Systematic Reviews
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Virol. Mar 25, 2024; 13(1): 88946
Published online Mar 25, 2024. doi: 10.5501/wjv.v13.i1.88946
Outcomes of liver resection in hepatitis C virus-related intrahepatic cholangiocarcinoma: A systematic review and meta-analysis
Feng Yi Cheo, Kai Siang Chan, Vishal G Shelat
Feng Yi Cheo, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
Kai Siang Chan, Vishal G Shelat, Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore
Author contributions: Cheo FY conception and design of the study, acquisition of data, analysis and interpretation of data, drafting the article, revising the article, final approval; Chan KS conception and design of the study, acquisition of data, analysis and interpretation of data, drafting the article, critical revision, final approval; Shelat VG interpretation of data, revising the article, critical revision, final approval.
Conflict-of-interest statement: The authors deny any conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kai Siang Chan, MBBS, Doctor, Department of General Surgery, Tan Tock Seng Hospital, No. 11 Jalan Tan Tock Seng, Singapore 308433, Singapore. kchan023@e.ntu.edu.sg
Received: October 16, 2023
Peer-review started: October 16, 2023
First decision: November 2, 2023
Revised: November 10, 2023
Accepted: December 28, 2023
Article in press: December 28, 2023
Published online: March 25, 2024
Core Tip

Core Tip: Impact of hepatitis C virus (HCV) infection on survival outcomes in patients with intrahepatic cholangiocarcinoma (ICC) undergoing curative resection remains unclear. This is the first systematic review and meta-analysis comparing outcomes of surgical resection of ICC in HCV-positive patients vs HCV-negative patients. Our primary outcomes include overall survival (OS) and recurrence-free survival; secondary outcomes include perioperative mortality, operation duration, blood loss and recurrence. Our review and analysis demonstrated worse OS in HCV-positive patients compared to HCV-negative patients.