Choosing inclusion criteria that minimize the time and cost of clinical trials

Figure 5 Cost estimates in a model study of heterogeneous responders. Cost constants in thousands of dollars are as follows: screening cost per case c₁ = 1, treatment cost c₂ = 10, opportunity cost c₃ = 100/yr, case rate r = 50/yr, follow up time t =1 yr. Other details as in Figure 4.