Advances in para-aortic nodal dissection in gastric cancer surgery: A review of research progress over the last decade

Table 4 Adverse effects in three Japanese prospective randomized trials exploring neoadjuvant chemotherapy plus surgery for patients with extensive lymph node metastasis (Para-aortic lymph nodes metastasis or bulky lymph nodes)

Adverse effect	JCOG0001[61]	JCOG0405[33]	JCOG1002[62,63]
Grade 3/4 toxicity from chemotherapy
Leucopenia	31%	4%	18.9%
Neutropenia	55%	19%	39.6%
Anemia	24%	13%	7.5%
Febrile neutropenia	16%	2%	5.7%
Thrombocytopenia	—	4%	1.9%
Hyponatremia	—	—	15.1%
Hypokalemia	—	—	5.7%
Anorexia	—	10%	9.4%
Vomiting	13%	—	—
Chemotherapy-related mortality	2/55	0/51	0/52
Surgical complications
Leakage	1/49	3/49	2/49
Pancreatic fistula	6/49	11/49	9/49
Abdominal abscess	2/49	8/49	—
Pneumonia	2/49	2/49	4/49
Wound infection	2/49	0/49	2/49
Anastomotic stenosis	1/49	0/49	1/49
Intestinal obstruction	0/49	0/49	2/49
Cardiac failure	1/49	—	—
Renal dysfunction	1/49	—	—
Atelectasis	—	3/49	—
Abdominal infection	—	—	5/49
Pleural effusion	—	—	6/49
Chylous ascites	—	—	3/49
Delayed gastric emptying	—	—	1/49
Thromboembolic event	—	2/49	2/49
Other	6/49	11/49	—
Postoperative mortality	1/49	0/49	0/49