Risk factors, clinical features, and short-term prognosis of spontaneous fungal peritonitis in cirrhosis: A matched case-control study

Table 4 Cox regression analyses of risk factors associated with 15-d mortality (dead: n = 13; alive: n = 22) in patients with spontaneous fungal peritonitis or fungiascites

	Univariate		Multivariate
	HR (95%CI)	P-value	HR (95%CI)	P-value
Age	0.959 (0.918-1.003)	0.066
Variceal bleeding	0.872 (0.285-2.666)	0.81
Hepatorenal syndrome	7.3 (2.216-24.435)	0.001	5.328 (1.050-18.900)	0.01
HE	2.654 (0.889-7.925)	0.08
Charlson index	1.155 (0.742-1.796)	0.523
WBC, 109 cells/L	1.064 (1.009-1.122)	0.023	1.062 (0.933-1.137)	0.081
C-reactive protein, mg/L	1.003 (0.992-1.015)	0.564
INR	1.201 (0.520-2.776)	0.668
Total bilirubin, μmol/L	1.005 (1.003-1.008)	<0.001	1.005 (1.002-1.008)	0.002
Creatinine, μmol/L	1.010 (1.003-1.017)	0.005
Serum sodium, mmol/L	0.883 (0.814-0.958)	0.003	0.949 (0.867-1.039)	0.256
Concurrent bacterial infection	0.715 (0.240-2.129)	0.546
Anti-fungal therapy	0.758 (0.248-2.319)	0.627
SIRS	3.458 (0.948-12.611)	0.06
SOFA	1.305 (1.132-1.505)	<0.001
MELD	1.080 (1.021-1142)	0.008
CTP	1.727 (1.214-2.483)	0.002
APACHE II	1.113 (1.025-1.207)	0.01

HE: Hepatic encephalopathy; INR: International normalized rate; SIRS: Systemic inflammatory response; SOFA: Sequential organ failure assessment; APACHE II: Chronic liver failure-sequential organ failure assessment; MELD: Model for end-stage liver disease; CTP: Child-Turcotte-Pugh; OR: Odds ratio; CI: Confidence interval; HR: Hazard ratio.