Meta-Analysis
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2022; 10(20): 6927-6935
Published online Jul 16, 2022. doi: 10.12998/wjcc.v10.i20.6927
Prognostic value of computed tomography derived skeletal muscle mass index in lung cancer: A meta-analysis
Xue-Lin Pan, Hong-Jun Li, Zhen Li, Zhen-Lin Li
Xue-Lin Pan, Zhen Li, Zhen-Lin Li, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Hong-Jun Li, West China Hospital of Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Li ZL made substantial contributions to the conception and design of the work; Pan XL and Li HJ searched and selected the materials and extracted the data; Pan XL wrote the manuscript; Pan XL, Li HJ, Li Z, and Li ZL revised the paper carefully and also contributed to the statistical analysis; all authors have read and approved the final manuscript.
Supported by 1·3·5 Project for Disciplines of Excellence, West China Hospital, Sichuan University, No. ZYGD18019.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-Lin Li, MD, Professor, Department of Radiology, West China Hospital, Sichuan University, No. 37 Guoxuexiang, Chengdu 610041, Sichuan Province, China. 17380096151@163.com
Received: December 5, 2021
Peer-review started: December 5, 2021
First decision: January 25, 2022
Revised: January 26, 2022
Accepted: May 22, 2022
Article in press: May 22, 2022
Published online: July 16, 2022
Core Tip

Core Tip: We searched the PubMed, Web of Science, and Embase electronic databases up to November 5, 2021, and a total of 12 studies involving 3002 patients were included. The pooled results demonstrated that a lower skeletal muscle mass index (SMI) was significantly related to poorer overall survival (P < 0.001). In addition, the subgroup analyses stratified by treatment (nonsurgery vs surgery), tumor stage (advanced stage vs early stage), and tumor type (non-small cell lung cancer vs lung cancer) showed similar results. The computed tomography-derived SMI is a novel and valuable prognostic indicator in lung cancer and might contribute to the clinical management and treatment of lung cancer patients.