• funding

• Feature extraction
• Machine learning
• Prediction
• Urinary tract infection

• Humans
• Urinary Tract Infections/diagnosis
• Machine Learning
• Female
• Male
• Adult
• Middle Aged
• Aged
• Young Adult

• 1403 Hamadan University of Medical Sciences

• Acute tonsillitis
• biomarkers
• mean platelet volume
• peritonsillar abscess
• plateletcrit
• systemic immune-inflammation index

• Humans
• Peritonsillar Abscess/blood
• Peritonsillar Abscess/diagnosis
• Peritonsillar Abscess/microbiology
• Peritonsillar Abscess/pathology
• Tonsillitis/blood
• Tonsillitis/complications
• Tonsillitis/microbiology
• Tonsillitis/pathology
• Tonsillitis/surgery
• Biomarkers/blood
• Female
• Male
• Adult
• ROC Curve
• Lymphocytes/pathology
• Acute Disease
• Neutrophils
• Streptococcal Infections/blood
• Streptococcal Infections/diagnosis
• Streptococcal Infections/complications
• Streptococcal Infections/microbiology
• Adolescent
• Mean Platelet Volume
• Middle Aged
• Monocytes
• Blood Platelets/pathology
• Young Adult

• appendicitis
• erythrocyte indices
• mean platelet volume
• apendicite
• índices de eritrócitos
• volume plaquetário médio

• Humans
• Female
• Male
• Adolescent
• Young Adult
• Adult
• Appendicitis/diagnosis
• Appendicitis/surgery
• Erythrocyte Indices
• Appendectomy
• Acute Disease
• Biomarkers

• Acute appendicitis
• complicated appendicitis
• leukocyte count
• platelet distribution width
• surgery

• Humans
• Male
• Appendicitis/complications
• Appendicitis/diagnosis
• Appendicitis/surgery
• Retrospective Studies
• Erythrocyte Indices
• Mean Platelet Volume
• Peritonitis

• Acute appendicitis
• leukocyte
• neutrophil
• sensitivity
• specificity
• total bilirubin

Inflammatory bowel disease (IBD) is a chronic gastrointestinal tract inflammatory state, which is affecting millions of individuals in the world. It can affect alimentary canals such as colon, rectum, ileum and other parts. In IBD, platelet parameters underwent several changes. Therefore, the aim of this review was determining the estimated pooled mean platelet volume and mean difference in inflammatory bowel disease to elucidate its potential diagnostic value.

Articles were extensively searched in bibliographic databases using Medical Subject Heading and entry phrases or terms. In addition, articles were directly searched in Google Scholar to account for the studies omission in searching bibliographic databases. Observational (cohort, cross-sectional and case-control) studies, published in English language and conducted on IBD were included. For studies meeting the eligibility criteria, the first author’s name, publication year, population, study design, study area, sample size, mean platelet volume and standard deviation were extracted and entered in to Microsoft-excel. The analysis was done by Stata version 11. In order to estimate the pooled mean platelet volume and mean difference, random effect model was done. The heterogeneity was quantified using Higgin’s I² statistics. Publication bias was determined using Egger’s test statistics and funnel plot. Sub-group analysis based on population carried to reduce heterogeneity.

A total of 17 relevant articles with 2957 participants (1823 IBD cases and 1134 healthy controls) were included to this study. The pooled estimated MPV was 9.29fl; 95% CI: 9.01–9.57 and 9.50fl; 95% CI: 8.81–10.20 in IBD and control groups, respectively. The standardized pooled estimate of mean difference in mean platelet volume was -0.83fl; 95% CI: -1.15, -0.51; I²: 93.1%; P-value < 0.001. In subgroup analysis based on population, the highest estimated mean difference in MPV was observed among patients of CD; -2.30; 95% CI: -3.46, -1.14; I²: 97.8%; P-value < 0.001.

According to the current systematic review and meta-analysis, mean platelet volume was lower in IBD compared to control. The decreased mean platelet volume could be attributed to platelet consumption or sequestration associated with the progression of IBD. As a result, in IBD, mean platelet volume can provide diagnostic and prognostic information.

• Case-Control Studies
• Chronic Disease
• Cross-Sectional Studies
• Humans
• Inflammatory Bowel Diseases/diagnosis
• Mean Platelet Volume
• Prognosis

• Appendicitis
• Differential diagnosis
• Hematologic tests
• Henoch–Schönlein Purpura

• CBC
• acute appendicitis
• appendectomy
• lymphocytes
• neutrophils
• parameters

• Acute appendicitis (AA)
• Mean platelet volume (MPV)
• Meta-analysis
• Platelet (PLT)
• Platelet distribution width (PDW)
• Platelet indices

• Acute Disease
• Aged
• Appendicitis/surgery
• Biomarkers
• Humans
• Mean Platelet Volume
• Platelet Count

• 81774112 National Natural Science Foundation of China
• SGXZ-201913 a grant from Siming Scholars from Shuguang Hospital

• Adult
• Aged
• Appendectomy
• Appendicitis/drug therapy
• Appendicitis/surgery
• Erythrocyte Indices
• Humans
• Mean Platelet Volume
• Middle Aged
• Retrospective Studies
• Young Adult

• Acute appendicitis
• Mean platelet volume
• Platelet indices

• Acute appendicitis
• geriatric patients
• laboratory parameters

• acute appendicitis
• biomarker
• neutrophil to lymphocyte ratio
• perforated appendicitis
• platelet to lymphocyte ratio

• CCECAI
• Enteritis
• Inflammation
• Thrombocytes

Introduction

The role of whole blood count parameters in the diagnosis of diseases in which inflammatory processes play a role is one of the more frequently mentioned topics in the literature in recent years. Studies of acute appendicitis have also been carried out in this regard, but studies focused on platelet parameters are few and contradictory. We aimed to investigate the role of mean platelet volume (MPV) and platelet distribution width (PDW) in the diagnosis of acute appendicitis.

Materials and methods

We retrospectively screened the medical records of patients older than 15 years who had an appendectomy from January 2012 to January 2015 at a training hospital in Kocaeli, Turkey. Patients were divided into three groups according to their pathology results: non-appendicitis (Group 1), uncomplicated appendicitis (Group 2), and complicated appendicitis (Group 3). We calculated the sensitivity, specificity, positive and negative predictive values, the likelihood ratios in the diagnosis of appendicitis for white blood cell (WBC), neutrophil count, c-reactive protein (CRP), MPV, and PDW values were calculated.

Results

There were no significant differences in the MPV between Group 1 (n = 39; 7.89 ± 1.32 fL), Group 2 (n = 119; 7.80 ± 1.19 fL), and Group 3 (n = 89; 7.70 ± 0.80 fL; p = 0.141). Also, we found no significant differences in PDW between Group 1 (117.38% ± 1.17), Group 2 (17.17% ± 1.04), and Group 3 (17.12% ± 0.64; p = 0.228).

Conclusions

Only nine of the 208 patients whose pathology reports confirmed appendicitis had healthy values for both CRP and WBC. Many factors affect MPV and PDW. Therefore, platelet indices are not useful markers in diagnosing acute appendicitis.

• appendicitis
• blood cell count
• mean platelet volume

Brucellosis is a multi-system infectious disease that is associated with inflammation, which causes an increase in acute phase reactants. Hematological inflammatory markers of brucellosis include mean platelet volume (MPV), red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR). In this study, we aimed to evaluate the diagnostic value of hematological inflammatory markers in Brucella epididymo-orchitis (BEO), and to investigate the utility of these markers for differential diagnosis from non-Brucella epididymo-orchitis (non-BEO).

We retrospectively reviewed the records of 22 BEO and 50 non-BEO patients. Hematological parameters were recorded and compared between the two groups. The main diagnostic criteria for BEO were positive clinical findings (i.e., testicular pain, tenderness and scrotal swelling), a positive Rose Bengal test result, standard tube agglutination (STA) titer ≥ 1/160, and/or a positive blood culture.

The most decisive factors in discriminating between BEO and non-BEO were NLR, RDW, and MPV, in decreasing order of their strength. Regardless of other factors, NLR values < 2.3 significantly increased the odds of BEO (OR=8.080, 95% CI: 1.929-33.843, p=0.004). After adjusting for other factors, RDW values >14.45% significantly increased the odds of BEO (OR=7.020, 95% CI: 1.749-28.176, p=0.006). Independent of the other factors, patients with MPV < 7.65 fL had a 6.336 times higher risk for BEO (95% CI: 1.393 - 28.822, p=0.017).

Hematological inflammatory markers such as NLR, RDW, and MPV can aid in the differential diagnosis of BEO and non-BEO.

• Brucella
• Hematologic Neoplasms
• Infectious Disease Medicine

• Acute pancreatitis
• C-reactive protein
• Lactate dehydrogenase
• Mean platelet volume
• Persistent organ failure
• White blood cell

• Adult
• Case-Control Studies
• Female
• Humans
• Male
• Mean Platelet Volume
• Middle Aged
• Organ Dysfunction Scores
• Pancreatitis/blood

• Acute appendicitis
• Children
• Under 5 years

High mobility group box-1 (HMGB1) is a proinflammatory, DAMP protein that participates in many pathological conditions. In this study, we evaluated the usability of CSF HMGB1 as a biomarker for the diagnosis of tuberculous meningitis (TBM).

A total of 59 TBM patients and 169 control patients were included in our study. CSF samples were obtained and analyzed for HMGB1 using a commercial ELISA kit.

The mean CSF HMGB1 was 19.36 ng/ml in TBM patients (n = 59) versus 3.12 ng/ml in non-TB meningitis patients (n = 30), 2.13 ng/ml in patients with extra neural tuberculosis (n = 73), and 1.06 ng/m in controls (n = 66). According to the receiver operator characteristic curves, a cut-off value of 3.4 ng/ml was calculated, indicating that the sensitivity and specificity of CSF HMGB1 alone in diagnosis of TBM were 61.02 and 89.94 %, respectively. In patients with extra neural tuberculosis and a high risk of TBM, CSF HMGB1 seemed to be a good candidate for early differential diagnosis of TBM at the cut-off value of 3.8 ng/ml, when the sensitivity and specificity were 79.49 and 94.52 % respectively.

Our finding may prove to be clinically useful, because CSF HMGB1 ELISA can be performed in almost all clinical laboratories, especially when sophisticated technologies are either time consuming or unavailable.

• Biomarker
• Cerebrospinal fluid
• HMGB1
• Tuberculous meningitis

• acute appendicitis
• acute cholecystitis
• acute mesenteric ischemia
• platelet indices
• platelets

Acute appendicitis (AA) is the most common indication for emergency abdominal surgery, although it remains difficult to diagnose. In this study, we investigated the the clinical utility of mean platelet volume in the diagnosis of acute appendicitis.

The medical records of 241 patients who had undergone appendectomy between June 2013 and March 2014 were investigated retrospectively. Sixty patients who had undergone at least one complete blood count during preoperative hospital admission and who had no other active inflammatory conditions at the time the sample was taken were included in the study. Mean platelet volume and leukocyte count values were determined in each patient at hospital admission and during active acute appendicitis. Age, sex, mean platelet volume and leukocyte counts were recorded for each patient.

The mean age of patients was 33.15±10.94 years and the male to female ratio was 1.5:1. The mean leukocyte count prior to acute appendicitis was 7.42±2.12×10³/mm³. Mean leukocyte count was significantly higher (13.14±2.99×10³/mm³) in acute appendicitis. The optimal leukocyte count cutoff point for the diagnosis of acute appendicitis was 10.10×10³/mm³, with sensitivity of 94% and a specificity of 75%. The mean platelet volume prior to acute appendicitis was 7.58±1.11 fL. Mean platelet volume was significantly lower (7.03±0.8 fL) in acute appendicitis. The optimal mean platelet volume cutoff point for the diagnosis of AA was 6.10 fL, with a sensitivity of 83% and a specificity of 42%. Area under the curve for leukocyte count diagnosis was 0.67 and 0.69 for the diagnosis of AA by mean platelet volume.

Mean platelet volume was significantly decreased in acute appendicitis. Mean platelet volume can be used as a supportive diagnostic parameter in the diagnosis of acute appendicitis.

• Acute appendicitis
• diagnosis
• mean platelet volume

Mean platelet volume (MPV) has not yet been well-established in urinary tract infection (UTI). The purpose of this study was to evaluate the role of MPV as an acute phase reactant in children with UTI. Data from 118 young children (<2 years) with UTI between 2012 and 2013 were grouped as acute pyelonephritis (APN) and lower UTI according to the dimercaptosuccinic acid (DMSA) scan abnormalities. MPV, platelet distribution width (PDW) platelet count, and other infection markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], and C-reactive protein [CRP]) were measured. WBC (P = 0.001), ESR (P = 0.005), CRP (P < 0.001) and MPV levels (P = 0.011) were significantly higher in the APN group than those in the lower UTI group. MPV positively correlated with PDW, CRP and negatively with platelet count. Multiple logistic regression analyses showed that CRP and MPV were independent predictive factors for APN patients. However, the area under the Receiver Operating Characteristic (ROC) curve analysis for MPV was lower than CRP. Our results suggest that MPV can be an inflammatory marker in UTI, but the predictive value of MPV was not superior to CRP in the diagnosis of APN.

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Appendicitis/blood
• Appendicitis/pathology
• Biomarkers/blood
• Case-Control Studies
• Female
• Gangrene/blood
• Hematocrit
• Humans
• Leukocyte Count
• Male
• Mean Platelet Volume
• Middle Aged

• Adnexal torsion
• leukocyte
• leukocytosis
• mean platelet volume
• neutrophils to lymphocytes ratio
• platelet

• Appendicitis
• Blood platelets
• Complications
• Intestinal perforation
• Mean platelet volume

AIM: To investigate the diagnostic accuracy of the mean platelet volume and platelet distribution width in acute appendicitis.

METHODS: This retrospective, case-controlled study compared 295 patients with acute appendicitis (Group I), 100 patients with other intra-abdominal infections (Group II), and 100 healthy individuals (Group III) between January 2012 and January 2013. The age, gender, and white blood cell count, neutrophil percentage, mean platelet volume, and platelet distribution width values from blood samples were compared among the groups. Statistical analyses were performed using SPSS for Windows 21.0 software. In addition, the sensitivity, specificity, positive and negative predictive values and likelihood ratios, and diagnostic accuracy were calculated.

RESULTS: The mean ages of patients were 29.9 ± 12.0 years for Group I, 31.5 ± 14.0 years for Group II, and 30.4 ± 13.0 years for Group III. Demographic features such as age and gender were not significantly different among the groups. White blood cell count, neutrophil percentage and platelet distribution width were significantly higher in Group I compared to groups II and III (P < 0.05). Diagnostically, the sensitivity, specificity and diagnostic accuracy were 73.1%, 94.0%, and 78% for white blood cell count, 70.0%, 96.0%, and 76.0% for neutrophil percentage, 29.5%, 49.0%, and 34.0% for mean platelet volume, and 97.1%, 93.0%, and 96.0% for platelet distribution width, respectively. The highest diagnostic accuracy detected was for platelet distribution width between Group I and Group III (P < 0.01).

CONCLUSION: Platelet distribution width analysis can be used for diagnosis of acute appendicitis without requiring additional tests, thus reducing the cost and loss of time.

• Appendicitis
• Diagnosis
• Platelet function test
• Platelet distribution width

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Appendicitis/blood
• Appendicitis/diagnosis
• Blood Platelets
• Female
• Humans
• Leukocyte Count
• Male
• Mean Platelet Volume
• Middle Aged
• Neutrophils
• Predictive Value of Tests
• Retrospective Studies
• Young Adult

Acute appendicitis (AA) is one of the most common causes of emergent surgeries. Many methods are used for its diagnosis.

This study was conducted to investigate the diagnostic value of MPV and RDW in acute appendicitis.

This study was a retrospective multi-center cross sectional planned study. The study included 260 patients operated for AA and 158 patients as the control group. Groups were compared in terms of MPV, RDW, white blood cell count (WBC), neutrophil predominance (NP) and platelet count (PC).

MPV was significantly lower in AA group, compared to the control group (P < 0.001). The best cut-off level for MVP in AA was ≤ 7.3 fL and the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and overall accuracy ratio were 45%, 89.2%, 87.3%, 49.6% and 61.7%, respectively. There was no significant difference between the two groups in terms of RDW and platelet values.

MPV is a routinely measured parameter in complete blood count (CBC) and requires no additional cost. It significantly decreased in AA, having a greater sensitivity and NPV when combined with WBC and NP.

• Appendicitis
• Blood Platelets
• Erythrocyte Indices

There is evidence that inflammatory bowel diseases (IBD) combine both inflammation and coagulation in their pathogenesis and clinical manifestations. Although platelets (PLT) are well known for their role in hemostasis, there are a rising number of studies supporting their considerable role as inflammatory amplifiers in chronic inflammatory conditions. IBD are associated with several alterations of PLT, including number, shape, and function, and these abnormalities are mainly attributed to the highly activated state of circulating PLT in IBD patients. When PLT activate, they increase in size, release a great variety of bio-active inflammatory and procoagulant molecules/particles, and express a variety of inflammatory receptors. These inflammatory products may represent a part of the missing link between coagulation and inflammation, and can be considered as possible IBD pathogenesis instigators. In clinical practice, thrombocytosis is associated both with disease activity and iron deficiency anemia. Controlling inflammation and iron replacement in anemic patients usually leads to a normalization of PLT count. The aim of this review is to update the role of PLT in IBD and present recent data revealing the possible therapeutic implications of anti-PLT agents in future IBD remedies.

• Anemia
• Crohn’s disease
• Platelets
• Thrombocytosis
• Ulcerative colitis

• Anemia, Iron-Deficiency/complications
• Blood Coagulation
• Blood Platelets/cytology
• Cell-Derived Microparticles/metabolism
• Colitis, Ulcerative/blood
• Colitis, Ulcerative/therapy
• Crohn Disease/blood
• Crohn Disease/therapy
• Hemostasis
• Humans
• Inflammation
• Inflammatory Bowel Diseases/blood
• Inflammatory Bowel Diseases/therapy
• Platelet Aggregation Inhibitors/therapeutic use
• Platelet Count
• Thrombocytosis

The level of platelet volume (MPV) has been reported to be a laboratory marker in inflammatory cases.

The aim of this study was to seek whether MPV has a role in the diagnosis of acute appendicitis. It was also aimed to show the relationship of MPV with leukocyte count and C-reactive protein (CRP) level.

This study was conducted via retrospective assessment of the hospital records of the adult patients who were operated for acute appendicitis between January 2010 and December 2012 and had a pathology report that confirmed the diagnosis of acute appendicitis. The patients in the control group were selected from healthy adults of similar age who applied to check-up clinic. The number of essential cases was defined by performing power analysis. Age, gender, leukocyte count, CRP, and MPV values were recorded. This study is a case controlled retrospective clinical study.

A total of 503 patients in the acute appendicitis group and 121 patients in the control group were included, making up a total of 624 subjects. The median MPV levels were 7.92 ± 1.68 fL in the acute appendicitis group, while 7.43 ± 1.34 fL in the control group. CRP, leukocyte count, and MPV level were significantly higher in the acute appendicitis group (P < 0.001). MPV, leukocyte count, and CRP had a sensitivity and specificity of 66% and 51%; 91% and 74%; and 97% and 41%, respectively. No correlation was found between MPV, CRP, and leukocyte count.

MPV level was higher in patients with acute appendicitis. MPV may guide the diagnostic process of acute appendicitis. However, we detected that the sensitivity and specificity of leukocyte count and CRP were superior to those of MPV in the diagnosis of acute appendicitis.

• Appendicitis
• Blood Platelets
• C-Reactive Protein
• Leukocytes

• Acute appendicitis
• Complete blood count
• Mean platelet volume
• Perforated appendicitis
• Platelet distribution width

Introduction. Acute appendicitis is the leading cause of abdominal pain in children requiring emergency surgical intervention. The aim of this study is to investigate the diagnostic value of MPV in early diagnosis of acute appendicitis cases in pediatric age group. Methods. This study was performed retrospectively. Three hundred five patients operated on with the diagnosis of appendicitis and pathologically found to be acute appendicitis were classified as Group 1 and 305 healthy children were classified as control Group 2. Results. One hundred ninety-seven of 305 cases in Group 1 are males (64.6%), in Group 2, 151 of 305 cases are males (49.5%). The mean MPV in Group 1 was 7.9 ± 0.9 (fL), and whereas in Group 2 was 7.7 ± 0.8 (fL). There was no statistically significant difference regarding MPV values (P > 0.05). Conclusion. In our study we detected that mean platelet volume has no diagnostic value in pediatric acute appendicitis cases.