Isotretinoin was not associated with depression or anxiety: A twelve-week study

Table 4 Correlation matrix between the physician assessment of the acne severity at baseline and the depression and anxiety scores before and during treatment

Treatment group		Depression score (baseline)	Depression score (week 6)	Depression score (week 12)	Anxiety score (baseline)	Anxiety score (week 6)	Anxiety score (week 12)
ITT	PAB vs	0.1 (0.4)	0.08 (0.6)	0.02 (0.9)	0.1 (0.5)	0.1 (0.4)	0.05 (0.8)
OT	PAB vs	0.48 (0.01)1	0.5 (0.01)1	0.5 (0.01)1	0.25 (0.2)	0.39 (0.054)	0.37 (0.07)

PAB: Physician assessment of acne severity at baseline with a scale ranging from minimal = 0 to very severe = 5. Values are the Pearson correlation coefficient and its associated probability in parentheses.

¹Significant association. OT: Other treatments; ITT: Isotretinoine.