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©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2018; 6(6): 121-126
Published online Jun 16, 2018. doi: 10.12998/wjcc.v6.i6.121
Published online Jun 16, 2018. doi: 10.12998/wjcc.v6.i6.121
T-cell/histiocyte-rich large B-cell lymphoma in a child: A case report and review of literature
Chapman Wei, George Washington University School of Medicine and Health Sciences at Washington, DC 20052, United States
Chaplin Wei, St. George’s University School of Medicine, West Indies, Grenada
Omar Alhalabi, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center at Houston, TX 77030, United States
Lei Chen, Department of Pathology and Laboratory Medicine, University of Texas McGovern Medical School at Houston, TX 77030, United States
Author contributions: Chen L designed the study; Alhalabi O and Chen L collected patient’s clinical data; Wei C performed literature search and constructed table; all authors contributed in manuscript preparation.
Informed consent statement: This study was exempted by the IRB Committee for Protection of Human Subjects.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lei Chen, MD, Associate Professor, Department of Pathology and Laboratory Medicine, University of Texas McGovern Medical School at Houston, 6431 Fannin, MSB2.250, Houston, TX 77030, United States. lei.chen.1@uth.tmc.edu
Telephone: +1-713-5005374 Fax: +1-713-5000733
Received: January 12, 2018
Peer-review started: January 14, 2018
First decision: February 9, 2018
Revised: April 8, 2018
Accepted: April 16, 2018
Article in press: April 17, 2018
Published online: June 16, 2018
Peer-review started: January 14, 2018
First decision: February 9, 2018
Revised: April 8, 2018
Accepted: April 16, 2018
Article in press: April 17, 2018
Published online: June 16, 2018
Core Tip
Core tip: We report a case of a 10-year-old boy presenting with intermittent fevers, fatigue, weight loss, and head and neck lymphadenopathy. A cervical lymph node biopsy revealed scattered large neoplastic cells surrounded by small reactive lymphocytes and histiocytes without residual germinal center meshwork. These pathologic features are consistent with T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) which tends to be rare in the pediatric population and can be easily missed leading to inappropriate treatment and poorer outcome. Therefore, THRLBCL should be consisted as a differential diagnosis for persistent lymphadenopathy in the pediatric population.