Shu Q, Luo JN, Liu XL, Jing M, Mou TG, Xie F. Extraskeletal Ewing sarcoma of the stomach: A rare case report. World J Clin Cases 2023; 11(1): 201-209 [PMID: 36687198 DOI: 10.12998/wjcc.v11.i1.201]
Corresponding Author of This Article
Fei Xie, PhD, Doctor, Professor, Department of Hepatic-Biliary-Pancreatic Surgery, Neijiang First People’s Hospital Affiliated to Chongqing Medical University, Shizhong District, Neijiang 641000, Sichuan Province, China. whitetower@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Qiang Shu, Jia-Nong Luo, Ting-Gang Mou, Fei Xie, Department of Hepatic-Biliary-Pancreatic Surgery, Neijiang First People’s Hospital Affiliated to Chongqing Medical University, Neijiang 641000, Sichuan Province, China
Xiao-Ling Liu, Department of Hospital Infection Management, Neijiang Hospital of Traditional Chinese Medicine, Neijiang 641000, Sichuan Province, China
Min Jing, Department of Pathology, Neijiang First People’s Hospital Affiliated to Chongqing Medical University, Neijiang 641000, Sichuan Province, China
Author contributions: Xie F designed the report; Shu Q wrote the paper; Luo JN, Liu XL, Mou TG and Jing M collected the patient’s clinical data; all authors have read and approved the final version of this manuscript.
Supported bythe Science and Education Project of Neijiang First People’s Hospital.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fei Xie, PhD, Doctor, Professor, Department of Hepatic-Biliary-Pancreatic Surgery, Neijiang First People’s Hospital Affiliated to Chongqing Medical University, Shizhong District, Neijiang 641000, Sichuan Province, China. whitetower@163.com
Received: October 1, 2022 Peer-review started: October 1, 2022 First decision: October 21, 2022 Revised: November 5, 2022 Accepted: December 21, 2022 Article in press: December 21, 2022 Published online: January 6, 2023
Abstract
BACKGROUND
Extraskeletal Ewing sarcoma (EES) is a rare and highly malignant small round cell tumor associated with a poor clinical outcome. Ewing sarcoma (ES) involving the stomach is an uncommon presentation and can be easily confused with other small round cell tumors. We herein present a rare case of ES involving the gastric area.
CASE SUMMARY
We report a case of gastric ES in a 19-year-old female patient who initially presented with a complaint of a tender epigastric mass for 5 d. Contrast-enhanced abdominal computed tomography revealed a soft-tissue-density mass with a diameter of 8.5 cm between the liver and stomach; the mass was connected to the gastric antrum. Then, the mass was surgically excised completely. Upon histopathological, immunophenotype and molecular analysis, the mass was identified to be a primary gastric ES.
CONCLUSION
EES is an aggressive tumor with poor prognosis. Therefore, early diagnosis and timely intervention are essential for a good prognosis. It is imperative for us to raise awareness about this rare tumor. Surgical resection is still the best treatment option.
Core Tip: Ewing sarcoma (ES) is a rare and highly malignant small round cell tumor. Extraskeletal ES is more common in the paravertebral region, extremities, and retroperitoneum and very rarely occurs in the stomach. Due to its rarity, there are few studies on its clinicopathological characteristics and diagnostic protocols. It is an aggressive tumor with poor prognosis, and therefore, early diagnosis and timely intervention are vital for a good prognosis. Herein, we report on a case of primary gastric ES which was timely resected surgically. This was followed by chemotherapy, which was comprised of alternating vincristine–doxorubicin, cyclophosphamide, and ifosfamide–etoposide every 3 wk. Ultimately, the patient was tumor-free and achieved an excellent prognosis.
