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For: Au KP, Chok KSH. Multidisciplinary approach for post-liver transplant recurrence of hepatocellular carcinoma: A proposed management algorithm. World J Gastroenterol 2018; 24(45): 5081-5094 [PMID: 30568386 DOI: 10.3748/wjg.v24.i45.5081]
URL: https://www.wjgnet.com/1007-9327/full/v24/i45/5081.htm
Number Citing Articles
1
Dhandhukiya Manavkumar Kanubhai, Saiyed Musaratafrin Sabirali. Hepatocellular Carcinoma: A ReviewAsian Journal of Research in Pharmaceutical Sciences 2023; : 171 doi: 10.52711/2231-5659.2023.00030
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E. R. Virshke, I. A. Dzhanyan, I. V. Pogrebnyakov, V. V. Breder, M. S. Novruzbekov, O. D. Olisov, B. I. Dolgushin. Transarterial Chemoembolization in Therapy of Patients with Recurrence of Hepatocellular Cancer in a Liver Transplant: a Clinical CaseJournal of oncology: diagnostic radiology and radiotherapy 2023; 6(3): 81 doi: 10.37174/2587-7593-2023-6-3-81-89
3
Maen Abdelrahim, Abdullah Esmail. Transplant Oncology2025; : 87 doi: 10.1016/B978-0-443-21901-6.00008-2
4
Neus Basté Rotllan. Potential use of multikinase inhibitors in immunosuppressed patients with malignancies including thyroid cancerCancer Medicine 2022; 11(S1): 10 doi: 10.1002/cam4.5106
5
Carlo Sposito, Davide Citterio, Matteo Virdis, Carlo Battiston, Michele Droz Dit Busset, Maria Flores, Vincenzo Mazzaferro. Therapeutic strategies for post-transplant recurrence of hepatocellular carcinomaWorld Journal of Gastroenterology 2022; 28(34): 4929-4942 doi: 10.3748/wjg.v28.i34.4929
6
O. D. Olisov, I. A. Dzhanyan, M. S. Novruzbekov, V. V. Breder, M. E. Ilinskiy, L. N. Zimina, E. A. Moroz, K. K. Laktionov, V. A. Guliaev, K. N. Lutsyk, K. M. Magomedov. Multidisciplinary approach in hepatocellular carcinoma progression treatment after liver transplantation: the first experience in RussiaAnnaly khirurgicheskoy gepatologii = Annals of HPB Surgery 2019; 24(4): 65 doi: 10.16931/1995-5464.2019465-73
7
Bryan Cho Wing Li, Joanne Chiu, Kit Shing, Gerry Gin Wai Kwok, Vikki Tang, Roland Leung, Ka Wing Ma, Wong Hoi She, Josephine Tsang, Albert Chan, Tan To Cheung, Chung Mau Lo, Thomas Yau. The Outcomes of Systemic Treatment in Recurrent Hepatocellular Carcinomas Following Liver TransplantsAdvances in Therapy 2021; 38(7): 3900 doi: 10.1007/s12325-021-01800-z
8
Luckshi Rajendran, Tommy Ivanics, Marco PAW Claasen, Hala Muaddi, Gonzalo Sapisochin. The management of post-transplantation recurrence of hepatocellular carcinomaClinical and Molecular Hepatology 2022; 28(1): 1 doi: 10.3350/cmh.2021.0217
9
Kin Pan Au, Kenneth Siu Ho Chok. Immunotherapy after liver transplantation: Where are we now?World Journal of Gastrointestinal Surgery 2021; 13(10): 1266 doi: 10.4240/wjgs.v13.i10.1266
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10
Luca Grisetti, Niệm Văn Thành Võ, Như Nhật Quỳnh Nguyễn, Lory Saveria Crocè, Alessia Visintin, Claudio Tiribelli, Devis Pascut. MiR-3201 as a Prognostic Blood Biomarker for Curative Treatments in Hepatocellular CarcinomaTechnology in Cancer Research & Treatment 2022; 21 doi: 10.1177/15330338221132924
11
Nada El-domiaty, Faouzi Saliba, Eric Vibert, Vincent Karam, Rodolphe Sobesky, Wafaa Ibrahim, Gabriella Pittau, Oriana Ciacio, Chady Salloum, Khaled Amer, Maysaa A. Saeed, Jihan A. Shawky, Antonio Sa Cunha, Olivier Rosmorduc, Daniel Cherqui, René Adam, Didier Samuel. Early Versus Late Hepatocellular Carcinoma Recurrence After Transplantation: Predictive Factors, Patterns, and Long-term OutcomeTransplantation 2021; 105(8): 1778 doi: 10.1097/TP.0000000000003434
12
Dong-Sik Kim, Young-In Yoon, Beom Kyung Kim, Ashok Choudhury, Anand Kulkarni, Jun Yong Park, Jongman Kim, Dong Hyun Sinn, Dong Jin Joo, YoungRok Choi, Jeong-Hoon Lee, Ho Joong Choi, Ki Tae Yoon, Sun Young Yim, Cheon-Soo Park, Deok-Gie Kim, Hae Won Lee, Won-Mook Choi, Young Eun Chon, Woo-Hyoung Kang, Jinsoo Rhu, Jae Geun Lee, Yuri Cho, Pil Soo Sung, Han Ah Lee, Ji Hoon Kim, Si Hyun Bae, Jin Mo Yang, Kyung-Suk Suh, Mamun Al Mahtab, Soek Siam Tan, Zaigham Abbas, Ananta Shresta, Shahinul Alam, Anil Arora, Ashish Kumar, Pravin Rathi, Ruveena Bhavani, Charles Panackel, Kuei Chuan Lee, Jun Li, Ming-Lung Yu, Jacob George, Tawesak Tanwandee, Sen-Yung Hsieh, Chee Chien Yong, Mohamed Rela, H. C. Lin, Masao Omata, Shiv Kumar Sarin. Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantationHepatology International 2024; 18(2): 299 doi: 10.1007/s12072-023-10629-3
13
Pinzhe Zhang, Guanghao Zhu, Leping Li, Guanzhi Lai, Zekang Wang, Chengjun Sun, Wuzheng Xia, Linwei Wu. Immune checkpoint inhibitor therapy for malignant tumors in liver transplantation recipients: A systematic review of the literatureTransplantation Reviews 2022; 36(4): 100712 doi: 10.1016/j.trre.2022.100712
14
Baris Sarici, Burak Isik, Sezai Yilmaz. Management of Recurrent HCC After Liver TransplantationJournal of Gastrointestinal Cancer 2020; 51(4): 1197 doi: 10.1007/s12029-020-00498-6
15
Matthew T. Newman, Rasham Mittal, Dean La Barba, Amandeep Sahota. Remote Hepatocellular Carcinoma Recurrence to Lumbar Spine Post Orthotopic Liver Transplantation—A Report of Two Cases and a Review of the LiteratureTransplantation Proceedings 2024; 56(7): 1613 doi: 10.1016/j.transproceed.2024.08.017
16
Lauren A. Beste, Anne M. Larson. Primary Care of the Solid Organ Transplant Recipient2020; : 77 doi: 10.1007/978-3-030-50629-2_5
17
Kin-Pan Au, James Yan-Yue Fung, Wing-Chiu Dai, Albert Chi-Yan Chan, Chung-Mau Lo, Kenneth Siu-Ho Chok. Impact of Tumour Biology on Outcomes of Radical Therapy for Hepatocellular Carcinoma Oligo-Recurrence after Liver TransplantationJournal of Clinical Medicine 2022; 11(15): 4389 doi: 10.3390/jcm11154389
18
Rong Fu, Wenwu Ling. The current role of radiofrequency ablation in the treatment of intrahepatic recurrent hepatocellular carcinomaJournal of Surgical Oncology 2023; 128(8): 1340 doi: 10.1002/jso.27457
19
Cheng-Maw Ho, Hui-Ling Chen, Rey-Heng Hu, Po-Huang Lee. Harnessing immunotherapy for liver recipients with hepatocellular carcinoma: a review from a transplant oncology perspectiveTherapeutic Advances in Medical Oncology 2019; 11 doi: 10.1177/1758835919843463
20
Xiao Fang, Ying Liu, Wangwen Xiao, Nan Zhao, Chunmiao Zhu, Duonan Yu, Y a Zhao. Prognostic SLC family genes promote cell proliferation, migration, and invasion in hepatocellular carcinomaActa Biochimica et Biophysica Sinica 2021; 53(8): 1065 doi: 10.1093/abbs/gmab076
21
Zhuolin Li, Yao Lin, Bizhen Cheng, Qiaoxin Zhang, Yingmu Cai. Identification and Analysis of Potential Key Genes Associated With Hepatocellular Carcinoma Based on Integrated Bioinformatics MethodsFrontiers in Genetics 2021; 12 doi: 10.3389/fgene.2021.571231
22
Jun‐Cheng Guo, Yi‐Jun Yang, Jian‐Quan Zhang, Min Guo, Li Xiang, Shu‐Feng Yu, Huang Ping, Liu Zhuo. microRNA‐448 inhibits stemness maintenance and self‐renewal of hepatocellular carcinoma stem cells through the MAGEA6‐mediated AMPK signaling pathwayJournal of Cellular Physiology 2019; 234(12): 23461 doi: 10.1002/jcp.28915
23
Mehmet Akce, Bassel F. El-Rayes, Tanios S. Bekaii-Saab. Frontline therapy for advanced hepatocellular carcinoma: an updateTherapeutic Advances in Gastroenterology 2022; 15 doi: 10.1177/17562848221086126
24
Kin Pan Au, James Yan Yue Fung, Wing Chiu Dai, Albert Chi Yan Chan, Chung Mau Lo, Kenneth Siu Ho Chok. Verifying the Benefits of Radical Treatment in Posttransplant Hepatocellular Carcinoma Oligo‐recurrence: A Propensity Score AnalysisLiver Transplantation 2022; 28(1): 51 doi: 10.1002/lt.26251
25
Brian I. Shaw, Aaron Lucander, Kadiyala V. Ravindra. Very Late Recurrence of Hepatocellular Carcinoma After Orthotopic Liver Transplantation: Presentation and ManagementTransplantation Direct 2019; 5(9): e483 doi: 10.1097/TXD.0000000000000921
26
J. Chee, G.H. Lee, L.Y. Ooi, J.E. Seet, T. Loh, L.S. Ng. Parapharyngeal metastasis in hepatocellular carcinoma—a rare entityInternational Journal of Oral and Maxillofacial Surgery 2021; 50(12): 1550 doi: 10.1016/j.ijom.2021.05.012
27
Marina Berenguer, Patrizia Burra, Mark Ghobrial, Taizo Hibi, Herold Metselaar, Gonzalo Sapisochin, Sherrie Bhoori, Nancy Kwan Man, Valeria Mas, Masahiro Ohira, Bruno Sangro, Luc J.W. van der Laan. Posttransplant Management of Recipients Undergoing Liver Transplantation for Hepatocellular Carcinoma. Working Group Report From the ILTS Transplant Oncology Consensus ConferenceTransplantation 2020; 104(6): 1143 doi: 10.1097/TP.0000000000003196
28
Lin Zhou, Jing Wang, Shao-cheng Lyu, Li-chao Pan, Xian-jie Shi, Guo-sheng Du, Qiang He. PD-L1+NEUT, Foxp3+Treg, and NLR as New Prognostic Marker with Low Survival Benefits Value in Hepatocellular CarcinomaTechnology in Cancer Research & Treatment 2021; 20 doi: 10.1177/15330338211045820
29
Bianca Magro, Domenico Pinelli, Massimo De Giorgio, Maria Grazia Lucà, Arianna Ghirardi, Alessandra Carrobio, Giuseppe Baronio, Luca Del Prete, Franck Nounamo, Andrea Gianatti, Michele Colledan, Stefano Fagiuoli. Pre-Transplant Alpha-Fetoprotein > 25.5 and Its Dynamic on Waitlist Are Predictors of HCC Recurrence after Liver Transplantation for Patients Meeting Milan CriteriaCancers 2021; 13(23): 5976 doi: 10.3390/cancers13235976
30
Abdulahad Al-Ameri, Xiaobo Yu, Shusen Zheng. Predictors of post-recurrence survival in hepatocellular carcinoma patients following liver transplantation: Systematic review and meta-analysisTransplantation Reviews 2022; 36(1): 100676 doi: 10.1016/j.trre.2021.100676
31
Hidetoshi Nitta, Aline Younès, Nada El‐domiaty, Vincent Karam, Rodolphe Sobesky, Eric Vibert, Audrey Coilly, Teresa Maria Antonini, Eleonora De Martin, Daniel Cherqui, Hideo Baba, Olivier Rosmorduc, René Adam, Didier Samuel, Faouzi Saliba. High trough levels of everolimus combined to sorafenib improve patients survival after hepatocellular carcinoma recurrence in liver transplant recipientsTransplant International 2021; 34(7): 1293 doi: 10.1111/tri.13897
32
Francisco Villalba-López, Luis Francisco Sáenz-Mateos, Maria Isabel Sánchez-Lorencio, Virginia De La Orden-García, Felipe Alconchel-Gago, Pedro Antonio Cascales-Campos, Carmen García-Bernardo, José Antonio Noguera-Velasco, Alberto Baroja-Mazo, Pablo Ramírez-Romero. Usefulness of PIVKA-II for monitoring after liver transplantation in patients with hepatocellular carcinomaScientific Reports 2023; 13(1) doi: 10.1038/s41598-023-32879-9
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Cheng-Maw Ho, Chih-Hsin Lee, Ming-Chia Lee, Jun-Fu Zhang, Chin-Hua Chen, Jann-Yuan Wang, Rey-Heng Hu, Po-Huang Lee. Survival After Treatable Hepatocellular Carcinoma Recurrence in Liver Recipients: A Nationwide Cohort AnalysisFrontiers in Oncology 2021; 10 doi: 10.3389/fonc.2020.616094
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Jian Zhou, Huichuan Sun, Zheng Wang, Wenming Cong, Jianhua Wang, Mengsu Zeng, Weiping Zhou, Ping Bie, Lianxin Liu, Tianfu Wen, Guohong Han, Maoqiang Wang, Ruibao Liu, Ligong Lu, Zhengang Ren, Minshan Chen, Zhaochong Zeng, Ping Liang, Changhong Liang, Min Chen, Fuhua Yan, Wenping Wang, Yuan Ji, Jingping Yun, Dingfang Cai, Yongjun Chen, Wenwu Cheng, Shuqun Cheng, Chaoliu Dai, Wenzhi Guo, Baojin Hua, Xiaowu Huang, Weidong Jia, Yaming Li, Yexiong Li, Jun Liang, Tianshu Liu, Guoyue Lv, Yilei Mao, Tao Peng, Weixin Ren, Hongcheng Shi, Guoming Shi, Kaishan Tao, Wentao Wang, Xiaoying Wang, Zhiming Wang, Bangde Xiang, Baocai Xing, Jianming Xu, Jiamei Yang, Jianyong Yang, Yefa Yang, Yunke Yang, Shenglong Ye, Zhengyu Yin, Bixiang Zhang, Boheng Zhang, Leida Zhang, Shuijun Zhang, Ti Zhang, Yongfu Zhao, Honggang Zheng, Jiye Zhu, Kangshun Zhu, Rong Liu, Yinghong Shi, Yongsheng Xiao, Zhi Dai, Gaojun Teng, Jianqiang Cai, Weilin Wang, Xiujun Cai, Qiang Li, Feng Shen, Shukui Qin, Jiahong Dong, Jia Fan. Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition)Liver Cancer 2020; 9(6): 682 doi: 10.1159/000509424
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文燕 章. Molecular Markers and Recurrence of Hepatocellular Carcinoma after Liver TransplantationAdvances in Clinical Medicine 2019; 9(03): 310 doi: 10.12677/ACM.2019.93047
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Kin Pan Au, Chi Leung Chiang, Albert Chi Yan Chan, Tan To Cheung, Chung Mau Lo, Kenneth Siu Ho Chok. Initial experience with stereotactic body radiotherapy for intrahepatic hepatocellular carcinoma recurrence after liver transplantationWorld Journal of Clinical Cases 2020; 8(13): 2758-2768 doi: 10.12998/wjcc.v8.i13.2758
37
Li Zhuang, Hai-Bo Mou, Lan-Fang Yu, Heng-Kai Zhu, Zhe Yang, Qin Liao, Shu-Sen Zheng. Immune checkpoint inhibitor for hepatocellular carcinoma recurrence after liver transplantationHepatobiliary & Pancreatic Diseases International 2020; 19(1): 91 doi: 10.1016/j.hbpd.2019.09.011
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Kin Pan Au, Kenneth Siu Ho Chok. Mammalian target of rapamycin inhibitors after post-transplant hepatocellular carcinoma recurrence: Is it too late?World Journal of Gastrointestinal Surgery 2020; 12(4): 149-158 doi: 10.4240/wjgs.v12.i4.149
39
Kin-Pan Au, Wing-Chiu Dai, Albert Chi-Yan Chan, Tan-To Cheung, Chung-Mau Lo, Kenneth Siu-Ho Chok. Performance of Dual-tracer PET-CT for Staging Post–Liver Transplant Hepatocellular Carcinoma RecurrenceTransplantation Direct 2021; 7(10): e769 doi: 10.1097/TXD.0000000000001213
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Yiyang Gong, Minqin Zhou, Yanting Zhu, Jingying Pan, Xuanrui Zhou, Yike Jiang, Hong Zeng, Hao Zheng, Xitong Geng, Da Huang. PVALB Was Identified as an Independent Prognostic Factor for HCC Closely Related to Immunity, and Its Absence Accelerates Tumor Progression by Regulating NK Cell InfiltrationJournal of Hepatocellular Carcinoma 2024; : 813 doi: 10.2147/JHC.S450479
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Nourhan Badwei. Challenges related to clinical decision-making in hepatocellular carcinoma recurrence post-liver transplantation: Is there a hope?World Journal of Transplantation 2024; 14(3): 96637 doi: 10.5500/wjt.v14.i3.96637
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Jian Zhou, Huichuan Sun, Zheng Wang, Wenming Cong, Mengsu Zeng, Weiping Zhou, Ping Bie, Lianxin Liu, Tianfu Wen, Ming Kuang, Guohong Han, ZhiPing Yan, Maoqiang Wang, Ruibao Liu, Ligong Lu, Zhenggang Ren, ZhaoChong Zeng, Ping Liang, Changhong Liang, Min Chen, Fuhua Yan, Wenping Wang, Jinlin Hou, Yuan Ji, Jingping Yun, Xueli Bai, Dingfang Cai, Weixia Chen, Yongjun Chen, Wenwu Cheng, Shuqun Cheng, Chaoliu Dai, Wenzhi Guo, Yabing Guo, Baojin Hua, Xiaowu Huang, Weidong Jia, Qiu Li, Tao Li, Xun Li, Yaming Li, Yexiong Li, Jun Liang, Changquan Ling, Tianshu Liu, Xiufeng Liu, Shichun Lu, Guoyue Lv, Yilei Mao, Zhiqiang Meng, Tao Peng, Weixin Ren, Hongcheng Shi, Guoming Shi, Ming Shi, Tianqiang Song, Kaishan Tao, Jianhua Wang, Kui Wang, Lu Wang, Wentao Wang, Xiaoying Wang, Zhiming Wang, Bangde Xiang, Baocai Xing, Jianming Xu, Jiamei Yang, Jianyong Yang, Yefa Yang, Yunke Yang, Shenglong Ye, Zhenyu Yin, Yong Zeng, Bixiang Zhang, Boheng Zhang, Leida Zhang, Shuijun Zhang, Ti Zhang, Yanqiao Zhang, Ming Zhao, Yongfu Zhao, Honggang Zheng, Ledu Zhou, Jiye Zhu, Kangshun Zhu, Rong Liu, Yinghong Shi, Yongsheng Xiao, Lan Zhang, Chun Yang, Zhifeng Wu, Zhi Dai, Minshan Chen, Jianqiang Cai, Weilin Wang, Xiujun Cai, Qiang Li, Feng Shen, Shukui Qin, Gaojun Teng, Jiahong Dong, Jia Fan. Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2022 Edition)Liver Cancer 2023; 12(5): 405 doi: 10.1159/000530495
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Pietro Zucchetta, Carmelo Lacognata, Francesca Girardi, Alessandro Spimpolo, Filippo Crimì, Giulio Cabrelle, Chiara Zanon, Patrizia Boccagni, Laura Evangelista, Diego Cecchin, Umberto Cillo. [18F]FDG PET/MRI in the follow-up of hepatocellular carcinoma after liver transplantationNuclear Medicine Communications 2022; 43(3): 359 doi: 10.1097/MNM.0000000000001518
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Li-Hsiang Yen, John C. Sabatino. Imaging complications of liver transplantation: a multimodality pictorial reviewAbdominal Radiology 2021; 46(6): 2444 doi: 10.1007/s00261-019-02270-2
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Taiji Tohyama, Katsunori Sakamoto, Kei Tamura, Taro Nakamura, Jota Watanabe, Hiroyuki Wakisaka, Yasutsugu Takada. Pharyngeal metastasis following living-donor liver transplantation for hepatocellular carcinoma: a case report and literature reviewWorld Journal of Surgical Oncology 2020; 18(1) doi: 10.1186/s12957-020-01873-0
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Mohamed Awali, Maria El Homsi, Tyler J. Fraum, Anup S. Shetty, Maria R. Ponisio, Karem Gharzeddine, Joyce Mhlanga, Nadine Mallak, Spencer Behr, Malak Itani. PET/MRI: pictorial review of hepatobiliary and pancreatic applicationsAbdominal Radiology 2024;  doi: 10.1007/s00261-024-04548-6
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Tyler Walburn, Andrew M Moon, Paul H Hayashi, David Gerber, Hanna K Sanoff, Katrina A McGinty, David Mauro, Joel Tepper, Kyle Wang. Stereotactic Body Radiation Therapy for Recurrent, Isolated Hepatocellular Carcinoma Lymph Node Metastasis With or Without Prior Liver TransplantationCureus 2020;  doi: 10.7759/cureus.9988
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Ramin Raul Ossami Saidy, Maximilian Paul Postel, Michael Johannes Pflüger, Wenzel Schoening, Robert Öllinger, Safak Gül-Klein, Moritz Schmelzle, Frank Tacke, Johann Pratschke, Dennis Eurich. Minimization of Immunosuppressive Therapy Is Associated with Improved Survival of Liver Transplant Patients with Recurrent Hepatocellular CarcinomaCancers 2021; 13(7): 1617 doi: 10.3390/cancers13071617
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Giovanni Vitale, Stefano Gitto, Claudia Campani, Laura Turco, Anna Baldan, Fabio Marra, Maria Cristina Morelli. Biological therapies in patients with liver disease: are they really lifesavers?Expert Opinion on Biological Therapy 2022; 22(4): 473 doi: 10.1080/14712598.2022.2013799
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Kin Pan Au, Kenneth Siu Ho Chok. Immunotherapy after liver transplantation: Where are we now?World Journal of Gastrointestinal Surgery 2021; 13(10): 1267-1278 doi: 10.4240/wjgs.v13.i10.1267
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Christian R. Stephens, Julie R. Bloom, Eric J. Lehrer, Ren-Dih Sheu, Parissa Tabrizian, Chiara Rocha, Leona Kim-Schluger, Sander S. Florman, Michael H. Buckstein. Outcomes for salvage abdominal stereotactic body radiation therapy for hepatocellular carcinoma after liver transplantationLiver Transplantation 2023;  doi: 10.1097/LVT.0000000000000186
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Boram Lee, YoungRok Choi, Woohyung Lee, Youngmi Park, Kil Hwan Kim, In Gun Hyun, Sun Jong Han, Jai Young Cho, Yoo-Seok Yoon, Ho-Seong Han. Timing for Introduction of Total Laparoscopic Living Donor Right Hepatectomy; Initial Experience Based on the Data of Laparoscopic Major HepatectomyTransplantation 2021; 105(6): 1273 doi: 10.1097/TP.0000000000003344
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JinSuo Chen, LiNa Wang, XueMei Wu, ZhiJie Ding, WenXi Cao, LeiLei Yang, YongPing Zhou, Li Xia, Zhao Song. MicroRNA-34b-5p increases chemosensitivity of hepatocellular carcinoma cellsMolecular & Cellular Toxicology 2024;  doi: 10.1007/s13273-024-00431-z
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Emrah Sahin, Volkan Ince, Tolga T. Sahin, Ramazan Kutlu, Ramazan Pasahan, Sezai Yilmaz. Undetectable Brain Metastasis of Hepatocellular Carcinoma by PET-CT After Liver Transplantation: a Case ReportJournal of Gastrointestinal Cancer 2023; 54(1): 270 doi: 10.1007/s12029-021-00767-y