Reducing transfusion requirements in liver transplantation

Figure 10 Effect of plasma dilution and factor deficiency on thrombin generation and fibrin clot formation. Representative curves of tissue factor - induced thrombin generation (A-C) and fibrin clot formation (D-F) of undiluted normal plasma (undil.), 5 × diluted plasma (dil.), and plasma from patient taking oral anticoagulants (OAC, INR = 4). Effects of supplementing diluted plasma with fibrinogen concentrate (+ FC): Increase in clot strength with no effect on thrombin generation (B, E). Effects of supplementing diluted plasma with prothrombin complex concentrate (+ PCC): Increase in thrombin generation but no effect on clot strength (C, F). From Schols[105] 2010. OAC: Oral anticoagulatnts; INR: International normalized ratio.