Failure of memantine to “reverse” quinpirole-induced hypomotility

Figure 1 Spontaneous motor activity after 24 h discontinuation of chronic treatments (60 min habituation to the motility cage). Each value represents the mean ± SEM from 20 rats: Vehicle (VEH), memantine (MEM), imipramine (IMI). Number of long movements (A), rearing (B) and short movements (C) measured as indicated in the materials and methods: Motor activity. A: ^fP < 0.001, memantine vs vehicle [F (1.51) = 12.21; P = 0.0009]; ^bP < 10^-6, imipramine vs vehicle [F (1.51) = 31.71; P = 0.000001]; B: ^dP < 0.01, memantine vs vehicle [F (1.51) = 10.58; P = 0.0020]; ^hP < 10^-4, imipramine vs vehicle [F (1.51) = 19.90; P = 0.000045]; C: ^dP < 0.01, memantine vs vehicle [F (1.51) = 11.57; P = 0.0013]; ^dP < 0.01, imipramine vs vehicle [F (1.51) = 10.13; P = 0.0024]; ANOVA followed by Newman-Keuls-test.