Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 16, 2024; 12(11): 1885-1899
Published online Apr 16, 2024. doi: 10.12998/wjcc.v12.i11.1885
Unexpected focal fluorodeoxyglucose uptake in main organs; pass through or pass by?
Haejun Lee, Kyung-Hoon Hwang
Haejun Lee, Kyung-Hoon Hwang, Department of Nuclear Medicine, Gachon University College of Medicine, Gil Medical Center, Incheon 21565, South Korea
Author contributions: Lee H and Hwang KH contributed to this work, designed the editorial, searched the articles, analyzed the data, and wrote the manuscript; Lee H contributed analytic tools; all authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflicting interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kyung-Hoon Hwang, MD, PhD, Professor, Department of Nuclear Medicine, Gachon University College of Medicine, Gil Medical Center, 21 Namdong-daero 774 Beon-gil, Namdong-gu, Incheon 21565, South Korea. forrest88@hanmail.net
Received: December 30, 2023
Peer-review started: December 30, 2023
First decision: January 17, 2024
Revised: January 31, 2024
Accepted: March 21, 2024
Article in press: March 21, 2024
Published online: April 16, 2024
Core Tip

Core Tip: Unexpected incidental focal fluorine-18 fluorodeoxyglucose uptake on positron emission tomography/computed tomography is not an uncommon finding. The nature of this uptake has been the subject of various studies, with outcomes varying depending on the organ in which it manifests. A noteworthy finding from these investigations reveals that over one-third of such uptakes were determined to be malignant. This observation underscores the importance of conducting further examinations in cases where incidental uptake is identified, as it could potentially serve as a crucial indicator for malignancy.