Re-analysis of hepatitis B virus integration sites reveals potential new loci associated with oncogenesis in hepatocellular carcinoma

Figure 2 Integration breakpoints at chromosome 11. A: Circos plot of breakpoints at chromosome 11 in the human reference genomes; B: Integration breakpoints around 11q13.3 in relation to coding genes retrieved from Ensembl. Red represents tumor samples, and blue represents non-tumor samples; C: Comparison of integration breakpoints around 11q13.3 in the tumor samples. Actual represents actual number of integration breakpoints. Expected represents expected number of integration breakpoints assuming random distribution; D: Copy number of liver cancer samples from cBioPortal[18,19]. Red represents amplification, and blue represents deletion. E: Distribution of the number of fragments that provide breakend for the variant allele. T: Tumor; NT: Non-tumor.