Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2020; 8(16): 3431-3439
Published online Aug 26, 2020. doi: 10.12998/wjcc.v8.i16.3431
Published online Aug 26, 2020. doi: 10.12998/wjcc.v8.i16.3431
Application of molybdenum target X-ray photography in imaging analysis of caudal intervertebral disc degeneration in rats
Qi-Hang Su, Yan Zhang, Bin Shen, Yong-Chao Li, Jun Tan, Department of Orthopedics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China
Author contributions: Su QH designed the research and wrote the paper; Su QH, Zhang Y, Li YC and Shen B performed the research; Su QH and Zhang Y contributed new analytic tools; Su QH and Tan J analyzed the data.
Supported by the National Key Research and Development Program of China , No. 2017YFA0105404 .
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board at Shanghai East Hospital (East Hospital Affiliated to Tongji University) Medical Ethics Committee.
Institutional animal care and use committee statement: Shanghai East Hospital (East Hospital Affiliated to Tongji University) Medical Ethics Committee approved the study protocol, which met the relevant guidelines and regulations of Shanghai Medical Ethics Committee in accordance with internationally accepted principles for the use of laboratory animals.
Conflict-of-interest statement: The authors declare that they have no financial or other conflicts of interest in relation to this research and its publication.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Qi-Hang Su, MD, Doctor, Department of Orthopedics, Shanghai East Hospital, Tongji University School of Medicine, No. 150 Jimo Road, Shanghai 200120, China. 15221378017@163.com
Received: April 30, 2020
Peer-review started: April 30, 2020
First decision: June 4, 2020
Revised: June 9, 2020
Accepted: July 17, 2020
Article in press: July 17, 2020
Published online: August 26, 2020
Peer-review started: April 30, 2020
First decision: June 4, 2020
Revised: June 9, 2020
Accepted: July 17, 2020
Article in press: July 17, 2020
Published online: August 26, 2020
Core Tip
Core tip: Imaging evaluation is a crucial, easy to use, low-cost and effective technique, especially for evaluating intervertebral disc space height, and is the most commonly used quantitative indicator of intervertebral disc degeneration in animal models. However, in rats with small vertebral bodies and narrow intervertebral disc spaces, conventional plain X-ray images have poor definition and low contrast, micro-calcifications are unclear, and the imaging effect on the boundary of the narrow intervertebral disc space is poor. This is the first study to apply molybdenum target X-ray photography to the imaging evaluation of caudal intervertebral disc degeneration in rat models.