Evaluation of gut dysbiosis using serum and fecal bile acid profiles

Figure 2 Receiver operating characteristic analysis for the prediction of Clostridium difficile infection development in relation to the serum deoxycholic acid (DCA)/(DCA + cholic acid) ratio. AUC: Area under the curve. Sensitivity = true-positive number/(true-positive number + false-negative number); specificity = true-negative number/(true-negative number + false-positive number). The minimum distance from the upper left corner (0, 1) was considered the optimal cut-off value. The cut-off value of DCA/(DCA+CA) was < 0.349 in discriminating high-risk patients with Clostridium difficile infection before treatment with antibiotics. At this value, the sensitivity was 91.67% and the specificity was 66.10%. This figure was adapted from a previously published study[25].