Neuronal networks in mental diseases and neuropathic pain: Beyond brain derived neurotrophic factor and collapsin response mediator proteins

Figure 2 Localized interregional connectivity. Diagram shows pathway connections of hippocampus (blue), amygdala (dark red), thalamus (orange) and prefrontal cortex (green). HippoC-PFC pathway originating from the subiculum and the CA1 of the hippocampus to the PFC is unidirectional, direct in a monosynaptic manner in rodents and primates. HippoC-AmyG pathway shows bidirectional connection between ventral HippoC with AmyG and the pathway AmyG-PFC has also bidirectional connections. Together, both the HippoC and PFC are reciprocally connected with the AmyG and disruption of these pathways, anatomically or functionally may be a common origin of mental diseases. Moreover, there are bidirectional connections between PFC/HippoC with Thalamus. PFC: Prefrontal cortex.