Castellini G, Castellani W, Lelli L, Sauro CL, Dini C, Lazzeretti L, Bencini L, Mannucci E, Ricca V. Association between resting energy expenditure, psychopathology and HPA-axis in eating disorders. World J Clin Cases 2014; 2(7): 257-264 [PMID: 25032200 DOI: 10.12998/wjcc.v2.i7.257]
Corresponding Author of This Article
Valdo Ricca, MD, Psychiatric Unit, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Largo Brambilla 3, 50134 Firenze, Italy. valdo.ricca@unifi.it
Research Domain of This Article
Psychiatry
Article-Type of This Article
Evidence-Based Medicine
Open-Access Policy of This Article
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World J Clin Cases. Jul 16, 2014; 2(7): 257-264 Published online Jul 16, 2014. doi: 10.12998/wjcc.v2.i7.257
Association between resting energy expenditure, psychopathology and HPA-axis in eating disorders
Giovanni Castellini, Walter Castellani, Lorenzo Lelli, Carolina Lo Sauro, Carla Dini, Lisa Lazzeretti, Lorenza Bencini, Edoardo Mannucci, Valdo Ricca
Giovanni Castellini, Lorenzo Lelli, Lisa Lazzeretti, Lorenza Bencini, Valdo Ricca, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, 50134 Firenze, Italy
Walter Castellani, Department of Respiratory Physiopathology, Palagi Hospital, 50134 Firenze, Italy
Carolina Lo Sauro, Department of Health Science, University of Florence, 50134 Firenze, Italy
Carla Dini, Nutrition Service, University of Florence, 50134 Firenze, Italy
Edoardo Mannucci, Non Invasive Cardiology, Department of Heart and Vessels, University of Florence, 50134 Firenze, Italy
Author contributions: Castellini G, Lelli L and Ricca V contributed equally to this work; Castellini G, Lelli L, Lo Sauro C and Ricca V designed the research; Castellani W, Dini C, Lazzeretti L and Bencini L performed the research; Castellini G and Mannucci E analyzed the data; Castellini G, Lelli L and Ricca V wrote the paper.
Correspondence to: Valdo Ricca, MD, Psychiatric Unit, Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Largo Brambilla 3, 50134 Firenze, Italy. valdo.ricca@unifi.it
Telephone: +39-055-7947487 Fax: +39-055-7947487
Received: April 14, 2014 Revised: May 30, 2014 Accepted: June 18, 2014 Published online: July 16, 2014
Core Tip
Core tip: We have investigated the relationship between resting energy expenditure (REE), eating psychopathology, and hypothalamus adrenal axis in EDs. Twenty two anorexia nervosa (AN) and 21 bulimia nervosa (BN) patients were assessed. Both AN and BN showed a reduced REE as compared with predicted REE. AN and BN showed an opposite pattern of association between REE and Body Mass Index (BMI) which was positively associated with REE in BN, whereas a strong, negative association between BMI and REE was observed in AN. In AN only, a higher REE was associated with a more severe eating disorder psychopathology, and higher cortisol levels. The data supported a mediation model where cortisol levels mediated the relationship between eating psychopathology and REE.
