Published online Nov 6, 2022. doi: 10.12998/wjcc.v10.i31.11403
Peer-review started: May 8, 2022
First decision: July 12, 2022
Revised: July 26, 2022
Accepted: September 20, 2022
Article in press: September 20, 2022
Published online: November 6, 2022
Obstructive sleep apnea (OSA) has a negative effect on serum lipids, but the relationship between serum lipids and OSA is still uncertain.
We explored the direct effect of serum lipids on OSA.
We observed that lipids are not related to OSA, and we need to further look for other markers to predict OSA in the future.
First, compared with other observational studies, the genetic variants can be obtained from different sample of individuals, and genetic associations can be obtained from large genome-wide association studies, which can greatly improve the statistical ability to detect small effects of complex phenotypes. Second, the study excluded more confounding factors, excluded heterogeneity and level pleiotropy, and conducted sensitivity tests to make our results more convincing.
In Mendelian randomization, the inverse variance weighted method manifested that the level of serum lipids including low-density lipoprotein (odds ratio [OR] = 0.99, 95% confidence interval [CI] = 0.99 to 1.00, P = 0.58), high-density lipoprotein (OR = 0.99, 95%CI = 0.99 to 1.00, P = 0.91), triglyceride (OR = 1.00, 95%CI = 0.99 to 1.00, P = 0.92), and total cholesterol (OR = 0.99, 95%CI = 0.99 to 1.00, P = 0.33) was not causally associated with sleep apnea (SA).
Through MR analysis, this study concludes that serum lipids are not associated with SA.
We need to find other markers to predict SA in the future.