Voxel-based magnetic resonance imaging investigation of poor and preserved clinical insight in people with schizophrenia

Table 2 Group differences in grey matter volumes (height threshold P < 0.005)

Groups	BA	Size	Side	MNI			T value	Cluster P FWE-corrected unless in italics	Voxel P FWE-corrected
				X	Y	Z
Insight+ > Insight- patients
Superior temporal gyrus	22	46555	R	63	-3	5	4.91	0.001	0.020
				45	20	-33	4.74		0.034
				66	-8	4	4.68		0.040
Precentral gyrus	4			66	-5	22	4.55		0.057
Inferior frontal gyrus	47			54	19	0	4.52		0.063
Precentral gyrus	6			64	0	26	4.40		0.088
Postcentral gyrus	43			66	-8	16	4.33		0.106
parahippocampus	28			14	0	-27	4.07		0.406
Inferior frontal gyrus	47	103898	L	-41	15	-6	4.81	< 0.001	0.027
Middle frontal gyrus	9			-37	19	35	4.74		0.034
Inferior frontal gyrus	47			-37	15	-10	4.73		0.035
				-35	20	-10	4.54		0.059
Precentral gyrus	44			-59	8	7	4.39		0.091
Superior temporal gyrus	22			-62	-4	8	4.36		0.097
Precentral gyrus	6			-60	4	6	4.33		0.107
Middle temporal gyrus	21			-35	-3	-23	4.27		0.126
parahippocampal gyrus	20			-34	-5	-28	4.16		0.166
Cuneus	18	35993	L	-5	-83	5	4.43	0.003	0.082
Cerebellum	-		R	35	-90	-17	4.26		0.129
Cuneus	18		R	26	-93	-18	3.90		0.305
Cerebellum	-		R	4	-61	2	3.88		0.317
Cuneus	18		R	5	-98	10	3.50		0.630
			R	5	-96	3	3.44		0.674
Cerebellum	-		L	-36	-82	-15	3.38		0.730
Insight- > Insight+ patients
Nil significant
Healthy controls > Insight- patients
Inferior frontal gyrus	47	35300	L	-49	19	-3	4.63	0.004	0.046
Superior temporal gyrus	22			-60	1	3	4.30		0.115
Inferior frontal gyrus	47			-41	18	-5	4.21		0.144
				-38	22	-8	4.19		0.153
				-36	-1	-14	3.86		0.333
Inferior temporal gyrus	20			-28	-14	-41	3.61		0.530
Parahippocamal gyrus	34			-13	4	-23	3.58		0.552
Middle frontal gyrus	11			-42	40	-19	3.39		0.722
Inferior occipital gyrus	18	11168	L	-38	-92	-2	4.51	0.034	0.065
Middle occipital gyrus	19			-52	-76	-10	4.29		0.117
				-48	-80	-14	3.96		0.266
				-49	-81	7	3.90		0.302
Middle temporal gyrus	39/			-53	-72	22	3.37		0.740
	19			-52	-74	18	3.33		0.768
				-49	-76	20	3.29		0.797
Cerebellum	-	25235	R	35	-90	-17	4.46	0.016	0.074
(posterior lobe)				11	-90	-37	4.21		0.146
Occipital lobe	18			23	-94	-18	4.01		0.238
Cerebellum				34	-85	-40	3.93		0.355
(posterior lobe)				38	-82	-41	3.91		0.489
Insight- patients > healthy controls
Nil significant
Healthy control > Insight+ patients
Nil significant
Insight+ patients > healthy controls
Nil significant

BA: Brodmann area; L: Left; R: Right; MNI: Montreal Neurological Institute.