Journey of a patient with scleroderma from renal failure up to kidney transplantation

Figure 1 Pathology of scleroderma renal crisis. A: Normotensive patient with systemic sclerosis (SS) and acute renal failure. End-stage renal disease: Crescentic glomerulonephritis showing fibrous crescents. A mixed mononuclear cell infiltrate and considerable tubular loss[21,70] (Open access); B: Masson’s trichrome staining of a digital artery from a patient with SS[21,70] (Open access); C: Hematoxylin and eosin staining of a renal artery from a patient with SS. Note the striking fibrotic intimal hyperplasia and the adventitial fibrosis in the digital artery and the onion skin–like intimal thickening composed of smooth muscle cells and increased connective tissue matrix in the renal artery. The intimal hyperplasia results in critical luminal narrowing and even occlusion[21,70] (Open access). Citation: Soukup T, Toms J, Oreska S, Honsova E, Safranek R. Renal Involvement in Systemic Sclerosis, 9 July 2019. Copyright© The Authors 2019. Published by Open access peer-reviewed chapter. Matucci-Cerinic M, Kahaleh B, Wigley FM. Review: evidence that systemic sclerosis is a vascular disease. Arthritis Rheum 2013; 65: 1953-1962. Copyright© The Authors 2013. Published by Wiley Online Library.