Gene environment interaction in periphery and brain converge to modulate behavioral outcomes: Insights from the SP1 transient early in life interference rat model

Figure 1 Brain and periphery combined effects modulate behavior in the specificity protein 1 rat model. Early in life transient interference with specificity protein 1 activity by mithramycin and later in life exposure to chronic stress, affect availability of tryptophan (Trp) to the brain, both by reducing serum Trp ratio and brain LAT1 expression. Deficits in brain Trp levels may affect behavior. LAT1: BBB transporter.