Role of presynaptic phosphoprotein synapsin II in schizophrenia

Figure 3 Illustrated depiction of a synaptic vesicle and associated pre-synaptic membrane. This is a simplified depiction containing proteins and neurotransmitters that are most pertinent to the subject matter of this review; others have been omitted for simplicity sake (ex. Synapsin I, various transporter proteins, etc.). ¹Vesicular transporters (also specific to the type and function of synapse) may include: VGLUT1, VGLUT2, VGAT and VMAT2; ²Various synapsin isoforms have been implicated in the tethering of synaptic vesicles (depending on the type of neurotransmitter and vesicular transporters associated). Synapsin isoforms include Ia-b, IIa-b, and IIa-e; ³Neurotransmitters contain within synaptic vesicle, may include: glutamate, GABA, DA, etc. VGLUT: Vesicular glutamate transporter; VGAT: Vesicular GABA transporter; VMAT2: Vesicular monoamine transporter 2; GABA: γ-aminobutyric acid.