Isotretinoin was not associated with depression or anxiety: A twelve-week study

Table 3 Depression and anxiety levels at baseline and during treatment

ITT				OT
Depression scores
	Basal	Week 6	Week 12	Basal	Week 6	Week 12
GeDep scale1	38.3 ± 2.5	38.1 ± 2.3	36.8 ± 2.3	36.9 ± 3.1	34.9 ± 2.9	34.9 ± 2.9
Zung scale2	35.2 ± 1.3	33.8 ± 1.4	34.2 ± 1.4	34.9 ± 1.6	34.6 ± 1.7	35.0 ± 1.7
Anxiety scores
	Basal	Week 6	Week 12	Basal	Week 6	Week 12
GegDep scale3	43.3 ± 2.4	41.9 ± 2.3	40.8 ± 2.3	40.9 ± 2.9	38.1 ± 2.9	36.8 ± 2.9
Zung scale4	37.2 ± 1.1	36.7 ± 1.4	36.6 ± 1.6	34.5 ± 1.4	32.4 ± 1.7	32.8 ± 1.9

Values represent mean ± SD scores in the depression and anxiety scales.

¹Within-subject effect: F (2) = 0.5, P = 0.6; between-subject effect: F (1) = 0.3, P = 0.6;

²Within-subject effect: F (2) = 0.6, P = 0.6; between-subject effect: F (1) = 0.6, P = 0.5;

³Within-subject effect: F (2) = 0.5, P = 0.6; between-subject effect: F (1) = 0.9, P = 0.4;

⁴Within-subject effect: F (2) = 0.8, P = 0.5; between-subject effect: F (1) = 3.1, P = 0.09. OT: Other treatments; ITT: Isotretinoine.