Isotretinoin was not associated with depression or anxiety: A twelve-week study

Table 5 Correlation matrix of the patient and physician assessments of the acne severity change and the depression and anxiety scores during treatment

Treatment group		Depression score(week 6)	Depression score(week 12)	Anxiety score(week 6)	Anxiety score(week 12)
ITT	Patient evaluation vs	-0.31 (0.067)	-0.43 (0.009)1	-0.43 (0.01)1	-0.38 (0.02)1
	Physician evaluation vs	-0.28 (0.1)	-0.33 (0.049)1	-0.35 (0.03)1	-0.32 (0.057)
OT	Patient evaluation vs	-0.1 (0.6)	-0.-08 (0.7)	-0.3 (0.9)	0.25 (0.2)
	Physician evaluation vs	-0.15 (0.5)	-0.18 (0.4)	-0.03 (0.9)	-0.08 (0.7)

The assessment in acne severity change was conducted with a Likert-type scale ranging from severely worst = 1 to very much improved = 7. Values are the Pearson correlation coefficient and its associated probability in parentheses.

¹Significant association. OT: Other treatments; ITT: Isotretinoine.