Thrombotic microangiopathy after renal transplantation: Current insights in de novo and recurrent disease

Figure 5 Treatment of complement factor H autoantibody-mediated atypical hemolytic uremic syndrome. There are no prospective controlled studies in patients with atypical hemolytic uremic syndrome (aHUS) due to anti–factor H protein (FH) antibodies, and thus the proposed management is based on a pediatric consensus[84] (Adapted from: Goodship et al[58]). ^aAbnormal titer depends on the testing laboratory; ^bThe decision to use plasma therapy versus eculizumab will be based on patient age and local resource availability; ^cCyclophosphamide, rituximab, or mycophenolate mofetil; ^dThe decision to continue anticomplement therapy indefinitely is not informed by data; ^eThe interval may be monthly or quarterly and is based on local resources; ^fThis recommendation is based on limited retrospective case reviews[172-174].