Psychiatric aspects of brain tumors: A review

Table 3 Brain tumors and manic symptoms[41]

Ref.	Psychiatric symptoms	Tumor location	Tumor type	Remarks
Bhatia et al[76], 2013	Visual hallucinations, grandiosity, excessive talking, elated mood	Third ventricle	Neuroepithelial cyst	Psychiatric symptoms and diagnosis of brain tumor with no development of neurologic symptoms
Yetimalar et al[77], 2007	Personality change, psychomotor agitation, enhanced talkativeness and sex drive, decreased need for sleep	Pons	Cavernous angioma	Neurologic symptoms developed after the brain tumor was diagnosed
Ghaziuddin et al[31], 1999	Depressed mood, mania, suicidal ideation, irritability, guilt, grandiosity, early insomnia, olfactory hallucinations	Brainstem (ponto-mesencephalic)	Astrocytoma	Improvement with ECT
Mazure et al[78], 1999	Late-onset manic episode with psychotic features; no neurologic signs	Right temporal lobe	Glioblastoma multiforme	Good and rapid response of psychiatric symptoms to perphenazine
Filley et al[8], 1995	New-onset manic symptoms	Bitemporal	Glioblastoma multiforme
Mark et al[79], 1991	Treatment-resistant bipolar disorder	Acoustic nerve	Neurinoma	Symptoms resolved completely after tumor resection
Greenberg et al[29], 1988	Manic symptoms	Brainstem	Metastases, origin unknown
Jamieson et al[17], 1979	Mania	Right occipital, temporal and parietal lobes	Metastatic tumors- unknown primary source
Scherrer et al[72], 1974	Recurrent manic episodes	Frontal	Unknown
Avery[74], 1971	Mania, euphoria	Olfactory nerve	Meningioma	Some residual psychiatric disturbance following resection

Adapted from Trends in Brain Cancer Research. New York: Nova Science Publishers Inc., 2006. ECT: Emission computed tomography; CT: Computed tomography.