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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Virology. Nov 12, 2014; 3(4): 22-29
Published online Nov 12, 2014. doi: 10.5501/wjv.v3.i4.22
Published online Nov 12, 2014. doi: 10.5501/wjv.v3.i4.22
Nuclear factor κB represses the expression of latent membrane protein 1 in Epstein-Barr virus transformed cells
Mingxia Cao, Qianli Wang, Amy Lingel, Luwen Zhang, School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, United States
Luwen Zhang, 238 Morrison Center, School of Biological Sciences, Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68583-0900, United States
Author contributions: All authors contributed to this paper.
Supported by Grants from the NIH CA138213, RR15635, and Department of Defense W81XWH-12-1-0225 (Luwen Zhang); Qianli Wang was partially supported by Undergraduate Creative Activities and Research Experiences and Beckman Scholars Program
Correspondence to: Luwen Zhang, PhD, 238 Morrison Center, School of Biological Sciences, Nebraska Center for Virology, University of Nebraska, 4240 Fair St., Lincoln, NE 68583-0900, United States. lzhang2@unl.edu
Telephone: +1-402-4725905 Fax: +1-402-4723323
Received: April 15, 2014
Revised: July 14, 2014
Accepted: September 18, 2014
Published online: November 12, 2014
Revised: July 14, 2014
Accepted: September 18, 2014
Published online: November 12, 2014
Core Tip
Core tip: We find a classical feedback inhibition of Epstein Barr virus (EBV) Latent membrane protein 1 (LMP1) and nuclear factor κB (NF-κB): LMP1 activates NF-κB, and NF-κB inhibits LMP1 expression. The regulatory loop may benefit EBV transformation processes.