Brunner’s gland hyperplasia is an extremely rare benign hamartomatous lesion seen in proximal duodenum. Difficulty in diagnosing the condition pre-operatively puts the surgeon in dilemma for deciding appropriate management. We retrieved details from prospectively maintained retrospective data from January 2014 to April 2018. Four patients were identified of which three were males and one was female. Symptoms ranged from 4 days to 4 years, with abdominal pain, vomiting and malena being predominant. No patients were identified with diagnosis pre-operatively. Diagnosis was made on histopathological examination of the resected specimen and none of them were having malignant features. At a median follow up of 11 months, no patient had recurrence and were symptom free. Brunner’s gland hyperplasia is a rare elusive duodenal pathology, symptomatically mimicking alarming duodenal lesions and mostly diagnosed on histopathology of specimen. Patients may harbour the lesion for long periods with little symptoms and upon treatment have good outcomes.

Brunner gland hamartoma (brunneroma) is a rare benign tumor of the duodenum. It is usually asymptomatic and detected incidentally by endoscopy or other imaging modality. The definitive diagnosis is based on histopathological findings. These may mimic tumors of other natures, such as gastrointestinal stromal tumors (GIST), carcinoids, lipomas, and leiomyomas. Here, we present a case of duodenal polyp presenting with abdominal pain and obstructive symptoms that caused duodenal intussusception. It was surgically removed and found to be a brunneroma on histopathology.

• Brunner gland hamartoma
• Brunneroma
• Duodenal intussusception
• Duodenal polyp
• Endoscopic sonography
• Intussuscepting duodenal mass on computed tomography
• Submucosal duodenal lesion.

Cystic Brunner’s gland hamartoma in the duodenum is exceedingly rare, although microscopic examination may sometimes reveal a Brunner’s gland hamartoma containing dilated ducts in the duodenum. We present a case of large cystic Brunner’s gland hamartoma in the duodenum with a long stalk, which is described in light of multidetector-row computed tomography, magnetic resonance imaging, and a modified small bowel series, together with pathologic correlation and differential diagnosis.

• Brunner’s gland
• Hamartoma
• Duodenum
• Multidetector-row computed tomography
• Magnetic resonance imaging

Brunner’s gland adenoma (BGA）is a very rare benign tumour of the duodenum, which is usually asymptomatic and discovered incidentally at endoscopy. Occasionally, this lesion may be large, causing upper gastrointestinal haemorrhage or intestinal obstruction. The case had a large Brunner’s gland adenoma, presenting melena that was managed by endoscopic excision.

• Brunner’s gland adenoma
• Endoscopic resection
• Giant brunneroma

• Adenoma/diagnosis
• Adenoma/pathology
• Adenoma/surgery
• Brunner Glands/pathology
• Brunner Glands/surgery
• Duodenal Neoplasms/diagnosis
• Duodenal Neoplasms/pathology
• Duodenal Neoplasms/surgery
• Endoscopy
• Female
• Humans
• Middle Aged

• Abdominal Pain/etiology
• Adult
• Brunner Glands
• Choristoma
• Female
• Humans
• Intussusception/etiology
• Intussusception/pathology
• Intussusception/surgery
• Jejunal Diseases/etiology
• Jejunal Diseases/pathology
• Jejunal Diseases/surgery

• Adult
• Brunner Glands
• Duodenal Neoplasms/surgery
• Duodenoscopy/adverse effects
• Female
• Gastrointestinal Hemorrhage/etiology
• Hamartoma/surgery
• Humans

• Biopsy
• Brunner Glands/pathology
• Diagnosis, Differential
• Duodenal Diseases/complications
• Duodenal Diseases/pathology
• Duodenal Diseases/surgery
• Duodenal Neoplasms/complications
• Duodenal Neoplasms/diagnosis
• Duodenoscopy
• Electrosurgery/methods
• Hamartoma/complications
• Hamartoma/pathology
• Hamartoma/surgery
• Humans
• Intestinal Polyps/complications
• Intestinal Polyps/diagnosis
• Male
• Middle Aged
• Video Recording

• Administration, Oral
• Barium Sulfate/administration & dosage
• Contrast Media/administration & dosage
• Diagnosis, Differential
• Duodenal Neoplasms/complications
• Duodenal Neoplasms/diagnostic imaging
• Duodenal Neoplasms/physiopathology
• Duodenal Obstruction/diagnostic imaging
• Duodenal Obstruction/etiology
• Duodenal Obstruction/physiopathology
• Humans
• Peristalsis
• Tomography, X-Ray Computed

• Crohn Disease/diagnostic imaging
• Diverticulum/diagnostic imaging
• Duodenal Diseases/diagnostic imaging
• Duodenal Neoplasms/diagnostic imaging
• Duodenal Ulcer/diagnostic imaging
• Hematoma/diagnostic imaging
• Humans
• Tomography, X-Ray Computed