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1
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Tang B, Liu X, Zhang W. CT features of gastric calcifying fibrous tumors: differentiation from gastrointestinal stromal tumors. Abdom Radiol (NY) 2025; 50:1498-1504. [PMID: 39320495 DOI: 10.1007/s00261-024-04600-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/27/2024] [Revised: 09/11/2024] [Accepted: 09/16/2024] [Indexed: 09/26/2024]
Affiliation(s)
- Bo Tang
- Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
| | - Xisheng Liu
- The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
| | - Weidong Zhang
- Nanjing First Hospital, Nanjing Medical University, Nanjing, China
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2
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Wang J, Chen D, Shang J, Dong F. Rock on the Heart: A Case of Calcifying Fibrous Tumor Arising From the Pericardium and Literature Review. Int J Surg Pathol 2024; 32:1319-1326. [PMID: 38303517 DOI: 10.1177/10668969231225772] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/03/2024]
Abstract
Calcifying fibrous tumors are rare benign fibrous tumors that rarely occur in the heart. We report a 33-year-old woman who was found to have a benign pericardial tumor on health checkup, which was highly suspected to be a teratoma in clinical and imaging examination. After cardiac tumor resection, histopathological features showed scattered foci of psammoma bodies or calcification among collagenized fibrous connective tissues and foci of inflammatory cell infiltration in the interstitium. The pathological diagnosis was a calcifying fibrous tumor.
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Affiliation(s)
- Jiaqi Wang
- Department of Pathology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
| | - Dong Chen
- Department of Pathology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
| | - Jianfeng Shang
- Department of Pathology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
| | - Fang Dong
- Department of Pathology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
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3
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Raj A, Singh M, Buch AC, Gurwale S. Jejunal calcifying fibrous tumor: A jigsaw puzzle with a pool of diagnostic dilemma. INDIAN J PATHOL MICR 2024; 67:936-938. [PMID: 38427761 DOI: 10.4103/ijpm.ijpm_270_23] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/06/2023] [Accepted: 08/14/2023] [Indexed: 03/03/2024] Open
Abstract
ABSTRACT Calcifying fibrous tumor (CFT) is a very rare benign fibroblastic tumor featuring a wide anatomical distribution and mimicking various spindle cell tumors. CFT has been documented in soft tissues, gastrointestinal tract (GIT), neck, adrenal glands, and pleura. Within the GIT, it is reported in the stomach, small bowel, large intestine, stomach, esophagus, and appendix. The occurrence of CFTs in the gastrointestinal tract presents a diagnostic dilemma, firstly due to the rarity of the lesion and secondly, due to the occurrence of a variety of other stromal lesions in the gastrointestinal tract with histological features that overlap with CFT. In the jejunum, it is extremely rare. We present one such rare case of jejunal CFT at an unusual age, complicated by jejuno-jejunal intussusception resulting in acute intestinal obstruction.
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Affiliation(s)
- Akshi Raj
- Department of Pathology, Dr. D Y Patil Medical College, DPU, Pimpri, Pune, Maharashtra, India
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4
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Yu C, Wen X, Sun M, Luo J. CT and MRI imaging features of calcifying fibrous tumor: A case report. Asian J Surg 2024:S1015-9584(24)01683-X. [PMID: 39217009 DOI: 10.1016/j.asjsur.2024.07.320] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/04/2024] [Accepted: 07/25/2024] [Indexed: 09/04/2024] Open
Affiliation(s)
- Caiyun Yu
- Department of Radiology, The Second Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, People's Republic of China
| | - Xueling Wen
- Department of Radiology, The Second Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, People's Republic of China
| | - Mingyang Sun
- Department of Radiology, The Second Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, People's Republic of China
| | - Jiawen Luo
- Department of Radiology, The Second Hospital of Dalian Medical University, 467 Zhong Shan Road, Dalian, 116023, People's Republic of China.
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5
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Herrera Ortiz AF, Del Castillo V, Duarte JN, Gutiérrez MJ, Noguera V, Martínez de Los Ríos DA, Maldonado Acevedo SP, Torres JL, Pinzón B, Moreno A, Quiroz Alfaro AJ. Pulmonary Calcifying Fibrous Tumor in a Pediatric Patient: A Case Report. Cureus 2024; 16:e62053. [PMID: 38989355 PMCID: PMC11234803 DOI: 10.7759/cureus.62053] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 06/10/2024] [Indexed: 07/12/2024] Open
Abstract
A calcifying fibrous tumor (CFT), also known as calcifying fibrous pseudotumor, is an uncommon non-cancerous neoplasm usually located in the gastrointestinal tract. Its location in the lung is extremely rare, and only a few case reports have been published. This case report describes our diagnostic approach in a 9-year-old male patient with an incidental pulmonary mass. The mass was initially misdiagnosed, requiring multiple imaging tests and interventions to obtain the definitive diagnosis of pulmonary CFT. This paper aims to contribute to the limited information available on pulmonary CFT by presenting detailed findings from computed tomography and magnetic resonance imaging.
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Affiliation(s)
- Andrés Felipe Herrera Ortiz
- Department of Radiology, Fundación Santa Fe de Bogotá, Bogotá D.C., COL
- Department of Radiology, Universidad El Bosque, Bogotá D.C., COL
| | - Valeria Del Castillo
- Department of Radiology, Fundación Santa Fe de Bogotá, Bogotá D.C., COL
- Department of Radiology, Universidad El Bosque, Bogotá D.C., COL
| | - José N Duarte
- Department of Radiology, Fundación Santa Fe de Bogotá, Bogotá D.C., COL
- Department of Radiology, Universidad El Bosque, Bogotá D.C., COL
| | - María J Gutiérrez
- Department of Medicine and Health Sciences, Universidad del Rosario, Bogotá D.C., COL
| | - Valeria Noguera
- Department of Radiology, Fundación Santa Fe de Bogotá, Bogotá D.C., COL
- Department of Radiology, Universidad El Bosque, Bogotá D.C., COL
| | | | - Sandra P Maldonado Acevedo
- Department of Radiology, Fundación Santa Fe de Bogotá, Bogotá D.C., COL
- Department of Radiology, Universidad El Bosque, Bogotá D.C., COL
| | - Jhon L Torres
- Department of Radiology, Fundación Santa Fe de Bogotá, Bogotá D.C., COL
| | - Bibiana Pinzón
- Department of Radiology, Fundación Santa Fe de Bogotá, Bogotá D.C., COL
- Department of Radiology, Universidad El Bosque, Bogotá D.C., COL
| | - Angela Moreno
- Department of Radiology, Fundación Santa Fe de Bogotá, Bogotá D.C., COL
- Department of Radiology, Universidad El Bosque, Bogotá D.C., COL
| | - Alejandro J Quiroz Alfaro
- Department of Internal Medicine, North Mississippi Medical Center, Tupelo, USA
- Department of Medicine and Health Sciences, Universidad del Rosario, Bogotá D.C., COL
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6
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Yang J, Ma D, Zhao Z, Guo J, Ren K, Wang F, Guo J. Exploring the mechanism of action of the combination of cinnamon and motherwort in the treatment of benign prostatic hyperplasia: A network pharmacology study. Medicine (Baltimore) 2024; 103:e37902. [PMID: 38669415 PMCID: PMC11049697 DOI: 10.1097/md.0000000000037902] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/19/2023] [Accepted: 03/22/2024] [Indexed: 04/28/2024] Open
Abstract
Cinnamon and motherwort are traditional Chinese medicines and are often combined to treat benign prostatic hyperplasia; however, the specific therapeutic mechanisms involved remain unclear. Therefore, in this study, we applied a network pharmacology approach to investigate the potential mechanisms of action of the drug pair cinnamon and motherwort (PCM) for the treatment of benign prostatic hyperplasia. Relevant targets for the use of PCM to treat benign prostatic hyperplasia were obtained through databases. Protein-protein interactions were then identified by the STRING database and core targets were screened. Enrichment analysis was conducted through the Metascape platform. Finally, molecular docking experiments were carried out to evaluate the affinity between the target proteins and ligands of PCM. We identified 22 active ingredients in PCM, 315 corresponding targets and 130 effective targets of PCM for the treatment of benign prostatic hyperplasia. These targets were related to the PI3K-Akt, MAPK, FoxO, TNF, and IL-17 signaling pathways. Network pharmacology was used to identify the effective components and action targets of PCM. We also identified potential mechanisms of action for PCM in the treatment of benign prostatic hyperplasia. Our results provide a foundation for expanding the clinical application of PCM and provide new ideas and directions for further research on the mechanisms of action of PCM and its components for the treatment of benign prostatic hyperplasia.
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Affiliation(s)
- Jiutian Yang
- Graduate School of Beijing University of Chinese Medicine, Chaoyang District, Beijing, China
- Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Haidian District, Beijing, China
| | - Dongyue Ma
- Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Haidian District, Beijing, China
| | - Ziwei Zhao
- Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Haidian District, Beijing, China
| | - Jun Guo
- Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Haidian District, Beijing, China
- Graduate School of China Academy of Chinese Medical Sciences, Dongzhimen, Dongcheng District, Beijing, China
| | - Kai Ren
- Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Haidian District, Beijing, China
| | - Fu Wang
- Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Haidian District, Beijing, China
| | - Jun Guo
- Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Haidian District, Beijing, China
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7
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Cao Y, Li Z, Ma P, Qiao Z. Calcifying fibrous tumor and pathological analysis. REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS 2024; 116:172-173. [PMID: 37314138 DOI: 10.17235/reed.2023.9739/2023] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/15/2023]
Abstract
A 55-year-old male presented to our outpatient department with complaints of upper abdominal dull pain. Gastroscopy revealed a submucosal eminence at the greater curvature of the gastric body, with smooth surface mucosa, and biopsy pathology indicated inflammation. Physical examination showed no obvious abnormalities, and laboratory results were within the normal range. Computerized tomography (CT) showed thickening of the gastric body. Endoscopic submucosal dissection (ESD) was performed,and representative photomicrographs of histologic sections were shown.
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Affiliation(s)
| | - Zhuofan Li
- Suzhou Medical College of Soochow University
| | - Ping Ma
- Pathology, Gaochun People's Hospital of Nanjing
| | - Zhenguo Qiao
- Gastroenterology, Suzhou Ninth People's Hospital, China
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8
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Calcifying fibrous tumor: a rare case in the foot. Skeletal Radiol 2023:10.1007/s00256-023-04282-y. [PMID: 36695882 DOI: 10.1007/s00256-023-04282-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/28/2022] [Revised: 12/27/2022] [Accepted: 01/11/2023] [Indexed: 01/26/2023]
Abstract
Calcifying fibrous tumor is a rare fibroblastic tumor with distinctive histological presentation that shows benign characteristics. To our knowledge, there are no prior reports that have documented imaging findings of calcifying fibrous tumor in the distal lower extremity. We report the case of a 25-year-old man who presented with a mass in the medial aspect of the right foot that was first noted 4 years earlier. Medical attention was sought due to perceived increase in size as well as increasing pain in the right foot. The patient had no limitations in activity but reported worsening discomfort while walking. An anteroposterior radiograph obtained at first presentation demonstrated a large calcified soft mass in the medial aspect of the foot. Contrast-enhanced MRI showed a mildly enhancing 6.5 cm × 2.5 cm × 8.5 cm mass, hypointense on T1- and T2-weighted images, infiltrating the adjacent abductor hallucis and flexor digitorum brevis muscles. Histopathology demonstrated multiple irregular fragments of white-tan firm tissue with a gritty cut surface, positive for CD34 on immunohistochemistry and consistent with calcifying fibrous tumor. Although rare in the extremities, this diagnosis should be considered in patients with a calcifying soft tissue mass. Low signal intensity with low-grade enhancement on MRI as well as stable disease course could prompt a diagnosis of calcifying fibrous tumor even in previously unmanifested locations.
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9
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Llopis-Torremocha C, Rodríguez-Laiz G, Sevila-Micó S, Campo-Betancourth CF, Ramia JM. Retroperitoneal calcifying fibrous tumor involving the inferior vena cava. Cir Esp 2022; 100:595-597. [PMID: 35697240 DOI: 10.1016/j.cireng.2022.06.020] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/02/2021] [Accepted: 08/02/2021] [Indexed: 06/15/2023]
Affiliation(s)
- Clara Llopis-Torremocha
- Unidad de Cirugía Hepatobiliopancreática y Trasplante Hepático, Servicio de Cirugía General y del Aparato Digestivo, Hospital General Universitario de Alicante, Alicante, Spain.
| | - Gonzalo Rodríguez-Laiz
- Unidad de Cirugía Hepatobiliopancreática y Trasplante Hepático, Servicio de Cirugía General y del Aparato Digestivo, Hospital General Universitario de Alicante, Alicante, Spain; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain
| | - Silvia Sevila-Micó
- Unidad de Cirugía Hepatobiliopancreática y Trasplante Hepático, Servicio de Cirugía General y del Aparato Digestivo, Hospital General Universitario de Alicante, Alicante, Spain
| | - Carlos Felipe Campo-Betancourth
- Unidad de Cirugía Hepatobiliopancreática y Trasplante Hepático, Servicio de Cirugía General y del Aparato Digestivo, Hospital General Universitario de Alicante, Alicante, Spain
| | - José M Ramia
- Unidad de Cirugía Hepatobiliopancreática y Trasplante Hepático, Servicio de Cirugía General y del Aparato Digestivo, Hospital General Universitario de Alicante, Alicante, Spain; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain
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10
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Topcu FS, İpek T, Kapan M, Yılmaz S, Ensaroğlu F. OUP accepted manuscript. J Surg Case Rep 2022; 2022:rjac105. [PMID: 35382004 PMCID: PMC8975579 DOI: 10.1093/jscr/rjac105] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/16/2021] [Accepted: 03/01/2022] [Indexed: 11/28/2022] Open
Abstract
Calcified fibrous tumor (CFT) is a rare benign tumor of mesenchymal origin. Between 1988 and 2019, a total of 272 CFT cases were reported. CFTs can be seen in all anatomical regions with soft tissue. Histologically, mononuclear inflammatory infiltrates and the presence of psammomatous calcification in dense hyalinized collagen are characteristic features of the tumor. Currently, if the tumor is located in only one focus, surgical removal is recommended. Although CFT is a benign tumor, it may cause complications. Diagnosis is often difficult due to the confusion of tumor findings with many diseases. We present a patient with CFT, whose omental lesions were detected on abdominal computed tomography, and the diagnosis was confirmed by histopathological examination.
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Affiliation(s)
- Feyza Sönmez Topcu
- Correspondence address. Department of Radiology, Medicana International İstanbul Hospital, Beylikdüzü Caddesi No: 3 Beylikdüzü, Istanbul 34520, Turkey. Tel: +90-5058151352; Fax: +90-212-867-76-72; E-mail:
| | - Turgut İpek
- Department of General Surgery, Altınbaş University Medical School, Istanbul, Turkey
| | - Metin Kapan
- Department of General Surgery, Kolan Şişli International Hospital, Istanbul, Turkey
| | | | - Fatih Ensaroğlu
- Department of Gastroenterology, İstinye University Liv Hospital, Istanbul, Turkey
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11
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Llopis-Torremocha C, Rodríguez-Laiz G, Sevila-Micó S, Campo-Betancourth CF, Ramia JM. Retroperitoneal calcifying fibrous tumor involving the inferior vena cava. Cir Esp 2021; 100:S0009-739X(21)00248-7. [PMID: 35697240 DOI: 10.1016/j.ciresp.2021.08.001] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/02/2021] [Revised: 05/31/2021] [Accepted: 08/02/2021] [Indexed: 02/07/2023]
Affiliation(s)
- Clara Llopis-Torremocha
- Unidad de Cirugía Hepatobiliopancreática y Trasplante Hepático. Servicio de Cirugía General y del Aparato Digestivo. Hospital General Universitario de Alicante, Alicante, España.
| | - Gonzalo Rodríguez-Laiz
- Unidad de Cirugía Hepatobiliopancreática y Trasplante Hepático. Servicio de Cirugía General y del Aparato Digestivo. Hospital General Universitario de Alicante, Alicante, España; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, España
| | - Silvia Sevila-Micó
- Unidad de Cirugía Hepatobiliopancreática y Trasplante Hepático. Servicio de Cirugía General y del Aparato Digestivo. Hospital General Universitario de Alicante, Alicante, España
| | - Carlos Felipe Campo-Betancourth
- Unidad de Cirugía Hepatobiliopancreática y Trasplante Hepático. Servicio de Cirugía General y del Aparato Digestivo. Hospital General Universitario de Alicante, Alicante, España
| | - José M Ramia
- Unidad de Cirugía Hepatobiliopancreática y Trasplante Hepático. Servicio de Cirugía General y del Aparato Digestivo. Hospital General Universitario de Alicante, Alicante, España; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, España
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12
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Tsai MK, Chen HY, Chuang ML, Chen CW, Jong GP. Gastric Calcifying Fibrous Tumor: An Easy Misdiagnosis as Gastrointestinal Stromal Tumor-A Systemic Review. MEDICINA (KAUNAS, LITHUANIA) 2020; 56:E541. [PMID: 33066662 PMCID: PMC7602413 DOI: 10.3390/medicina56100541] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 09/01/2020] [Revised: 10/09/2020] [Accepted: 10/13/2020] [Indexed: 01/31/2023]
Abstract
Background and Objectives: Calcifying fibrous tumor (CFT) in the stomach is extremely rare and is easily misdiagnosed as a gastrointestinal stromal tumor (GIST). This study aims to determine the best method to differentiate between gastric CFT and GIST after a systemic review and meta-analysis. Materials and Methods: A systematic search of articles using electronic databases (MEDLINE, EMBASE, and LILACS) was conducted and resulted in 162 articles with 272 CFT cases published from January 1988 to September 2019. Results: Of these cases, 272 patients, 60 patients with gastric CFT (32 men and 28 women, mean age 49.2 years) were analyzed. The mean tumor size was 2.4 cm in patients with gastric CFT. Both endoscopic ultrasound (EUS) and computed tomography (CT) findings revealed well-defined (100% vs. 77.8%), heterogeneous (100% vs. 77.8%), iso-hypoechoic (71.4% vs. 33.3%), and calcified (85.7% vs. 77.8%) lesions, respectively. The majority of patients (53.3%) were symptomatic, with the most common symptom being abdominal discomfort (55.6%). None of the patients with gastric CFT showed recurrence after treatment, and most patients received nonendoscopic treatment (56%, n = 28/50). Both age and tumor size were statistically significant in patients with gastric CFT than GIST (49.2 vs. 65.0 years and 2.4 vs. 6.0 cm; both p < 0.001). The ratio of children among patients with CFT (5%) and GIST (0.05%) was also significantly different (p = 0.037). The calcification rates of gastric CFT had significantly higher calcification rates than GIST on images of EUS and CT (85.7% vs. 3.6% and 77.8% vs. 3.6%; both p < 0.001). Conclusions: Compared with patients with GIST, patients with gastric CFT were younger, had smaller tumor size, and were symptomatic. Furthermore, gastric CFT was well-defined, heterogeneous in the third layer, and had high calcification rates on the images.
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Affiliation(s)
- Meng-Ko Tsai
- Division of Rheumatology, Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung 41152, Taiwan;
- Division of Rheumatology, Department of Internal Medicine, National Defense Medical Center, Taipei 11490, Taiwan
| | - Hung-Yi Chen
- Department of Pharmacy, China Medical University, Taichung 40402, Taiwan;
- Department of Pharmacy, China Medical University Beigang Hospital, Yunlin County 65152, Taiwan
| | - Ming-Lung Chuang
- Division of Pulmonary Medicine, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan;
- School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
| | - Chun-Wen Chen
- Department of Radiology, Taichung Armed Forces General Hospital, Taichung 41168, Taiwan;
| | - Gwo-Ping Jong
- Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
- Department of Internal Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
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13
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Turbiville D, Zhang X. Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update. World J Gastroenterol 2020; 26:5597-5605. [PMID: 33071524 PMCID: PMC7545394 DOI: 10.3748/wjg.v26.i37.5597] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/06/2020] [Revised: 08/09/2020] [Accepted: 09/11/2020] [Indexed: 02/06/2023] Open
Abstract
Calcifying fibrous tumor (CFT) is a rare mesenchymal lesion that has been documented throughout the gastrointestinal tract. Gastrointestinal CFTs may occur at virtually any age, with a predilection for adults and for females. They occur most commonly in the stomach and the small and large intestines. CFTs are most often found incidentally, cured by local resection, and have a low risk of recurrence. Histology shows three characteristic features: Spindle cell proliferations within a densely hyalinized stroma, scattered calcifications, and lymphoplasmacytic inflammation. CFTs are immunoreactive for CD34, vimentin and factor XIIIa, helping to distinguish them from other benign mesenchymal neoplasms. The differential diagnosis of CFTs includes sclerosing gastrointestinal stromal tumor, leiomyoma, schwannoma, solitary fibrous tumor, inflammatory myofibroblastic tumor, plexiform fibromyxoma, fibromatosis, sclerosing mesenteritis, and reactive nodular fibrous pseudotumor. The pathogenesis of CFTs remains unclear, but some have hypothesized that they may be linked to IgG4-related disease, inflammatory myofibroblastic lesions, hyaline vascular type Castleman disease, sclerosing angiomatoid nodular transformation of the spleen, or trauma.
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Affiliation(s)
- Donald Turbiville
- Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, United States
| | - Xuchen Zhang
- Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, United States
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14
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El Jabbour T, Panarelli N, Muscarella P, Pease G. Calcifying Fibrous Pseudotumor of the Pancreas in a Patient With Metastatic Mammary Lobular Carcinoma and Gastric Gastrointestinal Stromal Tumor: A Previously Undescribed Benign Mimic of Metastatic Disease. Cureus 2020; 12:e9399. [PMID: 32864230 PMCID: PMC7449613 DOI: 10.7759/cureus.9399] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/09/2022] Open
Abstract
Calcifying fibrous pseudotumor, a benign spindle cell tumor, has not been reported previously in the pancreas. Herein, we report a case of pancreatic calcifying fibrous pseudotumor in a 74-year-old female with a history of metastatic breast carcinoma and gastric gastrointestinal stromal tumor (GIST), both confounding the diagnosis and rendering it more challenging. Microscopic examination showed a well-demarcated, paucicellular, densely fibrotic tumor with widespread dystrophic calcifications and sparse, cytologically bland polygonal and spindle cells. Histologic and immunohistochemical work-up helped to exclude relevant differential diagnoses, including metastatic carcinoma, solitary fibrous tumor, inflammatory myofibroblastic tumor, and GIST.
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Affiliation(s)
- Tony El Jabbour
- Pathology and Laboratory Medicine, Montefiore Hospital, Bronx, USA
| | - Nicole Panarelli
- Gastrointestinal and Liver Pathology, Montefiore Hospital, Bronx, USA
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15
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Businello G, Dal Pozzo CA, Sbaraglia M, Mastracci L, Milione M, Saragoni L, Grillo F, Parente P, Remo A, Bellan E, Cappellesso R, Pennelli G, Michelotto M, Fassan M. Histopathological landscape of rare oesophageal neoplasms. World J Gastroenterol 2020; 26:3865-3888. [PMID: 32774063 PMCID: PMC7385561 DOI: 10.3748/wjg.v26.i27.3865] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/25/2020] [Revised: 06/19/2020] [Accepted: 07/04/2020] [Indexed: 02/06/2023] Open
Abstract
The landscape of neoplastic pathology of the oesophagus is dominated by malignancies of epithelial origin, in particular by oesophageal adenocarcinoma and oesophageal squamous cell carcinoma. However, several other histopathological variants can be distinguished, some associated with peculiar histopathological profiles and prognostic behaviours and frequently underrecognized in clinical practice. The aim of this review is to provide a comprehensive characterization of the main morphological and clinical features of these rare variants of oesophageal neoplastic lesions.
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Affiliation(s)
- Gianluca Businello
- Department of Medicine (DIMED), Surgical Pathology and Cytopathology Unit, University of Padua, Padua 35121, Italy
| | - Carlo Alberto Dal Pozzo
- Department of Medicine (DIMED), Surgical Pathology and Cytopathology Unit, University of Padua, Padua 35121, Italy
| | - Marta Sbaraglia
- Department of Medicine (DIMED), Surgical Pathology and Cytopathology Unit, University of Padua, Padua 35121, Italy
| | - Luca Mastracci
- Department of Surgical and Diagnostic Sciences (DISC), Pathology Unit, University of Genova, Genova 16123, Italy
| | - Massimo Milione
- Department of Pathology and Laboratory Medicine, First Pathology Division, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan 20133, Italy
| | - Luca Saragoni
- Pathology Unit, Morgagni-Pierantoni Hospital, Forlì 47121, Italy
| | - Federica Grillo
- Department of Surgical and Diagnostic Sciences (DISC), Pathology Unit, University of Genova, Genova 16123, Italy
| | - Paola Parente
- Pathology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo 71013, Italy
| | - Andrea Remo
- Department of Pathology, Ospedale Mater Salutis di Legnago, Legnago 37045, Italy
| | - Elena Bellan
- Department of Medicine (DIMED), Surgical Pathology and Cytopathology Unit, University of Padua, Padua 35121, Italy
| | - Rocco Cappellesso
- Department of Medicine (DIMED), Surgical Pathology and Cytopathology Unit, University of Padua, Padua 35121, Italy
| | - Gianmaria Pennelli
- Department of Medicine (DIMED), Surgical Pathology and Cytopathology Unit, University of Padua, Padua 35121, Italy
| | - Mauro Michelotto
- Department of Medicine (DIMED), Surgical Pathology and Cytopathology Unit, University of Padua, Padua 35121, Italy
| | - Matteo Fassan
- Department of Medicine (DIMED), Surgical Pathology and Cytopathology Unit, University of Padua, Padua 35121, Italy
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16
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Hernandez M, Lin G, Zhang Y, Rajabnejad A, Balistrieri F, Thistlethwaite P. Multifocal Calcifying Fibrous Tumor at Seven Intrathoracic Sites in One Patient. Ann Thorac Surg 2020; 111:e85-e88. [PMID: 32682754 DOI: 10.1016/j.athoracsur.2020.05.100] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/10/2020] [Revised: 05/06/2020] [Accepted: 05/10/2020] [Indexed: 11/27/2022]
Abstract
Calcifying fibrous tumors are rare lesions that occur throughout the body. A 35-year-old man presented with exertional dyspnea. Computed tomography showed a polypoid mass abutting pericardium, diaphragm, and left chest wall, and a pleural-based lesion adjacent to T12. Thoracoscopy revealed a large mass with diaphragmatic stalk, two pleural-based nodules, and four diaphragmatic nodules. Pathologic analysis of resected lesions showed calcifying fibrous tumors. Three lesions contained heterogenous mutations associated with this tumor type. The patient is disease free 1 year later. Calcifying fibrous tumors should be recognized as rare multifocal pleural and diaphragmatic-based tumors. Complete resection leads to excellent survival for patients with this uncommon disease.
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Affiliation(s)
- Moises Hernandez
- Division of Cardiothoracic Surgery, University of California, San Diego, La Jolla, California
| | - Grace Lin
- Department of Pathology, University of California, San Diego, La Jolla, California
| | - Yu Zhang
- Division of Cardiothoracic Surgery, University of California, San Diego, La Jolla, California
| | - Ataollah Rajabnejad
- Division of Cardiothoracic Surgery, University of California, San Diego, La Jolla, California
| | - Francesca Balistrieri
- Division of Cardiothoracic Surgery, University of California, San Diego, La Jolla, California
| | - Patricia Thistlethwaite
- Division of Cardiothoracic Surgery, University of California, San Diego, La Jolla, California.
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17
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Sayida S, Malkin L, Naroditski I, Assalia A, Khamaysi I. Synchronous double gastric tumors: GIST or not GIST. Endosc Ultrasound 2020; 9:413-414. [PMID: 33318377 PMCID: PMC7811704 DOI: 10.4103/eus.eus_61_20] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/03/2022] Open
Affiliation(s)
- Sa'd Sayida
- Department of Surgery, Rambam Health Care Campus, Haifa, Israel
| | - Leonid Malkin
- Department of Cytopathology, Rambam Health Care Campus, Haifa, Israel
| | - Inna Naroditski
- Department of Cytopathology, Rambam Health Care Campus, Haifa, Israel
| | - Ahmad Assalia
- Department of Surgery, Rambam Health Care Campus; The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Technion, Haifa, Israel
| | - Iyad Khamaysi
- The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Technion; Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel
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