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Yamaoka Y. Roles of |
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URL: | https://www.wjgnet.com/1007-9327/full/v14/i27/4265.htm |
Number | Citing Articles |
1 |
Ebru Demiray‐Gürbüz, Özlem Yılmaz, Asalia Z Olivares, Can Gönen, Sülen Sarıoğlu, Müjde Soytürk, Sait Tümer, Oğuz Altungöz, İlkay Şimşek, Guillermo I Perez Perez. Rapid identification of Helicobacter pylori and assessment of clarithromycin susceptibility from clinical specimens using FISH. The Journal of Pathology: Clinical Research 2017; 3(1): 29 doi: 10.1002/cjp2.57
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2 |
Shamshul Ansari, Evariste Tshibangu Kabamba, Pradeep Krishna Shrestha, Hafeza Aftab, Thein Myint, Lotay Tshering, Rabi Prakash Sharma, Nwe Ni, Than Than Aye, Phawinee Subsomwong, Tomohisa Uchida, Thawee Ratanachu-ek, Ratha-korn Vilaichone, Varocha Mahachai, Takashi Matsumoto, Junko Akada, Yoshio Yamaoka, Masaru Katoh. Helicobacter pylori bab characterization in clinical isolates from Bhutan, Myanmar, Nepal and Bangladesh. PLOS ONE 2017; 12(11): e0187225 doi: 10.1371/journal.pone.0187225
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3 |
Breno Bittencourt de Brito, Fabian Fellipe Bueno Lemos, Caroline da Mota Carneiro, Andressa Santos Viana, Nilo Manoel Pereira Vieira Barreto, Gabriela Alves de Souza Assis, Barbara Dicarlo Costa Braga, Maria Luísa Cordeiro Santos, Filipe Antônio França da Silva, Hanna Santos Marques, Natália Oliveira e Silva, Fabrício Freire de Melo. Immune response to <i>Helicobacter pylori</i> infection and gastric cancer development. World Journal of Meta-Analysis 2021; 9(3): 257-276 doi: 10.13105/wjma.v9.i3.257
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4 |
Muhammad Miftahussurur, Yoshio Yamaoka. Helicobacter pylori. 2016; : 19 doi: 10.1007/978-4-431-55705-0_2
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5 |
Sung Woo Jung, Mitsushige Sugimoto, Seiji Shiota, David Y. Graham, Yoshio Yamaoka, S. R. Blanke.
The Intact
dupA
Cluster Is a More Reliable Helicobacter pylori Virulence Marker than
dupA
Alone
. Infection and Immunity 2012; 80(1): 381 doi: 10.1128/IAI.05472-11
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6 |
Ileana González, Jacqueline Romero, Boris Rodríguez, Jorge Llanos, Erik Morales, Héctor Figueroa, Ramón Perez-Castro, Eliana Valdés, Cecilia Cofre, Armando Rojas. High prevalence of virulence-associated genotypes in Helicobacter pylori clinical isolates in the Region del Maule, Chile. Scandinavian Journal of Infectious Diseases 2011; 43(8): 652 doi: 10.3109/00365548.2011.572909
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7 |
Bor‐Shyang Sheu, Hsiao‐Bai Yang, Yu‐Chun Yeh, Jiunn‐Jong Wu. Helicobacter pylori colonization of the human gastric epithelium: A bug's first step is a novel target for us. Journal of Gastroenterology and Hepatology 2010; 25(1): 26 doi: 10.1111/j.1440-1746.2009.06141.x
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8 |
Jo‐Lewis Banga Ndzouboukou, Qing Lei, Nadeem Ullah, Yandi Zhang, Ling Hao, Xionglin Fan. Helicobacter pylori adhesins: HpaA a potential antigen in experimental vaccines for H. pylori. Helicobacter 2021; 26(1) doi: 10.1111/hel.12758
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9 |
Farkhondeh Poursina, Jamshid Faghri, Sharareh Moghim, Hamid Zarkesh-Esfahani, Bahram Nasr-Esfahani, Hossein Fazeli, Akbar Hasanzadeh, Hajieh Ghasemian Safaei. Assessment of cagE and babA mRNA Expression During Morphological Conversion of Helicobacter pylori From Spiral to Coccoid. Current Microbiology 2013; 66(4): 406 doi: 10.1007/s00284-012-0280-7
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10 |
Mónica Oleastro, Armelle Ménard. The Role of Helicobacter pylori Outer Membrane Proteins in Adherence and Pathogenesis. Biology 2013; 2(3): 1110 doi: 10.3390/biology2031110
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11 |
Rajarshi Roy, Nisha Amarnath Jonniya, Md Fulbabu Sk, Parimal Kar. Comparative Structural Dynamics of Isoforms of Helicobacter pylori Adhesin BabA Bound to Lewis b Hexasaccharide via Multiple Replica Molecular Dynamics Simulations. Frontiers in Molecular Biosciences 2022; 9 doi: 10.3389/fmolb.2022.852895
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12 |
Shew-Meei Sheu, Bor-Shyang Sheu, Wen-Cheng Chiang, Cheng-Yen Kao, Hsiu-Mei Wu, Hsiao-Bai Yang, Jiunn-Jong Wu. H. pylori clinical isolates have diverse babAB genotype distributions over different topographic sites of stomach with correlation to clinical disease outcomes. BMC Microbiology 2012; 12(1): 89 doi: 10.1186/1471-2180-12-89
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13 |
Samaneh Saberi, Alexej Schmidt, Sana Eybpoosh, Maryam Esmaili, Yeganeh Talebkhan, Nazanin Mohajerani, Akbar Oghalaie, Mahmoud Eshagh Hosseini, Mohammad Ali Mohagheghi, Jeanna Bugaytova, Thomas Borén, Marjan Mohammadi. Helicobacter pylori Strains from Duodenal Ulcer Patients Exhibit Mixed babA/B Genotypes with Low Levels of BabA Adhesin and Lewis b Binding. Digestive Diseases and Sciences 2016; 61(10): 2868 doi: 10.1007/s10620-016-4217-z
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14 |
Muhammad Miftahussurur, Yoshio Yamaoka. Helicobacter pylorivirulence genes and host genetic polymorphisms as risk factors for peptic ulcer disease. Expert Review of Gastroenterology & Hepatology 2015; 9(12): 1535 doi: 10.1586/17474124.2015.1095089
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15 |
Wei-Lun Chang, Yi-Chun Yeh, Bor-Shyang Sheu. The impacts of H. pylori virulence factors on the development of gastroduodenal diseases. Journal of Biomedical Science 2018; 25(1) doi: 10.1186/s12929-018-0466-9
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16 |
Daniel Sijmons, Andrew J. Guy, Anna K. Walduck, Paul A. Ramsland. Helicobacter pylori and the Role of Lipopolysaccharide Variation in Innate Immune Evasion. Frontiers in Immunology 2022; 13 doi: 10.3389/fimmu.2022.868225
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17 |
Charu Sonkar, Tarun Verma, Debi Chatterji, Ajay Kumar Jain, Hem Chandra Jha. Status of kinases in Epstein-Barr virus and Helicobacter pylori Coinfection in gastric Cancer cells. BMC Cancer 2020; 20(1) doi: 10.1186/s12885-020-07377-0
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18 |
José Luiz Proença-Modena, Gustavo Olszanski Acrani, Marcelo Brocchi.
Helicobacter Pylori
: Phenotypes, Genotypes and Virulence Genes
. Future Microbiology 2009; 4(2): 223 doi: 10.2217/17460913.4.2.223
|
19 |
Médea Padra, John Benktander, Karen Robinson, Sara K. Lindén. Molecular Mechanisms of Inflammation: Induction, Resolution and Escape by Helicobacter pylori. Current Topics in Microbiology and Immunology 2019; 421: 179 doi: 10.1007/978-3-030-15138-6_8
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20 |
Nozomi Ishijima, Masato Suzuki, Hiroshi Ashida, Yusuke Ichikawa, Yumi Kanegae, Izumu Saito, Thomas Borén, Rainer Haas, Chihiro Sasakawa, Hitomi Mimuro. BabA-mediated Adherence Is a Potentiator of the Helicobacter pylori Type IV Secretion System Activity. Journal of Biological Chemistry 2011; 286(28): 25256 doi: 10.1074/jbc.M111.233601
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21 |
H.T. Nguyen, F. Herrmann, S. König, F.M. Goycoolea, A. Hensel. Structural characterization of the carbohydrate and protein part of arabinogalactan protein from Basella alba stem and antiadhesive activity of polysaccharides from B. alba against Helicobacter pylori. Fitoterapia 2022; 157: 105132 doi: 10.1016/j.fitote.2022.105132
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22 |
Séamus Hussey, Nicola L. Jones. Pediatric Gastrointestinal and Liver Disease. 2011; : 293 doi: 10.1016/B978-1-4377-0774-8.10028-4
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23 |
Brunella Posteraro, Patrizia Posteraro, Maurizio Sanguinetti. Molecular Medical Microbiology. 2015; : 1237 doi: 10.1016/B978-0-12-397169-2.00068-8
|
24 |
Eileen Crowley, Séamus Hussey. Pediatric Gastrointestinal and Liver Disease. 2021; : 275 doi: 10.1016/B978-0-323-67293-1.00027-X
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25 |
Jacek Baj, Alicja Forma, Monika Sitarz, Piero Portincasa, Gabriella Garruti, Danuta Krasowska, Ryszard Maciejewski. Helicobacter pylori Virulence Factors—Mechanisms of Bacterial Pathogenicity in the Gastric Microenvironment. Cells 2020; 10(1): 27 doi: 10.3390/cells10010027
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26 |
Christopher J Day, Greg Tram, Lauren E Hartley-Tassell, Joe Tiralongo, Victoria Korolik. Assessment of glycan interactions of clinical and avian isolates of Campylobacter jejuni. BMC Microbiology 2013; 13(1) doi: 10.1186/1471-2180-13-228
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27 |
Gernot Posselt, Steffen Backert, Silja Wessler. The functional interplay of Helicobacter pylori factors with gastric epithelial cells induces a multi-step process in pathogenesis. Cell Communication and Signaling 2013; 11(1) doi: 10.1186/1478-811X-11-77
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28 |
Karolina Rudnicka, Steffen Backert, Magdalena Chmiela. Molecular Mechanisms of Inflammation: Induction, Resolution and Escape by Helicobacter pylori. Current Topics in Microbiology and Immunology 2019; 421: 53 doi: 10.1007/978-3-030-15138-6_3
|
29 |
Seiji Shiota, Osamu Matsunari, Masahide Watada, Katsuhiro Hanada, Yoshio Yamaoka. Systematic review and meta-analysis: the relationship between the Helicobacter pylori dupA gene and clinical outcomes. Gut Pathogens 2010; 2(1) doi: 10.1186/1757-4749-2-13
|
30 |
Laura Cooling, Theresa Downs. Henry's Clinical Diagnosis and Management by Laboratory Methods. 2011; : 674 doi: 10.1016/B978-1-4377-0974-2.00035-X
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31 |
Miguel Angel Chiurillo, Yeinmy Moran, Miryan Cañas, Elvis Valderrama, Nashdalish Granda, Marjorie Sayegh, José Luis Ramírez. Genotyping of Helicobacter pylori virulence-associated genes shows high diversity of strains infecting patients in western Venezuela. International Journal of Infectious Diseases 2013; 17(9): e750 doi: 10.1016/j.ijid.2013.03.004
|
32 |
Nimet Yılmaz, Meltem Koruk Özer. The Prevalence of Helicobacter Pylori babA, homB, aspA, and sabA Genes and Its Relationship with Clinical Outcomes in Turkey. Canadian Journal of Gastroenterology and Hepatology 2019; 2019: 1 doi: 10.1155/2019/1271872
|
33 |
Sankaran Sathianarayanan, Aparna Viswanathan Ammanath, Raja Biswas, Anita B, Sunitha Sukumaran, Baskar Venkidasamy. A new approach against Helicobacter pylori using plants and its constituents: A review study. Microbial Pathogenesis 2022; 168: 105594 doi: 10.1016/j.micpath.2022.105594
|
34 |
S. Jalilian, N. Amiri, R. Abiri, M. Eyvazi, F. Jalilian, A. Alvandi. Are non-pylori helicobacters present in the human oral cavity?. Molecular Genetics, Microbiology and Virology 2017; 32(2): 125 doi: 10.3103/S0891416817020069
|
35 |
Shamshul Ansari, Yoshio Yamaoka. <i>Helicobacter pylori</i> BabA in adaptation for gastric colonization. World Journal of Gastroenterology 2017; 23(23): 4158-4169 doi: 10.3748/wjg.v23.i23.4158
|
36 |
Matjaž Homan, Anja Šterbenc, Boštjan J. Kocjan, Boštjan Luzar, Nina Zidar, Rok Orel, Mario Poljak. Prevalence of the Helicobacter pylori babA2 gene and correlation with the degree of gastritis in infected Slovenian children. Antonie van Leeuwenhoek 2014; 106(4): 637 doi: 10.1007/s10482-014-0234-0
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37 |
Yu-Li Chen, Xiao-Qiang Mo, Gan-Rong Huang, Yan-Qiang Huang, Juan Xiao, Li-Juan Zhao, Hong-Yu Wei, Qian Liang. Gene polymorphisms of pathogenic <i>Helicobacter pylori</i> in patients with different types of gastrointestinal diseases. World Journal of Gastroenterology 2016; 22(44): 9718-9726 doi: 10.3748/wjg.v22.i44.9718
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38 |
Jan Drnovsek, Matjaz Homan, Nina Zidar, Lojze M Smid. Pathogenesis and potential reversibility of intestinal metaplasia − a milestone in gastric carcinogenesis. Radiology and Oncology 2024; 58(2): 186 doi: 10.2478/raon-2024-0028
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39 |
Helicobacter pylori strains harboring babA2 from Indian sub population are associated with increased virulence in ex vivo study. Gut Pathogens 2016; 8(1) doi: 10.1186/s13099-015-0083-z
|
40 |
Emma C. Skoog, Médea Padra, Anna Åberg, Pär Gideonsson, Ikenna Obi, Macarena P. Quintana-Hayashi, Anna Arnqvist, Sara K. Lindén. BabA dependent binding of Helicobacter pylori to human gastric mucins cause aggregation that inhibits proliferation and is regulated via ArsS. Scientific Reports 2017; 7(1) doi: 10.1038/srep40656
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41 |
Angitha N. Nath, R. J. Retnakumar, Ashik Francis, Prakash Chhetri, Namrata Thapa, Santanu Chattopadhyay. Peptic Ulcer and Gastric Cancer: Is It All in the Complex Host–Microbiome Interplay That Is Encoded in the Genomes of “Us” and “Them”?. Frontiers in Microbiology 2022; 13 doi: 10.3389/fmicb.2022.835313
|
42 |
Yoshio Yamaoka. Mechanisms of disease: Helicobacter pylori virulence factors. Nature Reviews Gastroenterology & Hepatology 2010; 7(11): 629 doi: 10.1038/nrgastro.2010.154
|
43 |
Katsuhiro Hanada, Yoshio Yamaoka. Genetic battle between Helicobacter pylori and humans. The mechanism underlying homologous recombination in bacteria, which can infect human cells. Microbes and Infection 2014; 16(10): 833 doi: 10.1016/j.micinf.2014.08.001
|
44 |
Anja Šterbenc, Mario Poljak, Nina Zidar, Boštjan Luzar, Matjaž Homan. Prevalence of the Helicobacter pylori homA and homB genes and their correlation with histological parameters in children. Microbial Pathogenesis 2018; 125: 26 doi: 10.1016/j.micpath.2018.09.005
|
45 |
Qinghua Zou, Huifang Zhang, Fanliang Meng, Lihua He, Jianzhong Zhang, Di Xiao, Roger Chammas. Proteomic and transcriptomic studies of BGC823 cells stimulated with Helicobacter pylori isolates from gastric MALT lymphoma. PLOS ONE 2020; 15(9): e0238379 doi: 10.1371/journal.pone.0238379
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46 |
Vinícius Lima de Souza Gonçalves, Maria Luísa Cordeiro Santos, Marcel Silva Luz, Hanna Santos Marques, Breno Bittencourt de Brito, Filipe Antônio França da Silva, Cláudio Lima Souza, Márcio Vasconcelos Oliveira, Fabrício Freire de Melo. From <i>Helicobacter pylori </i>infection to gastric cancer: Current evidence on the immune response. World Journal of Clinical Oncology 2022; 13(3): 186-199 doi: 10.5306/wjco.v13.i3.186
|
47 |
Jianzhong Zhang. Molecular Medical Microbiology. 2024; : 1133 doi: 10.1016/B978-0-12-818619-0.00120-9
|
48 |
Detection of the baba2 adhesin protein gene in clinical isolates of helicobacter pylori. Russian Clinical Laboratory Diagnostics 2023; 67(9) doi: 10.51620/0869-2084-2022-67-9-538-543
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49 |
Anja Šterbenc, Maja M. Lunar, Matjaž Homan, Boštjan Luzar, Nina Zidar, Mario Poljak. Prevalence of the Helicobacter pylori babA2 Gene in Children Mainly Depends on the PCR Primer Set Used. Canadian Journal of Infectious Diseases and Medical Microbiology 2020; 2020: 1 doi: 10.1155/2020/4080248
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50 |
H.-M. A. Schmidt, S. Andres, C. Nilsson, Z. Kovach, N. O. Kaakoush, L. Engstrand, K.-L. Goh, K. M. Fock, D. Forman, H. Mitchell. The cag PAI is intact and functional but HP0521 varies significantly in Helicobacter pylori isolates from Malaysia and Singapore. European Journal of Clinical Microbiology & Infectious Diseases 2010; 29(4): 439 doi: 10.1007/s10096-010-0881-7
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51 |
Nienke Buddelmeijer, Olivera Francetic. Institut Pasteur Minisymposium on Bacterial Membranes 2013. Research in Microbiology 2013; 164(8): 886 doi: 10.1016/j.resmic.2013.06.006
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52 |
Caiyun He, Moye Chen, Jingwei Liu, Yuan Yuan. Host genetic factors respond to pathogenic step-specific virulence factors of Helicobacter pylori in gastric carcinogenesis. Mutation Research/Reviews in Mutation Research 2014; 759: 14 doi: 10.1016/j.mrrev.2013.09.002
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53 |
Cinara Cássia Brandão de Mattos, Luiz Carlos de Mattos. Histo-blood group carbohydrates as facilitators for infection by Helicobacter pylori. Infection, Genetics and Evolution 2017; 53: 167 doi: 10.1016/j.meegid.2017.05.025
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54 |
Seiji Shiota, Rumiko Suzuki, Yoshio Yamaoka. The significance of virulence factors in Helicobacter pylori. Journal of Digestive Diseases 2013; 14(7): 341 doi: 10.1111/1751-2980.12054
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55 |
Weronika Gonciarz, Maria Walencka, Anthony P. Moran, Krzysztof Hinc, Michał Obuchowski, Magdalena Chmiela. Upregulation of MUC5AC production and deposition of LEWIS determinants by HELICOBACTER PYLORI facilitate gastric tissue colonization and the maintenance of infection. Journal of Biomedical Science 2019; 26(1) doi: 10.1186/s12929-019-0515-z
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56 |
Alfizah Hanafiah, Bruno S. Lopes. Genetic diversity and virulence characteristics of Helicobacter pylori isolates in different human ethnic groups. Infection, Genetics and Evolution 2020; 78: 104135 doi: 10.1016/j.meegid.2019.104135
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57 |
Takahiro Uotani, Muhammad Miftahussurur, Yoshio Yamaoka. Effect of bacterial and host factors onHelicobacter pylorieradication therapy. Expert Opinion on Therapeutic Targets 2015; 19(12): 1637 doi: 10.1517/14728222.2015.1073261
|
58 |
Pauline Floch, Francis Mégraud, Philippe Lehours. Helicobacter pylori Strains and Gastric MALT Lymphoma. Toxins 2017; 9(4): 132 doi: 10.3390/toxins9040132
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59 |
Dalla Doohan, Yudith Annisa Ayu Rezkitha, Langgeng Agung Waskito, Yoshio Yamaoka, Muhammad Miftahussurur. Helicobacter pylori BabA–SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease Development. Toxins 2021; 13(7): 485 doi: 10.3390/toxins13070485
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60 |
Sarika Singh, Amresh Kumar Sharma, Anup Som, Valentina Gehlot, Shweta Mahant, Prateek Sharma, Kunal Das, Rajashree Das. Molecular characterization and phylogenetic analysis of babA gene of Helicobacter pylori isolated from Indian patients with gastrointestinal diseases. Gene 2024; 920: 148526 doi: 10.1016/j.gene.2024.148526
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61 |
Jyoti Mishra, Paolo Ruggiero, Fabio Bagnoli, Rino Rappuoli, Markus Stein. Infection and Cancer: Bi-Directorial Interactions. 2015; : 171 doi: 10.1007/978-3-319-20669-1_10
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62 |
Hilda A. Valdez-Salazar, Miguel A. Ares, Francisco J. Fernández, J Antonio Ibarra, Javier Torres, Víctor H. Bustamante, Miguel A. De la Cruz. Long-chain fatty acids alter transcription of Helicobacter pylori virulence and regulatory genes. PeerJ 2021; 9: e12270 doi: 10.7717/peerj.12270
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63 |
Masahide Watada, Seiji Shiota, Osamu Matsunari, Rumiko Suzuki, Kazunari Murakami, Toshio Fujioka, Yoshio Yamaoka. Association between Helicobacter pylori cagA-related genes and clinical outcomes in Colombia and Japan. BMC Gastroenterology 2011; 11(1) doi: 10.1186/1471-230X-11-141
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64 |
Ryo Kinoshita-Daitoku, Kotaro Kiga, Masatoshi Miyakoshi, Ryota Otsubo, Yoshitoshi Ogura, Takahito Sanada, Zhu Bo, Tuan Vo Phuoc, Tokuju Okano, Tamako Iida, Rui Yokomori, Eisuke Kuroda, Sayaka Hirukawa, Mototsugu Tanaka, Arpana Sood, Phawinee Subsomwong, Hiroshi Ashida, Tran Thanh Binh, Lam Tung Nguyen, Khien Vu Van, Dang Quy Dung Ho, Kenta Nakai, Toshihiko Suzuki, Yoshio Yamaoka, Tetsuya Hayashi, Hitomi Mimuro. A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment. Nature Communications 2021; 12(1) doi: 10.1038/s41467-021-22317-7
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65 |
S. E. Titov, G. V. Panasyuk, M. K. Ivanov, G. M. Dymshits. Detection of Helicobacter pylori in bioptates of gastric mucosa of patients with gastritis and gastric ulcers using real-time PCR. Molecular Genetics, Microbiology and Virology 2011; 26(3): 126 doi: 10.3103/S0891416811030074
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66 |
Mohammad Hadi Sadeghian, Mohammad Reza Keramati, Hossein Ayatollahi, Atefeh Shirinzadeh Feizabadi, Farahnaz Tehranaian, Hossein Shakibyee. Is there any relationship between expressions of minor blood group antigens with HTLV-I infection?. Transfusion and Apheresis Science 2012; 47(2): 151 doi: 10.1016/j.transci.2012.06.012
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67 |
Tanvi Somiah, Hanna G. Gebremariam, Fanglei Zuo, Ksenija Smirnova, Ann-Beth Jonsson. Lactate causes downregulation of Helicobacter pylori adhesin genes sabA and labA while dampening the production of proinflammatory cytokines. Scientific Reports 2022; 12(1) doi: 10.1038/s41598-022-24311-5
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68 |
Lyudmila Boyanova, Daniel Yordanov, Galina Gergova, Rumyana Markovska, Ivan Mitov. Association of iceA and babA genotypes in Helicobacter pylori strains with patient and strain characteristics. Antonie van Leeuwenhoek 2010; 98(3): 343 doi: 10.1007/s10482-010-9448-y
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69 |
Nuno Almeida, Maria Manuel Donato, José Manuel Romãozinho, Cristina Luxo, Olga Cardoso, Maria Augusta Cipriano, Carol Marinho, Alexandra Fernandes, Carlos Sofia. Correlation of Helicobacter pylori Genotypes with Gastric Histopathology in the Central Region of a South-European Country. Digestive Diseases and Sciences 2015; 60(1): 74 doi: 10.1007/s10620-014-3319-8
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70 |
Christopher J. Day, Elizabeth N. Tran, Evgeny A. Semchenko, Greg Tram, Lauren E. Hartley-Tassell, Preston S. K. Ng, Rebecca M. King, Rachel Ulanovsky, Sarah McAtamney, Michael A. Apicella, Joe Tiralongo, Renato Morona, Victoria Korolik, Michael P. Jennings. Glycan:glycan interactions: High affinity biomolecular interactions that can mediate binding of pathogenic bacteria to host cells. Proceedings of the National Academy of Sciences 2015; 112(52) doi: 10.1073/pnas.1421082112
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