Measurement of body composition as a surrogate evaluation of energy balance in obese patients

Figure 1 Physical activity increases the intramuscular expression of the membrane protein fibronectin type III domain containing 5 (FNDC5) which is cleaved to form Irisin, a myokin. Irisin may stimulate the transformation of white adipocytes into brite cells, thus suggested by a marked increase in the expression of uncoupling protein 1 (UCP-1). Adapted from Pedersen[82].