Failure of memantine to “reverse” quinpirole-induced hypomotility

Figure 3 Time course of quinpirole effect on motor activity after 24 h chronic imipramine and memantine withdrawal. Long movements (A), rearing (B) and short movements (C) measured as indicated in the materials and methods: Motor activity. Each value represents the mean ± SEM from 10 rats: vehicle + quinpirole (VEH Q), memantine + quinpirole (MEM Q), imipramine + quinpirole (IMI Q). A, B: ^bP < 0.01 imipramine-quinpirole vs vehicle-quinpirole and memantine-quinpirole; C: ^aP < 0.05 imipramine-quinpirole vs memantine-quinpirole (ANOVA followed by F test for contrast; horizontal lines represent contrast involving consecutive times).