Relationship between lipids and sleep apnea: Mendelian randomization analysis

Table 1 Detailed data of Mendelian randomization

Variable	Consortium	PMID	Population	Sex
Sleep apnea	UKB	-	European	Males and females
LDL-C	GLGC	24097068	European	Males and females
HDL-C	GLGC	24097068	European	Males and females
TG	GLGC	24097068	European	Males and females
TC	GLGC	24097068	European	Males and females

GLGC: Global Lipid Genetics Consortium; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; TC: Total cholesterol; TG: Triglyceride; UKB: United Kingdom Biobank.

Table 2 Results from two sample Mendelian randomization analysis

Lipid	Method	Number of SNPs	P value	OR	95%CI
LDL and Sleep apnea	MR Egger	42	0.58	0.99	0.99-1.00
	Weighted median	42	0.97	0.99	0.99-1.00
	Inverse variance weighted	42	0.85	1.00	0.99-1.00
	Simple mode	42	0.31	1.00	0.99-1.00
	Weighted mode	42	0.74	0.99	0.99-1.00
HDL and sleep apnea	MR Egger	55	0.91	0.99	0.99-1.00
	Weighted median	55	0.35	1.00	0.99-1.00
	Inverse variance weighted	55	0.29	1.00	0.99-1.00
	Simple mode	55	0.22	1.00	0.99-1.00
	Weighted mode	55	0.33	1.00	0.99-1.00
TG and Sleep apnea	MR Egger	35	0.92	1.00	0.99-1.00
	Weighted median	35	0.82	0.99	0.99-1.00
	Inverse variance weighted	35	0.57	1.00	0.99-1.00
	Simple mode	35	0.59	0.99	0.99-1.00
	Weighted mode	35	0.94	1.00	0.99-1.00
TC and Sleep apnea	MR Egger	51	0.33	0.99	0.99-1.00
	Weighted median	51	0.68	0.99	0.99-1.00
	Inverse variance weighted	51	0.82	1.00	0.99-1.00
	Simple mode	51	0.20	1.00	0.99-1.00
	Weighted mode	51	0.70	1.00	0.99-1.00

HDL: High-density lipoprotein; LDL: Low-density lipoprotein; MR: Mendelian randomization; OR: Odds ratio; SNPs: Single nucleotide polymorphisms; TC: Total cholesterol; TG: Triglyceride.

Table 3 Heterogeneity test and level pleiotropy test

Lipid	Heterogeneity test, inverse variance weighted			Level pleiotropy test
	Q	df	P value	P value
LDL	33.04	41	0.807	0.459
HDL	67.98	54	0.096	0.408
TG	34.87	34	0.427	0.823
TC	48.34	50	0.540	0.247

HDL: High-density lipoprotein; LDL: Low-density lipoprotein; TC: Total cholesterol; TG: Triglyceride.