Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up

Figure 2 Group (The Irritability Criterion with irritability vs No irritability) in relation to relative proportion of Pathognomonic Mania Ratio - Non-Specific Mania Ratio: Positive score 0 to +1. 0 links irritability to pathognomonic mania rather than non- specific mania and negative score -1.0 to 0 links the irritability status with non- specific mania rather than pathognomonic mania: Entire Model Random Regression Methods (df 3, 2523; F = 17.7; P < 0.0001). All Variables (Group status, assessments time, and the changes of group status over time) were linked to RP changes (effect of Irritability Status: F = 27.3; P < 0.0001; effect of Time: F = 32.5; P < 0.0001, and interaction of Irritability × Time: F = 4.3; P < 0.04). Irritability is linked at all time points with greater NSM than PM, and the linkage increases over time. Yes: Irritability present; No: Irritability not present. RP: Relative proportion; PM: Pathognomonic mania; NSM: Non- specific mania; ADHD: Attention deficit hyperactivity disorder; LNCG: Local normative comparison group; RRM: Random regression methods.