Platelets and Alzheimer’s disease: Potential of APP as a biomarker

Figure 1 Schematic diagram of the amyloid precursor protein. The diagram represents the structural domain arrangement of the amyloid precursor protein (APP) gene products. All domains are expressed in the APP₇₇₀ isoform. The OX-2 domain is missing in APP₇₅₁, whereas both the Kunitz protease inhibitor domain (KPI) and the OX-2 domain are missing in APP₆₉₅. SP: Signal peptide; E1: Ectodomain 1; E2: Ectodomain 2; TMD: Transmembrane domain; CD: Cytosolic domain; OX-2: Domain with homology to OX-2 leukocyte antigen; Ex 15: Exon 15 product; HB: Heparin-binding domain; MB: Metal ion-binding domain.