Case Report
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World J Clin Cases. Jun 16, 2014; 2(6): 228-231
Published online Jun 16, 2014. doi: 10.12998/wjcc.v2.i6.228
Cabazitaxel in castration resistant prostate cancer with brain metastases: 3 case reports
Sabino De Placido, Pasquale Rescigno, Piera Federico, Carlo Buonerba, Davide Bosso, Livio Puglia, Michela Izzo, Tania Policastro, Giuseppe Di Lorenzo
Pasquale Rescigno, Piera Federico, Carlo Buonerba, Davide Bosso, Livio Puglia, Michela Izzo, Tania Policastro, Sabino De Placido, Giuseppe Di Lorenzo, Genitourinary Cancer Section, Medical Oncology, Department of Clinical Medicine, Federico II University, Napoli 80140, Italy
Author contributions: De Placido S and Rescigno P contributed to the drafting of the manuscript; Federico P, Buonerba C, Bosso D, Puglia L, Izzo M and Policastro T contributed to the acquisition of the data; De Placido S and Di Lorenzo G contributed to the critical revision of the manuscript.
Correspondence to: Giuseppe Di Lorenzo, MD, PhD, Genitourinary Cancer Section, Medical Oncology, Department of Clinical Medicine, Federico II University, Corso Umberto I, Napoli 80140, Italy. giuseppedilorenzoncol@hotmail.com
Telephone: +39-081-7463660 Fax: +39-081-2203147
Received: January 5, 2014
Revised: March 31, 2014
Accepted: May 8, 2014
Published online: June 16, 2014
Core Tip

Core tip: Due to the improvement in terms of survival, the incidence of brain metastases (BMs) has increased in patients with metastatic castration resistant prostatic cancer (mCRPC). Despite the large number of treatments now available, the prognosis of patients with BMs is still poor. First, we demonstrate the efficacy of cabazitaxel on brain mestastases in three CRPC patients and then show its profile of tolerability in combination with whole brain radiotherapy.