Meta-Analysis
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2022; 10(20): 6915-6926
Published online Jul 16, 2022. doi: 10.12998/wjcc.v10.i20.6915
Endoscopic submucosal dissection for early signet ring cell gastric cancer: A systematic review and meta-analysis
Chun-Yan Weng, Shao-Peng Sun, Chang Cai, Jing-Li Xu, Bin Lv
Chun-Yan Weng, Shao-Peng Sun, Chang Cai, Department of Gastroenterology, The First Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, China
Jing-Li Xu, Department of Gastrointestinal Surgery, The First Clinical Medical University of Zhejiang Chinese Medical University, Hangzhou 310000, Zhejiang Province, China
Bin Lv, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China
Author contributions: Weng CY, Cai C, and Sun SP collected the data; Weng CY, Xu JL, and Lv B wrote the draft of the article; all authors contributed to offered critical revisions, and have read and approved the manuscript.
Supported by National Natural Science Foundation of China, No. 8177030774.
Conflict-of-interest statement: The authors have no conflicts of interest or financial ties to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bin Lv, MD, Chief Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou 310006, Zhejiang Province, China. lvbin@medmail.com.cn
Received: September 6, 2021
Peer-review started: September 6, 2021
First decision: November 7, 2021
Revised: November 11, 2021
Accepted: April 21, 2022
Article in press: April 21, 2022
Published online: July 16, 2022
Core Tip

Core Tip: Endoscopic submucosal dissection (ESD) is widely used as a curative treatment for early gastric cancer (EGC), whereas its efficacy and safety remain unclear. Totally 653 participants were included in this meta-analysis assessing the therapeutic efficacy and safety of ESD in EGC. Based on the data collected and presented, we conclude that ESD is a promising treatment option for undifferentiated signet ring cell carcinoma EGC. Large, long-term trials are warranted to confirm the current results.