For: | Sukawa Y, Yamamoto H, Nosho K, Kunimoto H, Suzuki H, Adachi Y, Nakazawa M, Nobuoka T, Kawayama M, Mikami M, Matsuno T, Hasegawa T, Hirata K, Imai K, Shinomura Y. Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer. World J Gastroenterol 2012; 18(45): 6577-6586 [PMID: 23236232 DOI: 10.3748/wjg.v18.i45.6577] |
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URL: | https://www.wjgnet.com/1007-9327/full/v18/i45/6577.htm |
Number | Citing Articles |
1 |
Magdalena K. Scheck, Ralf D. Hofheinz, Sylvie Lorenzen. HER2-Positive Gastric Cancer and Antibody Treatment: State of the Art and Future Developments. Cancers 2024; 16(7): 1336 doi: 10.3390/cancers16071336
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2 |
Dong Won Baek, Byung Woog Kang, Jong Gwang Kim. The Predictive Value of Epstein-Barr Virus-Positivity in Patients Undergoing Gastrectomy Followed by Adjuvant Chemotherapy. Chonnam Medical Journal 2018; 54(3): 173 doi: 10.4068/cmj.2018.54.3.173
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3 |
Li‑Jie Xia, Yan‑Ling Wu, Fu‑Chun Zhang. Combination of cecropinXJ and LY294002 induces synergistic cytotoxicity, and apoptosis in human gastric cancer cells via inhibition of the PI3K/Akt signaling pathway. Oncology Letters 2017; doi: 10.3892/ol.2017.7112
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4 |
Ying Wang, You Lv, Te Si Liu, Wen Di Yan, Li Yan Chen, Zhu Hu Li, Ying Shi Piao, Ren Bo An, Zhen Hua Lin, Xiang Shan Ren. Cordycepin suppresses cell proliferation and migration by targeting CLEC2 in human gastric cancer cells via Akt signaling pathway. Life Sciences 2019; 223: 110 doi: 10.1016/j.lfs.2019.03.025
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5 |
Hugo Manuel Lopes de Sousa, Joana Patrícia Costa Ribeiro, Mafalda Basílio Timóteo. Epstein-Barr Virus - New Trends. Infectious Diseases 2021; 11 doi: 10.5772/intechopen.93649
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6 |
Yi-wang Zhang, Dan He, Cui Tan, Min Dong, Lu Zhou, Chun-kui Shao. Differential expression of HER2 and downstream proteins in prediction of advanced tumor phenotypes and overall survival of patients with Epstein-Barr virus-positive vs. negative gastric cancers. Pathology - Research and Practice 2019; 215(11): 152675 doi: 10.1016/j.prp.2019.152675
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7 |
Comprehensive molecular characterization of gastric adenocarcinoma. Nature 2014; 513(7517): 202 doi: 10.1038/nature13480
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8 |
Sangjeong Ahn, So-Jeong Lee, Yonugkeum Kim, Ahrong Kim, Nari Shin, Kyung Un Choi, Chang-Hun Lee, Gi Yeong Huh, Kyong-Mee Kim, Namrata Setia, Gregory Y. Lauwers, Do Youn Park. High-throughput Protein and mRNA Expression–based Classification of Gastric Cancers Can Identify Clinically Distinct Subtypes, Concordant With Recent Molecular Classifications. American Journal of Surgical Pathology 2017; 41(1): 106 doi: 10.1097/PAS.0000000000000756
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9 |
Yi-wang Zhang, Xiao-xiao Zhao, Cui Tan, Zhi-gang Zhang, Ye Jiang, Jian-ning Chen, Hong-bo Wei, Ling Xue, Hai-gang Li, Hong Du, Chun-kui Shao. Epstein-Barr virus latent membrane protein 2A suppresses the expression of HER2 via a pathway involving TWIST and YB-1 in Epstein-Barr virus-associated gastric carcinomas. Oncotarget 2015; 6(1): 207 doi: 10.18632/oncotarget.2702
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10 |
Xiaolin Peng, Yao Liu, Xin Peng, Zhengming Wang, Zhe Zhang, Yuling Qiu, Meihua Jin, Ran Wang, Dexin Kong. Clinical features and the molecular biomarkers of olfactory neuroblastoma. Pathology - Research and Practice 2018; 214(8): 1123 doi: 10.1016/j.prp.2018.06.002
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11 |
Dong Won Baek, Byung Woog Kang, Soyoon Hwang, Jong Gwang Kim, An Na Seo, Han Ik Bae, Oh Kyoung Kwon, Seung Soo Lee, Ho Young Chung, Wansik Yu. Clinical Significance of p53 Protein Expression, Beta-catenin Expression and HER2 Expression for Epstein-Barr Virus-associated Gastric Cancer. Chonnam Medical Journal 2017; 53(2): 140 doi: 10.4068/cmj.2017.53.2.140
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12 |
Tasuku Matsuoka, Masakazu Yashiro. The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma. Cancers 2014; 6(3): 1441 doi: 10.3390/cancers6031441
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13 |
Yongji Zeng, Ramon U. Jin. Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer. Seminars in Cancer Biology 2022; 86: 566 doi: 10.1016/j.semcancer.2021.12.004
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14 |
Takafumi Naito, Katsuhiko Nosho, Miki Ito, Hisayoshi Igarashi, Kei Mitsuhashi, Shinji Yoshii, Hironori Aoki, Masafumi Nomura, Yasutaka Sukawa, Eiichiro Yamamoto, Yasushi Adachi, Hiroaki Takahashi, Masao Hosokawa, Masahiro Fujita, Toshinao Takenouchi, Reo Maruyama, Hiromu Suzuki, Yoshifumi Baba, Kohzoh Imai, Hiroyuki Yamamoto, Shuji Ogino, Yasuhisa Shinomura. <italic>IGF2</italic> differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions. World Journal of Gastroenterology 2014; 20(29): 10050-10061 doi: 10.3748/wjg.v20.i29.10050
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15 |
Daniela Lazar, Sorina Taban, Marioara Cornianu, Alexandra Faur, Ioan Romosan, Adrian Goldis. Gastric Cancer. 2017; doi: 10.5772/intechopen.69737
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16 |
Jin Wang, Xinye Shao, Yang Liu, Ruichuan Shi, Bowen Yang, Jiawen Xiao, Yunpeng Liu, Xiujuan Qu, Zhi Li. Mutations of key driver genes in gastric cancer metastasis risk: a systematic review and meta-analysis. Expert Review of Molecular Diagnostics 2021; 21(9): 963 doi: 10.1080/14737159.2021.1946394
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17 |
Xiaojuan Ren, Chao Feng, Yubo Wang, Pu Chen, Simeng Wang, Jianling Wang, Hongxin Cao, Yujun Li, Meiju Ji, Peng Hou. SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways. Experimental & Molecular Medicine 2023; 55(8): 1757 doi: 10.1038/s12276-023-01062-5
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18 |
Xinkui Liu, Jiarui Wu, Dan Zhang, Kaihuan Wang, Xiaojiao Duan, Ziqi Meng, Xiaomeng Zhang, Yoshiki Mukudai. Network Pharmacology‐Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer. Evidence-Based Complementary and Alternative Medicine 2018; 2018(1) doi: 10.1155/2018/7802639
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19 |
Alireza Tabibzadeh, Fahimeh Safarnezhad Tameshkel, Yousef Moradi, Saber Soltani, Maziar Moradi-Lakeh, G. Hossein Ashrafi, Nima Motamed, Farhad Zamani, Seyed Abbas Motevalian, Mahshid Panahi, Maryam Esghaei, Hossein Ajdarkosh, Alireza Mousavi-Jarrahi, Mohammad Hadi Karbalaie Niya. Signal transduction pathway mutations in gastrointestinal (GI) cancers: a systematic review and meta-analysis. Scientific Reports 2020; 10(1) doi: 10.1038/s41598-020-73770-1
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20 |
Diana Carli, Silvia Kalantari, Rosaria Manicone, Paola Coppo, Paola Francia di Celle, Roberta La Selva, Federica Santoro, Carlotta Ranieri, Simona Cardaropoli, Franca Fagioli, Giovanni Battista Ferrero, Nicoletta Resta, Alessandro Mussa. Kaposiform hemangioendothelioma further broadens the phenotype of PIK3CA‐related overgrowth spectrum. Clinical Genetics 2021; 100(5): 624 doi: 10.1111/cge.14047
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21 |
Lin-lin Li, Ao-yang Yu, Mei Zhu, Lu-yao Ma, Meng-han Cao, Wen-lou Liu, Xiao-bing Qin, Chao Gao, Zheng-xiang Han, Hong-mei Wang. Clinicopathological characteristics and prognosis of Epstein-Barr virus–associated gastric cancer. Archives of Virology 2024; 169(5) doi: 10.1007/s00705-024-06033-3
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22 |
Wen Kang, Xiao Zheng, Ping Wang, Shanyu Guo. Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro. International Journal of Molecular Medicine 2018; doi: 10.3892/ijmm.2018.3532
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23 |
Ziyu Ji, Jianlin Shen, Yujian Lan, Qian Yi, Huan Liu. Targeting signaling pathways in osteosarcoma: Mechanisms and clinical studies. MedComm 2023; 4(4) doi: 10.1002/mco2.308
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24 |
Sérgia Velho, Maria Sofia Fernandes, Marina Leite, Ceu Figueiredo, Raquel Seruca. Causes and consequences of microsatellite instability in gastric carcinogenesis. World Journal of Gastroenterology 2014; 20(44): 16433-16442 doi: 10.3748/wjg.v20.i44.16433
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25 |
Hadeel Kheraldine, Ishita Gupta, Farhan Sachal Cyprian, Semir Vranic, Halema F. Al-Farsi, Maysaloun Merhi, Said Dermime, Ala-Eddin Al Moustafa. Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways. Cancer Cell International 2024; 24(1) doi: 10.1186/s12935-023-03195-z
|
26 |
Zhihao Zhang, Mengmeng Dou, Xiaofang Yao, Hao Tang, Zhubo Li, Xiaoyan Zhao. Potential Biomarkers in Diagnosis of Human Gastric Cancer. Cancer Investigation 2016; 34(3): 115 doi: 10.3109/07357907.2015.1114122
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27 |
Ayda Baghery Saghchy Khorasani, Atieh Pourbagheri-Sigaroodi, Ali Pirsalehi, Ava Safaroghli-azar, Mohammad Reza Zali, Davood Bashash. The PI3K/Akt/mTOR signaling pathway in gastric cancer; from oncogenic variations to the possibilities for pharmacologic interventions. European Journal of Pharmacology 2021; 898: 173983 doi: 10.1016/j.ejphar.2021.173983
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28 |
Euno Choi, Sun-ju Byeon, Soo Hee Kim, Hyun Ju Lee, Hyeong Ju Kwon, HyeSeong Ahn, Dong Ha Kim, Mee Soo Chang, Joseph S Pagano. Implication of Leptin-Signaling Proteins and Epstein-Barr Virus in Gastric Carcinomas. PLOS ONE 2015; 10(7): e0130839 doi: 10.1371/journal.pone.0130839
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29 |
Joana Ribeiro, Andreia Oliveira, Mariana Malta, Claudia Oliveira, Fernanda Silva, Ana Galaghar, Luís Pedro Afonso, Maria Cassiano Neves, Rui Medeiros, Pedro Pimentel-Nunes, Hugo Sousa. Clinical and pathological characterization of Epstein-Barr virus-associated gastric carcinomas in Portugal. World Journal of Gastroenterology 2017; 23(40): 7292-7302 doi: 10.3748/wjg.v23.i40.7292
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30 |
Chiara Romano, Sandra Di Gregorio, Maria Stella Pennisi, Elena Tirrò, Giuseppe Broggi, Rosario Caltabiano, Livia Manzella, Martino Ruggieri, Paolo Vigneri, Antonio Di Cataldo. Multiple primary malignances managed with surgical excision: a case report with next generation sequencing analysis. Molecular Biology Reports 2022; 49(9): 9059 doi: 10.1007/s11033-022-07630-8
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31 |
Yu Sunakawa, Heinz-Josef Lenz. Molecular Classification of Gastric Adenocarcinoma: Translating New Insights from The Cancer Genome Atlas Research Network. Current Treatment Options in Oncology 2015; 16(4) doi: 10.1007/s11864-015-0331-y
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32 |
Xuechao Liu, Jianjun Liu, Haibo Qiu, Pengfei Kong, Shangxiang Chen, Wei Li, Youqing Zhan, Yuanfang Li, Yingbo Chen, Zhiwei Zhou, Dazhi Xu, Xiaowei Sun. Prognostic significance of Epstein-Barr virus infection in gastric cancer: a meta-analysis. BMC Cancer 2015; 15(1) doi: 10.1186/s12885-015-1813-9
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33 |
Dongmei Ji, Zhe Zhang, Lei Cheng, Jinjia Chang, Shanshan Wang, Biqiang Zheng, Rongliang Zheng, Zuojun Sun, Chenchen Wang, Zhiqing Zhang, Rujiao Liu, Xiaowei Zhang, Xin Liu, Xiaofeng Wang, Jin Li, Guillermo Velasco. The Combination of RAD001 and MK-2206 Exerts Synergistic Cytotoxic Effects against PTEN Mutant Gastric Cancer Cells: Involvement of MAPK-Dependent Autophagic, but Not Apoptotic Cell Death Pathway. PLoS ONE 2014; 9(1): e85116 doi: 10.1371/journal.pone.0085116
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34 |
Ying Zhang, Chang-Feng Li, Lian-Jun Ma, Meng Ding, Bin Zhang. MicroRNA-224 aggrevates tumor growth and progression by targeting mTOR in gastric cancer. International Journal of Oncology 2016; 49(3): 1068 doi: 10.3892/ijo.2016.3581
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35 |
Xiaobing Shen, Ying Zhao, Xiaowei Chen, Haixiang Sun, Mengqi Liu, Wenwen Zhang, Fei Jiang, Pengfei Li.
Associations of
PIK3CA
Mutations with Clinical Features and Prognosis in Gastric Cancer
. Future Oncology 2019; 15(16): 1873 doi: 10.2217/fon-2018-0335
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36 |
Takamitsu Sasaki, Hiroki Kuniyasu, Yi Luo, Misaho Kitayoshi, Eriko Tanabe, Daisuke Kato, Satoshi Shinya, Kiyomu Fujii, Hitoshi Ohmori, Yuichi Yamashita. AKT Activation and Telomerase Reverse Transcriptase Expression are Concurrently Associated with Prognosis of Gastric Cancer. Pathobiology 2014; 81(1): 36 doi: 10.1159/000351721
|
37 |
Gaetano Romano. The Role of the Dysfunctional Akt-Related Pathway in Cancer: Establishment and Maintenance of a Malignant Cell Phenotype, Resistance to Therapy, and Future Strategies for Drug Development. Scientifica 2013; 2013: 1 doi: 10.1155/2013/317186
|
38 |
TAKAMITSU SASAKI, HIROKI KUNIYASU. Significance of AKT in gastric cancer (Review). International Journal of Oncology 2014; 45(6): 2187 doi: 10.3892/ijo.2014.2678
|
39 |
Matthew J. Olnes, Holly A. Martinson. Recent advances in immune therapies for gastric cancer. Cancer Gene Therapy 2021; 28(9): 924 doi: 10.1038/s41417-021-00310-y
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40 |
Ji-Won Kim, Hye Seung Lee, Kyung Han Nam, Soyeon Ahn, Jin Won Kim, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Keun-Wook Lee. PIK3CA mutations are associated with increased tumor aggressiveness and Akt activation in gastric cancer. Oncotarget 2017; 8(53): 90948 doi: 10.18632/oncotarget.18770
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41 |
Vera Genitsch, Alexander Novotny, Christian A. Seiler, Dino Kröll, Axel Walch, Rupert Langer. Epstein–Barr Virus in Gastro-Esophageal Adenocarcinomas – Single Center Experiences in the Context of Current Literature. Frontiers in Oncology 2015; 5 doi: 10.3389/fonc.2015.00073
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42 |
AYA SHINOZAKI-USHIKU, AKIKO KUNITA, MASASHI FUKAYAMA. Update on Epstein-Barr virus and gastric cancer (Review). International Journal of Oncology 2015; 46(4): 1421 doi: 10.3892/ijo.2015.2856
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43 |
TAKAMITSU SASAKI, YUICHI YAMASHITA, HIROKI KUNIYASU. AKT plays a crucial role in gastric cancer. Oncology Letters 2015; 10(2): 607 doi: 10.3892/ol.2015.3260
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44 |
Mayo Hirabayashi, Damien Georges, Gary M. Clifford, Catherine de Martel. Estimating the Global Burden of Epstein-Barr Virus–Associated Gastric Cancer: A Systematic Review and Meta-Analysis. Clinical Gastroenterology and Hepatology 2023; 21(4): 922 doi: 10.1016/j.cgh.2022.07.042
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45 |
Pranshu Sahgal, Brandon M. Huffman, Deepa T. Patil, Walid K. Chatila, Rona Yaeger, James M. Cleary, Nilay S. Sethi. Early TP53 Alterations Shape Gastric and Esophageal Cancer Development. Cancers 2021; 13(23): 5915 doi: 10.3390/cancers13235915
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46 |
Jung-Soo Pyo, Nae-Yu Kim, Dong-Wook Kang. Prognostic Implication of EBV Infection in Gastric Carcinomas: A Systematic Review and Meta-Analysis. Medicina 2023; 59(5): 834 doi: 10.3390/medicina59050834
|
47 |
Sarah B. Fisher, Kevin E. Fisher, Malcolm H. Squires, Sameer H. Patel, David A. Kooby, Bassel F. El‐Rayes, Kenneth Cardona, Maria C. Russell, Charles A. Staley, Alton B. Farris, Shishir K. Maithel. HER2 in resected gastric cancer: Is there prognostic value?. Journal of Surgical Oncology 2014; 109(2): 61 doi: 10.1002/jso.23456
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48 |
Fang Cao, Cong Zhang, Wei Han, Xiao-Jiao Gao, Jun Ma, Yong-Wei Hu, Xing Gu, Hou-Zhong Ding, Li-Xia Zhu, Qin Liu. p-Akt as a potential poor prognostic factor for gastric cancer: a systematic review and meta-analysis. Oncotarget 2017; 8(35): 59878 doi: 10.18632/oncotarget.17001
|
49 |
Qing-Hai Li, Ying-Zhao Wang, Jian Tu, Chu-Wei Liu, Yu-Jie Yuan, Run Lin, Wei-Ling He, Shi-Rong Cai, Yu-Long He, Jin-Ning Ye. Anti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistance. Gastroenterology Report 2020; 8(3): 179 doi: 10.1093/gastro/goaa026
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50 |
Hua Li, Shubo Chen, Hui Li, Jianxin Cui, Yunhe Gao, Dianchao Wu, Shangfeng Luan, Yan Qin, Tongshan Zhai, Dengxiang Liu, Zhibin Huo. Association between PIK3CA alteration and prognosis of gastric cancer patients: a meta-analysis. Oncotarget 2018; 9(7): 7651 doi: 10.18632/oncotarget.23871
|
51 |
Zi-Ning Lei, Qiu-Xu Teng, Qin Tian, Wei Chen, Yuhao Xie, Kaiming Wu, Qianlin Zeng, Leli Zeng, Yihang Pan, Zhe-Sheng Chen, Yulong He. Signaling pathways and therapeutic interventions in gastric cancer. Signal Transduction and Targeted Therapy 2022; 7(1) doi: 10.1038/s41392-022-01190-w
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52 |
Joonhong Park, Han Mo Yoo, Woori Jang, Soyoung Shin, Myungshin Kim, Yonggoo Kim, Seung-Woo Lee, Jeong Goo Kim. Distribution of somatic mutations of cancer-related genes according to microsatellite instability status in Korean gastric cancer. Medicine 2017; 96(25): e7224 doi: 10.1097/MD.0000000000007224
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53 |
Antonio Pellino, Erika Riello, Floriana Nappo, Stefano Brignola, Sabina Murgioni, Selma Ahcene Djaballah, Sara Lonardi, Vittorina Zagonel, Massimo Rugge, Fotios Loupakis, Matteo Fassan. Targeted therapies in metastatic gastric cancer: Current knowledge and future perspectives. World Journal of Gastroenterology 2019; 25(38): 5773-5788 doi: 10.3748/wjg.v25.i38.5773
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54 |
Jing Shi, Yi-Ping Qu, Peng Hou. Pathogenetic mechanisms in gastric cancer. World Journal of Gastroenterology 2014; 20(38): 13804-13819 doi: 10.3748/wjg.v20.i38.13804
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55 |
Nick Baniak, Jenna-Lynn Senger, Shahid Ahmed, S. C. Kanthan, Rani Kanthan. Gastric biomarkers: a global review. World Journal of Surgical Oncology 2016; 14(1) doi: 10.1186/s12957-016-0969-3
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56 |
Małgorzata Skierucha, Anya NA Milne, G Johan A Offerhaus, Wojciech P Polkowski, Ryszard Maciejewski, Robert Sitarz. Molecular alterations in gastric cancer with special reference to the early-onset subtype. World Journal of Gastroenterology 2016; 22(8): 2460-2474 doi: 10.3748/wjg.v22.i8.2460
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57 |
Kazuto Harada, Yoshifumi Baba, Hironobu Shigaki, Takatsugu Ishimoto, Keisuke Miyake, Keisuke Kosumi, Ryuma Tokunaga, Daisuke Izumi, Mayuko Ohuchi, Kenichi Nakamura, Yuki Kiyozumi, Junji Kurashige, Masaaki Iwatsuki, Yuji Miyamoto, Yasuo Sakamoto, Naoya Yoshida, Masayuki Watanabe, Hideo Baba. Prognostic and clinical impact of PIK3CA mutation in gastric cancer: pyrosequencing technology and literature review. BMC Cancer 2016; 16(1) doi: 10.1186/s12885-016-2422-y
|
58 |
Hiroyuki Yamamoto, Kohzoh Imai. Microsatellite instability: an update. Archives of Toxicology 2015; 89(6): 899 doi: 10.1007/s00204-015-1474-0
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59 |
Aldo Giudice, Giovanni D’Arena, Anna Crispo, Mario Felice Tecce, Flavia Nocerino, Maria Grimaldi, Emanuela Rotondo, Anna Maria D’Ursi, Mario Scrima, Massimiliano Galdiero, Gennaro Ciliberto, Mario Capunzo, Gianluigi Franci, Antonio Barbieri, Sabrina Bimonte, Maurizio Montella, Denis Delic. Role of Viral miRNAs and Epigenetic Modifications in Epstein‐Barr Virus‐Associated Gastric Carcinogenesis. Oxidative Medicine and Cellular Longevity 2016; 2016(1) doi: 10.1155/2016/6021934
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60 |
Yiseul Choi, Young San Ko, Jinju Park, Youngsun Choi, Younghoon Kim, Jung-Soo Pyo, Bo Gun Jang, Douk Ho Hwang, Woo Ho Kim, Byung Lan Lee. HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer. World Journal of Gastroenterology 2016; 22(41): 9141-9153 doi: 10.3748/wjg.v22.i41.9141
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61 |
Adrian Murphy, Ronan J. Kelly. From Molecular Classification to Targeted Therapeutics: The Changing Face of Systemic Therapy in Metastatic Gastroesophageal Cancer. Gastroenterology Research and Practice 2015; 2015: 1 doi: 10.1155/2015/896560
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62 |
Assaf Moore, Elad Hikri, Tal Goshen-Lago, Tamar Barkan, Sara Morgenstern, Elena Brook, Annett Maderer, Wilfried Roth, Noa Gordon, Hanoch Kashtan, Baruch Brenner, Markus Moehler, Irit Ben Aharon. Young-onset gastric cancer and Epstein–Barr Virus (EBV) – a major player in the pathogenesis?. BMC Cancer 2020; 20(1) doi: 10.1186/s12885-020-6517-0
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