Beijing Sport University, Beijing 100084, China; (Y.S.); (Z.P.); (L.X.); (J.L.); (X.A.)
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19
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Vacca M, Spanetta M, Ballesio A, Fernandes M, Placidi F, Izzi F, Lombardo C, Mercuri NB, Laganà G, Liguori C. The Sleepiness-Depression Link in Obstructive Sleep Apnea: Preliminary Results on the Mediation of Impulsivity. J Clin Med 2023; 12:6467. [PMID: 37892605 PMCID: PMC10607807 DOI: 10.3390/jcm12206467] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/04/2023] [Revised: 09/23/2023] [Accepted: 10/07/2023] [Indexed: 10/29/2023] Open
Abstract
BACKGROUND Emotional impulsivity has been found to be relevant in explaining the association between sleep problems and depressive symptoms, suggesting the potential role of impulsivity as a key underlying mechanism of this link. The objective of this study was to take a preliminary step in understanding the mediating role of impulsivity in the relation between excessive daytime sleepiness (EDS) and depression in patients with obstructive sleep apnea syndrome (OSAS) and to compare psychological and demographic characteristics between different levels of daytime sleepiness. METHODS A total of 138 patients with OSAS underwent polygraphic cardiorespiratory monitoring and completed a series of questionnaires investigating perceived sleepiness, depression, impulsivity, and other psychological characteristics. A mediational model was tested in order to assess whether impulsivity mediated the relation between sleepiness and depressive symptoms while controlling for the effects of age, sex, BMI, and oxygen saturation parameters. RESULTS the mediation model showed that there was a significant indirect effect of impulsivity in the sleepiness-depression link (αβ = 0.084 [0.0243-0.1617]). CONCLUSIONS The here-presented results showed that the sleepiness-depression link is not direct as previous studies asserted, but instead it may be better explained by impulsivity. Research and practical implications are discussed.
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Affiliation(s)
- Mariacarolina Vacca
- Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy; (M.V.); (A.B.); (C.L.)
| | | | - Andrea Ballesio
- Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy; (M.V.); (A.B.); (C.L.)
| | - Mariana Fernandes
- Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy; (M.F.); (F.P.); (N.B.M.)
| | - Fabio Placidi
- Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy; (M.F.); (F.P.); (N.B.M.)
- Sleep Medicine Center, Neurology Unit, University Hospital of Rome “Tor Vergata”, 00133 Rome, Italy
| | - Francesca Izzi
- Sleep Medicine Center, Neurology Unit, University Hospital of Rome “Tor Vergata”, 00133 Rome, Italy
| | - Caterina Lombardo
- Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy; (M.V.); (A.B.); (C.L.)
| | - Nicola Biagio Mercuri
- Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy; (M.F.); (F.P.); (N.B.M.)
- Sleep Medicine Center, Neurology Unit, University Hospital of Rome “Tor Vergata”, 00133 Rome, Italy
| | - Giuseppina Laganà
- Department of Orthodontics, University of Rome “Tor Vergata”, 00133 Rome, Italy;
| | - Claudio Liguori
- Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy; (M.F.); (F.P.); (N.B.M.)
- Sleep Medicine Center, Neurology Unit, University Hospital of Rome “Tor Vergata”, 00133 Rome, Italy
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Tu Z, He J, Wang Z, Wang C, Tian J, Tang Y. Can limiting bedtime smartphone use improve next-day working memory among undergraduates with problematic smartphone use? Psychiatry Res 2023; 327:115371. [PMID: 37540944 DOI: 10.1016/j.psychres.2023.115371] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/19/2023] [Revised: 07/23/2023] [Accepted: 07/23/2023] [Indexed: 08/06/2023]
Abstract
This study implemented a longitudinal self-control intervention experiment to examine whether limiting bedtime smartphone use can improve next-day working memory among individuals with problematic smartphone use (PSU). 156 Chinese undergraduates with PSU completed the 6-day experiment (3 nights for intervention condition and 2 nights for control condition). All participants were asked to complete N-back tests in the afternoon everyday during the experiment. The results indicated that limiting smartphone use in bed improved next-day working memory. Therefore, limiting smartphone use in bed is a potential remedy for daily cognitive impairments induced by PSU.
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Affiliation(s)
- Zhihao Tu
- Navy Special Medical Center, Naval Medical University, Shanghai, 200433, China; Qingdao Special Servicemen Recuperation Center of PLA Navy, Qingdao, 266043, China
| | - Jingwen He
- Department of Medical Psychology, NO.96110 Hospital, Yinchuan, 750021, China; Department of Psychology, Naval Medical University, Shangahi, 200433, China
| | - Ziying Wang
- Navy Special Medical Center, Naval Medical University, Shanghai, 200433, China; Key Laboratory of Molecular Neurobiology of Ministry of Education, Shangahi, 200433, China
| | - Chuan Wang
- Navy Special Medical Center, Naval Medical University, Shanghai, 200433, China; Key Laboratory of Molecular Neurobiology of Ministry of Education, Shangahi, 200433, China.
| | - Jianquan Tian
- Navy Special Medical Center, Naval Medical University, Shanghai, 200433, China.
| | - Yunxiang Tang
- Department of Psychology, Naval Medical University, Shangahi, 200433, China.
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Yu X, Wang M, cen J, Ye M, Li S, Wang Y, Su Q, Chen H, Xu R, Zhang S, Wang S, Yu Y, Deng Z, Chen Z. Advice for smokers in smoking cessation clinic: a review. Afr Health Sci 2023; 23:374-379. [PMID: 38223627 PMCID: PMC10782343 DOI: 10.4314/ahs.v23i2.42] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/16/2024] Open
Abstract
Background Tobacco dependence has become a global public health concern. We chose to investigate the modifiable factors and motivations during the period of smoking cessation based on the mechanism of nicotine addiction. Methods We selected emotion, sleep, alcohol, caffeine beverages, mental activities after dinner, exercise and CYP2A6 genotype as influencing factors, and provided corresponding recommendations for smokers based on these factors. Based on these characteristics, we reviewed literature and summarized the relationship between these factors and nicotine dependence or smoking. Results Different emotion, sleep deficiency, caffeine intake, alcohol consumption, mental activities after dinner, physical exercises and CYP2A6 genotype have an effect on daily smoking and nicotine dependence. Conclusion These suggestions related literature-derived factors may increase the success rate of smoking cessation.
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Affiliation(s)
- Xuechan Yu
- Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Ningbo University No.247, Renmin Road, Jiangbei District Ningbo, Zhejiang Province, China, 315010
| | - Meihua Wang
- Department of Neurology, Ningbo ninth Hospital No.68, Xiangbei Road, Jiangbei District Ningbo, Zhejiang Province, China, 315010
| | - Jie cen
- Department of Pulmonary and Critical Care Medicine, Ningbo ninth Hospital, No.68, Xiangbei Road, Jiangbei District Ningbo, Zhejiang Province, China, 315010
| | - Mianzhi Ye
- Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Ningbo University No.247, Renmin Road, Jiangbei District Ningbo, Zhejiang Province, China, 315010
| | - Sha Li
- Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Ningbo University No.247, Renmin Road, Jiangbei District Ningbo, Zhejiang Province, China, 315010
| | - Younuo Wang
- Department of Prevention and Health Care, The First Affiliated Hospital of Ningbo University No.247, Renmin Road, Jiangbei District Ningbo, Zhejiang Province, China, 315020
| | - Qingwen Su
- Department of Prevention and Health Care, The First Affiliated Hospital of Ningbo University No.247, Renmin Road, Jiangbei District Ningbo, Zhejiang Province, China, 315020
| | - Hui Chen
- Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Ningbo University No.247, Renmin Road, Jiangbei District Ningbo, Zhejiang Province, China, 315010
| | - Ruyi Xu
- Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Ningbo University No.247, Renmin Road, Jiangbei District Ningbo, Zhejiang Province, China, 315010
| | - Shuya Zhang
- Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Ningbo University No.247, Renmin Road, Jiangbei District Ningbo, Zhejiang Province, China, 315010
| | - Shanshan Wang
- Department of Prevention and Health Care, The First Affiliated Hospital of Ningbo University No.247, Renmin Road, Jiangbei District Ningbo, Zhejiang Province, China, 315020
| | - Yiming Yu
- Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Ningbo University No.247, Renmin Road, Jiangbei District Ningbo, Zhejiang Province, China, 315010
| | - Zaichun Deng
- Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Ningbo University No.247, Renmin Road, Jiangbei District Ningbo, Zhejiang Province, China, 315010
| | - Zhongbo Chen
- Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Ningbo University No.247, Renmin Road, Jiangbei District Ningbo, Zhejiang Province, China, 315010
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Guttesen AÁV, Gaskell MG, Madden EV, Appleby G, Cross ZR, Cairney SA. Sleep loss disrupts the neural signature of successful learning. Cereb Cortex 2023; 33:1610-1625. [PMID: 35470400 PMCID: PMC9977378 DOI: 10.1093/cercor/bhac159] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/06/2021] [Revised: 03/31/2022] [Accepted: 04/01/2022] [Indexed: 11/13/2022] Open
Abstract
Sleep supports memory consolidation as well as next-day learning. The influential "Active Systems" account of offline consolidation suggests that sleep-associated memory processing paves the way for new learning, but empirical evidence in support of this idea is scarce. Using a within-subjects (n = 30), crossover design, we assessed behavioral and electrophysiological indices of episodic encoding after a night of sleep or total sleep deprivation in healthy adults (aged 18-25 years) and investigated whether behavioral performance was predicted by the overnight consolidation of episodic associations from the previous day. Sleep supported memory consolidation and next-day learning as compared to sleep deprivation. However, the magnitude of this sleep-associated consolidation benefit did not significantly predict the ability to form novel memories after sleep. Interestingly, sleep deprivation prompted a qualitative change in the neural signature of encoding: Whereas 12-20 Hz beta desynchronization-an established marker of successful encoding-was observed after sleep, sleep deprivation disrupted beta desynchrony during successful learning. Taken together, these findings suggest that effective learning depends on sleep but not necessarily on sleep-associated consolidation.
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Affiliation(s)
- Anna á V Guttesen
- Department of Psychology, University of York, Heslington, York, YO10 5DD, UK
| | - M Gareth Gaskell
- Department of Psychology, University of York, Heslington, York, YO10 5DD, UK
- York Biomedical Research Institute, University of York, Heslington, York, YO10 5DD, UK
| | - Emily V Madden
- Department of Psychology, University of York, Heslington, York, YO10 5DD, UK
| | - Gabrielle Appleby
- Department of Psychology, University of York, Heslington, York, YO10 5DD, UK
| | - Zachariah R Cross
- Cognitive Neuroscience Laboratory, Australian Research Centre for Interactive and Virtual Environments, Mawson Lakes Campus, Mawson Lakes, South Australia 5095, Australia
| | - Scott A Cairney
- Department of Psychology, University of York, Heslington, York, YO10 5DD, UK
- York Biomedical Research Institute, University of York, Heslington, York, YO10 5DD, UK
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Song T, Du F, Xu L, Peng Z, Wang L, Dai C, Xu M, Zhang Y, Shao Y, Weng X, Li S. Total sleep deprivation selectively impairs motor preparation sub-stages in visual search task: Evidence from lateralized readiness potentials. Front Neurosci 2023; 17:989512. [PMID: 36925740 PMCID: PMC10011076 DOI: 10.3389/fnins.2023.989512] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/08/2022] [Accepted: 02/09/2023] [Indexed: 03/06/2023] Open
Abstract
Introduction Many studies have provided evidence of a damage effect triggered by total sleep deprivation (TSD). However, it remains unclear whether the motor preparation processing is affected by TSD. Methods In the current study, 23 volunteers performed a stimulus-response compatibility visual search task before and after TSD while undergoing spontaneous electroencephalography (EEG). Results Repeated-measures analysis of variance revealed that: Compared with that at baseline, the visual search task's accuracy decreased after TSD, while the response time variance increased significantly. The peak amplitude of the stimulus-locked lateralized readiness potential (LRP) induced by a compatible stimulus was significantly more negative than that induced by an incompatible stimulus before TSD, whereas this difference was not significant after TSD. However, when taking sleep status into consideration, there were no significant main or interaction effects on response-locked LRPs. Discussion Our findings suggest that TSD damages visual search behavior, selectively impairs the earlier sub-stages of motor preparation (sensory integration). These findings will provide a new perspective for understanding the effects of sleep loss.
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Affiliation(s)
- Tao Song
- School of Psychology, Beijing Sport University, Beijing, China
| | - Fangchong Du
- Department of Xiangshan Road Outpatient General Clinic, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China
| | - Lin Xu
- School of Psychology, Beijing Sport University, Beijing, China
| | - Ziyi Peng
- School of Psychology, Beijing Sport University, Beijing, China
| | - Letong Wang
- School of Psychology, Beijing Sport University, Beijing, China
| | - Cimin Dai
- School of Psychology, Beijing Sport University, Beijing, China
| | - Mengmeng Xu
- School of Psychology, Beijing Sport University, Beijing, China
| | - Ying Zhang
- Department of Xiangshan Road Outpatient General Clinic, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China
| | - Yongcong Shao
- School of Psychology, Beijing Sport University, Beijing, China
| | - Xiechuan Weng
- Department of Neuroscience, Beijing Institute of Basic Medical Sciences, Beijing, China
| | - Shijun Li
- Department of Radiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China
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24
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Chen Z, Jiang T, Yin X, Li B, Tan Z, Guo J. The increased functional connectivity between the locus coeruleus and supramarginal gyrus in insomnia disorder with acupuncture modulation. Front Neurosci 2023; 17:1131916. [PMID: 37152608 PMCID: PMC10157050 DOI: 10.3389/fnins.2023.1131916] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/26/2022] [Accepted: 03/31/2023] [Indexed: 05/09/2023] Open
Abstract
Background Insomnia disorder (ID) seriously affects the quality of people's daily life, and acupuncture is an effective therapy for it. As an essential component of the upward activation system, the locus coeruleus (LC) plays a crucial role in sleep-wake regulation, its aberrant functional connectivity (FC) is found to be involved in ID. The purpose of this study was to explore the modulation effect of acupuncture on the resting state FC of LC in ID patients. Methods 60 ID patients were recruited and randomly assigned to real acupuncture (RA) or sham acupuncture (SA) treatment. Resting-state functional magnetic resonance imaging (fMRI) data were collected before and after the treatment. With LC as the region of interest, the FC method was adopted to examine acupuncture-related modulation of intrinsic connectivity in ID patients. The Pittsburgh Sleep Quality Index (PSQI), Hyperarousal Scale (HAS), and actigraphy were used to assess sleep quality and cortical hyperarousal states. Associations between clinical outcomes and FC features were calculated using Pearson's correlation analysis. Results The improvement in sleep quality and hyperarousal in the RA group was greater than that in the SA group. After treatment, the FC between the LC and left inferior frontal gyrus (IFG) decreased in the RA group. The FC between the LC and left insula and supramarginal gyrus (SMG) was higher in the RA group. The change of LC FC values with the SMG was negatively associated with the change in PSQI scores. Conclusion Acupuncture can modulate FC between the LC and IFG, insular gyrus, and SMG. This may imply the potential mechanism of acupuncture treatment for insomnia.
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Affiliation(s)
- Zhaoyi Chen
- Beijing Key Laboratory of Acupuncture Neuromodulation, Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China
| | - Tongfei Jiang
- Beijing Key Laboratory of Acupuncture Neuromodulation, Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China
| | - Xuejiao Yin
- Beijing Key Laboratory of Acupuncture Neuromodulation, Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China
| | - Bin Li
- Beijing Key Laboratory of Acupuncture Neuromodulation, Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China
| | - Zhongjian Tan
- Department of Radiology, Dong Zhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
| | - Jing Guo
- Beijing Key Laboratory of Acupuncture Neuromodulation, Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China
- *Correspondence: Jing Guo,
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25
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Wang L, Wu H, Dai C, Peng Z, Song T, Xu L, Xu M, Shao Y, Li S, Fu W. Dynamic hippocampal functional connectivity responses to varying working memory loads following total sleep deprivation. J Sleep Res 2022; 32:e13797. [PMID: 36528854 DOI: 10.1111/jsr.13797] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/26/2022] [Revised: 10/26/2022] [Accepted: 11/11/2022] [Indexed: 12/23/2022]
Abstract
Sleep loss with work overload can impact human cognitive performance. However, the brain's response to an increased working memory load following total sleep deprivation (TSD) remains unclear. In the present study, we focussed on the dynamic response of the hippocampus to increased working memory load before and after total sleep deprivation of 36 h. A total of 16 male participants completed a verbal working memory task under functional magnetic resonance imaging. After whole-brain activation analysis and region of interest analysis of the hippocampus, the generalised form of context-dependent psychophysiological interactions (gPPI) was used to analyse the hippocampal functional connectivity with the whole brain. The results revealed that as the working memory load increased within a small range, from 0-back to 1-back task, the left hippocampal functional connectivity decreased with the left supplementary motor area, left pars opercularis, left rolandic operculum, right superior frontal gyrus, bilateral precentral gyrus, and left middle cingulate cortex following total sleep deprivation compared with that observed in resting wakefulness. When the working memory load further increased from 1-back to 2-back task, the connectivity increased between the left hippocampus and the left superior parietal lobule as well as between the left hippocampus and right lingual gyrus after total sleep deprivation compared with that observed in resting wakefulness. Moreover, the left hippocampus gPPI effect on the left middle cingulate cortex and left superior parietal lobule could predict the behavioural test accuracy in 1-back and 2-back task, respectively, following total sleep deprivation. These findings indicated that increased working memory load after total sleep deprivation disrupts working memory processes. The brain reacts to these disruptions in a dynamic and flexible manner, involving not only brain activation but also hippocampus-related functional network connections.
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Affiliation(s)
- Letong Wang
- School of Psychology Beijing Sport University Beijing China
| | - Haijing Wu
- Department of Gynecologic Oncology Sichuan Cancer Hospital Chengdu China
| | - Cimin Dai
- School of Psychology Beijing Sport University Beijing China
| | - Ziyi Peng
- School of Psychology Beijing Sport University Beijing China
| | - Tao Song
- School of Psychology Beijing Sport University Beijing China
| | - Lin Xu
- School of Psychology Beijing Sport University Beijing China
| | - Mengmeng Xu
- School of Psychology Beijing Sport University Beijing China
| | - Yongcong Shao
- School of Psychology Beijing Sport University Beijing China
- School of Biological Science and Medical Engineering Beihang University Beijing China
- Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences Suzhou China
| | - Shijun Li
- Department of Radiology, First Medical Center Chinese PLA General Hospital Beijing China
| | - Weiwei Fu
- Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences Suzhou China
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26
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Sleep Deprivation-Induced Changes in Baseline Brain Activity and Vigilant Attention Performance. Brain Sci 2022; 12:brainsci12121690. [PMID: 36552150 PMCID: PMC9775863 DOI: 10.3390/brainsci12121690] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/04/2022] [Revised: 12/03/2022] [Accepted: 12/07/2022] [Indexed: 12/13/2022] Open
Abstract
Sleep deprivation (SD) negatively affects several aspects of cognitive performance, and one of the most widely-used tools to evaluate these effects is the Psychomotor Vigilance Test (PVT). The present study investigated the possibility of predicting changes induced by SD in vigilant attention performance by evaluating the baseline electroencephalographic (EEG) activity immediately preceding the PVT stimuli onset. All participants (n = 10) underwent EEG recordings during 10 min of PVT before and after a night of SD. For each participant, the root mean square (RMS) of the baseline EEG signal was evaluated for each 1 s time window, and the respective average value was computed. After SD, participants showed slower (and less accurate) performance in the PVT task. Moreover, a close relationship between the changes in the baseline activity with those in cognitive performance was identified at several electrodes (Fp2, F7, F8, P3, T6, O1, Oz, O2), with the highest predictive power at the occipital derivations. These results indicate that vigilant attention impairments induced by SD can be predicted by the pre-stimulus baseline activity changes.
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27
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Wofford N, Ceballos N, Elkins G, Westerberg CE. A brief nap during an acute stressor improves negative affect. J Sleep Res 2022; 31:e13701. [PMID: 35851731 PMCID: PMC9786543 DOI: 10.1111/jsr.13701] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/30/2022] [Revised: 06/27/2022] [Accepted: 06/29/2022] [Indexed: 12/30/2022]
Abstract
Overnight sleep can reduce perceived stress, and improve associated cognitive disruptions and negative affect after an acute stressor. Whether a brief nap can also bestow these benefits in a non-sleep-restricted population is currently unknown. In this study that used a between-subjects design, stress was triggered by administering a modified Trier Social Stress Test to two groups of participants (nap [n = 29], wake [n = 41]). All participants were instructed they would give a speech during the study but the topic would be withheld until later, and then completed a math task. After a 40-min break in which participants watched a neutral video or took a nap monitored with electroencephalography, stress was reinforced by presenting the speech topics and giving participants a 10-min preparation period. Next, instead of giving a speech, the study ended and participants were debriefed. Negative affect, perceived stress and working memory were measured at multiple time points before and after the break. Both groups showed lower perceived stress and improved working memory after the break than before, but a nap did not confer additional benefits for perceived stress or working memory beyond taking a break. However, the nap group exhibited lower negative affect after the break than the wake group, and only the nap group showed a reduction in negative affect compared with initial negative affect levels. These results indicate a nap can improve negative emotions accompanying a stressor to a greater extent than taking a break, and suggest that brief naps may be a useful way to improve mood while experiencing an acute stressor.
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Affiliation(s)
- Nathan Wofford
- Department of PsychologyTexas State UniversitySan MarcosTexasUSA,Department of Psychology and NeuroscienceBaylor UniversityWacoTexasUSA
| | - Natalie Ceballos
- Department of PsychologyTexas State UniversitySan MarcosTexasUSA
| | - Gary Elkins
- Department of Psychology and NeuroscienceBaylor UniversityWacoTexasUSA
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28
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Yang Y, Zhang J, Han F, Xiao F. Not Only Excessive Daytime Sleepiness but Also Depression Symptoms, Chronological Age and Onset-Age Were Associated with Impulsivity in Narcolepsy Type 1 Patients. Nat Sci Sleep 2022; 14:1857-1866. [PMID: 36275179 PMCID: PMC9586176 DOI: 10.2147/nss.s377372] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/04/2022] [Accepted: 10/11/2022] [Indexed: 11/23/2022] Open
Abstract
Objective To detect the factors associated with total and subscales impulsivity scores in narcolepsy and further explore the non-linear relationship between these factors and impulsivity score. Methods One hundred and fifty-eight narcolepsy type 1 (NT1) patients were involved in this cross-sectional study. Patients completed questionnaires evaluating impulsivity symptoms (Barratt impulse scale-11, BIS-11), depression symptoms (Center for Epidemiologic Studies Depression Scale for Children, CES-DC or Self-Rating Depression Scale, SDS) and sleepiness (Epworth Sleepiness Scale, ESS). Parameters from polysomnography and multiple sleep latency test were also collected. Linear regression analysis was performed to detect the factors associated with total and subscales impulsivity scores. Then, generalized additive models and smooth curve fitting were performed to explore the non-linear relationship between chronological age and impulsivity scores. Results Factors associated with higher total impulsivity score were higher ESS, older onset and adolescents. Factors associated with higher attentional impulsivity score were higher ESS, older onset and adolescents. Factors associated with higher motor impulsivity score were higher ESS, younger onset and depression symptoms. Factors associated with higher non-planning impulsivity score were adolescents, older onset and depression symptoms. A non-linear relationship between age and impulsivity scores (total impulsivity score, attentional impulsivity score and non-planning impulsivity score) was detected in NT1 patients. Conclusion Not only excessive daytime sleepiness but also onset-age, depression symptoms and chronological age were associated with impulsivity in NT1 patients. The non-linear relationship between age and impulsivity scores suggested brain and mental development alterations in NT1 patients.
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Affiliation(s)
- Yang Yang
- Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China
| | - Jun Zhang
- Department of Neurology, Peking University People’s Hospital, Beijing, 100044, People’s Republic of China
| | - Fang Han
- Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Peking University People’s Hospital, Beijing, 100044, People’s Republic of China
| | - Fulong Xiao
- Department of General Internal Medicine, Peking University People’s Hospital, Beijing, 100044, People’s Republic of China
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29
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Vo TT, Pahlen S, Kremen WS, McGue M, Dahl Aslan A, Nygaard M, Christensen K, Reynolds CA. Does sleep duration moderate genetic and environmental contributions to cognitive performance? Sleep 2022; 45:zsac140. [PMID: 35727734 PMCID: PMC9548666 DOI: 10.1093/sleep/zsac140] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/15/2022] [Revised: 05/06/2022] [Indexed: 01/27/2023] Open
Abstract
While prior research has demonstrated a relationship between sleep and cognitive performance, how sleep relates to underlying genetic and environmental etiologies contributing to cognitive functioning, regardless of the level of cognitive function, is unclear. The present study assessed whether the importance of genetic and environmental contributions to cognition vary depending on an individual's aging-related sleep characteristics. The large sample consisted of twins from six studies within the Interplay of Genes and Environment across Multiple Studies (IGEMS) consortium spanning mid- to late-life (Average age [Mage] = 57.6, range = 27-91 years, N = 7052, Female = 43.70%, 1525 complete monozygotic [MZ] pairs, 2001 complete dizygotic [DZ] pairs). Quantitative genetic twin models considered sleep duration as a primary moderator of genetic and environmental contributions to cognitive performance in four cognitive abilities (Semantic Fluency, Spatial-Visual Reasoning, Processing Speed, and Episodic Memory), while accounting for age moderation. Results suggested genetic and both shared and nonshared environmental contributions for Semantic Fluency and genetic and shared environmental contributions for Episodic Memory vary by sleep duration, while no significant moderation was observed for Spatial-Visual Reasoning or Processing Speed. Results for Semantic Fluency and Episodic Memory illustrated patterns of higher genetic influences on cognitive function at shorter sleep durations (i.e. 4 hours) and higher shared environmental contributions to cognitive function at longer sleep durations (i.e. 10 hours). Overall, these findings may align with associations of upregulation of neuroinflammatory processes and ineffective beta-amyloid clearance in short sleep contexts and common reporting of mental fatigue in long sleep contexts, both associated with poorer cognitive functioning.
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Affiliation(s)
- Tina T Vo
- Department of Psychology, University of California, Riverside, Riverside, CA, USA
| | - Shandell Pahlen
- Department of Psychology, University of California, Riverside, Riverside, CA, USA
| | - William S Kremen
- Department of Psychiatry, University of California, San Diego, San Diego, CA, USA
| | - Matt McGue
- Department of Psychology, University of Minnesota, Minneapolis, MN, USA
| | - Anna Dahl Aslan
- School of Health Sciences, University of Skövde, Skövde, Sweden
- Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
| | - Marianne Nygaard
- The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark
| | - Kaare Christensen
- The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark
| | - Chandra A Reynolds
- Department of Psychology, University of California, Riverside, Riverside, CA, USA
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30
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Li Y, Ma M, Shao Y, Wang W. Enhanced effective connectivity from the middle frontal gyrus to the parietal lobe is associated with impaired mental rotation after total sleep deprivation: An electroencephalogram study. Front Neurosci 2022; 16:910618. [PMID: 36248651 PMCID: PMC9566834 DOI: 10.3389/fnins.2022.910618] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/01/2022] [Accepted: 09/07/2022] [Indexed: 11/13/2022] Open
Abstract
Sleep deprivation impairs cognitive functions, including attention, memory, and decision-making. Studies on the neuro-electro-physiological mechanisms underlying total sleep deprivation (TSD) that impairs spatial cognition are limited. Based on electroencephalogram (EEG) and Exact Low Resolution Brain Electromagnetic Tomography (eLORETA), this study focused on the effects of TSD on mental rotation and the cognitive neural mechanisms underlying its damage. Twenty-four healthy college students completed mental rotation tasks while resting and after 36 h of TSD; their EEG data were simultaneously recorded. The amplitude of P300 component associated with mental rotation was observed and localized through source reconstruction, while changes in effective connectivity between multiple brain regions associated with mental rotation cognitive processing were calculated using isolated effective coherence (iCoh) of eLORETA. Compared with the baseline before TSD, the amplitude of the P300 component related to mental rotation decreased. The task-state data of P300 were localized to the source of the difference in ERP current density, and it was found that the brain regions related to the difference in the decrease in P300 amplitude included the superior parietal lobule, precuneus, prefrontal lobe, and other related regions. Effective connectivity analysis found that TSD enhanced the effective connectivity from the left middle frontal gyrus to the left superior parietal lobule, left inferior parietal lobule, and left precuneus under the identical condition. Pearson correlation analysis showed a positive correlation between the decrease in accuracy of mental rotation and increase in effective connectivity. Thus, our study suggests that TSD impairs the ability of the mental rotation, showing a decrease in P300 amplitude and an enhanced effective connectivity between the middle frontal gyrus and the parietal lobe in the task state.
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Affiliation(s)
- Yutong Li
- School of Psychology, Beijing Sport University, Beijing, China
| | - Mengke Ma
- School of Psychology, Beijing Sport University, Beijing, China
| | - Yongcong Shao
- School of Psychology, Beijing Sport University, Beijing, China
- *Correspondence: Yongcong Shao,
| | - Wei Wang
- Department of Criminal Psychology, Northwest University of Political Science and Law, Xi’an, China
- Wei Wang,
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Lima NC, Kirov R, de Almondes KM. Impairment of executive functions due to sleep alterations: An integrative review on the use of P300. Front Neurosci 2022; 16:906492. [PMID: 35937880 PMCID: PMC9355472 DOI: 10.3389/fnins.2022.906492] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/28/2022] [Accepted: 06/30/2022] [Indexed: 11/13/2022] Open
Abstract
Objective Cognitive impairment due to sleep deprivation (SD) is an important global health concern as part of the growing rates of sleep disorders and sleep deprivation worldwide. Amongst the affected cognitive processes, the effects of SD on the executive functions (EFs) show diverse methods and inconclusive or contradictory results, highlighting the importance of further research in this field. Considering this scenario, we evaluate one of the most used methods for objectively evaluating EFs on SD: the event-related potential (ERP) P300. Methods Our study provides a comprehensive review on the use of P300 for evaluating executive functions in sleep alterations on subjects of all ages, as well as an analysis on the efficiency of P300 as an assessment method for executive functions compared to traditional neurocognitive batteries. We review the benefits of P300 application for multiple sleep/wake alterations, whether evoked in laboratory or as part of pre-existing sleep disorders. Results We assess the diverse protocols used to elicit and complement P300, the most identified alterations in amplitude and latency, and suggest new lines of study that could benefit from P300 within the field. Conclusion We conclude that P300 is a valuable asset for evaluating executive dysfunction under sleep deprivation both as a standalone protocol and in conjunction with subjective methods, with consistently significant results in assessing executive dysfunction in a diversity of subjects and etiologies.
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Affiliation(s)
- Nathalya Chrispim Lima
- Postgraduate Program in Psychobiology, Federal University of Rio Grande do Norte, Natal, Brazil
- *Correspondence: Nathalya Chrispim Lima
| | - Roumen Kirov
- Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
| | - Katie Moraes de Almondes
- Department of Psychology and Postgraduate Program in Psychobiology, Federal University of Rio Grande do Norte, Natal, Brazil
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Desai RI, Limoli CL, Stark CEL, Stark SM. Impact of spaceflight stressors on behavior and cognition: A molecular, neurochemical, and neurobiological perspective. Neurosci Biobehav Rev 2022; 138:104676. [PMID: 35461987 DOI: 10.1016/j.neubiorev.2022.104676] [Citation(s) in RCA: 16] [Impact Index Per Article: 5.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/13/2021] [Revised: 03/15/2022] [Accepted: 04/18/2022] [Indexed: 11/19/2022]
Abstract
The response of the human body to multiple spaceflight stressors is complex, but mounting evidence implicate risks to CNS functionality as significant, able to threaten metrics of mission success and longer-term behavioral and neurocognitive health. Prolonged exposure to microgravity, sleep disruption, social isolation, fluid shifts, and ionizing radiation have been shown to disrupt mechanisms of homeostasis and neurobiological well-being. The overarching goal of this review is to document the existing evidence of how the major spaceflight stressors, including radiation, microgravity, isolation/confinement, and sleep deprivation, alone or in combination alter molecular, neurochemical, neurobiological, and plasma metabolite/lipid signatures that may be linked to operationally-relevant behavioral and cognitive performance. While certain brain region-specific and/or systemic alterations titrated in part with neurobiological outcome, variations across model systems, study design, and the conspicuous absence of targeted studies implementing combinations of spaceflight stressors, confounded the identification of specific signatures having direct relevance to human activities in space. Summaries are provided for formulating new research directives and more predictive readouts of portending change in neurobiological function.
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Affiliation(s)
- Rajeev I Desai
- Harvard Medical School, McLean Hospital, Behavioral Biology Program, Belmont, MA 02478, USA.
| | - Charles L Limoli
- Department of Radiation Oncology, University of California Irvine, Medical Sciences I, B146B, Irvine, CA 92697, USA
| | - Craig E L Stark
- Department of Neurobiology of Behavior, University of California Irvine, 1400 Biological Sciences III, Irvine, CA 92697, USA
| | - Shauna M Stark
- Department of Neurobiology of Behavior, University of California Irvine, 1400 Biological Sciences III, Irvine, CA 92697, USA
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33
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Kim T, Kim S, Kang J, Kwon M, Lee SH. The Common Effects of Sleep Deprivation on Human Long-Term Memory and Cognitive Control Processes. Front Neurosci 2022; 16:883848. [PMID: 35720688 PMCID: PMC9201256 DOI: 10.3389/fnins.2022.883848] [Citation(s) in RCA: 15] [Impact Index Per Article: 5.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/25/2022] [Accepted: 05/11/2022] [Indexed: 11/17/2022] Open
Abstract
Sleep deprivation is known to have adverse effects on various cognitive abilities. In particular, a lack of sleep has been reported to disrupt memory consolidation and cognitive control functions. Here, focusing on long-term memory and cognitive control processes, we review the consistency and reliability of the results of previous studies of sleep deprivation effects on behavioral performance with variations in the types of stimuli and tasks. Moreover, we examine neural response changes related to these behavioral changes induced by sleep deprivation based on human fMRI studies to determine the brain regions in which neural responses increase or decrease as a consequence of sleep deprivation. Additionally, we discuss about the possibility that light as an environmentally influential factor affects our sleep cycles and related cognitive processes.
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Affiliation(s)
- Taehyun Kim
- Department of Bio and Brain Engineering, College of Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
| | - Sejin Kim
- Department of Bio and Brain Engineering, College of Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
| | - Joonyoung Kang
- Department of Bio and Brain Engineering, College of Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
- Program of Brain and Cognitive Engineering, College of Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
| | - Minjae Kwon
- Department of Bio and Brain Engineering, College of Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
| | - Sue-Hyun Lee
- Department of Bio and Brain Engineering, College of Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
- Program of Brain and Cognitive Engineering, College of Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea
- *Correspondence: Sue-Hyun Lee,
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34
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Hirano D, Kimura N, Yano H, Enoki M, Aikawa M, Goto Y, Taniguchi T. Different brain activation patterns in the prefrontal area between self-paced and high-speed driving tasks. JOURNAL OF BIOPHOTONICS 2022; 15:e202100295. [PMID: 35103406 DOI: 10.1002/jbio.202100295] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 09/23/2021] [Revised: 01/18/2022] [Accepted: 01/28/2022] [Indexed: 06/14/2023]
Abstract
The purpose of this study was to investigate the effects on prefrontal cortex brain activity when participants attempted to stop a car accurately at a stop line when driving at different speeds using functional near-infrared spectroscopy (fNIRS). Twenty healthy subjects with driving experience drove their own cars for a distance of 60 m five times each at their own pace or as fast as possible. The variation in the distance between the stop line and the car was not significantly different between the self-paced and high-speed tasks. However, oxygenated hemoglobin concentration in the prefrontal cortex was significantly higher in the high-speed task than in the self-paced task. These findings suggest that driving at high speed requires more divided attention than driving at self-paced speed, even though the participants were able to stop the car at the same distance from the target. This study shows the advantages and usefulness of fNIRS .
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Affiliation(s)
- Daisuke Hirano
- Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Minato, Tokyo, Japan
- Department of Occupational Therapy, School of Health Sciences, International University of Health and Welfare, Otawara, Tochigi, Japan
| | - Naotoshi Kimura
- Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Minato, Tokyo, Japan
- Department of Rehabilitation, International University of Health and Welfare Ichikawa Hospital, Ichikawa, Chiba, Japan
| | - Hana Yano
- Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Minato, Tokyo, Japan
- Department of Occupational Therapy, School of Health Sciences, International University of Health and Welfare, Otawara, Tochigi, Japan
| | - Miku Enoki
- Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Minato, Tokyo, Japan
- Department of Rehabilitation, International University of Health and Welfare Shioya Hospital, Yaita, Tochigi, Japan
| | - Maya Aikawa
- Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Minato, Tokyo, Japan
- Department of Rehabilitation, International University of Health and Welfare Shioya Hospital, Yaita, Tochigi, Japan
| | - Yoshinobu Goto
- Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Minato, Tokyo, Japan
- Faculty of Medicine, School of Medicine, International University of Health and Welfare, Narita, Chiba, Japan
- Department of Occupational Therapy, School of Health Sciences at Fukuoka, International University of Health and Welfare, Okawa, Fukuoka, Japan
| | - Takamichi Taniguchi
- Graduate School of Health and Welfare Sciences, International University of Health and Welfare, Minato, Tokyo, Japan
- Department of Occupational Therapy, School of Health Sciences, International University of Health and Welfare, Otawara, Tochigi, Japan
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35
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Smith M, Mendl M, Murrell JC. Associations between osteoarthritis and duration and quality of night-time rest in dogs. Appl Anim Behav Sci 2022. [DOI: 10.1016/j.applanim.2022.105661] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/28/2022]
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36
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Song T, Yu K, Wang L, Xu L, Xu M, Peng Z, Dai C, Wang H, Yang T, Shao Y, Wang X, Lv J. Total Sleep Deprivation Triggers Greater Activation in the Parietal Brain in the Visual Working Memory Updating Processes: An Event-Related Potentials Study. Front Neurosci 2022; 16:736437. [PMID: 35368284 PMCID: PMC8966886 DOI: 10.3389/fnins.2022.736437] [Citation(s) in RCA: 6] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/05/2021] [Accepted: 02/17/2022] [Indexed: 12/21/2022] Open
Abstract
Working memory functions are known to be altered after total sleep deprivation (TSD). However, few studies have explored the deficits of working memory updating (WMU) after TSD, or the underlying electrophysiological mechanisms of these alterations. In the current exploratory study, we enrolled 14 young male volunteers who performed two kinds of WMU tasks—spatial and object two-back tasks—with simultaneous electroencephalography recordings under two sleep conditions: a normal sleep baseline condition and after 36 h of TSD. Repeated-measures analysis of variance showed that compared with those at baseline, the rates of correct responses in the WMU tasks decreased significantly after TSD. Analysis of event-related potentials revealed that the average amplitude of P3 components decreased significantly in the frontal and central brain regions and increased significantly in the parietal brain regions. Our findings suggest that TSD damages WMU behavior, impairs cognitive functions in the frontal and central brain regions, and triggers greater activation in the parietal brain regions. This is the first study to report the existence of event-related compensatory neural activity. This event-related compensatory effect may provide a new perspective for understanding the mechanisms underlying the influences triggered by sleep loss.
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Affiliation(s)
- Tao Song
- School of Psychology, Beijing Sport University, Beijing, China
| | - Ke Yu
- Department of General Practice, The General Hospital of Western Theater Command, Chengdu, China
| | - Letong Wang
- School of Psychology, Beijing Sport University, Beijing, China
| | - Lin Xu
- School of Psychology, Beijing Sport University, Beijing, China
| | - Mengmeng Xu
- School of Psychology, Beijing Sport University, Beijing, China
| | - Ziyi Peng
- School of Psychology, Beijing Sport University, Beijing, China
| | - Cimin Dai
- School of Psychology, Beijing Sport University, Beijing, China
| | - Haiteng Wang
- School of Psychology, Beijing Sport University, Beijing, China
| | - Tianyi Yang
- School of Psychology, Beijing Sport University, Beijing, China
| | - Yongcong Shao
- School of Psychology, Beijing Sport University, Beijing, China
- *Correspondence: Yongcong Shao,
| | - Xiaoming Wang
- Tianjin Institute of Environmental and Operational Medicine, Tianjin, China
- Xiaoming Wang,
| | - Jing Lv
- Department of Psychology, The Second Medical Center, Chinese PLA General Hospital, Beijing, China
- Jing Lv,
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37
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White-Matter Integrity and Working Memory: Links to Aging and Dopamine-Related Genes. eNeuro 2022; 9:ENEURO.0413-21.2022. [PMID: 35346961 PMCID: PMC9014983 DOI: 10.1523/eneuro.0413-21.2022] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/24/2021] [Revised: 01/22/2022] [Accepted: 02/07/2022] [Indexed: 11/21/2022] Open
Abstract
Working memory, a core function underlying many higher-level cognitive processes, requires cooperation of multiple brain regions. White matter refers to myelinated axons, which are critical to interregional brain communication. Past studies on the association between white-matter integrity and working memory have yielded mixed findings. Using voxelwise tract-based spatial statistics analysis, we investigated this relationship in a sample of 328 healthy adults from 25 to 80 years of age. Given the important role of dopamine (DA) in working-memory functioning and white matter, we also analyzed the effects of dopamine-related genes on them. There were associations between white-matter integrity and working memory in multiple tracts, indicating that working-memory functioning relies on global connections between different brain areas across the adult life span. Moreover, a mediation analysis suggested that white-matter integrity contributes to age-related differences in working memory. Finally, there was an effect of the COMT Val158Met polymorphism on white-matter integrity, such that Val/Val carriers had lower fractional anisotropy values than any Met carriers in the internal capsule, corona radiata, and posterior thalamic radiation. As this polymorphism has been associated with dopaminergic tone in the prefrontal cortex, this result provides evidence for a link between DA neurotransmission and white matter. Together, the results support a link between white-matter integrity and working memory, and provide evidence for its interplay with age- and DA-related genes.
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38
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Wassan S, Xi C, Shen T, Gulati K, Ibraheem K, Amir Latif Rajpoot RM. The Impact of Online Learning System on Students Affected with Stroke Disease. Behav Neurol 2022; 2022:4847066. [PMID: 35178124 PMCID: PMC8843983 DOI: 10.1155/2022/4847066] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/31/2021] [Revised: 12/24/2021] [Accepted: 12/28/2021] [Indexed: 12/27/2022] Open
Abstract
Stroke, also known as a cerebrovascular accident, is a medical emergency that causes temporary or permanent behavioral dysfunction in people. Sleep deprivation affects our brains in a variety of ways. The advantages of sleep much justify the risks of not having enough sleep. Sleep deprivation (SD) includes a variety of factors, including prolonged awake. Neuroimaging investigates SD's impact on attention, working memory, mood, and hippocampal learning. We analyzed how this data enriches our mechanistic understanding of these alterations and the clinical illnesses linked with sleep disruption. We have used Cronbach's alpha to test the reliability of a scale, so we then have 19 individual attributes responding to 174 participants via survey. The evaluated result shows the reliability statistics; the value for Cronbach's alpha is .962, which is very excellent as it reaches 1. So, there is very strong reliability. If the value falls under .6, we look back to the mean and standard deviation table and remove the attribute with low values for mean or standard deviation and try the remaining attributes. Cronbach's alpha tells us which attribute or item to delete to increase the reliability, and we also have analyzed the correlation among the class students while watching the same video lecture. We have collected data for at least ten students watching the same video using a webcam. Once the data is collected, we then have applied some correlation techniques to determine the class students' behavior towards the same video lecture. This way, we can see the overall behavior of the class upon a specific video lecture. The study further reveals that subjective happiness is influenced by its efficiency, entertainment value, and effectiveness. Does the research offer an original emphasis on analyzing how does lack of sleep affect our brains? Sleep loss frameworks are minimal compared to the benefits of sleep.
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Affiliation(s)
| | - Chen Xi
- Business School, Nanjing University, China
| | - Tian Shen
- School of International Education, Nanjing University of CM, China
| | - Kamal Gulati
- Amity University, Noida, Uttar, Pradesh, India
- Stratford University, Virginia, USA
| | - Kinza Ibraheem
- Department of Computer Science COMSATS University Islamabad, Sahiwal Campus, Pakistan
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39
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Federico G, Alfano V, Garramone F, Mele G, Salvatore M, Aiello M, Cavaliere C. Self-Reported Sleep Quality Across Age Modulates Resting-State Functional Connectivity in Limbic and Fronto-Temporo-Parietal Networks: An Exploratory Cross-Sectional fMRI Study. Front Aging Neurosci 2022; 14:806374. [PMID: 35197843 PMCID: PMC8859450 DOI: 10.3389/fnagi.2022.806374] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/31/2021] [Accepted: 01/12/2022] [Indexed: 11/13/2022] Open
Abstract
Sleep problems are increasingly present in the general population at any age, and they are frequently concurrent with—or predictive of—memory disturbances, anxiety, and depression. In this exploratory cross-sectional study, 54 healthy participants recruited in Naples (Italy; 23 females; mean age = 37.1 years, range = 20–68) completed the Pittsburgh Sleep Quality Index (PSQI) and a neurocognitive assessment concerning both verbal and visuospatial working memory as well as subjective measures of anxiety and depression. Then, 3T fMRI images with structural and resting-state functional sequences were acquired. A whole-brain seed-to-seed functional connectivity (FC) analysis was conducted by contrasting good (PSQI score <5) vs. bad (PSQI score ≥5) sleepers. Results highlighted FC differences in limbic and fronto-temporo-parietal brain areas. Also, bad sleepers showed an anxious/depressive behavioural phenotype and performed worse than good sleepers at visuospatial working-memory tasks. These findings may help to reveal the effects of sleep quality on daily-life cognitive functioning and further elucidate pathophysiological mechanisms of sleep disorders.
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40
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Griggs S, Harper A, Hickman RL. A systematic review of sleep deprivation and neurobehavioral function in young adults. Appl Nurs Res 2022; 63:151552. [PMID: 35034695 PMCID: PMC8766996 DOI: 10.1016/j.apnr.2021.151552] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/22/2021] [Revised: 10/04/2021] [Accepted: 12/06/2021] [Indexed: 02/03/2023]
Abstract
AIM To examine the effect of sleep deprivation (total and partial) on neurobehavioral function compared to a healthy sleep opportunity (7-9 h) in young adults 18-30 years. BACKGROUND More than one-third of young adults are sleep deprived, which negatively affects a range of neurobehavioral functions, including psychomotor vigilance performance (cognitive), affect, and daytime sleepiness. METHODS A systematic review of randomized controlled trials (RCTs) on sleep deprivation and neurobehavioral function. Multiple electronic databases (Cochrane Central Registry of Controlled Trials [CENTRAL], PubMed, PsycINFO, CINAHL, and Web of Science) were searched for relevant RCTs published in English from the establishment of each database to December 31, 2020. RESULTS Nineteen RCTs were selected (N = 766, mean age = 23.7 ± 3.1 years; 44.8% female). Seven were between-person (5 were parallel-group designs and 2 had multiple arms), and 12 were within-person designs (9 were cross over and 3 used a Latin square approach). Total sleep deprivation had the strongest detrimental effect on psychomotor vigilance performance, with the largest effects on vigilance tasks in young adults in the included studies. CONCLUSION Acute sleep deprivation degrades multiple dimensions of neurobehavioral function including psychomotor vigilance performance, affect, and daytime sleepiness in young adults. The effect of chronic sleep deprivation on the developing brain and associated neurobehavioral functions in young adults remains unclear.
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Affiliation(s)
- Stephanie Griggs
- Case Western Reserve University, Frances Payne Bolton School of Nursing, Cleveland, Ohio, USA 44106
| | - Alison Harper
- Case Western Reserve University, Frances Payne Bolton School of Nursing, Department of Anthropology, Cleveland, Ohio, USA 44106
| | - Ronald L. Hickman
- Ruth M. Anderson Endowed Professor of Nursing and Associate Dean for Research Case Western Reserve University, Frances Payne Bolton School of Nursing, Cleveland, OH, USA 44106
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41
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Cacciatore M, Magnani FG, Leonardi M, Rossi Sebastiano D, Sattin D. Sleep Treatments in Disorders of Consciousness: A Systematic Review. Diagnostics (Basel) 2021; 12:diagnostics12010088. [PMID: 35054255 PMCID: PMC8775271 DOI: 10.3390/diagnostics12010088] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/30/2021] [Revised: 12/24/2021] [Accepted: 12/30/2021] [Indexed: 12/23/2022] Open
Abstract
Sleep disorders are among the main comorbidities in patients with a Disorder of Consciousness (DOC). Given the key role of sleep in neural and cognitive functioning, detecting and treating sleep disorders in DOCs might be an effective therapeutic strategy to boost consciousness recovery and levels of awareness. To date, no systematic reviews have been conducted that explore the effect of sleep treatments in DOCs; thus, we systematically reviewed the existing studies on both pharmacological and non-pharmacological treatments for sleep disorders in DOCs. Among 2267 assessed articles, only 7 were included in the systematic review. The studies focused on two sleep disorder categories (sleep-related breathing disorders and circadian rhythm dysregulation) treated with both pharmacological (Modafinil and Intrathecal Baclofen) and non-pharmacological (positive airway pressure, bright light stimulation, and central thalamic deep brain stimulation) interventions. Although the limited number of studies and their heterogeneity do not allow generalized conclusions, all the studies highlighted the effectiveness of treatments on both sleep disorders and levels of awareness. For this reason, clinical and diagnostic evaluations able to detect sleep disorders in DOC patients should be adopted in the clinical routine for the purpose of intervening promptly with the most appropriate treatment.
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Affiliation(s)
- Martina Cacciatore
- UOC Neurologia, Salute Pubblica, Disabilità, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy; (M.C.); (M.L.)
| | - Francesca G. Magnani
- UOC Neurologia, Salute Pubblica, Disabilità, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy; (M.C.); (M.L.)
- Correspondence: ; Tel.: +39-02-23942188
| | - Matilde Leonardi
- UOC Neurologia, Salute Pubblica, Disabilità, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy; (M.C.); (M.L.)
| | - Davide Rossi Sebastiano
- Unità di Neurofisiopatologia, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milan, Italy;
| | - Davide Sattin
- IRCCS Istituti Clinici Scientifici Maugeri di Milano, 20138 Milan, Italy;
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42
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Stevens D, D'Rozario A, Openshaw H, Bartlett D, Rae CD, Catcheside P, Wong K, McEvoy RD, Grunstein RR, Vakulin A. Clinical predictors of working memory performance in obstructive sleep apnoea patients before and during extended wakefulness. Sleep 2021; 45:6460438. [PMID: 34897504 DOI: 10.1093/sleep/zsab289] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/16/2021] [Revised: 11/04/2021] [Indexed: 11/14/2022] Open
Abstract
STUDY OBJECTIVES Extended wakefulness (EW) and obstructive sleep apnoea (OSA) impair working memory (WM), but their combined effects are unclear. This study examined the impact of EW on WM function in OSA patients and identified clinical predictors of WM impairment. METHODS Following polysomnography (PSG), 56 OSA patients (Mean ± SD, age 49.5 ± 8.9, AHI 38.1 ± 25.0) completed WM 2-back performance tasks 10 times over 24 hours of wakefulness to assess average accuracy and completion times measured after 6-12 hours awake (baseline) compared to 18-24 hours awake (EW). Hierarchical cluster analysis classified participants with poorer versus better WM performance at baseline and during EW. Clinical predictors of performance were examined via regression and receiver operator characteristic (ROC) analyses. RESULTS WM performance decreased following EW and showed consistent correlations with age, ESS, total sleep time and hypoxemia (O2 nadir and mean O2 desaturation) at baseline and with EW (all p<0.01). O2 nadir and age were significant independent predictors of performance at baseline (adjusted R 2=0.30, p<0.01), while O2 nadir and ESS were predictors of WM following EW (adjusted R 2=0.38, p<0.001). ROC analysis demonstrated high sensitivity and specificity of models to predict poorer vs better performing participants at baseline (83% and 69%) and during EW (84% and 74%). CONCLUSIONS O2 nadir, age and sleepiness show prognostic value for predicting WM impairment in both rested and sleep deprived OSA patients and may guide clinicians in identifying patients most at risk of impaired WM under both rested and heightened sleep pressure conditions.
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Affiliation(s)
- David Stevens
- Flinders Health and Medical Research Institute, Sleep Health / Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, Australia.,Centre for Nutrition and Gastrointestinal Diseases, South Australian Health & Medical Research Institute, Adelaide, Australia
| | - Angela D'Rozario
- CIRUS and NeuroSleep, Centres of Research Excellence, Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, Australia.,Sydney Medical School, The University of Sydney, Sydney, Australia.,School of Psychology, Faculty of Science, Brain and Mind Centre and Charles Perkins Centre, University of Sydney, Sydney, Australia
| | - Hannah Openshaw
- Flinders Health and Medical Research Institute, Sleep Health / Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, Australia
| | - Delwyn Bartlett
- CIRUS and NeuroSleep, Centres of Research Excellence, Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, Australia.,Sydney Medical School, The University of Sydney, Sydney, Australia
| | - Caroline D Rae
- Neuroscience Research Australia, Sydney, Australia.,School of Medical Sciences, The University of New South Wales, Sydney, Australia
| | - Peter Catcheside
- Flinders Health and Medical Research Institute, Sleep Health / Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, Australia
| | - Keith Wong
- CIRUS and NeuroSleep, Centres of Research Excellence, Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, Australia.,Sydney Medical School, The University of Sydney, Sydney, Australia.,Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, and Sydney Health Partners, Sydney, Australia
| | - R Doug McEvoy
- Flinders Health and Medical Research Institute, Sleep Health / Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, Australia
| | - Ronald R Grunstein
- CIRUS and NeuroSleep, Centres of Research Excellence, Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, Australia.,Sydney Medical School, The University of Sydney, Sydney, Australia.,Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, and Sydney Health Partners, Sydney, Australia
| | - Andrew Vakulin
- Flinders Health and Medical Research Institute, Sleep Health / Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University, Adelaide, Australia.,CIRUS and NeuroSleep, Centres of Research Excellence, Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, Australia
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43
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Stepan ME, Altmann EM, Fenn KM. Slow-wave sleep during a brief nap is related to reduced cognitive deficits during sleep deprivation. Sleep 2021; 44:zsab152. [PMID: 34156468 PMCID: PMC8598175 DOI: 10.1093/sleep/zsab152] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/19/2020] [Revised: 04/23/2021] [Indexed: 11/12/2022] Open
Abstract
Sleeping for a short period (i.e. napping) may help mitigate impairments in cognitive processing caused by sleep deprivation, but there is limited research on effects of brief naps in particular. Here, we tested the effect of a brief nap opportunity (30- or 60-min) during a period of sleep deprivation on two cognitive processes with broad scope, placekeeping and vigilant attention. In the evening, participants (N = 280) completed a placekeeping task (UNRAVEL) and a vigilant attention task (Psychomotor Vigilance Task [PVT]) and were randomly assigned to either stay awake overnight or sleep at home. Sleep-deprived participants were randomly assigned to receive either no nap opportunity, a 30-min opportunity, or a 60-min opportunity. Participants who napped were set up with polysomnography. The next morning, sleep participants returned, and all participants completed UNRAVEL and the PVT. Sleep deprivation impaired performance on both tasks, but nap opportunity did not reduce the impairment, suggesting that naps longer than those tested may be necessary to cause group differences. However, in participants who napped, more time spent in slow-wave sleep (SWS) was associated with reduced performance deficits on both tasks, effects we interpret in terms of the role of SWS in alleviating sleep pressure and facilitating memory consolidation.
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Affiliation(s)
- Michelle E Stepan
- Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
| | - Erik M Altmann
- Department of Psychology, Michigan State University, East Lansing, MI, USA
| | - Kimberly M Fenn
- Department of Psychology, Michigan State University, East Lansing, MI, USA
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44
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Interindividual differences in attentional vulnerability moderate cognitive performance during sleep restriction and subsequent recovery in healthy young men. Sci Rep 2021; 11:19147. [PMID: 34580319 PMCID: PMC8476607 DOI: 10.1038/s41598-021-95884-w] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/24/2021] [Accepted: 07/23/2021] [Indexed: 11/30/2022] Open
Abstract
We investigated whether interindividual attentional vulnerability moderates performance on domain-specific cognitive tasks during sleep restriction (SR) and subsequent recovery sleep. Fifteen healthy men (M ± SD, 22.3 ± 2.8 years) were exposed to three nights of baseline, five nights of 5-h time in bed SR, and two nights of recovery sleep. Participants completed tasks assessing working memory, visuospatial processing, and processing speed approximately every two hours during wake. Analyses examined performance across SR and recovery (linear predictor day or quadratic predictor day2) moderated by attentional vulnerability per participant (difference between mean psychomotor vigilance task lapses after the fifth SR night versus the last baseline night). For significant interactions between day/day2 and vulnerability, we investigated the effect of day/day2 at 1 SD below (less vulnerable level) and above (more vulnerable level) the mean of attentional vulnerability (N = 15 in all analyses). Working memory accuracy and speed on the Fractal 2-Back and visuospatial processing speed and efficiency on the Line Orientation Task improved across the entire study at the less vulnerable level (mean − 1SD) but not the more vulnerable level (mean + 1SD). Therefore, vulnerability to attentional lapses after SR is a marker of susceptibility to working memory and visuospatial processing impairment during SR and subsequent recovery.
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45
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Flynn-Evans EE, Wong LR, Kuriyagawa Y, Gowda N, Cravalho PF, Pradhan S, Feick NH, Bathurst NG, Glaros ZL, Wilaiprasitporn T, Bansal K, Garcia JO, Hilditch CJ. Supervision of a self-driving vehicle unmasks latent sleepiness relative to manually controlled driving. Sci Rep 2021; 11:18530. [PMID: 34521862 PMCID: PMC8440771 DOI: 10.1038/s41598-021-92914-5] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/05/2020] [Accepted: 06/15/2021] [Indexed: 11/15/2022] Open
Abstract
Human error has been implicated as a causal factor in a large proportion of road accidents. Automated driving systems purport to mitigate this risk, but self-driving systems that allow a driver to entirely disengage from the driving task also require the driver to monitor the environment and take control when necessary. Given that sleep loss impairs monitoring performance and there is a high prevalence of sleep deficiency in modern society, we hypothesized that supervising a self-driving vehicle would unmask latent sleepiness compared to manually controlled driving among individuals following their typical sleep schedules. We found that participants felt sleepier, had more involuntary transitions to sleep, had slower reaction times and more attentional failures, and showed substantial modifications in brain synchronization during and following an autonomous drive compared to a manually controlled drive. Our findings suggest that the introduction of partial self-driving capabilities in vehicles has the potential to paradoxically increase accident risk.
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Affiliation(s)
- Erin E Flynn-Evans
- Fatigue Countermeasures Laboratory, Human Systems Integration Division, NASA Ames Research Center, Moffett Field, CA, USA.
| | - Lily R Wong
- Fatigue Countermeasures Laboratory, San José State University, Moffett Field, CA, USA
| | | | - Nikhil Gowda
- Fatigue Countermeasures Laboratory, San José State University, Moffett Field, CA, USA
| | - Patrick F Cravalho
- Fatigue Countermeasures Laboratory, San José State University, Moffett Field, CA, USA
| | - Sean Pradhan
- Fatigue Countermeasures Laboratory, San José State University, Moffett Field, CA, USA.,School of Business Administration, Menlo College, Atherton, CA, USA
| | - Nathan H Feick
- Fatigue Countermeasures Laboratory, San José State University, Moffett Field, CA, USA
| | - Nicholas G Bathurst
- Fatigue Countermeasures Laboratory, San José State University, Moffett Field, CA, USA
| | - Zachary L Glaros
- Fatigue Countermeasures Laboratory, Human Systems Integration Division, NASA Ames Research Center, Moffett Field, CA, USA
| | - Theerawit Wilaiprasitporn
- School of Information Science and Technology, Vidyasirimedhi Institute of Science and Technology, Rayong, Thailand
| | - Kanika Bansal
- Army Research Laboratory, U.S. CCDC, Aberdeen Proving Ground, MD, USA.,Department of Biomedical Engineering, Columbia University, New York, NY, USA
| | - Javier O Garcia
- Army Research Laboratory, U.S. CCDC, Aberdeen Proving Ground, MD, USA
| | - Cassie J Hilditch
- Fatigue Countermeasures Laboratory, San José State University, Moffett Field, CA, USA
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46
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Fifel K, Deboer T. Heterogenous electrophysiological responses of functionally distinct striatal subregions to circadian and sleep-related homeostatic processes. Sleep 2021; 45:6369544. [PMID: 34516641 DOI: 10.1093/sleep/zsab230] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/04/2021] [Revised: 07/08/2021] [Indexed: 11/13/2022] Open
Abstract
Basal Ganglia (BG) are a set of subcortical nuclei that are involved in the control of a wide variety of motor, cognitive and affective behaviors. Although many behavioral abnormalities associated with BG dysfunction overlap with the clinical picture precipitated by the lack of sleep, the impact of sleep alterations on neuronal activity in BG is unknown. Using wildtype C57BI mice, we investigated the circadian and sleep-related homeostatic modulation of neuronal activity in the 3 functional subdivisions of the striatum (i.e. sensorimotor, associative and limbic striatum). We found no circadian modulation of activity in both ventral and dorso-medial striatum while the dorso-lateral striatum displayed a significant circadian rhythm with increased firing rates during the subjective dark, active phase. By combining neuronal activity recordings with electroencephalogram (EEG) recordings, we found a strong modulation of neuronal activity by the nature of vigilance states with increased activity during wakefulness and rapid eye movement sleep relative to non-rapid eye movement sleep in all striatal subregions. Depriving animals of sleep for 6 hours induced significant, but heterogenous alterations in the neuronal activity across striatal subregions. Notably, these alterations lasted for up to 48 hours in the sensorimotor striatum and persisted even after the normalization of cortical EEG power densities. Our results show that vigilance and sleep states as well as their disturbances significantly affect neuronal activity within the striatum. We propose that these changes in neuronal activity underlie both the well-established links between sleep alterations and several disorders involving BG dysfunction as well as the maladaptive changes in behavior induced in healthy subjects following sleep loss.
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Affiliation(s)
- Karim Fifel
- Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.,International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan
| | - Tom Deboer
- Laboratory for Neurophysiology, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands
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47
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Cui G, Yin Y, Li S, Chen L, Liu X, Tang K, Li Y. Longitudinal relationships among problematic mobile phone use, bedtime procrastination, sleep quality and depressive symptoms in Chinese college students: a cross-lagged panel analysis. BMC Psychiatry 2021; 21:449. [PMID: 34507561 PMCID: PMC8431882 DOI: 10.1186/s12888-021-03451-4] [Citation(s) in RCA: 49] [Impact Index Per Article: 12.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/11/2021] [Accepted: 08/28/2021] [Indexed: 11/30/2022] Open
Abstract
BACKGROUND Cross-sectional and longitudinal studies have found that problematic mobile phone use, bedtime procrastination, sleep quality, and depressive symptoms are strongly associated. However, studies are inconsistent regarding whether problematic mobile phone use predicts depressive symptoms or vice versa, and sleep factors have been infrequently focused on in this regard. In addition, few studies have examined the longitudinal associations and directions of effects between these factors. Therefore, this study aims to explore the longitudinal relationship among problematic mobile phone use, bedtime procrastination, sleep quality, and depressive symptoms in college students. METHODS Overall, 1181 college students completed questionnaires on problematic mobile phone use, bedtime procrastination, sleep quality, and depressive symptoms at two time points 12 months apart. A cross-lagged model was used to examine the longitudinal relationship between these factors. RESULTS Cross-lagged analyses showed significant bidirectional relationships of problematic mobile phone use with bedtime procrastination and depressive symptoms. Additionally, there were also significant bidirectional relationships of sleep quality with bedtime procrastination and depressive symptoms. Problematic mobile phone use predicted subsequent sleep quality one-way, and bedtime procrastination predicted subsequent depressive symptoms one-way. CONCLUSIONS This study further expands our understanding of the longitudinal and bidirectional relationships among problematic mobile phone use, bedtime procrastination, sleep quality and depressive symptoms and helps school mental health educators design targeted interventions to reduce problematic mobile phone use, sleep problems, and depressive symptoms among college students.
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Affiliation(s)
- Guanghui Cui
- grid.464402.00000 0000 9459 9325School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, 250355 China
| | - Yongtian Yin
- School of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
| | - Shaojie Li
- Department of Social Medicine and Health Service Management, Xiangya School of Public Health, Central South University, Changsha, 410078, China.
| | - Lei Chen
- grid.464402.00000 0000 9459 9325School of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, 250355 China
| | - Xinyao Liu
- grid.464402.00000 0000 9459 9325School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355 China
| | - Kaixuan Tang
- grid.464402.00000 0000 9459 9325School of Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355 China
| | - Yawen Li
- grid.464402.00000 0000 9459 9325School of Ophthalmology and Optometry, Shandong University of Traditional Chinese Medicine, Jinan, 250355 China
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48
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Xu S, Akioma M, Yuan Z. Relationship between circadian rhythm and brain cognitive functions. FRONTIERS OF OPTOELECTRONICS 2021; 14:278-287. [PMID: 36637731 PMCID: PMC9743892 DOI: 10.1007/s12200-021-1090-y] [Citation(s) in RCA: 12] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/30/2020] [Accepted: 02/02/2021] [Indexed: 05/31/2023]
Abstract
Circadian rhythms are considered a masterstroke of natural selection, which gradually increase the adaptability of species to the Earth's rotation. Importantly, the nervous system plays a key role in allowing organisms to maintain circadian rhythmicity. Circadian rhythms affect multiple aspects of cognitive functions (mainly via arousal), particularly those needed for effort-intensive cognitive tasks, which require considerable top-down executive control. These include inhibitory control, working memory, task switching, and psychomotor vigilance. This mini review highlights the recent advances in cognitive functioning in the optical and multimodal neuroimaging fields; it discusses the processing of brain cognitive functions during the circadian rhythm phase and the effects of the circadian rhythm on the cognitive component of the brain and the brain circuit supporting cognition.
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Affiliation(s)
- Shiyang Xu
- Faculty of Health Sciences, Centre for Cognitive and Brain Sciences, University of Macau, Taipa, Macau SAR, China
| | - Miriam Akioma
- Faculty of Health Sciences, Centre for Cognitive and Brain Sciences, University of Macau, Taipa, Macau SAR, China
| | - Zhen Yuan
- Faculty of Health Sciences, Centre for Cognitive and Brain Sciences, University of Macau, Taipa, Macau SAR, China.
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49
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Seehagen S, Charlton S, Starkey N, Fallaize A, Brown J, Jones K. The role of prior sleep for divergent thinking in infants. J Sleep Res 2021; 31:e13457. [PMID: 34337813 DOI: 10.1111/jsr.13457] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/16/2021] [Revised: 07/09/2021] [Accepted: 07/22/2021] [Indexed: 11/29/2022]
Abstract
Higher-order cognitive functions seem particularly vulnerable to disruptions in prior sleep in school-aged children and adult populations. This study tested whether divergent thinking in infants varied as a function of prior sleep. Forty-three infants aged 13-16 months participated in a behavioural assessment of divergent thinking. Length of wakefulness since last sleep was experimentally manipulated. In addition, potential relations between divergent thinking and sleep quantity and quality during the night immediately before the assessment, as well as during three consecutive nights preceding the assessment, were examined using actigraphy recordings in combination with parent diaries. Divergent thinking was not impaired by lack of sleep within the previous 4 h. Divergent thinking was consistently related to night-time sleep quality and quantity prior to the assessment. These results suggest that timing of prior naturally occurring daytime sleep is less relevant for emergent divergent thinking capacity than quality and quantity of preceding night-time sleep.
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Affiliation(s)
- Sabine Seehagen
- University of Waikato, Hamilton, New Zealand.,Faculty of Psychology, Ruhr University Bochum, Bochum, Germany
| | | | | | - Amy Fallaize
- Auckland University of Technology, Auckland, New Zealand
| | | | - Kelly Jones
- Auckland University of Technology, Auckland, New Zealand
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50
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Zhou L, Tang Z, Zuo Z, Zhou K. Neural Mechanism Underlying the Sleep Deprivation-Induced Abnormal Bistable Perception. Cereb Cortex 2021; 32:583-592. [PMID: 34322696 DOI: 10.1093/cercor/bhab235] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/04/2021] [Revised: 06/20/2021] [Accepted: 06/21/2021] [Indexed: 11/12/2022] Open
Abstract
Quality sleep is vital for physical and mental health. No matter whether sleep problems are a consequence of or contributory factor to mental disorders, people with psychosis often suffer from severe sleep disturbances. Previous research has shown that acute sleep deprivation (SD) can cause transient brain dysfunction and lead to various cognitive impairments in healthy individuals. However, the relationship between sleep disturbance and bistable perception remains unclear. Here, we investigated whether the bistable perception could be affected by SD and elucidated the functional brain changes accompanying SD effects on bistable perception using functional magnetic resonance imaging. We found that the 28-h SD resulted in slower perceptual transitions in healthy individuals. The reduced perceptual transition was accompanied by the decreased activations in rivalry-related frontoparietal areas, including the right superior parietal lobule, right frontal eye field, and right temporoparietal junction. We speculated that SD might disrupt the normal function of these regions crucial for bistable perception, which mediated the slower rivalry-related perceptual transitions in behavior. Our findings revealed the neural changes underlying the abnormal bistable perception following the SD. It also suggested that SD might offer a new window to understand the neural mechanisms underlying the bistable perception.
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