Protein-protein interactions: Methods, databases, and applications in virus-host study

Figure 3 Protein interaction networks can help find new disease-related genes. The concept depicts that diseases 1, 2, and 3 are caused subsequently by genes A, C, and E, and the genes causing disease 4 are unknown but disease 4 is phenotypically associated with diseases 1, 2, and 3. If the known genes, i.e., A, C, and E are closely associated functionally, it can be hypothesized that genes B and D are the cause of disease 4[86].