Copyright
©The Author(s) 2019.
World J Clin Cases. Sep 6, 2019; 7(17): 2438-2449
Published online Sep 6, 2019. doi: 10.12998/wjcc.v7.i17.2438
Published online Sep 6, 2019. doi: 10.12998/wjcc.v7.i17.2438
Table 1 Comparison of clinical manifestations between spontaneous fungal peritonitis (case) and spontaneous bacteria peritonitis with a positive (control-1) or negative bacterial culture (control-2)
Variable | Case (n = 22) | Control-1 (n = 44) | P-value | Control-2 (n = 72) | P-value |
Demographics data | |||||
Age (yr), M ± SD | 60.0 ± 11.6 | 58.0 ± 12.5 | 0.55 | 56.9 ± 10.5 | 0.32 |
Sex (% male) | 17 (77.3%) | 37 (82.2%) | 0.51 | 55 (74.3%) | 1 |
Current smoking n (%) | 7 (31.8%) | 20 (45.5%) | 0.43 | 32 (44.4%) | 0.33 |
Alcohol abuse n (%) | 7 (31.8%) | 16 (36.4%) | 0.79 | 30 (41.3%) | 0.46 |
Aetiology of cirrhosis | |||||
Viral n (%) | 14 (63.6%) | 27 (61.4%) | 44 (61.1%) | ||
Alcohol n (%) | 2 (9.1%) | 8 (18.2%) | 0.66 | 18 (25.0%) | 0.334 |
Others n (%) | 6 (27.3%) | 9 (20.5%) | 13 (18.1%) | ||
Complication | |||||
Variceal bleeding n (%) | 8 (36.4%) | 6 (13.6%) | 0.05 | 18 (25.0%) | 0.41 |
Hepatorenal syndrome n (%) | 8 (36.4%) | 10 (22.7%) | 0.26 | 9 (12.5%) | 0.023 |
HE n (%) | 8 (36.4%) | 12 (27.3%) | 0.57 | 14 (19.4%) | 0.15 |
Charlson index (IQR) | 4 (3.7-5.0) | 4 (3.0-5.0) | 0.46 | 3 (3-5) | 0.007 |
Laboratory examination | |||||
WBC, 109 cells/L (IQR) | 11.7 (8.2-19.1) | 5.6 (2.9-11.2) | 0.001 | 6.2 (4.0-9.5) | <0.001 |
C-reactive protein, mg/L (IQR) | 77.4 (55.9-138.2) | 31.4 (14.7-50.6) | <0.001 | 22.7 (8.9-42.1) | <0.001 |
Creatinine, μmol/L (IQR) | 98.0 (69.5-147.8) | 86.0 (60.5-165.0) | 0.75 | 81 (67.0-105.0) | 0.228 |
Albumin, g/dL (M ± SD) | 28.1 ± 4.1 | 26.6±7.5 | 0.41 | 29.8 ± 4.9 | 0.09 |
Total bilirubin, μmol/L(IQR) | 103.5 (27.5-271.5) | 85 (34.2-196.5) | 0.96 | 59.5 (30.0-129.0) | 0.51 |
INR (IQR) | 1.40 (1.2-2.0) | 1.6 (1.3-2.1) | 0.37 | 1.5 (1.3-1.7) | 0.56 |
Ascites PMN (IQR) | 2550 (338-4700) | 1800 (650-4500) | 0.56 | 550 (302-1375) | 0.004 |
Ascites albumin g/dL (M ± SD) | 18.0±8.2 | 11.4 ± 7.3 | 0.002 | 13.1 ± 9.5 | 0.009 |
Clinical presentation | |||||
Abdominal pain | 7 (31.8%) | 17 (38.6%) | 0.79 | 17 (23.6%) | 0.578 |
Fever (T ≥ 38°C) | 12 (54.5%) | 22 (50.0%) | 0.79 | 19 (26.4%) | 0.02 |
Antibiotic treatment before peritonitis (d) | 15.4 (3.8-24.8) | 2 (0.3-10.0) | 0.001 | 2 (0-8.0) | <0.001 |
PPI administration | 8 (36.4%) | 27 (61.4%) | 0.07 | 43(59.7%) | 0.086 |
Nosocomial infection | 13 (59.1%) | 30 (68.2%) | 0.59 | 44 (61.1%) | 1 |
ICU admission | 1 (4.5%) | 2 (4.5%) | 1 | 1 (1.4%) | 0.42 |
Septic shock n (%) | 7 (31.8%) | 8 (18.2%) | 0.23 | 3 (4.2%) | 0.001 |
SIRS n (%) | 14 (63.6%) | 20 (45.5%) | 0.2 | 14 (19.4%) | <0.001 |
Concomitant bacterial infection | 12 (54.5%) | 13 (29.5%) | 0.12 | 3 (4.2%) | <0.001 |
Blood infection | 6 (27.2%) | 9 (20.5%) | 1 | 1 (1.4%) | <0.001 |
Pneumonia | 3 (13.6%) | 3 (6.8%) | 0.39 | 2 (2.8%) | 0.048 |
Bacterial peritonitis | 9 (40.9%) | - | - | - | - |
Other sites | 1 (4.5%) | 1 (2.3%) | - | 1 (1.4%) | - |
Severity score | |||||
SOFA (M ± SD) | 7.1 ± 3.8 | 7.6 ± 4.7 | 0.65 | 5.2 ± 2.6 | 0.035 |
CLIF-SOFA | 7.1 ± 3.4 | 8.1 ± 4.4 | 0.33 | 5.6 ± 3.0 | 0.048 |
APACHE II | 7.6 ± 6.1 | 6.7 ± 5.4 | 0.58 | 3.0 ± 3.1 | <0.001 |
MELD (IQR) | 15.9 (7.5-25.2) | 18.3 (9.3-25.9) | 0.76 | 14.6 (9.7-20.3) | 0.57 |
MELD-Na (IQR) | 23.0 (10.4-35.1) | 20.4 (9.7-31.1) | 0.88 | 15.5 (10.1-25.0) | 0.17 |
CTP (IQR) | 11.0 (8-12.3) | 11.5 (10.0-12.0) | 0.39 | 10 (9.0-12.0) | 0.48 |
15-d mortality | 10 (45.1%) | 9 (20.4%) | 0.046 | 5 (6.9%) | <0.001 |
- Citation: Huang CH, Pang LT, Xu LC, Ge TT, Xu QM, Chen Z. Risk factors, clinical features, and short-term prognosis of spontaneous fungal peritonitis in cirrhosis: A matched case-control study. World J Clin Cases 2019; 7(17): 2438-2449
- URL: https://www.wjgnet.com/2307-8960/full/v7/i17/2438.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v7.i17.2438