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For: Peluso I, Pallone F, Monteleone G. Interleukin-12 and Th1 immune response in Crohn’s disease: Pathogenetic relevance and therapeutic inplication. World J Gastroenterol 2006; 12(35): 5606-5610 [PMID: 17007011 DOI: 10.3748/wjg.v12.i35.5606]
URL: https://www.wjgnet.com/1007-9327/full/v12/i35/5606.htm
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Claire Painchart, Séverine Brabant, Nicolas Duveau, Maria Nachury, Pierre Desreumaux, Julien Branche, Romain Gérard, Clémentine Lauriot Dit Prevost, Pauline Wils, Thomas Lambin, Médina Boualit, Myriam Labalette, Benjamin Pariente. Ustekinumab Serum Trough Levels May Identify Suboptimal Responders to Ustekinumab in Crohn’s DiseaseDigestive Diseases and Sciences 2020; 65(5): 1445 doi: 10.1007/s10620-019-05865-3
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Toshimi Chiba, Mikiya Endo, Shoko Matsushita, Mika Sasaki, Shoichi Chida, Yosuke Toya, Satoshi Kasugai, Nozomi Matsuda, Shunsuke Orikasa, Yukito Abiko, Norihiko Kudara, Shuhei Oana, Masaki Endo, Kazuyuki Suzuki. Peripheral Blood CD64 Levels Decrease in Crohn’s Disease following Granulocyte and Monocyte Adsorptive ApheresisCase Reports in Gastroenterology 2011; 5(3): 667 doi: 10.1159/000335316
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Le-Ning Xue, Ke-Qun Xu, Wei Zhang, Qiang Wang, Jia Wu, Xiao-Yong Wang. Associations Between Vitamin D Receptor Polymorphisms and Susceptibility to Ulcerative Colitis and Crohnʼs DiseaseInflammatory Bowel Diseases 2013; 19(1): 54 doi: 10.1002/ibd.22966
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Sarah C Davies, Tran M Nguyen, Claire E Parker, John K MacDonald, Vipul Jairath, Reena Khanna. Anti-IL-12/23p40 antibodies for maintenance of remission in Crohn's diseaseCochrane Database of Systematic Reviews 2019; 2019(12) doi: 10.1002/14651858.CD012804.pub2
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Bingcheng Feng, Lin Lin, Lixiang Li, Xin Long, Chao Liu, Zixiao Zhao, Shiyang Li, Yanqing Li. Glucocorticoid induced group 2 innate lymphoid cell overactivation exacerbates experimental colitisFrontiers in Immunology 2022; 13 doi: 10.3389/fimmu.2022.863034
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Bram Verstockt, Clémentine Perrier, Gert De Hertogh, Jonathan Cremer, Brecht Creyns, Gert Van Assche, Marc Ferrante, Jan L. Ceuppens, Séverine Vermeire, Christine Breynaert. Effects of Epithelial IL-13Rα2 Expression in Inflammatory Bowel DiseaseFrontiers in Immunology 2018; 9 doi: 10.3389/fimmu.2018.02983
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Andrés Sansó Sureda, Vicenç Rocamora Durán, Amparo Sapiña Camaró, Vanesa Royo Escosa, María José Bosque López. Ustekinumab en paciente con enfermedad de Crohn y psoriasis inducida por anti-TNF-αGastroenterología y Hepatología 2011; 34(8): 546 doi: 10.1016/j.gastrohep.2011.04.003
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Anja Schulz-Kuhnt, Stefan Wirtz, Markus F. Neurath, Imke Atreya. Regulation of Human Innate Lymphoid Cells in the Context of Mucosal InflammationFrontiers in Immunology 2020; 11 doi: 10.3389/fimmu.2020.01062
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Jun Gu, Gang Liu, Junjie Xing, Haihan Song, Zhongchuan Wang. Fecal bacteria from Crohn's disease patients more potently activated NOD-like receptors and Toll-like receptors in macrophages, in an IL-4-repressible fashionMicrobial Pathogenesis 2018; 121: 40 doi: 10.1016/j.micpath.2018.05.009
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Sonia Ghilas, Ryan O’Keefe, Lisa Anna Mielke, Dinesh Raghu, Michael Buchert, Matthias Ernst. Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and diseaseFrontiers in Immunology 2022; 13 doi: 10.3389/fimmu.2022.944982
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Caitriona Ryan, Breck Thrash, Richard B Warren, Alan Menter. The use of ustekinumab in autoimmune diseaseExpert Opinion on Biological Therapy 2010; 10(4): 587 doi: 10.1517/14712591003724670
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Sam Khorrami, Daniel Ginard, Ignacio Marín-Jiménez, María Chaparro, Mónica Sierra, Mariam Aguas, Beatriz Sicilia, Valle García-Sánchez, Cristina Suarez, Albert Villoria, Carlos Taxonera, Antonio Velasco-Guardado, Javier Martínez-González, Javier P. Gisbert. Ustekinumab for the Treatment of Refractory Crohnʼs DiseaseInflammatory Bowel Diseases 2016; 22(7): 1662 doi: 10.1097/MIB.0000000000000842
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John K MacDonald, Tran M Nguyen, Reena Khanna, Antje Timmer. Anti-IL-12/23p40 antibodies for induction of remission in Crohn's diseaseCochrane Database of Systematic Reviews 2016; 2016(11) doi: 10.1002/14651858.CD007572.pub3
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Michael Elliott, Jacqueline Benson, Marion Blank, Carrie Brodmerkel, Daniel Baker, Kristin Ruley Sharples, Philippe Szapary. Ustekinumab: Lessons Learned from Targeting Interleukin‐12/23p40 in Immune‐Mediated DiseasesAnnals of the New York Academy of Sciences 2009; 1182(1): 97 doi: 10.1111/j.1749-6632.2009.05070.x
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Nair Campos, Fernando Magro, Ana Rita Castro, Joana Cabral, Pedro Rodrigues, Ricardo Silva, Rui Appelberg, Susana Rodrigues, Susana Lopes, Guilherme Macedo, Amélia Sarmento. Macrophages from IBD patients exhibit defective tumour necrosis factor-α secretion but otherwise normal or augmented pro-inflammatory responses to infectionImmunobiology 2011; 216(8): 961 doi: 10.1016/j.imbio.2011.01.002
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Rebecca Faleiro, Ji Liu, Deshapriya Karunarathne, Aleksandra Edmundson, Clay Winterford, Tam Hong Nguyen, Lisa A Simms, Graham Radford‐Smith, Michelle Wykes. Crohn's disease is facilitated by a disturbance of programmed death‐1 ligand 2 on blood dendritic cellsClinical & Translational Immunology 2019; 8(7) doi: 10.1002/cti2.1071
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Murat KEKİLLİ, Alpaslan TANOĞLU, Fatih KARAAHMET, Zeynal DOĞAN, Murat CAN, Abdurrahim SAYILIR, Başak ÇAKAL, Tolga DÜZENLİ, Yavuz BEYAZIT. Midkine level may be used as a noninvasive biomarker in Crohn’s diseaseTURKISH JOURNAL OF MEDICAL SCIENCES 2020; 44(2): 324 doi: 10.3906/sag-1904-167
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Laszlo Bene, Andras Falus, Noemi Baffy, Andras Kristof Fulop. Cellular and Molecular Mechanisms in the Two Major Forms of Inflammatory Bowel DiseasePathology & Oncology Research 2011; 17(3): 463 doi: 10.1007/s12253-011-9397-4
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Braden T Wong, Sangwoo Park, Lauren Kovanda, Yijie He, Kwangwook Kim, Shiyu Xu, Christopher Lingga, Monika Hejna, Emma Wall, Ravichandran Sripathy, Xunde Li, Yanhong Liu. Dietary supplementation of botanical blends enhanced performance and disease resistance of weaned pigs experimentally infected with enterotoxigenic Escherichia coli F18Journal of Animal Science 2022; 100(12) doi: 10.1093/jas/skac353
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Zhenggang Jiang, Wei Xu, Kang Li, Yan Yue, Lin Xu, Fei Ye, Sidong Xiong. Remission of CVB3‐induced viral myocarditis by in vivo Th2 polarization via hydrodynamics‐based interleukin‐4 gene transferThe Journal of Gene Medicine 2008; 10(8): 918 doi: 10.1002/jgm.1215
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Kan Shida, Junko Kiyoshima‐Shibata, Rumi Kaji, Masato Nagaoka, Masanobu Nanno. Peptidoglycan from lactobacilli inhibits interleukin‐12 production by macrophages induced by Lactobacillus casei through Toll‐like receptor 2‐dependent and independent mechanismsImmunology 2009; 128(1pt2) doi: 10.1111/j.1365-2567.2009.03095.x
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Omri Wolk, Svetlana Epstein, Viktoriya Ioffe-Dahan, Shimon Ben-Shabat, Arik Dahan. New targeting strategies in drug therapy of inflammatory bowel disease: mechanistic approaches and opportunitiesExpert Opinion on Drug Delivery 2013; 10(9): 1275 doi: 10.1517/17425247.2013.800480
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Yoshihiro Hirata, Sozaburo Ihara, Kazuhiko Koike. Targeting the complex interactions between microbiota, host epithelial and immune cells in inflammatory bowel diseasePharmacological Research 2016; 113: 574 doi: 10.1016/j.phrs.2016.09.044
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Nina Holland, Jing Dong, Elizabeth Garnett, Nishat Shaikh, Karen Huen, Paul Harmatz, Anthony Olive, Harland S Winter, Benjamin D Gold, Stanley A Cohen, Robert N Baldassano, Barbara S Kirschner, Melvin B Heyman. Reduced Intracellular T-Helper 1 Interferon-Gamma in Blood of Newly Diagnosed Children With Crohn's Disease and Age-Related Changes in Th1/Th2 Cytokine ProfilesPediatric Research 2008; 63(3): 257 doi: 10.1203/PDR.0b013e318163a897
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Parthasarathy Chandrakesan, Ishfaq Ahmed, Anisha Chinthalapally, Pomila Singh, Shanjana Awasthi, Shrikant Anant, Shahid Umar, S. M. Payne. Distinct Compartmentalization of NF-κB Activity in Crypt and Crypt-Denuded Lamina Propria Precedes and Accompanies Hyperplasia and/or Colitis following Bacterial InfectionInfection and Immunity 2012; 80(2): 753 doi: 10.1128/IAI.06101-11
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Rafael Cardoso Maciel Costa Silva, Leonardo Holanda Travassos, Fabianno Ferreira Dutra. The dichotomic role of single cytokines: Fine-tuning immune responsesCytokine 2024; 173: 156408 doi: 10.1016/j.cyto.2023.156408
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Luisa Bertin, Brigida Barberio, Alessandro Gubbiotti, Lorenzo Bertani, Francesco Costa, Linda Ceccarelli, Pierfrancesco Visaggi, Giorgia Bodini, Andrea Pasta, Renato Sablich, Maria Teresa Urbano, Antonio Ferronato, Andrea Buda, Manuela De Bona, Giulio Del Corso, Alessandro Massano, Imerio Angriman, Marco Scarpa, Fabiana Zingone, Edoardo Vincenzo Savarino. Association between Ustekinumab Trough Levels, Serum IL-22, and Oncostatin M Levels and Clinical and Biochemical Outcomes in Patients with Crohn’s DiseaseJournal of Clinical Medicine 2024; 13(6): 1539 doi: 10.3390/jcm13061539
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Shining Ma, Tao Jiang, Rui Jiang. Constructing tissue-specific transcriptional regulatory networks via a Markov random fieldBMC Genomics 2018; 19(S10) doi: 10.1186/s12864-018-5277-6
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Silvio Danese, Stefanos Bonovas, Laurent Peyrin-Biroulet. Positioning Ustekinumab in Crohn’s Disease: From Clinical Evidence to Clinical PracticeJournal of Crohn's and Colitis 2017; 11(10): 1258 doi: 10.1093/ecco-jcc/jjx079
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Mark Löwenberg, Geert D’Haens. Novel Targets for Inflammatory Bowel Disease TherapeuticsCurrent Gastroenterology Reports 2013; 15(2) doi: 10.1007/s11894-012-0311-3
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Luiza Moraes Holst, Jonas Halfvarson, Marie Carlson, Charlotte Hedin, Robert Kruse, Carl Mårten Lindqvist, Daniel Bergemalm, Sven Almér, Francesca Bresso, Maria Ling Lundström, Dirk Repsilber, Mauro D'Amato, Åsa Keita, Henrik Hjortswang, Johan Söderholm, Johanna Sundin, Hans Törnblom, Magnus Simrén, Hans Strid, Maria K Magnusson, Lena Öhman. Downregulated Mucosal Autophagy, Alpha Kinase-1 and IL-17 Signaling Pathways in Active and Quiescent Ulcerative ColitisClinical and Experimental Gastroenterology 2022; : 129 doi: 10.2147/CEG.S368040
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Qingdong Guan, Jiguo Zhang. Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel DiseaseMediators of Inflammation 2017; 2017: 1 doi: 10.1155/2017/4810258
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Ebrahim Eskandari-Nasab, Adel Sepanjnia, Mehdi Moghadampour, Mehdi Hadadi-fishani, Alireza Rezaeifar, Abolghasem Asadi-Saghandi, Behrooz Sadeghi-Kalani, Mahdi Dehghan Manshadi, Fatemeh Pourrajab, Hossein Pourmasoumi. Circulating levels of interleukin (IL)-12 and IL-13 in Helicobacter pylori-infected patients, and their associations with bacterial CagA and VacA virulence factorsScandinavian Journal of Infectious Diseases 2013; 45(5): 342 doi: 10.3109/00365548.2012.737930
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Stefan Harsanyi, Ida Kupcova, Lubos Danisovic, Martin Klein. Selected Biomarkers of Depression: What Are the Effects of Cytokines and Inflammation?International Journal of Molecular Sciences 2022; 24(1): 578 doi: 10.3390/ijms24010578
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Reena Khanna, Brian G Feagan. Safety of infliximab for the treatment of inflammatory bowel disease: current understanding of the potential for serious adverse eventsExpert Opinion on Drug Safety 2015; 14(6): 987 doi: 10.1517/14740338.2015.1029915
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Špela Konjar, Cristina Ferreira, Birte Blankenhaus, Marc Veldhoen. Intestinal Barrier Interactions with Specialized CD8 T CellsFrontiers in Immunology 2017; 8 doi: 10.3389/fimmu.2017.01281
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Nadeem O. Kaakoush, Nandan P. Deshpande, Marc R. Wilkins, Chew Gee Tan, Jose A. Burgos-Portugal, Mark J. Raftery, Andrew S. Day, Daniel A. Lemberg, Hazel Mitchell, Dipshikha Chakravortty. The Pathogenic Potential of Campylobacter concisus Strains Associated with Chronic Intestinal DiseasesPLoS ONE 2011; 6(12): e29045 doi: 10.1371/journal.pone.0029045
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Reena Khanna, Nilesh Chande, Séverine Vermeire, William J. Sandborn, Claire E. Parker, Brian G. Feagan. The Next Wave of Biological Agents for the Treatment of IBDInflammatory Bowel Diseases 2016; 22(7): 1737 doi: 10.1097/MIB.0000000000000808
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Sarah C Davies, Tran M Nguyen, Claire E Parker, Reena Khanna, Vipul Jairath, John K MacDonald. Anti-IL-12/23p40 antibodies for maintenance of remission in Crohn's diseaseCochrane Database of Systematic Reviews 2017;  doi: 10.1002/14651858.CD012804
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Yunpeng Hua, Yi Yang, Shaoli Sun, Stephen Iwanowycz, Caroline Westwater, Boris Reizis, Zihai Li, Bei Liu. Gut homeostasis and regulatory T cell induction depend on molecular chaperone gp96 in CD11c+ cellsScientific Reports 2017; 7(1) doi: 10.1038/s41598-017-02415-7
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Maria Lia Scribano, Laura Cantoro, Marzia Marrollo, Rocco Cosintino, Anna Kohn. Mucosal Healing With Thalidomide in Refractory Crohn’s Disease Patients Intolerant of Anti-TNF-α DrugsJournal of Clinical Gastroenterology 2014; 48(6): 530 doi: 10.1097/MCG.0000000000000122
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Marianna Roselli, Alberto Finamore, Silvia Nuccitelli, Paola Carnevali, Patrizia Brigidi, Beatrice Vitali, Fabio Nobili, Rita Rami, Ivana Garaguso, Elena Mengheri. Prevention of TNBS-induced colitis by different Lactobacillus and Bifidobacterium strains is associated with an expansion of γδT and regulatory T cells of intestinal intraepithelial lymphocytesInflammatory Bowel Diseases 2009; 15(10): 1526 doi: 10.1002/ibd.20961
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David Schwartz. Anti-IL-12/23Inflammatory Bowel Diseases 2009; 15(12): 1927 doi: 10.1002/ibd.20990
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Holger Schäffler, Dogan Doruk Demircioglu, Daniel Kühner, Sarah Menz, Annika Bender, Ingo B. Autenrieth, Peggy Bodammer, Georg Lamprecht, Friedrich Götz, Julia-Stefanie Frick, A. J. Bäumler. NOD2 Stimulation by Staphylococcus aureus-Derived Peptidoglycan Is Boosted by Toll-Like Receptor 2 Costimulation with Lipoproteins in Dendritic CellsInfection and Immunity 2014; 82(11): 4681 doi: 10.1128/IAI.02043-14
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William J. Sandborn, Brian G. Feagan, Richard N. Fedorak, Ellen Scherl, Mark R. Fleisher, Seymour Katz, Jewel Johanns, Marion Blank, Paul Rutgeerts. A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's DiseaseGastroenterology 2008; 135(4): 1130 doi: 10.1053/j.gastro.2008.07.014
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Chiara Grazia De Ciucis, Floriana Fruscione, Livia De Paolis, Samanta Mecocci, Susanna Zinellu, Lisa Guardone, Giulia Franzoni, Katia Cappelli, Elisabetta Razzuoli. Toll-like Receptors and Cytokine Modulation by Goat Milk Extracellular Vesicles in a Model of Intestinal InflammationInternational Journal of Molecular Sciences 2023; 24(13): 11096 doi: 10.3390/ijms241311096
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Tao Liu, Shao-Heng He, Peng-Yuan Zheng, Tao-Yuan Zhang, Bin-Quan Wang, Ping-Chang Yang. Staphylococcal enterotoxin B increases TIM4 expression in human dendritic cells that drives naïve CD4 T cells to differentiate into Th2 cellsMolecular Immunology 2007; 44(14): 3580 doi: 10.1016/j.molimm.2007.03.004
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Thanh-Huyen Tran, Mansoor M Amiji. Targeted delivery systems for biological therapies of inflammatory diseasesExpert Opinion on Drug Delivery 2015; 12(3): 393 doi: 10.1517/17425247.2015.972931
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