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World J Clin Cases. Oct 16, 2014; 2(10): 541-545
Published online Oct 16, 2014. doi: 10.12998/wjcc.v2.i10.541
Published online Oct 16, 2014. doi: 10.12998/wjcc.v2.i10.541
HLA antigens in individuals with down syndrome and alopecia areata
Juliany L Estefan, Eliane D Abad, Simone B Saintive, Pediatric Dermatology Service, Martagão Gesteira Pediatric Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-901, Brazil
Juliany L Estefan, Marcia Ribeiro, Medical Genetics Service, Martagão Gesteira Pediatric Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-901, Brazil
Juliana C Oliveira, Luis Cristóvão MS Porto, Histocompatibility and Cryopreservation-HLA Laboratory, State University of Rio de Janeiro, Policlínica Piquet Carneiro/UERJ, Rio de Janeiro, RJ 21941-901, Brazil
Author contributions: Estefan JL contributed to research design, analysis and interpretation of data, drafting the paper and revising it critically; Oliveira JC, Abad ED and Saintive SB contributed to drafting the paper and revising it critically; Porto LCMS contributed to substantial contributions to research conception and design; drafting the paper and revising it critically; Ribeiro M contributed to substantial contributions to research conception and design, analysis and interpretation of data, drafting the paper and revising it critically; all authors contributed to final approval of the version to be published.
Correspondence to: Juliany L Estefan, MD, Msc, Medical Genetics Service, Martagão Gesteira Pediatrics Institute, Federal University of Rio de Janeiro, Rua Bruno Lobo, 50, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ 21941-901, Brazil. ju_estefan@yahoo.com.br
Telephone: +55-21-25626148
Received: April 2, 2014
Revised: June 3, 2014
Accepted: August 27, 2014
Published online: October 16, 2014
Revised: June 3, 2014
Accepted: August 27, 2014
Published online: October 16, 2014
Core Tip
Core tip: The prevalence of alopecia areata (AA) in down syndrome (DS) individuals ranges from 1% to 11%, higher than in general population. The frequency distribution of human leukocyte antigen alleles in the groups was heterogeneous; there was a tendency of alleles A-36 and B-15 in DS group. The cause of AA in DS remains unknown.